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N-acetyltransferase 2 Phenotype, Occupation, and Bladder Cancer Risk: Results from the EPIC Cohort
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| Zeitschriftentitel: | Cancer Epidemiology, Biomarkers & Prevention |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| In: | Cancer Epidemiology, Biomarkers & Prevention, 22, 2013, 11, S. 2055-2065 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Association for Cancer Research (AACR)
|
| Schlagwörter: |
| author_facet |
Pesch, Beate Gawrych, Katarzyna Rabstein, Sylvia Weiss, Tobias Casjens, Swaantje Rihs, Hans-Peter Ding, Hui Angerer, Jürgen Illig, Thomas Klopp, Norman Bueno-de-Mesquita, Bas Ros, Martine M. Kaaks, Rudolf Chang-Claude, Jenny Roswall, Nina Tjønneland, Anne Overvad, Kim Clavel-Chapelon, Françoise Boutron-Ruault, Marie-Christine Dossus, Laure Boeing, Heiner Weikert, Steffen Trichopoulos, Dimitrios Palli, Domenico Sieri, Sabina Tumino, Rosario Panico, Salvatore Quirós, José Ramón González, Carlos Sánchez, Mariá José Dorronsoro, Miren Navarro, Carmen Barricarte, Aurelio Ljungberg, Börje Johansson, Mattias Ulmert, David Ehrnström, Roy Khaw, Kay-Tee Wareham, Nick Key, Timothy J. Ferrari, Pietro Romieu, Isabelle Riboli, Elio Brüning, Thomas Vineis, Paolo Pesch, Beate Gawrych, Katarzyna Rabstein, Sylvia Weiss, Tobias Casjens, Swaantje Rihs, Hans-Peter Ding, Hui Angerer, Jürgen Illig, Thomas Klopp, Norman Bueno-de-Mesquita, Bas Ros, Martine M. Kaaks, Rudolf Chang-Claude, Jenny Roswall, Nina Tjønneland, Anne Overvad, Kim Clavel-Chapelon, Françoise Boutron-Ruault, Marie-Christine Dossus, Laure Boeing, Heiner Weikert, Steffen Trichopoulos, Dimitrios Palli, Domenico Sieri, Sabina Tumino, Rosario Panico, Salvatore Quirós, José Ramón González, Carlos Sánchez, Mariá José Dorronsoro, Miren Navarro, Carmen Barricarte, Aurelio Ljungberg, Börje Johansson, Mattias Ulmert, David Ehrnström, Roy Khaw, Kay-Tee Wareham, Nick Key, Timothy J. Ferrari, Pietro Romieu, Isabelle Riboli, Elio Brüning, Thomas Vineis, Paolo |
|---|---|
| author |
Pesch, Beate Gawrych, Katarzyna Rabstein, Sylvia Weiss, Tobias Casjens, Swaantje Rihs, Hans-Peter Ding, Hui Angerer, Jürgen Illig, Thomas Klopp, Norman Bueno-de-Mesquita, Bas Ros, Martine M. Kaaks, Rudolf Chang-Claude, Jenny Roswall, Nina Tjønneland, Anne Overvad, Kim Clavel-Chapelon, Françoise Boutron-Ruault, Marie-Christine Dossus, Laure Boeing, Heiner Weikert, Steffen Trichopoulos, Dimitrios Palli, Domenico Sieri, Sabina Tumino, Rosario Panico, Salvatore Quirós, José Ramón González, Carlos Sánchez, Mariá José Dorronsoro, Miren Navarro, Carmen Barricarte, Aurelio Ljungberg, Börje Johansson, Mattias Ulmert, David Ehrnström, Roy Khaw, Kay-Tee Wareham, Nick Key, Timothy J. Ferrari, Pietro Romieu, Isabelle Riboli, Elio Brüning, Thomas Vineis, Paolo |
| spellingShingle |
Pesch, Beate Gawrych, Katarzyna Rabstein, Sylvia Weiss, Tobias Casjens, Swaantje Rihs, Hans-Peter Ding, Hui Angerer, Jürgen Illig, Thomas Klopp, Norman Bueno-de-Mesquita, Bas Ros, Martine M. Kaaks, Rudolf Chang-Claude, Jenny Roswall, Nina Tjønneland, Anne Overvad, Kim Clavel-Chapelon, Françoise Boutron-Ruault, Marie-Christine Dossus, Laure Boeing, Heiner Weikert, Steffen Trichopoulos, Dimitrios Palli, Domenico Sieri, Sabina Tumino, Rosario Panico, Salvatore Quirós, José Ramón González, Carlos Sánchez, Mariá José Dorronsoro, Miren Navarro, Carmen Barricarte, Aurelio Ljungberg, Börje Johansson, Mattias Ulmert, David Ehrnström, Roy Khaw, Kay-Tee Wareham, Nick Key, Timothy J. Ferrari, Pietro Romieu, Isabelle Riboli, Elio Brüning, Thomas Vineis, Paolo Cancer Epidemiology, Biomarkers & Prevention N-acetyltransferase 2 Phenotype, Occupation, and Bladder Cancer Risk: Results from the EPIC Cohort Oncology Epidemiology |
| author_sort |
pesch, beate |
| spelling |
