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Effect of Early Metoprolol on Infarct Size in ST-Segment–Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention : The Effect of Metoprolol i...
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| Zeitschriftentitel: | Circulation |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| In: | Circulation, 128, 2013, 14, S. 1495-1503 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Ovid Technologies (Wolters Kluwer Health)
|
| Schlagwörter: |
| author_facet |
Ibanez, Borja Macaya, Carlos Sánchez-Brunete, Vicente Pizarro, Gonzalo Fernández-Friera, Leticia Mateos, Alonso Fernández-Ortiz, Antonio García-Ruiz, José M. García-Álvarez, Ana Iñiguez, Andrés Jiménez-Borreguero, Jesús López-Romero, Pedro Fernández-Jiménez, Rodrigo Goicolea, Javier Ruiz-Mateos, Borja Bastante, Teresa Arias, Mercedes Iglesias-Vázquez, José A. Rodriguez, Maite D. Escalera, Noemí Acebal, Carlos Cabrera, José A. Valenciano, Juan Pérez de Prado, Armando Fernández-Campos, María J. Casado, Isabel García-Rubira, Juan C. García-Prieto, Jaime Sanz-Rosa, David Cuellas, Carlos Hernández-Antolín, Rosana Albarrán, Agustín Fernández-Vázquez, Felipe de la Torre-Hernández, José M. Pocock, Stuart Sanz, Ginés Fuster, Valentin Ibanez, Borja Macaya, Carlos Sánchez-Brunete, Vicente Pizarro, Gonzalo Fernández-Friera, Leticia Mateos, Alonso Fernández-Ortiz, Antonio García-Ruiz, José M. García-Álvarez, Ana Iñiguez, Andrés Jiménez-Borreguero, Jesús López-Romero, Pedro Fernández-Jiménez, Rodrigo Goicolea, Javier Ruiz-Mateos, Borja Bastante, Teresa Arias, Mercedes Iglesias-Vázquez, José A. Rodriguez, Maite D. Escalera, Noemí Acebal, Carlos Cabrera, José A. Valenciano, Juan Pérez de Prado, Armando Fernández-Campos, María J. Casado, Isabel García-Rubira, Juan C. García-Prieto, Jaime Sanz-Rosa, David Cuellas, Carlos Hernández-Antolín, Rosana Albarrán, Agustín Fernández-Vázquez, Felipe de la Torre-Hernández, José M. Pocock, Stuart Sanz, Ginés Fuster, Valentin |
|---|---|
| author |
Ibanez, Borja Macaya, Carlos Sánchez-Brunete, Vicente Pizarro, Gonzalo Fernández-Friera, Leticia Mateos, Alonso Fernández-Ortiz, Antonio García-Ruiz, José M. García-Álvarez, Ana Iñiguez, Andrés Jiménez-Borreguero, Jesús López-Romero, Pedro Fernández-Jiménez, Rodrigo Goicolea, Javier Ruiz-Mateos, Borja Bastante, Teresa Arias, Mercedes Iglesias-Vázquez, José A. Rodriguez, Maite D. Escalera, Noemí Acebal, Carlos Cabrera, José A. Valenciano, Juan Pérez de Prado, Armando Fernández-Campos, María J. Casado, Isabel García-Rubira, Juan C. García-Prieto, Jaime Sanz-Rosa, David Cuellas, Carlos Hernández-Antolín, Rosana Albarrán, Agustín Fernández-Vázquez, Felipe de la Torre-Hernández, José M. Pocock, Stuart Sanz, Ginés Fuster, Valentin |
| spellingShingle |
Ibanez, Borja Macaya, Carlos Sánchez-Brunete, Vicente Pizarro, Gonzalo Fernández-Friera, Leticia Mateos, Alonso Fernández-Ortiz, Antonio García-Ruiz, José M. García-Álvarez, Ana Iñiguez, Andrés Jiménez-Borreguero, Jesús López-Romero, Pedro Fernández-Jiménez, Rodrigo Goicolea, Javier Ruiz-Mateos, Borja Bastante, Teresa Arias, Mercedes Iglesias-Vázquez, José A. Rodriguez, Maite D. Escalera, Noemí Acebal, Carlos Cabrera, José A. Valenciano, Juan Pérez de Prado, Armando Fernández-Campos, María J. Casado, Isabel García-Rubira, Juan C. García-Prieto, Jaime Sanz-Rosa, David Cuellas, Carlos Hernández-Antolín, Rosana Albarrán, Agustín Fernández-Vázquez, Felipe de la Torre-Hernández, José M. Pocock, Stuart Sanz, Ginés Fuster, Valentin Circulation Effect of Early Metoprolol on Infarct Size in ST-Segment–Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention : The Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) Trial Physiology (medical) Cardiology and Cardiovascular Medicine |
| author_sort |
ibanez, borja |
| spelling |
