Eintrag weiter verarbeiten
A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers
Gespeichert in:
Zeitschriftentitel: | Cancer Epidemiology, Biomarkers & Prevention |
---|---|
Personen und Körperschaften: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
In: | Cancer Epidemiology, Biomarkers & Prevention, 21, 2012, 8, S. 1362-1370 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
American Association for Cancer Research (AACR)
|
Schlagwörter: |
author_facet |
Ding, Yuan C. McGuffog, Lesley Healey, Sue Friedman, Eitan Laitman, Yael Paluch–Shimon, Shani- Kaufman, Bella Liljegren, Annelie Lindblom, Annika Olsson, Håkan Kristoffersson, Ulf Stenmark-Askmalm, Marie Melin, Beatrice Domchek, Susan M. Nathanson, Katherine L. Rebbeck, Timothy R. Jakubowska, Anna Lubinski, Jan Jaworska, Katarzyna Durda, Katarzyna Gronwald, Jacek Huzarski, Tomasz Cybulski, Cezary Byrski, Tomasz Osorio, Ana Cajal, Teresa Ramóny Stavropoulou, Alexandra V. Benítez, Javier Hamann, Ute Rookus, Matti Aalfs, Cora M. de Lange, Judith L. Meijers-Heijboer, Hanne E.J. Oosterwijk, Jan C. van Asperen, Christi J. Gómez García, Encarna B. Hoogerbrugge, Nicoline Jager, Agnes van der Luijt, Rob B. Easton, Douglas F. Peock, Susan Frost, Debra Ellis, Steve D. Platte, Radka Fineberg, Elena Evans, D. Gareth Lalloo, Fiona Izatt, Louise Eeles, Ros Adlard, Julian Davidson, Rosemarie Eccles, Diana Cole, Trevor Cook, Jackie Brewer, Carole Tischkowitz, Marc Godwin, Andrew K. Pathak, Harsh Stoppa-Lyonnet, Dominique Sinilnikova, Olga M. Mazoyer, Sylvie Barjhoux, Laure Léoné, Mélanie Gauthier-Villars, Marion Caux-Moncoutier, Virginie de Pauw, Antoine Hardouin, Agnès Berthet, Pascaline Dreyfus, Hélène Ferrer, Sandra Fert Collonge-Rame, Marie-Agnès Sokolowska, Johanna Buys, Saundra Daly, Mary Miron, Alex Terry, Mary Beth Chung, Wendy John, Esther M. Southey, Melissa Goldgar, David Singer, Christian F. Tea, Muy-Kheng Maria Gschwantler-Kaulich, Daphne Fink-Retter, Anneliese Hansen, Thomas V.O. Ejlertsen, Bent Johannsson, Oskar T. Offit, Kenneth Sarrel, Kara Gaudet, Mia M. Vijai, Joseph Robson, Mark Piedmonte, Marion R. Andrews, Lesley Cohn, David DeMars, Leslie R. DiSilvestro, Paul Rodriguez, Gustavo Toland, Amanda Ewart Montagna, Marco Agata, Simona Imyanitov, Evgeny Isaacs, Claudine Janavicius, Ramunas Lazaro, Conxi Blanco, Ignacio Ramus, Susan J. Sucheston, Lara Karlan, Beth Y. Gross, Jenny Ganz, Patricia A. Beattie, Mary S. Schmutzler, Rita K. Wappenschmidt, Barbara Meindl, Alfons Arnold, Norbert Niederacher, Dieter Preisler-Adams, Sabine Gadzicki, Dorotehea Varon-Mateeva, Raymonda Deissler, Helmut Gehrig, Andrea Sutter, Christian Kast, Karin Nevanlinna, Heli Aittomäki, Kristiina Simard, Jacques Spurdle, Amanda B. Beesley, Jonathan Chen, Xiaoqing Tomlinson, Gail E. Weitzel, Jeffrey Garber, Judy E. Olopade, Olufunmilayo I. Rubinstein, Wendy S. Tung, Nadine Blum, Joanne L. Narod, Steven A. Brummel, Sean Gillen, Daniel