Pesch, Beate Gawrych, Katarzyna Rabstein, Sylvia Weiss, Tobias Casjens, Swaantje Rihs, Hans-Peter Ding, Hui Angerer, Jürgen Illig, Thomas Klopp, Norman Bueno-de-Mesquita, Bas Ros, Martine M. Kaaks, Rudolf Chang-Claude, Jenny Roswall, Nina Tjønneland, Anne Overvad, Kim Clavel-Chapelon, Françoise Boutron-Ruault, Marie-Christine Dossus, Laure Boeing, Heiner Weikert, Steffen Trichopoulos, Dimitrios Palli, Domenico Sieri, Sabina Tumino, Rosario Panico, Salvatore Quirós, José Ramón González, Carlos Sánchez, Mariá José Dorronsoro, Miren Navarro, Carmen Barricarte, Aurelio Ljungberg, Börje Johansson, Mattias Ulmert, David Ehrnström, Roy Khaw, Kay-Tee Wareham, Nick Key, Timothy J. Ferrari, Pietro Romieu, Isabelle Riboli, Elio Brüning, Thomas Vineis, Paolo 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-13-0119-t <jats:title>Abstract</jats:title><jats:p>Background: An association between N-acetyltransferase 2 (NAT2) slow acetylation and bladder cancer has been consistently observed in epidemiologic studies. However, evidence has been mainly derived from case–control studies and was sparse from cohort studies. We evaluated the association between NAT2 slow acetylation and bladder cancer in a case–control study nested in the European Prospective Investigation into Cancer and Nutrition.</jats:p><jats:p>Methods: Exposure to aromatic amines and polycyclic aromatic hydrocarbons (PAH) could be assessed for 754 cases and 833 controls for whom occupational information was documented. A semiquantitative job-exposure matrix was applied to at-risk occupations to estimate the exposure as low, medium, or high based on tertiles of the distribution of the exposure score in controls. Using a comprehensive genotyping, NAT2 acetylation status could be categorized from 6-single-nucleotide polymorphism genotypes as slow or fast in 607 cases and 695 controls with DNA from archived blood samples.</jats:p><jats:p>Results: Occupational exposure to aromatic amines and PAH was associated with an increased bladder cancer risk [upper tertile of the distribution of the exposure score: OR = 1.37; 95% confidence interval (CI), 1.02–1.84, and OR = 1.50; 95% CI, 1.09–2.05, respectively]. NAT2 slow acetylation did not modify these risk estimates and was not itself associated with bladder cancer risk (OR = 1.02; 95% CI, 0.81–1.29).</jats:p><jats:p>Conclusions: These findings confirm established or suspected occupational risk factors but not the anticipated role of NAT2 slow acetylation in bladder cancer. No interaction was detected between NAT2 and any exposure of interest, including smoking.</jats:p><jats:p>Impact: Genetic testing for NAT2 would be inappropriate in occupational settings. Cancer Epidemiol Biomarkers Prev; 22(11); 2055–65. ©2013 AACR.</jats:p> N-acetyltransferase 2 Phenotype, Occupation, and Bladder Cancer Risk: Results from the EPIC Cohort Cancer Epidemiology, Biomarkers & Prevention |
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10.1158/1055-9965.epi-13-0119-t |
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American Association for Cancer Research (AACR), 2013 |
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American Association for Cancer Research (AACR), 2013 |
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1538-7755 1055-9965 |
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American Association for Cancer Research (AACR) |
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Cancer Epidemiology, Biomarkers & Prevention |
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49 |
| title |
N-acetyltransferase 2 Phenotype, Occupation, and Bladder Cancer Risk: Results from the EPIC Cohort |
| title_unstemmed |
N-acetyltransferase 2 Phenotype, Occupation, and Bladder Cancer Risk: Results from the EPIC Cohort |
| title_full |
N-acetyltransferase 2 Phenotype, Occupation, and Bladder Cancer Risk: Results from the EPIC Cohort |
| title_fullStr |
N-acetyltransferase 2 Phenotype, Occupation, and Bladder Cancer Risk: Results from the EPIC Cohort |
| title_full_unstemmed |
