Eintrag weiter verarbeiten
Inhibition of Factor Xa Reduces Ischemic Brain Damage After Thromboembolic Stroke in Rats
Gespeichert in:
| Zeitschriftentitel: | Stroke |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , |
| In: | Stroke, 34, 2003, 2, S. 468-474 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Ovid Technologies (Wolters Kluwer Health)
|
| Schlagwörter: |
| author_facet |
Wang, Xinkang Xu, Lin Wang, Hugh Grzanna, Reinhard Zhan, Yutian Knabb, Robert M. Luettgen, Joseph M. Bozarth, Tracy A. Galemmo, Robert A. Wong, Pancras C. Bernard, Roberta Vargas, Hugo Chopp, Michael Friedman, Steven M. Feuerstein, Giora Z. Wang, Xinkang Xu, Lin Wang, Hugh Grzanna, Reinhard Zhan, Yutian Knabb, Robert M. Luettgen, Joseph M. Bozarth, Tracy A. Galemmo, Robert A. Wong, Pancras C. Bernard, Roberta Vargas, Hugo Chopp, Michael Friedman, Steven M. Feuerstein, Giora Z. |
|---|---|
| author |
Wang, Xinkang Xu, Lin Wang, Hugh Grzanna, Reinhard Zhan, Yutian Knabb, Robert M. Luettgen, Joseph M. Bozarth, Tracy A. Galemmo, Robert A. Wong, Pancras C. Bernard, Roberta Vargas, Hugo Chopp, Michael Friedman, Steven M. Feuerstein, Giora Z. |
| spellingShingle |
Wang, Xinkang Xu, Lin Wang, Hugh Grzanna, Reinhard Zhan, Yutian Knabb, Robert M. Luettgen, Joseph M. Bozarth, Tracy A. Galemmo, Robert A. Wong, Pancras C. Bernard, Roberta Vargas, Hugo Chopp, Michael Friedman, Steven M. Feuerstein, Giora Z. Stroke Inhibition of Factor Xa Reduces Ischemic Brain Damage After Thromboembolic Stroke in Rats Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) |
| author_sort |
wang, xinkang |
| spelling |
Wang, Xinkang Xu, Lin Wang, Hugh Grzanna, Reinhard Zhan, Yutian Knabb, Robert M. Luettgen, Joseph M. Bozarth, Tracy A. Galemmo, Robert A. Wong, Pancras C. Bernard, Roberta Vargas, Hugo Chopp, Michael Friedman, Steven M. Feuerstein, Giora Z. 0039-2499 1524-4628 Ovid Technologies (Wolters Kluwer Health) Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) http://dx.doi.org/10.1161/01.str.0000049765.81774.a3 <jats:p> <jats:bold> <jats:italic>Background and Purpose—</jats:italic> </jats:bold> Factor Xa (FXa) is a key coagulation protease and target for novel antithrombotic agents for prevention and treatment of diverse thromboembolic disorders. In the present study we describe the effect of a novel, potent, and selective FXa inhibitor, DPC602, on brain damage and neurobehavioral consequence in a rat thromboembolic model of stroke. </jats:p> <jats:p> <jats:bold> <jats:italic>Methods—</jats:italic> </jats:bold> Thromboembolic stroke was induced in rats by placement of an autologous clot into the middle cerebral artery. </jats:p> <jats:p> <jats:bold> <jats:italic>Results—</jats:italic> </jats:bold> Laser-Doppler monitoring of cerebral blood flow demonstrated that DPC602 (8 mg/kg, single IV/IP bolus pretreatment) markedly improved cerebral blood flow after thromboembolic stroke by 25% to 160% (n=6; <jats:italic>P</jats:italic> <0.001) at 1 to 6 hours. DPC602 demonstrated concentration- and time-dependent reductions in infarct size, with maximal effect (89% reduction; n=14; <jats:italic>P</jats:italic> <0.001) at the highest dose over controls. Neurological function was also significantly improved in DPC602-treated rats at days 1, 3, and 7 (n=13; <jats:italic>P</jats:italic> <0.01). DPC602 treatment did not cause cerebral hemorrhage, assessed by free hemoglobin in the ischemic brain tissues. </jats:p> <jats:p> <jats:bold> <jats:italic>Conclusions—</jats:italic> </jats:bold> These data suggest that anticoagulation with a selective FXa inhibitor might ameliorate the extent of ischemic brain damage and neurological deficits after a thromboembolic event. Enhanced clot dissolution and early reperfusion may account for the cerebrovascular-protective effect of the drug. </jats:p> Inhibition of Factor Xa Reduces Ischemic Brain Damage After Thromboembolic Stroke in Rats Stroke |
