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Surfactant Protein A Gene Deletion and Prognostics for Patients with Stage I Non–Small Cell Lung Cancer
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| Zeitschriftentitel: | Clinical Cancer Research |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , |
| In: | Clinical Cancer Research, 11, 2005, 15, S. 5417-5424 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Association for Cancer Research (AACR)
|
| Schlagwörter: |
| author_facet |
Jiang, Feng Caraway, Nancy P. Nebiyou Bekele, Benjamin Zhang, Hua-Zhong Khanna, Abha Wang, Huijun Li, Ruiyun Fernandez, Ricardo L. Zaidi, Tanweer M. Johnston, Dennis A. Katz, Ruth L. Jiang, Feng Caraway, Nancy P. Nebiyou Bekele, Benjamin Zhang, Hua-Zhong Khanna, Abha Wang, Huijun Li, Ruiyun Fernandez, Ricardo L. Zaidi, Tanweer M. Johnston, Dennis A. Katz, Ruth L. |
|---|---|
| author |
Jiang, Feng Caraway, Nancy P. Nebiyou Bekele, Benjamin Zhang, Hua-Zhong Khanna, Abha Wang, Huijun Li, Ruiyun Fernandez, Ricardo L. Zaidi, Tanweer M. Johnston, Dennis A. Katz, Ruth L. |
| spellingShingle |
Jiang, Feng Caraway, Nancy P. Nebiyou Bekele, Benjamin Zhang, Hua-Zhong Khanna, Abha Wang, Huijun Li, Ruiyun Fernandez, Ricardo L. Zaidi, Tanweer M. Johnston, Dennis A. Katz, Ruth L. Clinical Cancer Research Surfactant Protein A Gene Deletion and Prognostics for Patients with Stage I Non–Small Cell Lung Cancer Cancer Research Oncology |
| author_sort |
jiang, feng |
| spelling |
Jiang, Feng Caraway, Nancy P. Nebiyou Bekele, Benjamin Zhang, Hua-Zhong Khanna, Abha Wang, Huijun Li, Ruiyun Fernandez, Ricardo L. Zaidi, Tanweer M. Johnston, Dennis A. Katz, Ruth L. 1078-0432 1557-3265 American Association for Cancer Research (AACR) Cancer Research Oncology http://dx.doi.org/10.1158/1078-0432.ccr-04-2087 <jats:title>Abstract</jats:title> <jats:p>Purpose: The present study was conducted to determine clinical relevance of surfactant protein A (SP-A) genetic aberrations in early-stage non–small cell lung cancer (NSCLC).</jats:p> <jats:p>Experimental Design: To determine whether SP-A aberrations are lung cancer–specific and indicate smoking-related damage, tricolor fluorescence in situ hybridization with SP-A and PTEN probes was done on touch imprints from the lung tumors obtained prospectively from 28 patients with primary NSCLC. To further define the clinical relevance of SP-A aberrations, fluorescence in situ hybridization was done on both tumor cells and adjacent bronchial tissue cells from paraffin-embedded tissue blocks from 130 patients NSCLC for whom we had follow-up information.</jats:p> <jats:p>Results: SP-A was deleted from 89% of cancer tissues and the deletion was related to the smoking status of patients (P &lt; 0.001). PTEN was deleted from 16% in the cancer tissues and the deletion was not related to the smoking status of patients (P &gt; 0.05). In the cells isolated from paraffin-embedded tissue blocks, SP-A was deleted from 87% of the carcinoma tissues and 32% of the adjacent normal-appearing bronchial tissues. SP-A deletions in tumors and adjacent normal-appearing bronchial tissues were associated with increases in the risk of disease relapse (P = 0.0035 and P &lt; 0.001, respectively). SP-A deletions in the bronchial epithelium were the strongest prognostic indicators of disease-specific survival (P = 0.025).</jats:p> <jats:p>Conclusions: Deletions of the SP-A gene are specific genomic aberrations in bronchial epithelial cells adjacent to and within NSCLC, and are associated with tumor progression and a history of smoking. SP-A deletions might be a useful biomarker to identify poor prognoses in patients with NSCLC who might therefore benefit from adjuvant treatment.</jats:p> Surfactant Protein A Gene Deletion and Prognostics for Patients with Stage I Non–Small Cell Lung Cancer Clinical Cancer Research |
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American Association for Cancer Research (AACR), 2005 |
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1078-0432 1557-3265 |
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| title |
Surfactant Protein A Gene Deletion and Prognostics for Patients with Stage I Non–Small Cell Lung Cancer |
| title_unstemmed |
Surfactant Protein A Gene Deletion and Prognostics for Patients with Stage I Non–Small Cell Lung Cancer |
| title_full |
Surfactant Protein A Gene Deletion and Prognostics for Patients with Stage I Non–Small Cell Lung Cancer |
| title_fullStr |
