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Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis
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| Zeitschriftentitel: | Kidney and Blood Pressure Research |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Kidney and Blood Pressure Research, 29, 2006, 4, S. 210-215 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
S. Karger AG
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| Schlagwörter: |
| author_facet |
Seeman, Tomáš Patzer, Ludwig John, Ulrike Dušek, Jiří Vondrák, Karel Janda, Jan Misselwitz, Joachim Seeman, Tomáš Patzer, Ludwig John, Ulrike Dušek, Jiří Vondrák, Karel Janda, Jan Misselwitz, Joachim |
|---|---|
| author |
Seeman, Tomáš Patzer, Ludwig John, Ulrike Dušek, Jiří Vondrák, Karel Janda, Jan Misselwitz, Joachim |
| spellingShingle |
Seeman, Tomáš Patzer, Ludwig John, Ulrike Dušek, Jiří Vondrák, Karel Janda, Jan Misselwitz, Joachim Kidney and Blood Pressure Research Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis Cardiology and Cardiovascular Medicine Nephrology Cardiology and Cardiovascular Medicine Nephrology |
| author_sort |
seeman, tomáš |
| spelling |
Seeman, Tomáš Patzer, Ludwig John, Ulrike Dušek, Jiří Vondrák, Karel Janda, Jan Misselwitz, Joachim 1420-4096 1423-0143 S. Karger AG Cardiology and Cardiovascular Medicine Nephrology Cardiology and Cardiovascular Medicine Nephrology http://dx.doi.org/10.1159/000095735 <jats:p><i>Background/Aim:</i> Unilateral renal agenesis (URA) is a model for a reduced nephron number that is believed to be a risk factor for blood pressure (BP) elevation and reduced renal function. The aim of the study was to investigate BP and renal function in children with URA. <i>Methods:</i> Data on children with URA from two pediatric nephrology centers were firstly retrospectively reviewed (renal ultrasound and scintigraphy, clinical BP, creatinine clearance, urinalysis). Children with normal renal ultrasound and scintigraphy were thereafter investigated using ambulatory BP monitoring. <i>Results:</i> Twenty-nine children with URA were investigated – 14 children with an abnormal kidney (mostly scarring) and 15 children with healthy kidneys. Hypertension was diagnosed on the basis of clinical BP in 57% of the children with abnormal kidneys and on the basis of ambulatory BP monitoring in 1 child (7%) with healthy kidneys. The mean ambulatory BP in children with normal kidneys was not significantly different from that in controls. Forty-three percent of the children with abnormal kidneys had a reduced renal function, but none of children with normal kidneys. <i>Conclusions:</i> Children with abnormalities of a solitary kidney have often hypertension, proteinuria, or a reduced renal function. In contrast, children with healthy solitary kidneys have BP and renal function similar to those of healthy children.</jats:p> Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis Kidney and Blood Pressure Research |
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10.1159/000095735 |
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S. Karger AG, 2006 |
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S. Karger AG, 2006 |
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1420-4096 1423-0143 |
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Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis |
| title_unstemmed |
Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis |
| title_full |
Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis |
| title_fullStr |
Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis |
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Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis |
| title_short |
Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis |
| title_sort |
blood pressure, renal function, and proteinuria in children with unilateral renal agenesis |
| topic |
Cardiology and Cardiovascular Medicine Nephrology Cardiology and Cardiovascular Medicine Nephrology |
| url |
http://dx.doi.org/10.1159/000095735 |
| publishDate |
2006 |
| physical |
210-215 |
| description |
<jats:p><i>Background/Aim:</i> Unilateral renal agenesis (URA) is a model for a reduced nephron number that is believed to be a risk factor for blood pressure (BP) elevation and reduced renal function. The aim of the study was to investigate BP and renal function in children with URA. <i>Methods:</i> Data on children with URA from two pediatric nephrology centers were firstly retrospectively reviewed (renal ultrasound and scintigraphy, clinical BP, creatinine clearance, urinalysis). Children with normal renal ultrasound and scintigraphy were thereafter investigated using ambulatory BP monitoring. <i>Results:</i> Twenty-nine children with URA were investigated – 14 children with an abnormal kidney (mostly scarring) and 15 children with healthy kidneys. Hypertension was diagnosed on the basis of clinical BP in 57% of the children with abnormal kidneys and on the basis of ambulatory BP monitoring in 1 child (7%) with healthy kidneys. The mean ambulatory BP in children with normal kidneys was not significantly different from that in controls. Forty-three percent of the children with abnormal kidneys had a reduced renal function, but none of children with normal kidneys. <i>Conclusions:</i> Children with abnormalities of a solitary kidney have often hypertension, proteinuria, or a reduced renal function. In contrast, children with healthy solitary kidneys have BP and renal function similar to those of healthy children.</jats:p> |