N-acetyltransferase 2 Phenotype, Occupation, and Bladder Cancer Risk: Results from the EPIC Cohort |
| title_short |
N-acetyltransferase 2 Phenotype, Occupation, and Bladder Cancer Risk: Results from the EPIC Cohort |
| title_sort |
n-acetyltransferase 2 phenotype, occupation, and bladder cancer risk: results from the epic cohort |
| topic |
Oncology Epidemiology |
| url |
http://dx.doi.org/10.1158/1055-9965.epi-13-0119-t |
| publishDate |
2013 |
| physical |
2055-2065 |
| description |
<jats:title>Abstract</jats:title><jats:p>Background: An association between N-acetyltransferase 2 (NAT2) slow acetylation and bladder cancer has been consistently observed in epidemiologic studies. However, evidence has been mainly derived from case–control studies and was sparse from cohort studies. We evaluated the association between NAT2 slow acetylation and bladder cancer in a case–control study nested in the European Prospective Investigation into Cancer and Nutrition.</jats:p><jats:p>Methods: Exposure to aromatic amines and polycyclic aromatic hydrocarbons (PAH) could be assessed for 754 cases and 833 controls for whom occupational information was documented. A semiquantitative job-exposure matrix was applied to at-risk occupations to estimate the exposure as low, medium, or high based on tertiles of the distribution of the exposure score in controls. Using a comprehensive genotyping, NAT2 acetylation status could be categorized from 6-single-nucleotide polymorphism genotypes as slow or fast in 607 cases and 695 controls with DNA from archived blood samples.</jats:p><jats:p>Results: Occupational exposure to aromatic amines and PAH was associated with an increased bladder cancer risk [upper tertile of the distribution of the exposure score: OR = 1.37; 95% confidence interval (CI), 1.02–1.84, and OR = 1.50; 95% CI, 1.09–2.05, respectively]. NAT2 slow acetylation did not modify these risk estimates and was not itself associated with bladder cancer risk (OR = 1.02; 95% CI, 0.81–1.29).</jats:p><jats:p>Conclusions: These findings confirm established or suspected occupational risk factors but not the anticipated role of NAT2 slow acetylation in bladder cancer. No interaction was detected between NAT2 and any exposure of interest, including smoking.</jats:p><jats:p>Impact: Genetic testing for NAT2 would be inappropriate in occupational settings. Cancer Epidemiol Biomarkers Prev; 22(11); 2055–65. ©2013 AACR.</jats:p> |
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| author | Pesch, Beate, Gawrych, Katarzyna, Rabstein, Sylvia, Weiss, Tobias, Casjens, Swaantje, Rihs, Hans-Peter, Ding, Hui, Angerer, Jürgen, Illig, Thomas, Klopp, Norman, Bueno-de-Mesquita, Bas, Ros, Martine M., Kaaks, Rudolf, Chang-Claude, Jenny, Roswall, Nina, Tjønneland, Anne, Overvad, Kim, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Dossus, Laure, Boeing, Heiner, Weikert, Steffen, Trichopoulos, Dimitrios, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Panico, Salvatore, Quirós, José Ramón, González, Carlos, Sánchez, Mariá José, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Ljungberg, Börje, Johansson, Mattias, Ulmert, David, Ehrnström, Roy, Khaw, Kay-Tee, Wareham, Nick, Key, Timothy J., Ferrari, Pietro, Romieu, Isabelle, Riboli, Elio, Brüning, Thomas, Vineis, Paolo |
| author_facet | Pesch, Beate, Gawrych, Katarzyna, Rabstein, Sylvia, Weiss, Tobias, Casjens, Swaantje, Rihs, Hans-Peter, Ding, Hui, Angerer, Jürgen, Illig, Thomas, Klopp, Norman, Bueno-de-Mesquita, Bas, Ros, Martine M., Kaaks, Rudolf, Chang-Claude, Jenny, Roswall, Nina, Tjønneland, Anne, Overvad, Kim, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Dossus, Laure, Boeing, Heiner, Weikert, Steffen, Trichopoulos, Dimitrios, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Panico, Salvatore, Quirós, José Ramón, González, Carlos, Sánchez, Mariá José, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Ljungberg, Börje, Johansson, Mattias, Ulmert, David, Ehrnström, Roy, Khaw, Kay-Tee, Wareham, Nick, Key, Timothy J., Ferrari, Pietro, Romieu, Isabelle, Riboli, Elio, Brüning, Thomas, Vineis, Paolo, Pesch, Beate, Gawrych, Katarzyna, Rabstein, Sylvia, Weiss, Tobias, Casjens, Swaantje, Rihs, Hans-Peter, Ding, Hui, Angerer, Jürgen, Illig, Thomas, Klopp, Norman, Bueno-de-Mesquita, Bas, Ros, Martine M., Kaaks, Rudolf, Chang-Claude, Jenny, Roswall, Nina, Tjønneland, Anne, Overvad, Kim, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Dossus, Laure, Boeing, Heiner, Weikert, Steffen, Trichopoulos, Dimitrios, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Panico, Salvatore, Quirós, José Ramón, González, Carlos, Sánchez, Mariá José, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Ljungberg, Börje, Johansson, Mattias, Ulmert, David, Ehrnström, Roy, Khaw, Kay-Tee, Wareham, Nick, Key, Timothy J., Ferrari, Pietro, Romieu, Isabelle, Riboli, Elio, Brüning, Thomas, Vineis, Paolo |
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| description | <jats:title>Abstract</jats:title><jats:p>Background: An association between N-acetyltransferase 2 (NAT2) slow acetylation and bladder cancer has been consistently observed in epidemiologic studies. However, evidence has been mainly derived from case–control studies and was sparse from cohort studies. We evaluated the association between NAT2 slow acetylation and bladder cancer in a case–control study nested in the European Prospective Investigation into Cancer and Nutrition.</jats:p><jats:p>Methods: Exposure to aromatic amines and polycyclic aromatic hydrocarbons (PAH) could be assessed for 754 cases and 833 controls for whom occupational information was documented. A semiquantitative job-exposure matrix was applied to at-risk occupations to estimate the exposure as low, medium, or high based on tertiles of the distribution of the exposure score in controls. Using a comprehensive genotyping, NAT2 acetylation status could be categorized from 6-single-nucleotide polymorphism genotypes as slow or fast in 607 cases and 695 controls with DNA from archived blood samples.</jats:p><jats:p>Results: Occupational exposure to aromatic amines and PAH was associated with an increased bladder cancer risk [upper tertile of the distribution of the exposure score: OR = 1.37; 95% confidence interval (CI), 1.02–1.84, and OR = 1.50; 95% CI, 1.09–2.05, respectively]. NAT2 slow acetylation did not modify these risk estimates and was not itself associated with bladder cancer risk (OR = 1.02; 95% CI, 0.81–1.29).</jats:p><jats:p>Conclusions: These findings confirm established or suspected occupational risk factors but not the anticipated role of NAT2 slow acetylation in bladder cancer. No interaction was detected between NAT2 and any exposure of interest, including smoking.</jats:p><jats:p>Impact: Genetic testing for NAT2 would be inappropriate in occupational settings. Cancer Epidemiol Biomarkers Prev; 22(11); 2055–65. ©2013 AACR.</jats:p> |
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| spelling | Pesch, Beate Gawrych, Katarzyna Rabstein, Sylvia Weiss, Tobias Casjens, Swaantje Rihs, Hans-Peter Ding, Hui Angerer, Jürgen Illig, Thomas Klopp, Norman Bueno-de-Mesquita, Bas Ros, Martine M. Kaaks, Rudolf Chang-Claude, Jenny Roswall, Nina Tjønneland, Anne Overvad, Kim Clavel-Chapelon, Françoise Boutron-Ruault, Marie-Christine Dossus, Laure Boeing, Heiner Weikert, Steffen Trichopoulos, Dimitrios Palli, Domenico Sieri, Sabina Tumino, Rosario Panico, Salvatore Quirós, José Ramón González, Carlos Sánchez, Mariá José Dorronsoro, Miren Navarro, Carmen Barricarte, Aurelio Ljungberg, Börje Johansson, Mattias Ulmert, David Ehrnström, Roy Khaw, Kay-Tee Wareham, Nick Key, Timothy J. Ferrari, Pietro Romieu, Isabelle Riboli, Elio Brüning, Thomas Vineis, Paolo 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-13-0119-t <jats:title>Abstract</jats:title><jats:p>Background: An association between N-acetyltransferase 2 (NAT2) slow acetylation and bladder cancer has been consistently observed in epidemiologic studies. However, evidence has been mainly derived from case–control studies and was sparse from cohort studies. We evaluated the association between NAT2 slow acetylation and bladder cancer in a case–control study nested in the European Prospective Investigation into Cancer and Nutrition.