Surfactant Protein A Gene Deletion and Prognostics for Patients with Stage I Non–Small Cell Lung Cancer |
| title_full_unstemmed |
Surfactant Protein A Gene Deletion and Prognostics for Patients with Stage I Non–Small Cell Lung Cancer |
| title_short |
Surfactant Protein A Gene Deletion and Prognostics for Patients with Stage I Non–Small Cell Lung Cancer |
| title_sort |
surfactant protein a gene deletion and prognostics for patients with stage i non–small cell lung cancer |
| topic |
Cancer Research Oncology |
| url |
http://dx.doi.org/10.1158/1078-0432.ccr-04-2087 |
| publishDate |
2005 |
| physical |
5417-5424 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>Purpose: The present study was conducted to determine clinical relevance of surfactant protein A (SP-A) genetic aberrations in early-stage non–small cell lung cancer (NSCLC).</jats:p>
<jats:p>Experimental Design: To determine whether SP-A aberrations are lung cancer–specific and indicate smoking-related damage, tricolor fluorescence in situ hybridization with SP-A and PTEN probes was done on touch imprints from the lung tumors obtained prospectively from 28 patients with primary NSCLC. To further define the clinical relevance of SP-A aberrations, fluorescence in situ hybridization was done on both tumor cells and adjacent bronchial tissue cells from paraffin-embedded tissue blocks from 130 patients NSCLC for whom we had follow-up information.</jats:p>
<jats:p>Results: SP-A was deleted from 89% of cancer tissues and the deletion was related to the smoking status of patients (P &lt; 0.001). PTEN was deleted from 16% in the cancer tissues and the deletion was not related to the smoking status of patients (P &gt; 0.05). In the cells isolated from paraffin-embedded tissue blocks, SP-A was deleted from 87% of the carcinoma tissues and 32% of the adjacent normal-appearing bronchial tissues. SP-A deletions in tumors and adjacent normal-appearing bronchial tissues were associated with increases in the risk of disease relapse (P = 0.0035 and P &lt; 0.001, respectively). SP-A deletions in the bronchial epithelium were the strongest prognostic indicators of disease-specific survival (P = 0.025).</jats:p>
<jats:p>Conclusions: Deletions of the SP-A gene are specific genomic aberrations in bronchial epithelial cells adjacent to and within NSCLC, and are associated with tumor progression and a history of smoking. SP-A deletions might be a useful biomarker to identify poor prognoses in patients with NSCLC who might therefore benefit from adjuvant treatment.</jats:p> |
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| author | Jiang, Feng, Caraway, Nancy P., Nebiyou Bekele, Benjamin, Zhang, Hua-Zhong, Khanna, Abha, Wang, Huijun, Li, Ruiyun, Fernandez, Ricardo L., Zaidi, Tanweer M., Johnston, Dennis A., Katz, Ruth L. |
| author_facet | Jiang, Feng, Caraway, Nancy P., Nebiyou Bekele, Benjamin, Zhang, Hua-Zhong, Khanna, Abha, Wang, Huijun, Li, Ruiyun, Fernandez, Ricardo L., Zaidi, Tanweer M., Johnston, Dennis A., Katz, Ruth L., Jiang, Feng, Caraway, Nancy P., Nebiyou Bekele, Benjamin, Zhang, Hua-Zhong, Khanna, Abha, Wang, Huijun, Li, Ruiyun, Fernandez, Ricardo L., Zaidi, Tanweer M., Johnston, Dennis A., Katz, Ruth L. |
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| description | <jats:title>Abstract</jats:title> <jats:p>Purpose: The present study was conducted to determine clinical relevance of surfactant protein A (SP-A) genetic aberrations in early-stage non–small cell lung cancer (NSCLC).</jats:p> <jats:p>Experimental Design: To determine whether SP-A aberrations are lung cancer–specific and indicate smoking-related damage, tricolor fluorescence in situ hybridization with SP-A and PTEN probes was done on touch imprints from the lung tumors obtained prospectively from 28 patients with primary NSCLC. To further define the clinical relevance of SP-A aberrations, fluorescence in situ hybridization was done on both tumor cells and adjacent bronchial tissue cells from paraffin-embedded tissue blocks from 130 patients NSCLC for whom we had follow-up information.</jats:p> <jats:p>Results: SP-A was deleted from 89% of cancer tissues and the deletion was related to the smoking status of patients (P &lt; 0.001). PTEN was deleted from 16% in the cancer tissues and the deletion was not related to the smoking status of patients (P &gt; 0.05). In the cells isolated from paraffin-embedded tissue blocks, SP-A was deleted from 87% of the carcinoma tissues and 32% of the adjacent normal-appearing bronchial tissues. SP-A deletions in tumors and adjacent normal-appearing bronchial tissues were associated with increases in the risk of disease relapse (P = 0.0035 and P &lt; 0.001, respectively). SP-A deletions in the bronchial epithelium were the strongest prognostic indicators of disease-specific survival (P = 0.025).</jats:p> <jats:p>Conclusions: Deletions of the SP-A gene are specific genomic aberrations in bronchial epithelial cells adjacent to and within NSCLC, and are associated with tumor progression and a history of smoking. SP-A deletions might be a useful biomarker to identify poor prognoses in patients with NSCLC who might therefore benefit from adjuvant treatment.</jats:p> |