L. Lindor, Noralane Fredericksen, Zachary Pankratz, Vernon S. Couch, Fergus J. Radice, Paolo Peterlongo, Paolo Greene, Mark H. Loud, Jennifer T. Mai, Phuong L. Andrulis, Irene L. Glendon, Gord Ozcelik, Hilmi Gerdes, Anne-Marie Thomassen, Mads Jensen, Uffe Birk Skytte, Anne-Bine Caligo, Maria A. Lee, Andrew Chenevix-Trench, Georgia Antoniou, Antonis C. Neuhausen, Susan L. Ding, Yuan C. McGuffog, Lesley Healey, Sue Friedman, Eitan Laitman, Yael Paluch–Shimon, Shani- Kaufman, Bella Liljegren, Annelie Lindblom, Annika Olsson, Håkan Kristoffersson, Ulf Stenmark-Askmalm, Marie Melin, Beatrice Domchek, Susan M. Nathanson, Katherine L. Rebbeck, Timothy R. Jakubowska, Anna Lubinski, Jan Jaworska, Katarzyna Durda, Katarzyna Gronwald, Jacek Huzarski, Tomasz Cybulski, Cezary Byrski, Tomasz Osorio, Ana Cajal, Teresa Ramóny Stavropoulou, Alexandra V. Benítez, Javier Hamann, Ute Rookus, Matti Aalfs, Cora M. de Lange, Judith L. Meijers-Heijboer, Hanne E.J. Oosterwijk, Jan C. van Asperen, Christi J. Gómez García, Encarna B. Hoogerbrugge, Nicoline Jager, Agnes van der Luijt, Rob B. Easton, Douglas F. Peock, Susan Frost, Debra Ellis, Steve D. Platte, Radka Fineberg, Elena Evans, D. Gareth Lalloo, Fiona Izatt, Louise Eeles, Ros Adlard, Julian Davidson, Rosemarie Eccles, Diana Cole, Trevor Cook, Jackie Brewer, Carole Tischkowitz, Marc Godwin, Andrew K. Pathak, Harsh Stoppa-Lyonnet, Dominique Sinilnikova, Olga M. Mazoyer, Sylvie Barjhoux, Laure Léoné, Mélanie Gauthier-Villars, Marion Caux-Moncoutier, Virginie de Pauw, Antoine Hardouin, Agnès Berthet, Pascaline Dreyfus, Hélène Ferrer, Sandra Fert Collonge-Rame, Marie-Agnès Sokolowska, Johanna Buys, Saundra Daly, Mary Miron, Alex Terry, Mary Beth Chung, Wendy John, Esther M. Southey, Melissa Goldgar, David Singer, Christian F. Tea, Muy-Kheng Maria Gschwantler-Kaulich, Daphne Fink-Retter, Anneliese Hansen, Thomas V.O. Ejlertsen, Bent Johannsson, Oskar T. Offit, Kenneth Sarrel, Kara Gaudet, Mia M. Vijai, Joseph Robson, Mark Piedmonte, Marion R. Andrews, Lesley Cohn, David DeMars, Leslie R. DiSilvestro, Paul Rodriguez, Gustavo Toland, Amanda Ewart Montagna, Marco Agata, Simona Imyanitov, Evgeny Isaacs, Claudine Janavicius, Ramunas Lazaro, Conxi Blanco, Ignacio Ramus, Susan J. Sucheston, Lara Karlan, Beth Y. Gross, Jenny Ganz, Patricia A. Beattie, Mary S. Schmutzler, Rita K. Wappenschmidt, Barbara Meindl, Alfons Arnold, Norbert Niederacher, Dieter Preisler-Adams, Sabine Gadzicki, Dorotehea Varon-Mateeva, Raymonda Deissler, Helmut Gehrig, Andrea Sutter, Christian Kast, Karin Nevanlinna, Heli Aittomäki, Kristiina Simard, Jacques Spurdle, Amanda B. Beesley, Jonathan Chen, Xiaoqing Tomlinson, Gail E. Weitzel, Jeffrey Garber, Judy E. Olopade, Olufunmilayo I. Rubinstein, Wendy S. Tung, Nadine Blum, Joanne L. Narod, Steven A. Brummel, Sean Gillen, Daniel L. Lindor, Noralane Fredericksen, Zachary Pankratz, Vernon S. Couch, Fergus J. Radice, Paolo Peterlongo, Paolo Greene, Mark H. Loud, Jennifer T. Mai, Phuong L. Andrulis, Irene L. Glendon, Gord Ozcelik, Hilmi Gerdes, Anne-Marie Thomassen, Mads Jensen, Uffe Birk Skytte, Anne-Bine Caligo, Maria A. Lee, Andrew Chenevix-Trench, Georgia Antoniou, Antonis C. Neuhausen, Susan L. |