</jats:p><jats:p>Methods: Exposure to aromatic amines and polycyclic aromatic hydrocarbons (PAH) could be assessed for 754 cases and 833 controls for whom occupational information was documented. A semiquantitative job-exposure matrix was applied to at-risk occupations to estimate the exposure as low, medium, or high based on tertiles of the distribution of the exposure score in controls. Using a comprehensive genotyping, NAT2 acetylation status could be categorized from 6-single-nucleotide polymorphism genotypes as slow or fast in 607 cases and 695 controls with DNA from archived blood samples.</jats:p><jats:p>Results: Occupational exposure to aromatic amines and PAH was associated with an increased bladder cancer risk [upper tertile of the distribution of the exposure score: OR = 1.37; 95% confidence interval (CI), 1.02–1.84, and OR = 1.50; 95% CI, 1.09–2.05, respectively]. NAT2 slow acetylation did not modify these risk estimates and was not itself associated with bladder cancer risk (OR = 1.02; 95% CI, 0.81–1.29).</jats:p><jats:p>Conclusions: These findings confirm established or suspected occupational risk factors but not the anticipated role of NAT2 slow acetylation in bladder cancer. No interaction was detected between NAT2 and any exposure of interest, including smoking.</jats:p><jats:p>Impact: Genetic testing for NAT2 would be inappropriate in occupational settings. Cancer Epidemiol Biomarkers Prev; 22(11); 2055–65. ©2013 AACR.</jats:p> N-acetyltransferase 2 Phenotype, Occupation, and Bladder Cancer Risk: Results from the EPIC Cohort Cancer Epidemiology, Biomarkers & Prevention |
| spellingShingle | Pesch, Beate, Gawrych, Katarzyna, Rabstein, Sylvia, Weiss, Tobias, Casjens, Swaantje, Rihs, Hans-Peter, Ding, Hui, Angerer, Jürgen, Illig, Thomas, Klopp, Norman, Bueno-de-Mesquita, Bas, Ros, Martine M., Kaaks, Rudolf, Chang-Claude, Jenny, Roswall, Nina, Tjønneland, Anne, Overvad, Kim, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Dossus, Laure, Boeing, Heiner, Weikert, Steffen, Trichopoulos, Dimitrios, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Panico, Salvatore, Quirós, José Ramón, González, Carlos, Sánchez, Mariá José, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Ljungberg, Börje, Johansson, Mattias, Ulmert, David, Ehrnström, Roy, Khaw, Kay-Tee, Wareham, Nick, Key, Timothy J., Ferrari, Pietro, Romieu, Isabelle, Riboli, Elio, Brüning, Thomas, Vineis, Paolo, Cancer Epidemiology, Biomarkers & Prevention, N-acetyltransferase 2 Phenotype, Occupation, and Bladder Cancer Risk: Results from the EPIC Cohort, Oncology, Epidemiology |
| title | N-acetyltransferase 2 Phenotype, Occupation, and Bladder Cancer Risk: Results from the EPIC Cohort |
| title_full | N-acetyltransferase 2 Phenotype, Occupation, and Bladder Cancer Risk: Results from the EPIC Cohort |
| title_fullStr | N-acetyltransferase 2 Phenotype, Occupation, and Bladder Cancer Risk: Results from the EPIC Cohort |
| title_full_unstemmed | N-acetyltransferase 2 Phenotype, Occupation, and Bladder Cancer Risk: Results from the EPIC Cohort |
| title_short | N-acetyltransferase 2 Phenotype, Occupation, and Bladder Cancer Risk: Results from the EPIC Cohort |
| title_sort | n-acetyltransferase 2 phenotype, occupation, and bladder cancer risk: results from the epic cohort |
| title_unstemmed | N-acetyltransferase 2 Phenotype, Occupation, and Bladder Cancer Risk: Results from the EPIC Cohort |
| topic | Oncology, Epidemiology |
| url | http://dx.doi.org/10.1158/1055-9965.epi-13-0119-t |