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| imprint_str_mv | American Association for Cancer Research (AACR), 2005 |
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| spelling | Jiang, Feng Caraway, Nancy P. Nebiyou Bekele, Benjamin Zhang, Hua-Zhong Khanna, Abha Wang, Huijun Li, Ruiyun Fernandez, Ricardo L. Zaidi, Tanweer M. Johnston, Dennis A. Katz, Ruth L. 1078-0432 1557-3265 American Association for Cancer Research (AACR) Cancer Research Oncology http://dx.doi.org/10.1158/1078-0432.ccr-04-2087 <jats:title>Abstract</jats:title> <jats:p>Purpose: The present study was conducted to determine clinical relevance of surfactant protein A (SP-A) genetic aberrations in early-stage non–small cell lung cancer (NSCLC).</jats:p> <jats:p>Experimental Design: To determine whether SP-A aberrations are lung cancer–specific and indicate smoking-related damage, tricolor fluorescence in situ hybridization with SP-A and PTEN probes was done on touch imprints from the lung tumors obtained prospectively from 28 patients with primary NSCLC. To further define the clinical relevance of SP-A aberrations, fluorescence in situ hybridization was done on both tumor cells and adjacent bronchial tissue cells from paraffin-embedded tissue blocks from 130 patients NSCLC for whom we had follow-up information.</jats:p> <jats:p>Results: SP-A was deleted from 89% of cancer tissues and the deletion was related to the smoking status of patients (P &lt; 0.001). PTEN was deleted from 16% in the cancer tissues and the deletion was not related to the smoking status of patients (P &gt; 0.05). In the cells isolated from paraffin-embedded tissue blocks, SP-A was deleted from 87% of the carcinoma tissues and 32% of the adjacent normal-appearing bronchial tissues. SP-A deletions in tumors and adjacent normal-appearing bronchial tissues were associated with increases in the risk of disease relapse (P = 0.0035 and P &lt; 0.001, respectively). SP-A deletions in the bronchial epithelium were the strongest prognostic indicators of disease-specific survival (P = 0.025).</jats:p> <jats:p>Conclusions: Deletions of the SP-A gene are specific genomic aberrations in bronchial epithelial cells adjacent to and within NSCLC, and are associated with tumor progression and a history of smoking. SP-A deletions might be a useful biomarker to identify poor prognoses in patients with NSCLC who might therefore benefit from adjuvant treatment.</jats:p> Surfactant Protein A Gene Deletion and Prognostics for Patients with Stage I Non–Small Cell Lung Cancer Clinical Cancer Research |
| spellingShingle | Jiang, Feng, Caraway, Nancy P., Nebiyou Bekele, Benjamin, Zhang, Hua-Zhong, Khanna, Abha, Wang, Huijun, Li, Ruiyun, Fernandez, Ricardo L., Zaidi, Tanweer M., Johnston, Dennis A., Katz, Ruth L., Clinical Cancer Research, Surfactant Protein A Gene Deletion and Prognostics for Patients with Stage I Non–Small Cell Lung Cancer, Cancer Research, Oncology |
| title | Surfactant Protein A Gene Deletion and Prognostics for Patients with Stage I Non–Small Cell Lung Cancer |
| title_full | Surfactant Protein A Gene Deletion and Prognostics for Patients with Stage I Non–Small Cell Lung Cancer |
| title_fullStr | Surfactant Protein A Gene Deletion and Prognostics for Patients with Stage I Non–Small Cell Lung Cancer |
| title_full_unstemmed | Surfactant Protein A Gene Deletion and Prognostics for Patients with Stage I Non–Small Cell Lung Cancer |
| title_short | Surfactant Protein A Gene Deletion and Prognostics for Patients with Stage I Non–Small Cell Lung Cancer |
| title_sort | surfactant protein a gene deletion and prognostics for patients with stage i non–small cell lung cancer |
| title_unstemmed | Surfactant Protein A Gene Deletion and Prognostics for Patients with Stage I Non–Small Cell Lung Cancer |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.1158/1078-0432.ccr-04-2087 |