Ibanez, Borja Macaya, Carlos Sánchez-Brunete, Vicente Pizarro, Gonzalo Fernández-Friera, Leticia Mateos, Alonso Fernández-Ortiz, Antonio García-Ruiz, José M. García-Álvarez, Ana Iñiguez, Andrés Jiménez-Borreguero, Jesús López-Romero, Pedro Fernández-Jiménez, Rodrigo Goicolea, Javier Ruiz-Mateos, Borja Bastante, Teresa Arias, Mercedes Iglesias-Vázquez, José A. Rodriguez, Maite D. Escalera, Noemí Acebal, Carlos Cabrera, José A. Valenciano, Juan Pérez de Prado, Armando Fernández-Campos, María J. Casado, Isabel García-Rubira, Juan C. García-Prieto, Jaime Sanz-Rosa, David Cuellas, Carlos Hernández-Antolín, Rosana Albarrán, Agustín Fernández-Vázquez, Felipe de la Torre-Hernández, José M. Pocock, Stuart Sanz, Ginés Fuster, Valentin 0009-7322 1524-4539 Ovid Technologies (Wolters Kluwer Health) Physiology (medical) Cardiology and Cardiovascular Medicine http://dx.doi.org/10.1161/circulationaha.113.003653 <jats:sec> <jats:title>Background—</jats:title> <jats:p>The effect of β-blockers on infarct size when used in conjunction with primary percutaneous coronary intervention is unknown. We hypothesize that metoprolol reduces infarct size when administered early (intravenously before reperfusion).</jats:p> </jats:sec> <jats:sec> <jats:title>Methods and Results—</jats:title> <jats:p> Patients with Killip class II or less anterior ST-segment–elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention within 6 hours of symptoms onset were randomized to receive intravenous metoprolol (n=131) or not (control, n=139) before reperfusion. All patients without contraindications received oral metoprolol within 24 hours. The predefined primary end point was infarct size on magnetic resonance imaging performed 5 to 7 days after STEMI. Magnetic resonance imaging was performed in 220 patients (81%). Mean±SD infarct size by magnetic resonance imaging was smaller after intravenous metoprolol compared with control (25.6±15.3 versus 32.0±22.2 g; adjusted difference, −6.52; 95% confidence interval, −11.39 to −1.78; <jats:italic>P</jats:italic> =0.012). In patients with pre–percutaneous coronary intervention Thrombolysis in Myocardial Infarction grade 0 to 1 flow, the adjusted treatment difference in infarct size was −8.13 (95% confidence interval, −13.10 to −3.16; <jats:italic>P</jats:italic> =0.0024). Infarct size estimated by peak and area under the curve creatine kinase release was measured in all study populations and was significantly reduced by intravenous metoprolol. Left ventricular ejection fraction was higher in the intravenous metoprolol group (adjusted difference, 2.67%; 95% confidence interval, 0.09–5.21; <jats:italic>P</jats:italic> =0.045). The composite of death, malignant ventricular arrhythmia, cardiogenic shock, atrioventricular block, and reinfarction at 24 hours in the intravenous metoprolol and control groups was 7.1% and 12.3%, respectively ( <jats:italic>P</jats:italic> =0.21). </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p>In patients with anterior Killip class II or less ST-segment–elevation myocardial infarction undergoing primary percutaneous coronary intervention, early intravenous metoprolol before reperfusion reduced infarct size and increased left ventricular ejection fraction with no excess of adverse events during the first 24 hours after STEMI.</jats:p> </jats:sec> <jats:sec> <jats:title>Clinical Trial Registration—</jats:title> <jats:p> URL: <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.clinicaltrials.gov">http://www.clinicaltrials.gov</jats:ext-link> . Unique identifier: NCT01311700. EUDRACT number: 2010-019939-35. </jats:p> </jats:sec> The Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) Trial Effect of Early Metoprolol on Infarct Size in ST-Segment–Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention : The Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) Trial Circulation |
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Online Free |
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Biologie Medizin |
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Ovid Technologies (Wolters Kluwer Health), 2013 |
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Ovid Technologies (Wolters Kluwer Health), 2013 |
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Circulation |
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| title_sub |
The Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) Trial |
| title |
Effect of Early Metoprolol on Infarct Size in ST-Segment–Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention : The Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) Trial |