---|---|
author |
Ding, Yuan C. McGuffog, Lesley Healey, Sue Friedman, Eitan Laitman, Yael Paluch–Shimon, Shani- Kaufman, Bella Liljegren, Annelie Lindblom, Annika Olsson, Håkan Kristoffersson, Ulf Stenmark-Askmalm, Marie Melin, Beatrice Domchek, Susan M. Nathanson, Katherine L. Rebbeck, Timothy R. Jakubowska, Anna Lubinski, Jan Jaworska, Katarzyna Durda, Katarzyna Gronwald, Jacek Huzarski, Tomasz Cybulski, Cezary Byrski, Tomasz Osorio, Ana Cajal, Teresa Ramóny Stavropoulou, Alexandra V. Benítez, Javier Hamann, Ute Rookus, Matti Aalfs, Cora M. de Lange, Judith L. Meijers-Heijboer, Hanne E.J. Oosterwijk, Jan C. van Asperen, Christi J. Gómez García, Encarna B. Hoogerbrugge, Nicoline Jager, Agnes van der Luijt, Rob B. Easton, Douglas F. Peock, Susan Frost, Debra Ellis, Steve D. Platte, Radka Fineberg, Elena Evans, D. Gareth Lalloo, Fiona Izatt, Louise Eeles, Ros Adlard, Julian Davidson, Rosemarie Eccles, Diana Cole, Trevor Cook, Jackie Brewer, Carole Tischkowitz, Marc Godwin, Andrew K. Pathak, Harsh Stoppa-Lyonnet, Dominique Sinilnikova, Olga M. Mazoyer, Sylvie Barjhoux, Laure Léoné, Mélanie Gauthier-Villars, Marion Caux-Moncoutier, Virginie de Pauw, Antoine Hardouin, Agnès Berthet, Pascaline Dreyfus, Hélène Ferrer, Sandra Fert Collonge-Rame, Marie-Agnès Sokolowska, Johanna Buys, Saundra Daly, Mary Miron, Alex Terry, Mary Beth Chung, Wendy John, Esther M. Southey, Melissa Goldgar, David Singer, Christian F. Tea, Muy-Kheng Maria Gschwantler-Kaulich, Daphne Fink-Retter, Anneliese Hansen, Thomas V.O. Ejlertsen, Bent Johannsson, Oskar T. Offit, Kenneth Sarrel, Kara Gaudet, Mia M. Vijai, Joseph Robson, Mark Piedmonte, Marion R. Andrews, Lesley Cohn, David DeMars, Leslie R. DiSilvestro, Paul Rodriguez, Gustavo Toland, Amanda Ewart Montagna, Marco Agata, Simona Imyanitov, Evgeny Isaacs, Claudine Janavicius, Ramunas Lazaro, Conxi Blanco, Ignacio Ramus, Susan J. Sucheston, Lara Karlan, Beth Y. Gross, Jenny Ganz, Patricia A. Beattie, Mary S. Schmutzler, Rita K. Wappenschmidt, Barbara Meindl, Alfons Arnold, Norbert Niederacher, Dieter Preisler-Adams, Sabine Gadzicki, Dorotehea Varon-Mateeva, Raymonda Deissler, Helmut Gehrig, Andrea Sutter, Christian Kast, Karin Nevanlinna, Heli Aittomäki, Kristiina Simard, Jacques Spurdle, Amanda B. Beesley, Jonathan Chen, Xiaoqing Tomlinson, Gail E. Weitzel, Jeffrey Garber, Judy E. Olopade, Olufunmilayo I. Rubinstein, Wendy S. Tung, Nadine Blum, Joanne L. Narod, Steven A. Brummel, Sean Gillen, Daniel L. Lindor, Noralane Fredericksen, Zachary Pankratz, Vernon S. Couch, Fergus J. Radice, Paolo Peterlongo, Paolo Greene, Mark H. Loud, Jennifer T. Mai, Phuong L. Andrulis, Irene L. Glendon, Gord Ozcelik, Hilmi Gerdes, Anne-Marie Thomassen, Mads Jensen, Uffe Birk Skytte, Anne-Bine Caligo, Maria A. Lee, Andrew Chenevix-Trench, Georgia Antoniou, Antonis C. Neuhausen, Susan L. |
