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Conjunctival Metastasis of a Cutaneous Melanoma

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Zeitschriftentitel: Ocular Oncology and Pathology
Personen und Körperschaften: Brouwer, Niels J., Marinkovic, Marina, Jochems, Anouk, Kapiteijn, Ellen W., van Duinen, Sjoerd G., Haeseker, Barbara I., Jager, Martine J., Luyten, Gregorius P.M.
In: Ocular Oncology and Pathology, 4, 2018, 2, S. 107-111
Format: E-Article
Sprache: Englisch
veröffentlicht:
S. Karger AG
Schlagwörter:
General Nursing
author_facet Brouwer, Niels J.
Marinkovic, Marina
Jochems, Anouk
Kapiteijn, Ellen W.
van Duinen, Sjoerd G.
Haeseker, Barbara I.
Jager, Martine J.
Luyten, Gregorius P.M.
Brouwer, Niels J.
Marinkovic, Marina
Jochems, Anouk
Kapiteijn, Ellen W.
van Duinen, Sjoerd G.
Haeseker, Barbara I.
Jager, Martine J.
Luyten, Gregorius P.M.
author Brouwer, Niels J.
Marinkovic, Marina
Jochems, Anouk
Kapiteijn, Ellen W.
van Duinen, Sjoerd G.
Haeseker, Barbara I.
Jager, Martine J.
Luyten, Gregorius P.M.
spellingShingle Brouwer, Niels J.
Marinkovic, Marina
Jochems, Anouk
Kapiteijn, Ellen W.
van Duinen, Sjoerd G.
Haeseker, Barbara I.
Jager, Martine J.
Luyten, Gregorius P.M.
Ocular Oncology and Pathology
Conjunctival Metastasis of a Cutaneous Melanoma
General Nursing
author_sort brouwer, niels j.
spelling Brouwer, Niels J. Marinkovic, Marina Jochems, Anouk Kapiteijn, Ellen W. van Duinen, Sjoerd G. Haeseker, Barbara I. Jager, Martine J. Luyten, Gregorius P.M. 2296-4681 2296-4657 S. Karger AG General Nursing http://dx.doi.org/10.1159/000479114 <jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;/i&gt;&lt;/b&gt; To report a patient who presented with a conjunctival tumour as a first sign of distant metastasis of cutaneous melanoma. The patient was treated successfully with BRAF/MEK-inhibitors and anti-PD-1 antibodies. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; Clinical and histopathological examination of the conjunctival lesion. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; A 74-year-old man was referred to our hospital with a pigmented conjunctival tumour, 5 months after having been diagnosed with cutaneous melanoma on his right scapula with loco-regional axillary lymph node metastases. The conjunctival lesion was excised and showed a BRAF V600E mutation. Histopathology showed a melanoma with characteristics suspicious for metastasis, as the lesion did not have a relation with the overlying epithelium. Systemic screening showed multiple distant metastases of the cutaneous melanoma in spleen, liver, and bone. Systemic treatment with the combination of a BRAF-inhibitor (dabrafenib) and MEK-inhibitor (trametinib) was started and followed by a switch to an anti-PD-1 antibody (pembrolizumab). Twenty-two months later, the patient is alive and in good clinical health. &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; Conjunctival metastases of cutaneous melanoma may mimic primary conjunctival melanoma. A good medical history and systemic work-up are required to differentiate these diseases. Identification of the proper diagnosis including mutation analysis is crucial, allowing patients to benefit from newly introduced treatment strategies for metastatic cutaneous melanoma.</jats:p> Conjunctival Metastasis of a Cutaneous Melanoma Ocular Oncology and Pathology
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title Conjunctival Metastasis of a Cutaneous Melanoma
title_unstemmed Conjunctival Metastasis of a Cutaneous Melanoma
title_full Conjunctival Metastasis of a Cutaneous Melanoma
title_fullStr Conjunctival Metastasis of a Cutaneous Melanoma
title_full_unstemmed Conjunctival Metastasis of a Cutaneous Melanoma
title_short Conjunctival Metastasis of a Cutaneous Melanoma
title_sort conjunctival metastasis of a cutaneous melanoma
topic General Nursing
url http://dx.doi.org/10.1159/000479114
publishDate 2018
physical 107-111
description <jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;/i&gt;&lt;/b&gt; To report a patient who presented with a conjunctival tumour as a first sign of distant metastasis of cutaneous melanoma. The patient was treated successfully with BRAF/MEK-inhibitors and anti-PD-1 antibodies. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; Clinical and histopathological examination of the conjunctival lesion. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; A 74-year-old man was referred to our hospital with a pigmented conjunctival tumour, 5 months after having been diagnosed with cutaneous melanoma on his right scapula with loco-regional axillary lymph node metastases. The conjunctival lesion was excised and showed a BRAF V600E mutation. Histopathology showed a melanoma with characteristics suspicious for metastasis, as the lesion did not have a relation with the overlying epithelium. Systemic screening showed multiple distant metastases of the cutaneous melanoma in spleen, liver, and bone. Systemic treatment with the combination of a BRAF-inhibitor (dabrafenib) and MEK-inhibitor (trametinib) was started and followed by a switch to an anti-PD-1 antibody (pembrolizumab). Twenty-two months later, the patient is alive and in good clinical health. &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; Conjunctival metastases of cutaneous melanoma may mimic primary conjunctival melanoma. A good medical history and systemic work-up are required to differentiate these diseases. Identification of the proper diagnosis including mutation analysis is crucial, allowing patients to benefit from newly introduced treatment strategies for metastatic cutaneous melanoma.</jats:p>
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author Brouwer, Niels J., Marinkovic, Marina, Jochems, Anouk, Kapiteijn, Ellen W., van Duinen, Sjoerd G., Haeseker, Barbara I., Jager, Martine J., Luyten, Gregorius P.M.
