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Chemokine Expression in the Obstructed Kidney
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| Zeitschriftentitel: | Nephron Experimental Nephrology |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Nephron Experimental Nephrology, 9, 2001, 4, S. 241-248 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
S. Karger AG
|
| Schlagwörter: |
| author_facet |
Crisman, Jacqueline M. Richards, Laura L. Valach, Daniel P. Franzoni, David F. Diamond, Jonathan R. Crisman, Jacqueline M. Richards, Laura L. Valach, Daniel P. Franzoni, David F. Diamond, Jonathan R. |
|---|---|
| author |
Crisman, Jacqueline M. Richards, Laura L. Valach, Daniel P. Franzoni, David F. Diamond, Jonathan R. |
| spellingShingle |
Crisman, Jacqueline M. Richards, Laura L. Valach, Daniel P. Franzoni, David F. Diamond, Jonathan R. Nephron Experimental Nephrology Chemokine Expression in the Obstructed Kidney Nephrology Genetics Physiology General Medicine |
| author_sort |
crisman, jacqueline m. |
| spelling |
Crisman, Jacqueline M. Richards, Laura L. Valach, Daniel P. Franzoni, David F. Diamond, Jonathan R. 1660-2129 S. Karger AG Nephrology Genetics Physiology General Medicine http://dx.doi.org/10.1159/000052618 <jats:p>Chemokines are chemotactic cytokines that are important mediators of leukocyte extravasation and chemotaxis. Herein, we provide evidence that after 1 day of unilateral ureteral obstruction (UUO), the mouse obstructed kidney (OBK) expresses MCP-1 (monocyte chemoattractant protein-1), RANTES (Regulated on activation normal T-cell expressed and secreted) and IP-10 (interferon-γ-induced protein-10). In addition, by day 7, MIP-2 (macrophage inflammatory protein-2) expression is elevated in the obstructed kidneys compared to the contralateral control kidneys (CLK). After 7 days of obstruction, RANTES was the most abundant of the four chemokines detected in the OBK. In situ hybridization results indicate that several cellular compartments contribute to the expression of RANTES in the OBK. However, clearly cortical tubules within the OBK contribute substantially to the elevated expression of RANTES. These data support the contention that the cortical tubular epithelium plays a pivotal role in the inflammation associated with experimental hydronephrosis.</jats:p> Chemokine Expression in the Obstructed Kidney Nephron Experimental Nephrology |
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| title |
Chemokine Expression in the Obstructed Kidney |
| title_unstemmed |
Chemokine Expression in the Obstructed Kidney |
| title_full |
Chemokine Expression in the Obstructed Kidney |
| title_fullStr |
Chemokine Expression in the Obstructed Kidney |
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Chemokine Expression in the Obstructed Kidney |
| title_short |
Chemokine Expression in the Obstructed Kidney |
| title_sort |
chemokine expression in the obstructed kidney |
| topic |
Nephrology Genetics Physiology General Medicine |
| url |
http://dx.doi.org/10.1159/000052618 |
| publishDate |
2001 |
| physical |
241-248 |
| description |
<jats:p>Chemokines are chemotactic cytokines that are important mediators of leukocyte extravasation and chemotaxis. Herein, we provide evidence that after 1 day of unilateral ureteral obstruction (UUO), the mouse obstructed kidney (OBK) expresses MCP-1 (monocyte chemoattractant protein-1), RANTES (Regulated on activation normal T-cell expressed and secreted) and IP-10 (interferon-γ-induced protein-10). In addition, by day 7, MIP-2 (macrophage inflammatory protein-2) expression is elevated in the obstructed kidneys compared to the contralateral control kidneys (CLK). After 7 days of obstruction, RANTES was the most abundant of the four chemokines detected in the OBK. In situ hybridization results indicate that several cellular compartments contribute to the expression of RANTES in the OBK. However, clearly cortical tubules within the OBK contribute substantially to the elevated expression of RANTES. These data support the contention that the cortical tubular epithelium plays a pivotal role in the inflammation associated with experimental hydronephrosis.</jats:p> |
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| author | Crisman, Jacqueline M., Richards, Laura L., Valach, Daniel P., Franzoni, David F., Diamond, Jonathan R. |
| author_facet | Crisman, Jacqueline M., Richards, Laura L., Valach, Daniel P., Franzoni, David F., Diamond, Jonathan R., Crisman, Jacqueline M., Richards, Laura L., Valach, Daniel P., Franzoni, David F., Diamond, Jonathan R. |
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| description | <jats:p>Chemokines are chemotactic cytokines that are important mediators of leukocyte extravasation and chemotaxis. Herein, we provide evidence that after 1 day of unilateral ureteral obstruction (UUO), the mouse obstructed kidney (OBK) expresses MCP-1 (monocyte chemoattractant protein-1), RANTES (Regulated on activation normal T-cell expressed and secreted) and IP-10 (interferon-γ-induced protein-10). In addition, by day 7, MIP-2 (macrophage inflammatory protein-2) expression is elevated in the obstructed kidneys compared to the contralateral control kidneys (CLK). After 7 days of obstruction, RANTES was the most abundant of the four chemokines detected in the OBK. In situ hybridization results indicate that several cellular compartments contribute to the expression of RANTES in the OBK. However, clearly cortical tubules within the OBK contribute substantially to the elevated expression of RANTES. These data support the contention that the cortical tubular epithelium plays a pivotal role in the inflammation associated with experimental hydronephrosis.</jats:p> |
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| physical | 241-248 |
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| series | Nephron Experimental Nephrology |
| source_id | 49 |
| spelling | Crisman, Jacqueline M. Richards, Laura L. Valach, Daniel P. Franzoni, David F. Diamond, Jonathan R. 1660-2129 S. Karger AG Nephrology Genetics Physiology General Medicine http://dx.doi.org/10.1159/000052618 <jats:p>Chemokines are chemotactic cytokines that are important mediators of leukocyte extravasation and chemotaxis. Herein, we provide evidence that after 1 day of unilateral ureteral obstruction (UUO), the mouse obstructed kidney (OBK) expresses MCP-1 (monocyte chemoattractant protein-1), RANTES (Regulated on activation normal T-cell expressed and secreted) and IP-10 (interferon-γ-induced protein-10). In addition, by day 7, MIP-2 (macrophage inflammatory protein-2) expression is elevated in the obstructed kidneys compared to the contralateral control kidneys (CLK). After 7 days of obstruction, RANTES was the most abundant of the four chemokines detected in the OBK. In situ hybridization results indicate that several cellular compartments contribute to the expression of RANTES in the OBK. However, clearly cortical tubules within the OBK contribute substantially to the elevated expression of RANTES. These data support the contention that the cortical tubular epithelium plays a pivotal role in the inflammation associated with experimental hydronephrosis.</jats:p> Chemokine Expression in the Obstructed Kidney Nephron Experimental Nephrology |
| spellingShingle | Crisman, Jacqueline M., Richards, Laura L., Valach, Daniel P., Franzoni, David F., Diamond, Jonathan R., Nephron Experimental Nephrology, Chemokine Expression in the Obstructed Kidney, Nephrology, Genetics, Physiology, General Medicine |
| title | Chemokine Expression in the Obstructed Kidney |
| title_full | Chemokine Expression in the Obstructed Kidney |
| title_fullStr | Chemokine Expression in the Obstructed Kidney |
| title_full_unstemmed | Chemokine Expression in the Obstructed Kidney |
| title_short | Chemokine Expression in the Obstructed Kidney |
| title_sort | chemokine expression in the obstructed kidney |
| title_unstemmed | Chemokine Expression in the Obstructed Kidney |
| topic | Nephrology, Genetics, Physiology, General Medicine |
| url | http://dx.doi.org/10.1159/000052618 |