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Metabolic Syndrome and Breast Cancer: Is There a Link?
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| Zeitschriftentitel: | Breast Care |
|---|---|
| Personen und Körperschaften: | , |
| In: | Breast Care, 9, 2014, 4, S. 277-281 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
S. Karger AG
|
| Schlagwörter: |
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Hauner, Dagmar Hauner, Hans Hauner, Dagmar Hauner, Hans |
|---|---|
| author |
Hauner, Dagmar Hauner, Hans |
| spellingShingle |
Hauner, Dagmar Hauner, Hans Breast Care Metabolic Syndrome and Breast Cancer: Is There a Link? Oncology Surgery |
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hauner, dagmar |
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Hauner, Dagmar Hauner, Hans 1661-3791 1661-3805 S. Karger AG Oncology Surgery http://dx.doi.org/10.1159/000365951 <jats:p><b><i>Summary</i></b> Epidemiological data suggest a close link between obesity and breast cancer, the most frequently occurring cancer in women. The metabolic syndrome is typically associated with abdominal obesity and comprises disturbances in glucose and/or lipid metabolism and/or hypertension. Recent studies have established a specific association between the metabolic syndrome - as well as its components - and breast cancer, indicating both an increased risk of developing breast cancer and a poorer prognosis. In premenopausal women, obesity might have a protective effect only on receptor-positive tumors, whereas a positive association was observed between obesity/abdominal obesity and an increased risk of triple-negative breast cancer (TNBC). Overall survival and disease-free survival were reported to be significantly shorter in premenopausal obese women with TNBC compared to non-obese women, but these results are still inconsistent and need further research. The metabolic syndrome is characterized by a state of insulin resistance/hyperinsulinemia and subacute chronic inflammation, with both conditions offering a plausible mechanistic link towards breast cancer. Thus, in addition to their increased risk of cardiovascular morbidity and mortality, women with this syndrome represent a group at elevated risk of developing breast cancer and with poorer prognosis.</jats:p> Metabolic Syndrome and Breast Cancer: Is There a Link? Breast Care |
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Metabolic Syndrome and Breast Cancer: Is There a Link? |
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Metabolic Syndrome and Breast Cancer: Is There a Link? |
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Metabolic Syndrome and Breast Cancer: Is There a Link? |
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Metabolic Syndrome and Breast Cancer: Is There a Link? |
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Metabolic Syndrome and Breast Cancer: Is There a Link? |
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Metabolic Syndrome and Breast Cancer: Is There a Link? |
| title_sort |
metabolic syndrome and breast cancer: is there a link? |
| topic |
Oncology Surgery |
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http://dx.doi.org/10.1159/000365951 |
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2014 |
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277-281 |
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<jats:p><b><i>Summary</i></b> Epidemiological data suggest a close link between obesity and breast cancer, the most frequently occurring cancer in women. The metabolic syndrome is typically associated with abdominal obesity and comprises disturbances in glucose and/or lipid metabolism and/or hypertension. Recent studies have established a specific association between the metabolic syndrome - as well as its components - and breast cancer, indicating both an increased risk of developing breast cancer and a poorer prognosis. In premenopausal women, obesity might have a protective effect only on receptor-positive tumors, whereas a positive association was observed between obesity/abdominal obesity and an increased risk of triple-negative breast cancer (TNBC). Overall survival and disease-free survival were reported to be significantly shorter in premenopausal obese women with TNBC compared to non-obese women, but these results are still inconsistent and need further research. The metabolic syndrome is characterized by a state of insulin resistance/hyperinsulinemia and subacute chronic inflammation, with both conditions offering a plausible mechanistic link towards breast cancer. Thus, in addition to their increased risk of cardiovascular morbidity and mortality, women with this syndrome represent a group at elevated risk of developing breast cancer and with poorer prognosis.</jats:p> |
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| description | <jats:p><b><i>Summary</i></b> Epidemiological data suggest a close link between obesity and breast cancer, the most frequently occurring cancer in women. The metabolic syndrome is typically associated with abdominal obesity and comprises disturbances in glucose and/or lipid metabolism and/or hypertension. Recent studies have established a specific association between the metabolic syndrome - as well as its components - and breast cancer, indicating both an increased risk of developing breast cancer and a poorer prognosis. In premenopausal women, obesity might have a protective effect only on receptor-positive tumors, whereas a positive association was observed between obesity/abdominal obesity and an increased risk of triple-negative breast cancer (TNBC). Overall survival and disease-free survival were reported to be significantly shorter in premenopausal obese women with TNBC compared to non-obese women, but these results are still inconsistent and need further research. The metabolic syndrome is characterized by a state of insulin resistance/hyperinsulinemia and subacute chronic inflammation, with both conditions offering a plausible mechanistic link towards breast cancer. Thus, in addition to their increased risk of cardiovascular morbidity and mortality, women with this syndrome represent a group at elevated risk of developing breast cancer and with poorer prognosis.</jats:p> |
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| spelling | Hauner, Dagmar Hauner, Hans 1661-3791 1661-3805 S. Karger AG Oncology Surgery http://dx.doi.org/10.1159/000365951 <jats:p><b><i>Summary</i></b> Epidemiological data suggest a close link between obesity and breast cancer, the most frequently occurring cancer in women. The metabolic syndrome is typically associated with abdominal obesity and comprises disturbances in glucose and/or lipid metabolism and/or hypertension. Recent studies have established a specific association between the metabolic syndrome - as well as its components - and breast cancer, indicating both an increased risk of developing breast cancer and a poorer prognosis. In premenopausal women, obesity might have a protective effect only on receptor-positive tumors, whereas a positive association was observed between obesity/abdominal obesity and an increased risk of triple-negative breast cancer (TNBC). Overall survival and disease-free survival were reported to be significantly shorter in premenopausal obese women with TNBC compared to non-obese women, but these results are still inconsistent and need further research. The metabolic syndrome is characterized by a state of insulin resistance/hyperinsulinemia and subacute chronic inflammation, with both conditions offering a plausible mechanistic link towards breast cancer. Thus, in addition to their increased risk of cardiovascular morbidity and mortality, women with this syndrome represent a group at elevated risk of developing breast cancer and with poorer prognosis.</jats:p> Metabolic Syndrome and Breast Cancer: Is There a Link? Breast Care |
| spellingShingle | Hauner, Dagmar, Hauner, Hans, Breast Care, Metabolic Syndrome and Breast Cancer: Is There a Link?, Oncology, Surgery |
| title | Metabolic Syndrome and Breast Cancer: Is There a Link? |
| title_full | Metabolic Syndrome and Breast Cancer: Is There a Link? |
| title_fullStr | Metabolic Syndrome and Breast Cancer: Is There a Link? |
| title_full_unstemmed | Metabolic Syndrome and Breast Cancer: Is There a Link? |
| title_short | Metabolic Syndrome and Breast Cancer: Is There a Link? |
| title_sort | metabolic syndrome and breast cancer: is there a link? |
| title_unstemmed | Metabolic Syndrome and Breast Cancer: Is There a Link? |
| topic | Oncology, Surgery |
| url | http://dx.doi.org/10.1159/000365951 |