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Intracoronary Stenting and Angiographic Results : Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial: Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial
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| Zeitschriftentitel: | Circulation |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , |
| In: | Circulation, 103, 2001, 23, S. 2816-2821 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Ovid Technologies (Wolters Kluwer Health)
|
| Schlagwörter: |
| author_facet |
Kastrati, Adnan Mehilli, Julinda Dirschinger, Josef Dotzer, Franz Schühlen, Helmut Neumann, Franz-Josef Fleckenstein, Martin Pfafferott, Conrad Seyfarth, Melchior Schömig, Albert Kastrati, Adnan Mehilli, Julinda Dirschinger, Josef Dotzer, Franz Schühlen, Helmut Neumann, Franz-Josef Fleckenstein, Martin Pfafferott, Conrad Seyfarth, Melchior Schömig, Albert |
|---|---|
| author |
Kastrati, Adnan Mehilli, Julinda Dirschinger, Josef Dotzer, Franz Schühlen, Helmut Neumann, Franz-Josef Fleckenstein, Martin Pfafferott, Conrad Seyfarth, Melchior Schömig, Albert |
| spellingShingle |
Kastrati, Adnan Mehilli, Julinda Dirschinger, Josef Dotzer, Franz Schühlen, Helmut Neumann, Franz-Josef Fleckenstein, Martin Pfafferott, Conrad Seyfarth, Melchior Schömig, Albert Circulation Intracoronary Stenting and Angiographic Results : Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial Physiology (medical) Cardiology and Cardiovascular Medicine |
| author_sort |
kastrati, adnan |
| spelling |
Kastrati, Adnan Mehilli, Julinda Dirschinger, Josef Dotzer, Franz Schühlen, Helmut Neumann, Franz-Josef Fleckenstein, Martin Pfafferott, Conrad Seyfarth, Melchior Schömig, Albert 0009-7322 1524-4539 Ovid Technologies (Wolters Kluwer Health) Physiology (medical) Cardiology and Cardiovascular Medicine http://dx.doi.org/10.1161/01.cir.103.23.2816 <jats:p> <jats:italic>Background</jats:italic> —Increased thrombogenicity and smooth muscle cell proliferative response induced by the metal struts compromise the advantages of coronary stenting. The objective of this randomized, multicenter study was to assess whether a reduced strut thickness of coronary stents is associated with improved follow-up angiographic and clinical results. </jats:p> <jats:p> <jats:italic>Methods and Results</jats:italic> —A total of 651 patients with coronary lesions situated in native vessels >2.8 mm in diameter were randomly assigned to receive 1 of 2 commercially available stents of comparable design but different thickness: 326 patients to the thin-strut stent (strut thickness of 50 μm) and 325 patients to the thick-strut stent (strut thickness of 140 μm). The primary end point was the angiographic restenosis (≥50% diameter stenosis at follow-up angiography). Secondary end points were the incidence of reinterventions due to restenosis-induced ischemia and the combined rate of death and myocardial infarctions at 1 year. The incidence of angiographic restenosis was 15.0% in the thin-strut group and 25.8% in the thick-strut group (relative risk, 0.58; 95% CI, 0.39 to 0.87; <jats:italic>P</jats:italic> =0.003). Clinical restenosis was also significantly reduced, with a reintervention rate of 8.6% among thin-strut patients and 13.8% among thick-strut patients (relative risk, 0.62; 95% CI, 0.39 to 0.99; <jats:italic>P</jats:italic> =0.03). No difference was observed in the combined 1-year rate of death and myocardial infarction. </jats:p> <jats:p> <jats:italic>Conclusions</jats:italic> —The use of a thinner-strut device is associated with a significant reduction of angiographic and clinical restenosis after coronary artery stenting. These findings may have relevant implications for the currently most widely used percutaneous coronary intervention. </jats:p> Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial Intracoronary Stenting and Angiographic Results : Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial Circulation |
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10.1161/01.cir.103.23.2816 |
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Biologie Medizin |
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Ovid Technologies (Wolters Kluwer Health), 2001 |
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Ovid Technologies (Wolters Kluwer Health), 2001 |
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0009-7322 1524-4539 |
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| title_sub |
Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial |
| title |
Intracoronary Stenting and Angiographic Results : Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial |
| title_unstemmed |
Intracoronary Stenting and Angiographic Results : Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial |
| title_full |
Intracoronary Stenting and Angiographic Results : Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial |
| title_fullStr |
Intracoronary Stenting and Angiographic Results : Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial |
| title_full_unstemmed |
Intracoronary Stenting and Angiographic Results : Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial |
| title_short |
Intracoronary Stenting and Angiographic Results : Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial |
| title_sort |
intracoronary stenting and angiographic results : strut thickness effect on restenosis outcome (isar-stereo) trial |
| topic |
Physiology (medical) Cardiology and Cardiovascular Medicine |
| url |
http://dx.doi.org/10.1161/01.cir.103.23.2816 |
| publishDate |
2001 |
| physical |
2816-2821 |
| description |
<jats:p>
<jats:italic>Background</jats:italic>
—Increased thrombogenicity and smooth muscle cell proliferative response induced by the metal struts compromise the advantages of coronary stenting. The objective of this randomized, multicenter study was to assess whether a reduced strut thickness of coronary stents is associated with improved follow-up angiographic and clinical results.