| doi_str_mv |
10.1161/01.str.0000049765.81774.a3 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE2MS8wMS5zdHIuMDAwMDA0OTc2NS44MTc3NC5hMw |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE2MS8wMS5zdHIuMDAwMDA0OTc2NS44MTc3NC5hMw |
| institution |
DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 |
| imprint |
Ovid Technologies (Wolters Kluwer Health), 2003 |
| imprint_str_mv |
Ovid Technologies (Wolters Kluwer Health), 2003 |
| issn |
0039-2499 1524-4628 |
| issn_str_mv |
0039-2499 1524-4628 |
| language |
English |
| mega_collection |
Ovid Technologies (Wolters Kluwer Health) (CrossRef) |
| match_str |
wang2003inhibitionoffactorxareducesischemicbraindamageafterthromboembolicstrokeinrats |
| publishDateSort |
2003 |
| publisher |
Ovid Technologies (Wolters Kluwer Health) |
| recordtype |
ai |
| record_format |
ai |
| series |
Stroke |
| source_id |
49 |
| title |
Inhibition of Factor Xa Reduces Ischemic Brain Damage After Thromboembolic Stroke in Rats |
| title_unstemmed |
Inhibition of Factor Xa Reduces Ischemic Brain Damage After Thromboembolic Stroke in Rats |
| title_full |
Inhibition of Factor Xa Reduces Ischemic Brain Damage After Thromboembolic Stroke in Rats |
| title_fullStr |
Inhibition of Factor Xa Reduces Ischemic Brain Damage After Thromboembolic Stroke in Rats |
| title_full_unstemmed |
Inhibition of Factor Xa Reduces Ischemic Brain Damage After Thromboembolic Stroke in Rats |
| title_short |
Inhibition of Factor Xa Reduces Ischemic Brain Damage After Thromboembolic Stroke in Rats |
| title_sort |
inhibition of factor xa reduces ischemic brain damage after thromboembolic stroke in rats |
| topic |
Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) |
| url |
http://dx.doi.org/10.1161/01.str.0000049765.81774.a3 |
| publishDate |
2003 |
| physical |
468-474 |
| description |
<jats:p>
<jats:bold>
<jats:italic>Background and Purpose—</jats:italic>
</jats:bold>
Factor Xa (FXa) is a key coagulation protease and target for novel antithrombotic agents for prevention and treatment of diverse thromboembolic disorders. In the present study we describe the effect of a novel, potent, and selective FXa inhibitor, DPC602, on brain damage and neurobehavioral consequence in a rat thromboembolic model of stroke.
</jats:p>
<jats:p>
<jats:bold>
<jats:italic>Methods—</jats:italic>
</jats:bold>
Thromboembolic stroke was induced in rats by placement of an autologous clot into the middle cerebral artery.
</jats:p>
<jats:p>
<jats:bold>
<jats:italic>Results—</jats:italic>
</jats:bold>
Laser-Doppler monitoring of cerebral blood flow demonstrated that DPC602 (8 mg/kg, single IV/IP bolus pretreatment) markedly improved cerebral blood flow after thromboembolic stroke by 25% to 160% (n=6;
<jats:italic>P</jats:italic>
<0.001) at 1 to 6 hours. DPC602 demonstrated concentration- and time-dependent reductions in infarct size, with maximal effect (89% reduction; n=14;
<jats:italic>P</jats:italic>
<0.001) at the highest dose over controls. Neurological function was also significantly improved in DPC602-treated rats at days 1, 3, and 7 (n=13;
<jats:italic>P</jats:italic>
<0.01). DPC602 treatment did not cause cerebral hemorrhage, assessed by free hemoglobin in the ischemic brain tissues.
</jats:p>
<jats:p>
<jats:bold>
<jats:italic>Conclusions—</jats:italic>
</jats:bold>
These data suggest that anticoagulation with a selective FXa inhibitor might ameliorate the extent of ischemic brain damage and neurological deficits after a thromboembolic event. Enhanced clot dissolution and early reperfusion may account for the cerebrovascular-protective effect of the drug.
</jats:p> |
| container_issue |
2 |
| container_start_page |
468 |
| container_title |
Stroke |
| container_volume |
34 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792335318567878656 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T14:42:37.26Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Inhibition+of+Factor+Xa+Reduces+Ischemic+Brain+Damage+After+Thromboembolic+Stroke+in+Rats&rft.date=2003-02-01&genre=article&issn=1524-4628&volume=34&issue=2&spage=468&epage=474&pages=468-474&jtitle=Stroke&atitle=Inhibition+of+Factor+Xa+Reduces+Ischemic+Brain+Damage+After+Thromboembolic+Stroke+in+Rats&aulast=Feuerstein&aufirst=Giora+Z.&rft_id=info%3Adoi%2F10.1161%2F01.str.0000049765.81774.a3&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792335318567878656 |
| author | Wang, Xinkang, Xu, Lin, Wang, Hugh, Grzanna, Reinhard, Zhan, Yutian, Knabb, Robert M., Luettgen, Joseph M., Bozarth, Tracy A., Galemmo, Robert A., Wong, Pancras C., Bernard, Roberta, Vargas, Hugo, Chopp, Michael, Friedman, Steven M., Feuerstein, Giora Z. |
| author_facet | Wang, Xinkang, Xu, Lin, Wang, Hugh, Grzanna, Reinhard, Zhan, Yutian, Knabb, Robert M., Luettgen, Joseph M., Bozarth, Tracy A., Galemmo, Robert A., Wong, Pancras C., Bernard, Roberta, Vargas, Hugo, Chopp, Michael, Friedman, Steven M., Feuerstein, Giora Z., Wang, Xinkang, Xu, Lin, Wang, Hugh, Grzanna, Reinhard, Zhan, Yutian, Knabb, Robert M., Luettgen, Joseph M., Bozarth, Tracy A., Galemmo, Robert A., Wong, Pancras C., Bernard, Roberta, Vargas, Hugo, Chopp, Michael, Friedman, Steven M., Feuerstein, Giora Z. |
| author_sort | wang, xinkang |
| container_issue | 2 |
| container_start_page | 468 |
| container_title | Stroke |
| container_volume | 34 |
| description | <jats:p> <jats:bold> <jats:italic>Background and Purpose—</jats:italic> </jats:bold> Factor Xa (FXa) is a key coagulation protease and target for novel antithrombotic agents for prevention and treatment of diverse thromboembolic disorders. In the present study we describe the effect of a novel, potent, and selective FXa inhibitor, DPC602, on brain damage and neurobehavioral consequence in a rat thromboembolic model of stroke. </jats:p> <jats:p> <jats:bold> <jats:italic>Methods—</jats:italic> </jats:bold> Thromboembolic stroke was induced in rats by placement of an autologous clot into the middle cerebral artery. </jats:p> <jats:p> <jats:bold> <jats:italic>Results—</jats:italic> </jats:bold> Laser-Doppler monitoring of cerebral blood flow demonstrated that DPC602 (8 mg/kg, single IV/IP bolus pretreatment) markedly improved cerebral blood flow after thromboembolic stroke by 25% to 160% (n=6; <jats:italic>P</jats:italic> <0.001) at 1 to 6 hours. DPC602 demonstrated concentration- and time-dependent reductions in infarct size, with maximal effect (89% reduction; n=14; <jats:italic>P</jats:italic> <0.001) at the highest dose over controls. Neurological function was also significantly improved in DPC602-treated rats at days 1, 3, and 7 (n=13; <jats:italic>P</jats:italic> <0.01). DPC602 treatment did not cause cerebral hemorrhage, assessed by free hemoglobin in the ischemic brain tissues. </jats:p> <jats:p> <jats:bold> <jats:italic>Conclusions—</jats:italic> </jats:bold> These data suggest that anticoagulation with a selective FXa inhibitor might ameliorate the extent of ischemic brain damage and neurological deficits after a thromboembolic event. Enhanced clot dissolution and early reperfusion may account for the cerebrovascular-protective effect of the drug. </jats:p> |
| doi_str_mv | 10.1161/01.str.0000049765.81774.a3 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE2MS8wMS5zdHIuMDAwMDA0OTc2NS44MTc3NC5hMw |
| imprint | Ovid Technologies (Wolters Kluwer Health), 2003 |
| imprint_str_mv | Ovid Technologies (Wolters Kluwer Health), 2003 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
| issn | 0039-2499, 1524-4628 |
| issn_str_mv | 0039-2499, 1524-4628 |
| language | English |
| last_indexed | 2024-03-01T14:42:37.26Z |
| match_str | wang2003inhibitionoffactorxareducesischemicbraindamageafterthromboembolicstrokeinrats |