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| author | Seeman, Tomáš, Patzer, Ludwig, John, Ulrike, Dušek, Jiří, Vondrák, Karel, Janda, Jan, Misselwitz, Joachim |
| author_facet | Seeman, Tomáš, Patzer, Ludwig, John, Ulrike, Dušek, Jiří, Vondrák, Karel, Janda, Jan, Misselwitz, Joachim, Seeman, Tomáš, Patzer, Ludwig, John, Ulrike, Dušek, Jiří, Vondrák, Karel, Janda, Jan, Misselwitz, Joachim |
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| description | <jats:p><i>Background/Aim:</i> Unilateral renal agenesis (URA) is a model for a reduced nephron number that is believed to be a risk factor for blood pressure (BP) elevation and reduced renal function. The aim of the study was to investigate BP and renal function in children with URA. <i>Methods:</i> Data on children with URA from two pediatric nephrology centers were firstly retrospectively reviewed (renal ultrasound and scintigraphy, clinical BP, creatinine clearance, urinalysis). Children with normal renal ultrasound and scintigraphy were thereafter investigated using ambulatory BP monitoring. <i>Results:</i> Twenty-nine children with URA were investigated – 14 children with an abnormal kidney (mostly scarring) and 15 children with healthy kidneys. Hypertension was diagnosed on the basis of clinical BP in 57% of the children with abnormal kidneys and on the basis of ambulatory BP monitoring in 1 child (7%) with healthy kidneys. The mean ambulatory BP in children with normal kidneys was not significantly different from that in controls. Forty-three percent of the children with abnormal kidneys had a reduced renal function, but none of children with normal kidneys. <i>Conclusions:</i> Children with abnormalities of a solitary kidney have often hypertension, proteinuria, or a reduced renal function. In contrast, children with healthy solitary kidneys have BP and renal function similar to those of healthy children.</jats:p> |
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| imprint_str_mv | S. Karger AG, 2006 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| physical | 210-215 |
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| spelling | Seeman, Tomáš Patzer, Ludwig John, Ulrike Dušek, Jiří Vondrák, Karel Janda, Jan Misselwitz, Joachim 1420-4096 1423-0143 S. Karger AG Cardiology and Cardiovascular Medicine Nephrology Cardiology and Cardiovascular Medicine Nephrology http://dx.doi.org/10.1159/000095735 <jats:p><i>Background/Aim:</i> Unilateral renal agenesis (URA) is a model for a reduced nephron number that is believed to be a risk factor for blood pressure (BP) elevation and reduced renal function. The aim of the study was to investigate BP and renal function in children with URA. <i>Methods:</i> Data on children with URA from two pediatric nephrology centers were firstly retrospectively reviewed (renal ultrasound and scintigraphy, clinical BP, creatinine clearance, urinalysis). Children with normal renal ultrasound and scintigraphy were thereafter investigated using ambulatory BP monitoring. <i>Results:</i> Twenty-nine children with URA were investigated – 14 children with an abnormal kidney (mostly scarring) and 15 children with healthy kidneys. Hypertension was diagnosed on the basis of clinical BP in 57% of the children with abnormal kidneys and on the basis of ambulatory BP monitoring in 1 child (7%) with healthy kidneys. The mean ambulatory BP in children with normal kidneys was not significantly different from that in controls. Forty-three percent of the children with abnormal kidneys had a reduced renal function, but none of children with normal kidneys. <i>Conclusions:</i> Children with abnormalities of a solitary kidney have often hypertension, proteinuria, or a reduced renal function. In contrast, children with healthy solitary kidneys have BP and renal function similar to those of healthy children.</jats:p> Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis Kidney and Blood Pressure Research |
| spellingShingle | Seeman, Tomáš, Patzer, Ludwig, John, Ulrike, Dušek, Jiří, Vondrák, Karel, Janda, Jan, Misselwitz, Joachim, Kidney and Blood Pressure Research, Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis, Cardiology and Cardiovascular Medicine, Nephrology, Cardiology and Cardiovascular Medicine, Nephrology |
| title | Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis |
| title_full | Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis |
| title_fullStr | Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis |
| title_full_unstemmed | Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis |
| title_short | Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis |
| title_sort | blood pressure, renal function, and proteinuria in children with unilateral renal agenesis |
| title_unstemmed | Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis |
| topic | Cardiology and Cardiovascular Medicine, Nephrology, Cardiology and Cardiovascular Medicine, Nephrology |
| url | http://dx.doi.org/10.1159/000095735 |