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Revised Framingham Stroke Risk Profile to Reflect Temporal Trends
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| Zeitschriftentitel: | Circulation |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , , , , , , |
| In: | Circulation, 135, 2017, 12, S. 1145-1159 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Ovid Technologies (Wolters Kluwer Health)
|
| Schlagwörter: |
| author_facet |
Dufouil, Carole Beiser, Alexa McLure, Leslie A. Wolf, Philip A. Tzourio, Christophe Howard, Virginia J. Westwood, Andrew J. Himali, Jayandra J. Sullivan, Lisa Aparicio, Hugo J. Kelly-Hayes, Margaret Ritchie, Karen Kase, Carlos S. Pikula, Aleksandra Romero, Jose R. D’Agostino, Ralph B. Samieri, Cécilia Vasan, Ramachandran S. Chêne, Genevieve Howard, George Seshadri, Sudha Dufouil, Carole Beiser, Alexa McLure, Leslie A. Wolf, Philip A. Tzourio, Christophe Howard, Virginia J. Westwood, Andrew J. Himali, Jayandra J. Sullivan, Lisa Aparicio, Hugo J. Kelly-Hayes, Margaret Ritchie, Karen Kase, Carlos S. Pikula, Aleksandra Romero, Jose R. D’Agostino, Ralph B. Samieri, Cécilia Vasan, Ramachandran S. Chêne, Genevieve Howard, George Seshadri, Sudha |
|---|---|
| author |
Dufouil, Carole Beiser, Alexa McLure, Leslie A. Wolf, Philip A. Tzourio, Christophe Howard, Virginia J. Westwood, Andrew J. Himali, Jayandra J. Sullivan, Lisa Aparicio, Hugo J. Kelly-Hayes, Margaret Ritchie, Karen Kase, Carlos S. Pikula, Aleksandra Romero, Jose R. D’Agostino, Ralph B. Samieri, Cécilia Vasan, Ramachandran S. Chêne, Genevieve Howard, George Seshadri, Sudha |
| spellingShingle |
Dufouil, Carole Beiser, Alexa McLure, Leslie A. Wolf, Philip A. Tzourio, Christophe Howard, Virginia J. Westwood, Andrew J. Himali, Jayandra J. Sullivan, Lisa Aparicio, Hugo J. Kelly-Hayes, Margaret Ritchie, Karen Kase, Carlos S. Pikula, Aleksandra Romero, Jose R. D’Agostino, Ralph B. Samieri, Cécilia Vasan, Ramachandran S. Chêne, Genevieve Howard, George Seshadri, Sudha Circulation Revised Framingham Stroke Risk Profile to Reflect Temporal Trends Physiology (medical) Cardiology and Cardiovascular Medicine |
| author_sort |
dufouil, carole |
| spelling |
Dufouil, Carole Beiser, Alexa McLure, Leslie A. Wolf, Philip A. Tzourio, Christophe Howard, Virginia J. Westwood, Andrew J. Himali, Jayandra J. Sullivan, Lisa Aparicio, Hugo J. Kelly-Hayes, Margaret Ritchie, Karen Kase, Carlos S. Pikula, Aleksandra Romero, Jose R. D’Agostino, Ralph B. Samieri, Cécilia Vasan, Ramachandran S. Chêne, Genevieve Howard, George Seshadri, Sudha 0009-7322 1524-4539 Ovid Technologies (Wolters Kluwer Health) Physiology (medical) Cardiology and Cardiovascular Medicine http://dx.doi.org/10.1161/circulationaha.115.021275 <jats:sec> <jats:title>Background:</jats:title> <jats:p>Age-adjusted stroke incidence has decreased over the past 50 years, likely as a result of changes in the prevalence and impact of various stroke risk factors. An updated version of the Framingham Stroke Risk Profile (FSRP) might better predict current risks in the FHS (Framingham Heart Study) and other cohorts. We compared the accuracy of the standard (old) and of a revised (new) version of the FSRP in predicting the risk of all-stroke and ischemic stroke and validated this new FSRP in 2 external cohorts, the 3C (3 Cities) and REGARDS (Reasons for Geographic and Racial Differences in Stroke) studies.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>We computed the old FSRP as originally described and a new model that used the most recent epoch-specific risk factor prevalence and hazard ratios for individuals ≥55 years of age and for the subsample ≥65 years of age (to match the age range in REGARDS and 3C studies, respectively) and compared the efficacy of these models in predicting 5- and 10-year stroke risks.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p> The new FSRP was a better predictor of current stroke risks in all 3 samples than the old FSRP (calibration χ <jats:sup>2</jats:sup> of new/old FSRP: in men: 64.0/12.1, 59.4/30.6, and 20.7/12.5; in women: 42.5/4.1, 115.4/90.3, and 9.8/6.5 in FHS, REGARDS, and 3C, respectively). In the REGARDS, the new FSRP was a better predictor among whites compared with blacks. </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>A more contemporaneous, new FSRP better predicts current risks in 3 large community samples and could serve as the basis for examining geographic and racial differences in stroke risk and the incremental diagnostic utility of novel stroke risk factors.</jats:p> </jats:sec> Revised Framingham Stroke Risk Profile to Reflect Temporal Trends Circulation |
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10.1161/circulationaha.115.021275 |
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Circulation |
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| title |