| title_unstemmed |
Effect of Early Metoprolol on Infarct Size in ST-Segment–Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention : The Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) Trial |
| title_full |
Effect of Early Metoprolol on Infarct Size in ST-Segment–Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention : The Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) Trial |
| title_fullStr |
Effect of Early Metoprolol on Infarct Size in ST-Segment–Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention : The Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) Trial |
| title_full_unstemmed |
Effect of Early Metoprolol on Infarct Size in ST-Segment–Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention : The Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) Trial |
| title_short |
Effect of Early Metoprolol on Infarct Size in ST-Segment–Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention : The Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) Trial |
| title_sort |
effect of early metoprolol on infarct size in st-segment–elevation myocardial infarction patients undergoing primary percutaneous coronary intervention : the effect of metoprolol in cardioprotection during an acute myocardial infarction (metocard-cnic) trial |
| topic |
Physiology (medical) Cardiology and Cardiovascular Medicine |
| url |
http://dx.doi.org/10.1161/circulationaha.113.003653 |
| publishDate |
2013 |
| physical |
1495-1503 |
| description |
<jats:sec>
<jats:title>Background—</jats:title>
<jats:p>The effect of β-blockers on infarct size when used in conjunction with primary percutaneous coronary intervention is unknown. We hypothesize that metoprolol reduces infarct size when administered early (intravenously before reperfusion).</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Methods and Results—</jats:title>
<jats:p>
Patients with Killip class II or less anterior ST-segment–elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention within 6 hours of symptoms onset were randomized to receive intravenous metoprolol (n=131) or not (control, n=139) before reperfusion. All patients without contraindications received oral metoprolol within 24 hours. The predefined primary end point was infarct size on magnetic resonance imaging performed 5 to 7 days after STEMI. Magnetic resonance imaging was performed in 220 patients (81%). Mean±SD infarct size by magnetic resonance imaging was smaller after intravenous metoprolol compared with control (25.6±15.3 versus 32.0±22.2 g; adjusted difference, −6.52; 95% confidence interval, −11.39 to −1.78;
<jats:italic>P</jats:italic>
=0.012). In patients with pre–percutaneous coronary intervention Thrombolysis in Myocardial Infarction grade 0 to 1 flow, the adjusted treatment difference in infarct size was −8.13 (95% confidence interval, −13.10 to −3.16;
<jats:italic>P</jats:italic>
=0.0024). Infarct size estimated by peak and area under the curve creatine kinase release was measured in all study populations and was significantly reduced by intravenous metoprolol. Left ventricular ejection fraction was higher in the intravenous metoprolol group (adjusted difference, 2.67%; 95% confidence interval, 0.09–5.21;
<jats:italic>P</jats:italic>
=0.045). The composite of death, malignant ventricular arrhythmia, cardiogenic shock, atrioventricular block, and reinfarction at 24 hours in the intravenous metoprolol and control groups was 7.1% and 12.3%, respectively (
<jats:italic>P</jats:italic>
=0.21).
</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusions—</jats:title>
<jats:p>In patients with anterior Killip class II or less ST-segment–elevation myocardial infarction undergoing primary percutaneous coronary intervention, early intravenous metoprolol before reperfusion reduced infarct size and increased left ventricular ejection fraction with no excess of adverse events during the first 24 hours after STEMI.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Clinical Trial Registration—</jats:title>
<jats:p>
URL:
<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.clinicaltrials.gov">http://www.clinicaltrials.gov</jats:ext-link>
. Unique identifier: NCT01311700. EUDRACT number: 2010-019939-35.
