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The Molecular Mechanisms of Offspring Effects from Obese Pregnancy
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| Zeitschriftentitel: | Obesity Facts |
|---|---|
| Personen und Körperschaften: | , |
| In: | Obesity Facts, 6, 2013, 2, S. 134-145 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
S. Karger AG
|
| Schlagwörter: |
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Dowling, Daniel McAuliffe, Fionnuala M. Dowling, Daniel McAuliffe, Fionnuala M. |
|---|---|
| author |
Dowling, Daniel McAuliffe, Fionnuala M. |
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Dowling, Daniel McAuliffe, Fionnuala M. Obesity Facts The Molecular Mechanisms of Offspring Effects from Obese Pregnancy Physiology (medical) Health (social science) |
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dowling, daniel |
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Dowling, Daniel McAuliffe, Fionnuala M. 1662-4025 1662-4033 S. Karger AG Physiology (medical) Health (social science) http://dx.doi.org/10.1159/000350706 <jats:p>The incidence of obesity, increased weight gain and the popularity of high-fat / high-sugar diets are seriously impacting upon the global population. Billions of individuals are affected, and although diet and lifestyle are of paramount importance to the development of adult obesity, compelling evidence is emerging which suggests that maternal obesity and related disorders may be passed on to the next generation by non-genetic means. The processes acting within the uteri of obese mothers may permanently predispose offspring to a diverse plethora of diseases ranging from obesity and diabetes to psychiatric disorders. This review aims to summarise some of the molecular mechanisms and active processes currently known about maternal obesity and its effect on foetal and neonatal physiology and metabolism. Complex and multifactorial networks of molecules are intertwined and culminate in a pathologically synergistic manner to cause disruption and disorganisation of foetal physiology. This altered phenotype may potentiate the cycle of intergenerational transmission of obesity and related disorders.</jats:p> The Molecular Mechanisms of Offspring Effects from Obese Pregnancy Obesity Facts |
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| title |
The Molecular Mechanisms of Offspring Effects from Obese Pregnancy |
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The Molecular Mechanisms of Offspring Effects from Obese Pregnancy |
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The Molecular Mechanisms of Offspring Effects from Obese Pregnancy |
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The Molecular Mechanisms of Offspring Effects from Obese Pregnancy |
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The Molecular Mechanisms of Offspring Effects from Obese Pregnancy |
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The Molecular Mechanisms of Offspring Effects from Obese Pregnancy |
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the molecular mechanisms of offspring effects from obese pregnancy |
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Physiology (medical) Health (social science) |
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http://dx.doi.org/10.1159/000350706 |
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2013 |
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134-145 |
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<jats:p>The incidence of obesity, increased weight gain and the popularity of high-fat / high-sugar diets are seriously impacting upon the global population. Billions of individuals are affected, and although diet and lifestyle are of paramount importance to the development of adult obesity, compelling evidence is emerging which suggests that maternal obesity and related disorders may be passed on to the next generation by non-genetic means. The processes acting within the uteri of obese mothers may permanently predispose offspring to a diverse plethora of diseases ranging from obesity and diabetes to psychiatric disorders. This review aims to summarise some of the molecular mechanisms and active processes currently known about maternal obesity and its effect on foetal and neonatal physiology and metabolism. Complex and multifactorial networks of molecules are intertwined and culminate in a pathologically synergistic manner to cause disruption and disorganisation of foetal physiology. This altered phenotype may potentiate the cycle of intergenerational transmission of obesity and related disorders.</jats:p> |
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| author | Dowling, Daniel, McAuliffe, Fionnuala M. |
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| description | <jats:p>The incidence of obesity, increased weight gain and the popularity of high-fat / high-sugar diets are seriously impacting upon the global population. Billions of individuals are affected, and although diet and lifestyle are of paramount importance to the development of adult obesity, compelling evidence is emerging which suggests that maternal obesity and related disorders may be passed on to the next generation by non-genetic means. The processes acting within the uteri of obese mothers may permanently predispose offspring to a diverse plethora of diseases ranging from obesity and diabetes to psychiatric disorders. This review aims to summarise some of the molecular mechanisms and active processes currently known about maternal obesity and its effect on foetal and neonatal physiology and metabolism. Complex and multifactorial networks of molecules are intertwined and culminate in a pathologically synergistic manner to cause disruption and disorganisation of foetal physiology. This altered phenotype may potentiate the cycle of intergenerational transmission of obesity and related disorders.</jats:p> |
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| spelling | Dowling, Daniel McAuliffe, Fionnuala M. 1662-4025 1662-4033 S. Karger AG Physiology (medical) Health (social science) http://dx.doi.org/10.1159/000350706 <jats:p>The incidence of obesity, increased weight gain and the popularity of high-fat / high-sugar diets are seriously impacting upon the global population. Billions of individuals are affected, and although diet and lifestyle are of paramount importance to the development of adult obesity, compelling evidence is emerging which suggests that maternal obesity and related disorders may be passed on to the next generation by non-genetic means. The processes acting within the uteri of obese mothers may permanently predispose offspring to a diverse plethora of diseases ranging from obesity and diabetes to psychiatric disorders. This review aims to summarise some of the molecular mechanisms and active processes currently known about maternal obesity and its effect on foetal and neonatal physiology and metabolism. Complex and multifactorial networks of molecules are intertwined and culminate in a pathologically synergistic manner to cause disruption and disorganisation of foetal physiology. This altered phenotype may potentiate the cycle of intergenerational transmission of obesity and related disorders.</jats:p> The Molecular Mechanisms of Offspring Effects from Obese Pregnancy Obesity Facts |
| spellingShingle | Dowling, Daniel, McAuliffe, Fionnuala M., Obesity Facts, The Molecular Mechanisms of Offspring Effects from Obese Pregnancy, Physiology (medical), Health (social science) |
| title | The Molecular Mechanisms of Offspring Effects from Obese Pregnancy |
| title_full | The Molecular Mechanisms of Offspring Effects from Obese Pregnancy |
| title_fullStr | The Molecular Mechanisms of Offspring Effects from Obese Pregnancy |
| title_full_unstemmed | The Molecular Mechanisms of Offspring Effects from Obese Pregnancy |
| title_short | The Molecular Mechanisms of Offspring Effects from Obese Pregnancy |
| title_sort | the molecular mechanisms of offspring effects from obese pregnancy |
| title_unstemmed | The Molecular Mechanisms of Offspring Effects from Obese Pregnancy |
| topic | Physiology (medical), Health (social science) |
| url | http://dx.doi.org/10.1159/000350706 |