Revised Framingham Stroke Risk Profile to Reflect Temporal Trends |
| title_unstemmed |
Revised Framingham Stroke Risk Profile to Reflect Temporal Trends |
| title_full |
Revised Framingham Stroke Risk Profile to Reflect Temporal Trends |
| title_fullStr |
Revised Framingham Stroke Risk Profile to Reflect Temporal Trends |
| title_full_unstemmed |
Revised Framingham Stroke Risk Profile to Reflect Temporal Trends |
| title_short |
Revised Framingham Stroke Risk Profile to Reflect Temporal Trends |
| title_sort |
revised framingham stroke risk profile to reflect temporal trends |
| topic |
Physiology (medical) Cardiology and Cardiovascular Medicine |
| url |
http://dx.doi.org/10.1161/circulationaha.115.021275 |
| publishDate |
2017 |
| physical |
1145-1159 |
| description |
<jats:sec>
<jats:title>Background:</jats:title>
<jats:p>Age-adjusted stroke incidence has decreased over the past 50 years, likely as a result of changes in the prevalence and impact of various stroke risk factors. An updated version of the Framingham Stroke Risk Profile (FSRP) might better predict current risks in the FHS (Framingham Heart Study) and other cohorts. We compared the accuracy of the standard (old) and of a revised (new) version of the FSRP in predicting the risk of all-stroke and ischemic stroke and validated this new FSRP in 2 external cohorts, the 3C (3 Cities) and REGARDS (Reasons for Geographic and Racial Differences in Stroke) studies.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Methods:</jats:title>
<jats:p>We computed the old FSRP as originally described and a new model that used the most recent epoch-specific risk factor prevalence and hazard ratios for individuals ≥55 years of age and for the subsample ≥65 years of age (to match the age range in REGARDS and 3C studies, respectively) and compared the efficacy of these models in predicting 5- and 10-year stroke risks.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results:</jats:title>
<jats:p>
The new FSRP was a better predictor of current stroke risks in all 3 samples than the old FSRP (calibration χ
<jats:sup>2</jats:sup>
of new/old FSRP: in men: 64.0/12.1, 59.4/30.6, and 20.7/12.5; in women: 42.5/4.1, 115.4/90.3, and 9.8/6.5 in FHS, REGARDS, and 3C, respectively). In the REGARDS, the new FSRP was a better predictor among whites compared with blacks.
</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusions:</jats:title>
<jats:p>A more contemporaneous, new FSRP better predicts current risks in 3 large community samples and could serve as the basis for examining geographic and racial differences in stroke risk and the incremental diagnostic utility of novel stroke risk factors.</jats:p>
</jats:sec> |
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| author | Dufouil, Carole, Beiser, Alexa, McLure, Leslie A., Wolf, Philip A., Tzourio, Christophe, Howard, Virginia J., Westwood, Andrew J., Himali, Jayandra J., Sullivan, Lisa, Aparicio, Hugo J., Kelly-Hayes, Margaret, Ritchie, Karen, Kase, Carlos S., Pikula, Aleksandra, Romero, Jose R., D’Agostino, Ralph B., Samieri, Cécilia, Vasan, Ramachandran S., Chêne, Genevieve, Howard, George, Seshadri, Sudha |
| author_facet | Dufouil, Carole, Beiser, Alexa, McLure, Leslie A., Wolf, Philip A., Tzourio, Christophe, Howard, Virginia J., Westwood, Andrew J., Himali, Jayandra J., Sullivan, Lisa, Aparicio, Hugo J., Kelly-Hayes, Margaret, Ritchie, Karen, Kase, Carlos S., Pikula, Aleksandra, Romero, Jose R., D’Agostino, Ralph B., Samieri, Cécilia, Vasan, Ramachandran S., Chêne, Genevieve, Howard, George, Seshadri, Sudha, Dufouil, Carole, Beiser, Alexa, McLure, Leslie A., Wolf, Philip A., Tzourio, Christophe, Howard, Virginia J., Westwood, Andrew J., Himali, Jayandra J., Sullivan, Lisa, Aparicio, Hugo J., Kelly-Hayes, Margaret, Ritchie, Karen, Kase, Carlos S., Pikula, Aleksandra, Romero, Jose R., D’Agostino, Ralph B., Samieri, Cécilia, Vasan, Ramachandran S., Chêne, Genevieve, Howard, George, Seshadri, Sudha |
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| description | <jats:sec> <jats:title>Background:</jats:title> <jats:p>Age-adjusted stroke incidence has decreased over the past 50 years, likely as a result of changes in the prevalence and impact of various stroke risk factors. An updated version of the Framingham Stroke Risk Profile (FSRP) might better predict current risks in the FHS (Framingham Heart Study) and other cohorts. We compared the accuracy of the standard (old) and of a revised (new) version of the FSRP in predicting the risk of all-stroke and ischemic stroke and validated this new FSRP in 2 external cohorts, the 3C (3 Cities) and REGARDS (Reasons for Geographic and Racial Differences in Stroke) studies.