</jats:p>
<jats:p>
<jats:italic>Methods and Results</jats:italic>
—A total of 651 patients with coronary lesions situated in native vessels >2.8 mm in diameter were randomly assigned to receive 1 of 2 commercially available stents of comparable design but different thickness: 326 patients to the thin-strut stent (strut thickness of 50 μm) and 325 patients to the thick-strut stent (strut thickness of 140 μm). The primary end point was the angiographic restenosis (≥50% diameter stenosis at follow-up angiography). Secondary end points were the incidence of reinterventions due to restenosis-induced ischemia and the combined rate of death and myocardial infarctions at 1 year. The incidence of angiographic restenosis was 15.0% in the thin-strut group and 25.8% in the thick-strut group (relative risk, 0.58; 95% CI, 0.39 to 0.87;
<jats:italic>P</jats:italic>
=0.003). Clinical restenosis was also significantly reduced, with a reintervention rate of 8.6% among thin-strut patients and 13.8% among thick-strut patients (relative risk, 0.62; 95% CI, 0.39 to 0.99;
<jats:italic>P</jats:italic>
=0.03). No difference was observed in the combined 1-year rate of death and myocardial infarction.
</jats:p>
<jats:p>
<jats:italic>Conclusions</jats:italic>
—The use of a thinner-strut device is associated with a significant reduction of angiographic and clinical restenosis after coronary artery stenting. These findings may have relevant implications for the currently most widely used percutaneous coronary intervention.
</jats:p> |
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| author | Kastrati, Adnan, Mehilli, Julinda, Dirschinger, Josef, Dotzer, Franz, Schühlen, Helmut, Neumann, Franz-Josef, Fleckenstein, Martin, Pfafferott, Conrad, Seyfarth, Melchior, Schömig, Albert |
| author_facet | Kastrati, Adnan, Mehilli, Julinda, Dirschinger, Josef, Dotzer, Franz, Schühlen, Helmut, Neumann, Franz-Josef, Fleckenstein, Martin, Pfafferott, Conrad, Seyfarth, Melchior, Schömig, Albert, Kastrati, Adnan, Mehilli, Julinda, Dirschinger, Josef, Dotzer, Franz, Schühlen, Helmut, Neumann, Franz-Josef, Fleckenstein, Martin, Pfafferott, Conrad, Seyfarth, Melchior, Schömig, Albert |
| author_sort | kastrati, adnan |
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| description | <jats:p> <jats:italic>Background</jats:italic> —Increased thrombogenicity and smooth muscle cell proliferative response induced by the metal struts compromise the advantages of coronary stenting. The objective of this randomized, multicenter study was to assess whether a reduced strut thickness of coronary stents is associated with improved follow-up angiographic and clinical results. </jats:p> <jats:p> <jats:italic>Methods and Results</jats:italic> —A total of 651 patients with coronary lesions situated in native vessels >2.8 mm in diameter were randomly assigned to receive 1 of 2 commercially available stents of comparable design but different thickness: 326 patients to the thin-strut stent (strut thickness of 50 μm) and 325 patients to the thick-strut stent (strut thickness of 140 μm). The primary end point was the angiographic restenosis (≥50% diameter stenosis at follow-up angiography). Secondary end points were the incidence of reinterventions due to restenosis-induced ischemia and the combined rate of death and myocardial infarctions at 1 year. The incidence of angiographic restenosis was 15.0% in the thin-strut group and 25.8% in the thick-strut group (relative risk, 0.58; 95% CI, 0.39 to 0.87; <jats:italic>P</jats:italic> =0.003). Clinical restenosis was also significantly reduced, with a reintervention rate of 8.6% among thin-strut patients and 13.8% among thick-strut patients (relative risk, 0.62; 95% CI, 0.39 to 0.99; <jats:italic>P</jats:italic> =0.03). No difference was observed in the combined 1-year rate of death and myocardial infarction. </jats:p> <jats:p> <jats:italic>Conclusions</jats:italic> —The use of a thinner-strut device is associated with a significant reduction of angiographic and clinical restenosis after coronary artery stenting. These findings may have relevant implications for the currently most widely used percutaneous coronary intervention. </jats:p> |