</jats:p>
</jats:sec> |
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| author | Ibanez, Borja, Macaya, Carlos, Sánchez-Brunete, Vicente, Pizarro, Gonzalo, Fernández-Friera, Leticia, Mateos, Alonso, Fernández-Ortiz, Antonio, García-Ruiz, José M., García-Álvarez, Ana, Iñiguez, Andrés, Jiménez-Borreguero, Jesús, López-Romero, Pedro, Fernández-Jiménez, Rodrigo, Goicolea, Javier, Ruiz-Mateos, Borja, Bastante, Teresa, Arias, Mercedes, Iglesias-Vázquez, José A., Rodriguez, Maite D., Escalera, Noemí, Acebal, Carlos, Cabrera, José A., Valenciano, Juan, Pérez de Prado, Armando, Fernández-Campos, María J., Casado, Isabel, García-Rubira, Juan C., García-Prieto, Jaime, Sanz-Rosa, David, Cuellas, Carlos, Hernández-Antolín, Rosana, Albarrán, Agustín, Fernández-Vázquez, Felipe, de la Torre-Hernández, José M., Pocock, Stuart, Sanz, Ginés, Fuster, Valentin |
| author_facet | Ibanez, Borja, Macaya, Carlos, Sánchez-Brunete, Vicente, Pizarro, Gonzalo, Fernández-Friera, Leticia, Mateos, Alonso, Fernández-Ortiz, Antonio, García-Ruiz, José M., García-Álvarez, Ana, Iñiguez, Andrés, Jiménez-Borreguero, Jesús, López-Romero, Pedro, Fernández-Jiménez, Rodrigo, Goicolea, Javier, Ruiz-Mateos, Borja, Bastante, Teresa, Arias, Mercedes, Iglesias-Vázquez, José A., Rodriguez, Maite D., Escalera, Noemí, Acebal, Carlos, Cabrera, José A., Valenciano, Juan, Pérez de Prado, Armando, Fernández-Campos, María J., Casado, Isabel, García-Rubira, Juan C., García-Prieto, Jaime, Sanz-Rosa, David, Cuellas, Carlos, Hernández-Antolín, Rosana, Albarrán, Agustín, Fernández-Vázquez, Felipe, de la Torre-Hernández, José M., Pocock, Stuart, Sanz, Ginés, Fuster, Valentin, Ibanez, Borja, Macaya, Carlos, Sánchez-Brunete, Vicente, Pizarro, Gonzalo, Fernández-Friera, Leticia, Mateos, Alonso, Fernández-Ortiz, Antonio, García-Ruiz, José M., García-Álvarez, Ana, Iñiguez, Andrés, Jiménez-Borreguero, Jesús, López-Romero, Pedro, Fernández-Jiménez, Rodrigo, Goicolea, Javier, Ruiz-Mateos, Borja, Bastante, Teresa, Arias, Mercedes, Iglesias-Vázquez, José A., Rodriguez, Maite D., Escalera, Noemí, Acebal, Carlos, Cabrera, José A., Valenciano, Juan, Pérez de Prado, Armando, Fernández-Campos, María J., Casado, Isabel, García-Rubira, Juan C., García-Prieto, Jaime, Sanz-Rosa, David, Cuellas, Carlos, Hernández-Antolín, Rosana, Albarrán, Agustín, Fernández-Vázquez, Felipe, de la Torre-Hernández, José M., Pocock, Stuart, Sanz, Ginés, Fuster, Valentin |
| author_sort | ibanez, borja |
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| container_title | Circulation |
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| description | <jats:sec> <jats:title>Background—</jats:title> <jats:p>The effect of β-blockers on infarct size when used in conjunction with primary percutaneous coronary intervention is unknown. We hypothesize that metoprolol reduces infarct size when administered early (intravenously before reperfusion).</jats:p> </jats:sec> <jats:sec> <jats:title>Methods and Results—</jats:title> <jats:p> Patients with Killip class II or less anterior ST-segment–elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention within 6 hours of symptoms onset were randomized to receive intravenous metoprolol (n=131) or not (control, n=139) before reperfusion. All patients without contraindications received oral metoprolol within 24 hours. The predefined primary end point was infarct size on magnetic resonance imaging performed 5 to 7 days after STEMI. Magnetic resonance imaging was performed in 220 patients (81%). Mean±SD infarct size by magnetic resonance imaging was smaller after intravenous metoprolol compared with control (25.6±15.3 versus 32.0±22.2 g; adjusted difference, −6.52; 95% confidence interval, −11.39 to −1.78; <jats:italic>P</jats:italic> =0.012). In patients with pre–percutaneous coronary intervention Thrombolysis in Myocardial Infarction grade 0 to 1 flow, the adjusted treatment difference in infarct size was −8.13 (95% confidence interval, −13.10 to −3.16; <jats:italic>P</jats:italic> =0.0024). Infarct size