spellingShingle |
Ding, Yuan C. McGuffog, Lesley Healey, Sue Friedman, Eitan Laitman, Yael Paluch–Shimon, Shani- Kaufman, Bella Liljegren, Annelie Lindblom, Annika Olsson, Håkan Kristoffersson, Ulf Stenmark-Askmalm, Marie Melin, Beatrice Domchek, Susan M. Nathanson, Katherine L. Rebbeck, Timothy R. Jakubowska, Anna Lubinski, Jan Jaworska, Katarzyna Durda, Katarzyna Gronwald, Jacek Huzarski, Tomasz Cybulski, Cezary Byrski, Tomasz Osorio, Ana Cajal, Teresa Ramóny Stavropoulou, Alexandra V. Benítez, Javier Hamann, Ute Rookus, Matti Aalfs, Cora M. de Lange, Judith L. Meijers-Heijboer, Hanne E.J. Oosterwijk, Jan C. van Asperen, Christi J. Gómez García, Encarna B. Hoogerbrugge, Nicoline Jager, Agnes van der Luijt, Rob B. Easton, Douglas F. Peock, Susan Frost, Debra Ellis, Steve D. Platte, Radka Fineberg, Elena Evans, D. Gareth Lalloo, Fiona Izatt, Louise Eeles, Ros Adlard, Julian Davidson, Rosemarie Eccles, Diana Cole, Trevor Cook, Jackie Brewer, Carole Tischkowitz, Marc Godwin, Andrew K. Pathak, Harsh Stoppa-Lyonnet, Dominique Sinilnikova, Olga M. Mazoyer, Sylvie Barjhoux, Laure Léoné, Mélanie Gauthier-Villars, Marion Caux-Moncoutier, Virginie de Pauw, Antoine Hardouin, Agnès Berthet, Pascaline Dreyfus, Hélène Ferrer, Sandra Fert Collonge-Rame, Marie-Agnès Sokolowska, Johanna Buys, Saundra Daly, Mary Miron, Alex Terry, Mary Beth Chung, Wendy John, Esther M. Southey, Melissa Goldgar, David Singer, Christian F. Tea, Muy-Kheng Maria Gschwantler-Kaulich, Daphne Fink-Retter, Anneliese Hansen, Thomas V.O. Ejlertsen, Bent Johannsson, Oskar T. Offit, Kenneth Sarrel, Kara Gaudet, Mia M. Vijai, Joseph Robson, Mark Piedmonte, Marion R. Andrews, Lesley Cohn, David DeMars, Leslie R. DiSilvestro, Paul Rodriguez, Gustavo Toland, Amanda Ewart Montagna, Marco Agata, Simona Imyanitov, Evgeny Isaacs, Claudine Janavicius, Ramunas Lazaro, Conxi Blanco, Ignacio Ramus, Susan J. Sucheston, Lara Karlan, Beth Y. Gross, Jenny Ganz, Patricia A. Beattie, Mary S. Schmutzler, Rita K. Wappenschmidt, Barbara Meindl, Alfons Arnold, Norbert Niederacher, Dieter Preisler-Adams, Sabine Gadzicki, Dorotehea Varon-Mateeva, Raymonda Deissler, Helmut Gehrig, Andrea Sutter, Christian Kast, Karin Nevanlinna, Heli Aittomäki, Kristiina Simard, Jacques Spurdle, Amanda B. Beesley, Jonathan Chen, Xiaoqing Tomlinson, Gail E. Weitzel, Jeffrey Garber, Judy E. Olopade, Olufunmilayo I. Rubinstein, Wendy S. Tung, Nadine Blum, Joanne L. Narod, Steven A. Brummel, Sean Gillen, Daniel L. Lindor, Noralane Fredericksen, Zachary Pankratz, Vernon S. Couch, Fergus J. Radice, Paolo Peterlongo, Paolo Greene, Mark H. Loud, Jennifer T. Mai, Phuong L. Andrulis, Irene L. Glendon, Gord Ozcelik, Hilmi Gerdes, Anne-Marie Thomassen, Mads Jensen, Uffe Birk Skytte, Anne-Bine Caligo, Maria A. Lee, Andrew Chenevix-Trench, Georgia Antoniou, Antonis C. Neuhausen, Susan L. Cancer Epidemiology, Biomarkers & Prevention A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers Oncology Epidemiology |