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| imprint | Ovid Technologies (Wolters Kluwer Health), 2001 |
| imprint_str_mv | Ovid Technologies (Wolters Kluwer Health), 2001 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| spelling | Kastrati, Adnan Mehilli, Julinda Dirschinger, Josef Dotzer, Franz Schühlen, Helmut Neumann, Franz-Josef Fleckenstein, Martin Pfafferott, Conrad Seyfarth, Melchior Schömig, Albert 0009-7322 1524-4539 Ovid Technologies (Wolters Kluwer Health) Physiology (medical) Cardiology and Cardiovascular Medicine http://dx.doi.org/10.1161/01.cir.103.23.2816 <jats:p> <jats:italic>Background</jats:italic> —Increased thrombogenicity and smooth muscle cell proliferative response induced by the metal struts compromise the advantages of coronary stenting. The objective of this randomized, multicenter study was to assess whether a reduced strut thickness of coronary stents is associated with improved follow-up angiographic and clinical results. </jats:p> <jats:p> <jats:italic>Methods and Results</jats:italic> —A total of 651 patients with coronary lesions situated in native vessels >2.8 mm in diameter were randomly assigned to receive 1 of 2 commercially available stents of comparable design but different thickness: 326 patients to the thin-strut stent (strut thickness of 50 μm) and 325 patients to the thick-strut stent (strut thickness of 140 μm). The primary end point was the angiographic restenosis (≥50% diameter stenosis at follow-up angiography). Secondary end points were the incidence of reinterventions due to restenosis-induced ischemia and the combined rate of death and myocardial infarctions at 1 year. The incidence of angiographic restenosis was 15.0% in the thin-strut group and 25.8% in the thick-strut group (relative risk, 0.58; 95% CI, 0.39 to 0.87; <jats:italic>P</jats:italic> =0.003). Clinical restenosis was also significantly reduced, with a reintervention rate of 8.6% among thin-strut patients and 13.8% among thick-strut patients (relative risk, 0.62; 95% CI, 0.39 to 0.99; <jats:italic>P</jats:italic> =0.03). No difference was observed in the combined 1-year rate of death and myocardial infarction. </jats:p> <jats:p> <jats:italic>Conclusions</jats:italic> —The use of a thinner-strut device is associated with a significant reduction of angiographic and clinical restenosis after coronary artery stenting. These findings may have relevant implications for the currently most widely used percutaneous coronary intervention. </jats:p> Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial Intracoronary Stenting and Angiographic Results : Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial Circulation |
| spellingShingle | Kastrati, Adnan, Mehilli, Julinda, Dirschinger, Josef, Dotzer, Franz, Schühlen, Helmut, Neumann, Franz-Josef, Fleckenstein, Martin, Pfafferott, Conrad, Seyfarth, Melchior, Schömig, Albert, Circulation, Intracoronary Stenting and Angiographic Results : Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial, Physiology (medical), Cardiology and Cardiovascular Medicine |
| title | Intracoronary Stenting and Angiographic Results : Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial |
| title_full | Intracoronary Stenting and Angiographic Results : Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial |
| title_fullStr | Intracoronary Stenting and Angiographic Results : Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial |
| title_full_unstemmed | Intracoronary Stenting and Angiographic Results : Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial |
| title_short | Intracoronary Stenting and Angiographic Results : Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial |
| title_sort | intracoronary stenting and angiographic results : strut thickness effect on restenosis outcome (isar-stereo) trial |
| title_sub | Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial |
| title_unstemmed | Intracoronary Stenting and Angiographic Results : Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial |
| topic | Physiology (medical), Cardiology and Cardiovascular Medicine |
| url | http://dx.doi.org/10.1161/01.cir.103.23.2816 |