| mega_collection | Ovid Technologies (Wolters Kluwer Health) (CrossRef) |
| physical | 468-474 |
| publishDate | 2003 |
| publishDateSort | 2003 |
| publisher | Ovid Technologies (Wolters Kluwer Health) |
| record_format | ai |
| recordtype | ai |
| series | Stroke |
| source_id | 49 |
| spelling | Wang, Xinkang Xu, Lin Wang, Hugh Grzanna, Reinhard Zhan, Yutian Knabb, Robert M. Luettgen, Joseph M. Bozarth, Tracy A. Galemmo, Robert A. Wong, Pancras C. Bernard, Roberta Vargas, Hugo Chopp, Michael Friedman, Steven M. Feuerstein, Giora Z. 0039-2499 1524-4628 Ovid Technologies (Wolters Kluwer Health) Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) http://dx.doi.org/10.1161/01.str.0000049765.81774.a3 <jats:p> <jats:bold> <jats:italic>Background and Purpose—</jats:italic> </jats:bold> Factor Xa (FXa) is a key coagulation protease and target for novel antithrombotic agents for prevention and treatment of diverse thromboembolic disorders. In the present study we describe the effect of a novel, potent, and selective FXa inhibitor, DPC602, on brain damage and neurobehavioral consequence in a rat thromboembolic model of stroke. </jats:p> <jats:p> <jats:bold> <jats:italic>Methods—</jats:italic> </jats:bold> Thromboembolic stroke was induced in rats by placement of an autologous clot into the middle cerebral artery. </jats:p> <jats:p> <jats:bold> <jats:italic>Results—</jats:italic> </jats:bold> Laser-Doppler monitoring of cerebral blood flow demonstrated that DPC602 (8 mg/kg, single IV/IP bolus pretreatment) markedly improved cerebral blood flow after thromboembolic stroke by 25% to 160% (n=6; <jats:italic>P</jats:italic> <0.001) at 1 to 6 hours. DPC602 demonstrated concentration- and time-dependent reductions in infarct size, with maximal effect (89% reduction; n=14; <jats:italic>P</jats:italic> <0.001) at the highest dose over controls. Neurological function was also significantly improved in DPC602-treated rats at days 1, 3, and 7 (n=13; <jats:italic>P</jats:italic> <0.01). DPC602 treatment did not cause cerebral hemorrhage, assessed by free hemoglobin in the ischemic brain tissues. </jats:p> <jats:p> <jats:bold> <jats:italic>Conclusions—</jats:italic> </jats:bold> These data suggest that anticoagulation with a selective FXa inhibitor might ameliorate the extent of ischemic brain damage and neurological deficits after a thromboembolic event. Enhanced clot dissolution and early reperfusion may account for the cerebrovascular-protective effect of the drug. </jats:p> Inhibition of Factor Xa Reduces Ischemic Brain Damage After Thromboembolic Stroke in Rats Stroke |
| spellingShingle | Wang, Xinkang, Xu, Lin, Wang, Hugh, Grzanna, Reinhard, Zhan, Yutian, Knabb, Robert M., Luettgen, Joseph M., Bozarth, Tracy A., Galemmo, Robert A., Wong, Pancras C., Bernard, Roberta, Vargas, Hugo, Chopp, Michael, Friedman, Steven M., Feuerstein, Giora Z., Stroke, Inhibition of Factor Xa Reduces Ischemic Brain Damage After Thromboembolic Stroke in Rats, Advanced and Specialized Nursing, Cardiology and Cardiovascular Medicine, Neurology (clinical) |
| title | Inhibition of Factor Xa Reduces Ischemic Brain Damage After Thromboembolic Stroke in Rats |
| title_full | Inhibition of Factor Xa Reduces Ischemic Brain Damage After Thromboembolic Stroke in Rats |
| title_fullStr | Inhibition of Factor Xa Reduces Ischemic Brain Damage After Thromboembolic Stroke in Rats |
| title_full_unstemmed | Inhibition of Factor Xa Reduces Ischemic Brain Damage After Thromboembolic Stroke in Rats |
| title_short | Inhibition of Factor Xa Reduces Ischemic Brain Damage After Thromboembolic Stroke in Rats |
| title_sort | inhibition of factor xa reduces ischemic brain damage after thromboembolic stroke in rats |
| title_unstemmed | Inhibition of Factor Xa Reduces Ischemic Brain Damage After Thromboembolic Stroke in Rats |
| topic | Advanced and Specialized Nursing, Cardiology and Cardiovascular Medicine, Neurology (clinical) |
| url | http://dx.doi.org/10.1161/01.str.0000049765.81774.a3 |