author_facet Brouwer, Niels J., Marinkovic, Marina, Jochems, Anouk, Kapiteijn, Ellen W., van Duinen, Sjoerd G., Haeseker, Barbara I., Jager, Martine J., Luyten, Gregorius P.M., Brouwer, Niels J., Marinkovic, Marina, Jochems, Anouk, Kapiteijn, Ellen W., van Duinen, Sjoerd G., Haeseker, Barbara I., Jager, Martine J., Luyten, Gregorius P.M.
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description <jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;/i&gt;&lt;/b&gt; To report a patient who presented with a conjunctival tumour as a first sign of distant metastasis of cutaneous melanoma. The patient was treated successfully with BRAF/MEK-inhibitors and anti-PD-1 antibodies. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; Clinical and histopathological examination of the conjunctival lesion. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; A 74-year-old man was referred to our hospital with a pigmented conjunctival tumour, 5 months after having been diagnosed with cutaneous melanoma on his right scapula with loco-regional axillary lymph node metastases. The conjunctival lesion was excised and showed a BRAF V600E mutation. Histopathology showed a melanoma with characteristics suspicious for metastasis, as the lesion did not have a relation with the overlying epithelium. Systemic screening showed multiple distant metastases of the cutaneous melanoma in spleen, liver, and bone. Systemic treatment with the combination of a BRAF-inhibitor (dabrafenib) and MEK-inhibitor (trametinib) was started and followed by a switch to an anti-PD-1 antibody (pembrolizumab). Twenty-two months later, the patient is alive and in good clinical health. &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; Conjunctival metastases of cutaneous melanoma may mimic primary conjunctival melanoma. A good medical history and systemic work-up are required to differentiate these diseases. Identification of the proper diagnosis including mutation analysis is crucial, allowing patients to benefit from newly introduced treatment strategies for metastatic cutaneous melanoma.</jats:p>
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spelling Brouwer, Niels J. Marinkovic, Marina Jochems, Anouk Kapiteijn, Ellen W. van Duinen, Sjoerd G. Haeseker, Barbara I. Jager, Martine J. Luyten, Gregorius P.M. 2296-4681 2296-4657 S. Karger AG General Nursing http://dx.doi.org/10.1159/000479114 <jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;/i&gt;&lt;/b&gt; To report a patient who presented with a conjunctival tumour as a first sign of distant metastasis of cutaneous melanoma. The patient was treated successfully with BRAF/MEK-inhibitors and anti-PD-1 antibodies. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; Clinical and histopathological examination of the conjunctival lesion. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; A 74-year-old man was referred to our hospital with a pigmented conjunctival tumour, 5 months after having been diagnosed with cutaneous melanoma on his right scapula with loco-regional axillary lymph node metastases. The conjunctival lesion was excised and showed a BRAF V600E mutation. Histopathology showed a melanoma with characteristics suspicious for metastasis, as the lesion did not have a relation with the overlying epithelium. Systemic screening showed multiple distant metastases of the cutaneous melanoma in spleen, liver, and bone. Systemic treatment with the combination of a BRAF-inhibitor (dabrafenib) and MEK-inhibitor (trametinib) was started and followed by a switch to an anti-PD-1 antibody (pembrolizumab). Twenty-two months later, the patient is alive and in good clinical health. &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; Conjunctival metastases of cutaneous melanoma may mimic primary conjunctival melanoma. A good medical history and systemic work-up are required to differentiate these diseases. Identification of the proper diagnosis including mutation analysis is crucial, allowing patients to benefit from newly introduced treatment strategies for metastatic cutaneous melanoma.</jats:p> Conjunctival Metastasis of a Cutaneous Melanoma Ocular Oncology and Pathology
spellingShingle Brouwer, Niels J., Marinkovic, Marina, Jochems, Anouk, Kapiteijn, Ellen W., van Duinen, Sjoerd G., Haeseker, Barbara I., Jager, Martine J., Luyten, Gregorius P.M., Ocular Oncology and Pathology, Conjunctival Metastasis of a Cutaneous Melanoma, General Nursing
title Conjunctival Metastasis of a Cutaneous Melanoma
title_full Conjunctival Metastasis of a Cutaneous Melanoma
title_fullStr Conjunctival Metastasis of a Cutaneous Melanoma
title_full_unstemmed Conjunctival Metastasis of a Cutaneous Melanoma
title_short Conjunctival Metastasis of a Cutaneous Melanoma
title_sort conjunctival metastasis of a cutaneous melanoma
title_unstemmed Conjunctival Metastasis of a Cutaneous Melanoma
topic General Nursing
url http://dx.doi.org/10.1159/000479114