author_sort |
ding, yuan c. |
spelling |
Ding, Yuan C. McGuffog, Lesley Healey, Sue Friedman, Eitan Laitman, Yael Paluch–Shimon, Shani- Kaufman, Bella Liljegren, Annelie Lindblom, Annika Olsson, Håkan Kristoffersson, Ulf Stenmark-Askmalm, Marie Melin, Beatrice Domchek, Susan M. Nathanson, Katherine L. Rebbeck, Timothy R. Jakubowska, Anna Lubinski, Jan Jaworska, Katarzyna Durda, Katarzyna Gronwald, Jacek Huzarski, Tomasz Cybulski, Cezary Byrski, Tomasz Osorio, Ana Cajal, Teresa Ramóny Stavropoulou, Alexandra V. Benítez, Javier Hamann, Ute Rookus, Matti Aalfs, Cora M. de Lange, Judith L. Meijers-Heijboer, Hanne E.J. Oosterwijk, Jan C. van Asperen, Christi J. Gómez García, Encarna B. Hoogerbrugge, Nicoline Jager, Agnes van der Luijt, Rob B. Easton, Douglas F. Peock, Susan Frost, Debra Ellis, Steve D. Platte, Radka Fineberg, Elena Evans, D. Gareth Lalloo, Fiona Izatt, Louise Eeles, Ros Adlard, Julian Davidson, Rosemarie Eccles, Diana Cole, Trevor Cook, Jackie Brewer, Carole Tischkowitz, Marc Godwin, Andrew K. Pathak, Harsh Stoppa-Lyonnet, Dominique Sinilnikova, Olga M. Mazoyer, Sylvie Barjhoux, Laure Léoné, Mélanie Gauthier-Villars, Marion Caux-Moncoutier, Virginie de Pauw, Antoine Hardouin, Agnès Berthet, Pascaline Dreyfus, Hélène Ferrer, Sandra Fert Collonge-Rame, Marie-Agnès Sokolowska, Johanna Buys, Saundra Daly, Mary Miron, Alex Terry, Mary Beth Chung, Wendy John, Esther M. Southey, Melissa Goldgar, David Singer, Christian F. Tea, Muy-Kheng Maria Gschwantler-Kaulich, Daphne Fink-Retter, Anneliese Hansen, Thomas V.O. Ejlertsen, Bent Johannsson, Oskar T. Offit, Kenneth Sarrel, Kara Gaudet, Mia M. Vijai, Joseph Robson, Mark Piedmonte, Marion R. Andrews, Lesley Cohn, David DeMars, Leslie R. DiSilvestro, Paul Rodriguez, Gustavo Toland, Amanda Ewart Montagna, Marco Agata, Simona Imyanitov, Evgeny Isaacs, Claudine Janavicius, Ramunas Lazaro, Conxi Blanco, Ignacio Ramus, Susan J. Sucheston, Lara Karlan, Beth Y. Gross, Jenny Ganz, Patricia A. Beattie, Mary S. Schmutzler, Rita K. Wappenschmidt, Barbara Meindl, Alfons Arnold, Norbert Niederacher, Dieter Preisler-Adams, Sabine Gadzicki, Dorotehea Varon-Mateeva, Raymonda Deissler, Helmut Gehrig, Andrea Sutter, Christian Kast, Karin Nevanlinna, Heli Aittomäki, Kristiina Simard, Jacques Spurdle, Amanda B. Beesley, Jonathan Chen, Xiaoqing Tomlinson, Gail E. Weitzel, Jeffrey Garber, Judy E. Olopade, Olufunmilayo I. Rubinstein, Wendy S. Tung, Nadine Blum, Joanne L. Narod, Steven A. Brummel, Sean Gillen, Daniel L. Lindor, Noralane Fredericksen, Zachary Pankratz, Vernon S. Couch, Fergus J. Radice, Paolo Peterlongo, Paolo Greene, Mark H. Loud, Jennifer T. Mai, Phuong L. Andrulis, Irene L. Glendon, Gord Ozcelik, Hilmi Gerdes, Anne-Marie Thomassen, