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Autophagy in Pulmonary Innate Immunity
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| Zeitschriftentitel: | Journal of Innate Immunity |
|---|---|
| Personen und Körperschaften: | , |
| In: | Journal of Innate Immunity, 12, 2020, 1, S. 21-30 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
S. Karger AG
|
| Schlagwörter: |
| author_facet |
Rao, Lang Eissa, N. Tony Rao, Lang Eissa, N. Tony |
|---|---|
| author |
Rao, Lang Eissa, N. Tony |
| spellingShingle |
Rao, Lang Eissa, N. Tony Journal of Innate Immunity Autophagy in Pulmonary Innate Immunity Immunology and Allergy |
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rao, lang |
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Rao, Lang Eissa, N. Tony 1662-811X 1662-8128 S. Karger AG Immunology and Allergy http://dx.doi.org/10.1159/000497414 <jats:p>Autophagy is a major intracellular digestion system that delivers cytoplasmic components for degradation and recycling. In this capacity, autophagy plays an important role in maintaining cellular homeostasis by mediating the degradation of cellular macromolecules and dysfunctional organelles and regeneration of nutrients for cell growth. Autophagy is important in innate immunity, as it is responsible for the clearance of various pathogens. Deficiency of intracellular autophagy can result in exaggerated activation of the inflammasome. The latter is an innate immune complex that senses diverse pathogen-associated or danger-associated molecular patterns and activates the expression of inflammatory cytokines. In autophagy-deficient cells, accumulation of damaged organelles, misfolded proteins, and reactive oxygen species contribute to inflammasome activation. The lung is continuously exposed to pathogens from the environment, rendering it vulnerable to infection. The lung innate immune cells act as a crucial initial barrier against the continuous threat from pathogens. In this review, we will summarize recent findings on the regulation of autophagy and its interaction with innate immunity, focusing on the lung.</jats:p> Autophagy in Pulmonary Innate Immunity Journal of Innate Immunity |
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S. Karger AG, 2020 |
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S. Karger AG, 2020 |
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1662-811X 1662-8128 |
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Journal of Innate Immunity |
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| title |
Autophagy in Pulmonary Innate Immunity |
| title_unstemmed |
Autophagy in Pulmonary Innate Immunity |
| title_full |
Autophagy in Pulmonary Innate Immunity |
| title_fullStr |
Autophagy in Pulmonary Innate Immunity |
| title_full_unstemmed |
Autophagy in Pulmonary Innate Immunity |
| title_short |
Autophagy in Pulmonary Innate Immunity |
| title_sort |
autophagy in pulmonary innate immunity |
| topic |
Immunology and Allergy |
| url |
http://dx.doi.org/10.1159/000497414 |
| publishDate |
2020 |
| physical |
21-30 |
| description |
<jats:p>Autophagy is a major intracellular digestion system that delivers cytoplasmic components for degradation and recycling. In this capacity, autophagy plays an important role in maintaining cellular homeostasis by mediating the degradation of cellular macromolecules and dysfunctional organelles and regeneration of nutrients for cell growth. Autophagy is important in innate immunity, as it is responsible for the clearance of various pathogens. Deficiency of intracellular autophagy can result in exaggerated activation of the inflammasome. The latter is an innate immune complex that senses diverse pathogen-associated or danger-associated molecular patterns and activates the expression of inflammatory cytokines. In autophagy-deficient cells, accumulation of damaged organelles, misfolded proteins, and reactive oxygen species contribute to inflammasome activation. The lung is continuously exposed to pathogens from the environment, rendering it vulnerable to infection. The lung innate immune cells act as a crucial initial barrier against the continuous threat from pathogens. In this review, we will summarize recent findings on the regulation of autophagy and its interaction with innate immunity, focusing on the lung.</jats:p> |
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| author | Rao, Lang, Eissa, N. Tony |
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| description | <jats:p>Autophagy is a major intracellular digestion system that delivers cytoplasmic components for degradation and recycling. In this capacity, autophagy plays an important role in maintaining cellular homeostasis by mediating the degradation of cellular macromolecules and dysfunctional organelles and regeneration of nutrients for cell growth. Autophagy is important in innate immunity, as it is responsible for the clearance of various pathogens. Deficiency of intracellular autophagy can result in exaggerated activation of the inflammasome. The latter is an innate immune complex that senses diverse pathogen-associated or danger-associated molecular patterns and activates the expression of inflammatory cytokines. In autophagy-deficient cells, accumulation of damaged organelles, misfolded proteins, and reactive oxygen species contribute to inflammasome activation. The lung is continuously exposed to pathogens from the environment, rendering it vulnerable to infection. The lung innate immune cells act as a crucial initial barrier against the continuous threat from pathogens. In this review, we will summarize recent findings on the regulation of autophagy and its interaction with innate immunity, focusing on the lung.</jats:p> |
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| imprint_str_mv | S. Karger AG, 2020 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| physical | 21-30 |
| publishDate | 2020 |
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| publisher | S. Karger AG |
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| series | Journal of Innate Immunity |
| source_id | 49 |
| spelling | Rao, Lang Eissa, N. Tony 1662-811X 1662-8128 S. Karger AG Immunology and Allergy http://dx.doi.org/10.1159/000497414 <jats:p>Autophagy is a major intracellular digestion system that delivers cytoplasmic components for degradation and recycling. In this capacity, autophagy plays an important role in maintaining cellular homeostasis by mediating the degradation of cellular macromolecules and dysfunctional organelles and regeneration of nutrients for cell growth. Autophagy is important in innate immunity, as it is responsible for the clearance of various pathogens. Deficiency of intracellular autophagy can result in exaggerated activation of the inflammasome. The latter is an innate immune complex that senses diverse pathogen-associated or danger-associated molecular patterns and activates the expression of inflammatory cytokines. In autophagy-deficient cells, accumulation of damaged organelles, misfolded proteins, and reactive oxygen species contribute to inflammasome activation. The lung is continuously exposed to pathogens from the environment, rendering it vulnerable to infection. The lung innate immune cells act as a crucial initial barrier against the continuous threat from pathogens. In this review, we will summarize recent findings on the regulation of autophagy and its interaction with innate immunity, focusing on the lung.</jats:p> Autophagy in Pulmonary Innate Immunity Journal of Innate Immunity |
| spellingShingle | Rao, Lang, Eissa, N. Tony, Journal of Innate Immunity, Autophagy in Pulmonary Innate Immunity, Immunology and Allergy |
| title | Autophagy in Pulmonary Innate Immunity |
| title_full | Autophagy in Pulmonary Innate Immunity |
| title_fullStr | Autophagy in Pulmonary Innate Immunity |
| title_full_unstemmed | Autophagy in Pulmonary Innate Immunity |
| title_short | Autophagy in Pulmonary Innate Immunity |
| title_sort | autophagy in pulmonary innate immunity |
| title_unstemmed | Autophagy in Pulmonary Innate Immunity |
| topic | Immunology and Allergy |
| url | http://dx.doi.org/10.1159/000497414 |