estimated by peak and area under the curve creatine kinase release was measured in all study populations and was significantly reduced by intravenous metoprolol. Left ventricular ejection fraction was higher in the intravenous metoprolol group (adjusted difference, 2.67%; 95% confidence interval, 0.09–5.21; <jats:italic>P</jats:italic> =0.045). The composite of death, malignant ventricular arrhythmia, cardiogenic shock, atrioventricular block, and reinfarction at 24 hours in the intravenous metoprolol and control groups was 7.1% and 12.3%, respectively ( <jats:italic>P</jats:italic> =0.21). </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p>In patients with anterior Killip class II or less ST-segment–elevation myocardial infarction undergoing primary percutaneous coronary intervention, early intravenous metoprolol before reperfusion reduced infarct size and increased left ventricular ejection fraction with no excess of adverse events during the first 24 hours after STEMI.</jats:p> </jats:sec> <jats:sec> <jats:title>Clinical Trial Registration—</jats:title> <jats:p> URL: <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.clinicaltrials.gov">http://www.clinicaltrials.gov</jats:ext-link> . Unique identifier: NCT01311700. EUDRACT number: 2010-019939-35. </jats:p> </jats:sec> |
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| series | Circulation |
| source_id | 49 |
| spelling | Ibanez, Borja Macaya, Carlos Sánchez-Brunete, Vicente Pizarro, Gonzalo Fernández-Friera, Leticia Mateos, Alonso Fernández-Ortiz, Antonio García-Ruiz, José M. García-Álvarez, Ana Iñiguez, Andrés Jiménez-Borreguero, Jesús López-Romero, Pedro Fernández-Jiménez, Rodrigo Goicolea, Javier Ruiz-Mateos, Borja Bastante, Teresa Arias, Mercedes Iglesias-Vázquez, José A. Rodriguez, Maite D. Escalera, Noemí Acebal, Carlos Cabrera, José A. Valenciano, Juan Pérez de Prado, Armando Fernández-Campos, María J. Casado, Isabel García-Rubira, Juan C. García-Prieto, Jaime Sanz-Rosa, David Cuellas, Carlos Hernández-Antolín, Rosana Albarrán, Agustín Fernández-Vázquez, Felipe de la Torre-Hernández, José M. Pocock, Stuart Sanz, Ginés Fuster, Valentin 0009-7322 1524-4539 Ovid Technologies (Wolters Kluwer Health) Physiology (medical) Cardiology and Cardiovascular Medicine http://dx.doi.org/10.1161/circulationaha.113.003653 <jats:sec> <jats:title>Background—</jats:title> <jats:p>The effect of β-blockers on infarct size when used in conjunction with primary percutaneous coronary intervention is unknown. We hypothesize that metoprolol reduces infarct size when administered early (intravenously before reperfusion).</jats:p> </jats:sec> <jats:sec> <jats:title>Methods and Results—</jats:title> <jats:p> Patients with Killip class II or less anterior ST-segment–elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention within 6 hours of symptoms onset were randomized to receive intravenous metoprolol (n=131) or not (control, n=139) before reperfusion. All patients without contraindications received oral metoprolol within 24 hours. The predefined primary end point was infarct size on magnetic resonance imaging performed 5 to 7 days after STEMI. Magnetic resonance imaging was performed in 220 patients (81%). Mean±SD infarct size by magnetic resonance imaging was smaller after intravenous metoprolol compared with control (25.6±15.3 versus 32.0±22.2 g; adjusted difference, −6.52; 95% confidence interval, −11.39 to −1.78; <jats:italic>P</jats:italic> =0.012). In patients with pre–percutaneous coronary intervention Thrombolysis in Myocardial Infarction grade 0 to 1 flow, the adjusted treatment difference in infarct size was −8.13 (95% confidence interval, −13.10 to −3.16; <jats:italic>P</jats:italic> =0.0024). Infarct size estimated by peak and area under the curve creatine kinase release was measured in all study populations and was significantly reduced by intravenous metoprolol. Left ventricular ejection fraction was higher in the intravenous metoprolol group (adjusted difference, 2.67%; 95% confidence interval, 0.09–5.21; <jats:italic>P</jats:italic> =0.045). The composite of death, malignant ventricular arrhythmia, cardiogenic shock, atrioventricular block, and reinfarction at 24 hours in the intravenous metoprolol and control groups was 7.1% and 12.3%, respectively ( <jats:italic>P</jats:italic> =0.21). </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p>In patients with anterior Killip class II or less ST-segment–elevation myocardial infarction undergoing primary percutaneous coronary intervention, early intravenous metoprolol before reperfusion reduced infarct size and increased left ventricular ejection fraction with no excess of adverse events during the first 24 hours after STEMI.</jats:p> </jats:sec> <jats:sec> <jats:title>Clinical Trial Registration—</jats:title> <jats:p> URL: <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.clinicaltrials.gov">http://www.clinicaltrials.gov</jats:ext-link> . Unique identifier: NCT01311700. EUDRACT number: 2010-019939-35. </jats:p> </jats:sec> The Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) Trial Effect of Early Metoprolol on Infarct Size in ST-Segment–Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention : The Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) Trial Circulation |
| spellingShingle | Ibanez, Borja, Macaya, Carlos, Sánchez-Brunete, Vicente, Pizarro, Gonzalo, Fernández-Friera, Leticia, Mateos, Alonso, Fernández-Ortiz, Antonio, García-Ruiz, José M., García-Álvarez, Ana, Iñiguez, Andrés, Jiménez-Borreguero, Jesús, López-Romero, Pedro, Fernández-Jiménez, Rodrigo, Goicolea, Javier, Ruiz-Mateos, Borja, Bastante, Teresa, Arias, Mercedes, Iglesias-Vázquez, José A., Rodriguez, Maite D., Escalera, Noemí, Acebal, Carlos, Cabrera, José A., Valenciano, Juan, Pérez de Prado, Armando, Fernández-Campos, María J., Casado, Isabel, García-Rubira, Juan C., García-Prieto, Jaime, Sanz-Rosa, David, Cuellas, Carlos, Hernández-Antolín, Rosana, Albarrán, Agustín, Fernández-Vázquez, Felipe, de la Torre-Hernández, José M., Pocock, Stuart, Sanz, Ginés, Fuster, Valentin, Circulation, Effect of Early Metoprolol on Infarct Size in ST-Segment–Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention : The Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) Trial, Physiology (medical), Cardiology and Cardiovascular Medicine |
| title | Effect of Early Metoprolol on Infarct Size in ST-Segment–Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention : The Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) Trial |
| title_full | Effect of Early Metoprolol on Infarct Size in ST-Segment–Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention : The Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) Trial |
| title_fullStr | Effect of Early Metoprolol on Infarct Size in ST-Segment–Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention : The Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) Trial |
| title_full_unstemmed | Effect of Early Metoprolol on Infarct Size in ST-Segment–Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention : The Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) Trial |
| title_short | Effect of Early Metoprolol on Infarct Size in ST-Segment–Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention : The Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) Trial |
| title_sort | effect of early metoprolol on infarct size in st-segment–elevation myocardial infarction patients undergoing primary percutaneous coronary intervention : the effect of metoprolol in cardioprotection during an acute myocardial infarction (metocard-cnic) trial |
| title_sub | The Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) Trial |
| title_unstemmed | Effect of Early Metoprolol on Infarct Size in ST-Segment–Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention : The Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) Trial |
| topic | Physiology (medical), Cardiology and Cardiovascular Medicine |
| url | http://dx.doi.org/10.1161/circulationaha.113.003653 |