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>We computed the old FSRP as originally described and a new model that used the most recent epoch-specific risk factor prevalence and hazard ratios for individuals ≥55 years of age and for the subsample ≥65 years of age (to match the age range in REGARDS and 3C studies, respectively) and compared the efficacy of these models in predicting 5- and 10-year stroke risks.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p> The new FSRP was a better predictor of current stroke risks in all 3 samples than the old FSRP (calibration χ <jats:sup>2</jats:sup> of new/old FSRP: in men: 64.0/12.1, 59.4/30.6, and 20.7/12.5; in women: 42.5/4.1, 115.4/90.3, and 9.8/6.5 in FHS, REGARDS, and 3C, respectively). In the REGARDS, the new FSRP was a better predictor among whites compared with blacks. </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>A more contemporaneous, new FSRP better predicts current risks in 3 large community samples and could serve as the basis for examining geographic and racial differences in stroke risk and the incremental diagnostic utility of novel stroke risk factors.</jats:p> </jats:sec> |
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| spelling | Dufouil, Carole Beiser, Alexa McLure, Leslie A. Wolf, Philip A. Tzourio, Christophe Howard, Virginia J. Westwood, Andrew J. Himali, Jayandra J. Sullivan, Lisa Aparicio, Hugo J. Kelly-Hayes, Margaret Ritchie, Karen Kase, Carlos S. Pikula, Aleksandra Romero, Jose R. D’Agostino, Ralph B. Samieri, Cécilia Vasan, Ramachandran S. Chêne, Genevieve Howard, George Seshadri, Sudha 0009-7322 1524-4539 Ovid Technologies (Wolters Kluwer Health) Physiology (medical) Cardiology and Cardiovascular Medicine http://dx.doi.org/10.1161/circulationaha.115.021275 <jats:sec> <jats:title>Background:</jats:title> <jats:p>Age-adjusted stroke incidence has decreased over the past 50 years, likely as a result of changes in the prevalence and impact of various stroke risk factors. An updated version of the Framingham Stroke Risk Profile (FSRP) might better predict current risks in the FHS (Framingham Heart Study) and other cohorts. We compared the accuracy of the standard (old) and of a revised (new) version of the FSRP in predicting the risk of all-stroke and ischemic stroke and validated this new FSRP in 2 external cohorts, the 3C (3 Cities) and REGARDS (Reasons for Geographic and Racial Differences in Stroke) studies.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>We computed the old FSRP as originally described and a new model that used the most recent epoch-specific risk factor prevalence and hazard ratios for individuals ≥55 years of age and for the subsample ≥65 years of age (to match the age range in REGARDS and 3C studies, respectively) and compared the efficacy of these models in predicting 5- and 10-year stroke risks.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p> The new FSRP was a better predictor of current stroke risks in all 3 samples than the old FSRP (calibration χ <jats:sup>2</jats:sup> of new/old FSRP: in men: 64.0/12.1, 59.4/30.6, and 20.7/12.5; in women: 42.5/4.1, 115.4/90.3, and 9.8/6.5 in FHS, REGARDS, and 3C, respectively). In the REGARDS, the new FSRP was a better predictor among whites compared with blacks. </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>A more contemporaneous, new FSRP better predicts current risks in 3 large community samples and could serve as the basis for examining geographic and racial differences in stroke risk and the incremental diagnostic utility of novel stroke risk factors.</jats:p> </jats:sec> Revised Framingham Stroke Risk Profile to Reflect Temporal Trends Circulation |
| spellingShingle | Dufouil, Carole, Beiser, Alexa, McLure, Leslie A., Wolf, Philip A., Tzourio, Christophe, Howard, Virginia J., Westwood, Andrew J., Himali, Jayandra J., Sullivan, Lisa, Aparicio, Hugo J., Kelly-Hayes, Margaret, Ritchie, Karen, Kase, Carlos S., Pikula, Aleksandra, Romero, Jose R., D’Agostino, Ralph B., Samieri, Cécilia, Vasan, Ramachandran S., Chêne, Genevieve, Howard, George, Seshadri, Sudha, Circulation, Revised Framingham Stroke Risk Profile to Reflect Temporal Trends, Physiology (medical), Cardiology and Cardiovascular Medicine |
| title | Revised Framingham Stroke Risk Profile to Reflect Temporal Trends |
| title_full | Revised Framingham Stroke Risk Profile to Reflect Temporal Trends |
| title_fullStr | Revised Framingham Stroke Risk Profile to Reflect Temporal Trends |
| title_full_unstemmed | Revised Framingham Stroke Risk Profile to Reflect Temporal Trends |
| title_short | Revised Framingham Stroke Risk Profile to Reflect Temporal Trends |
| title_sort | revised framingham stroke risk profile to reflect temporal trends |
| title_unstemmed | Revised Framingham Stroke Risk Profile to Reflect Temporal Trends |
| topic | Physiology (medical), Cardiology and Cardiovascular Medicine |
| url | http://dx.doi.org/10.1161/circulationaha.115.021275 |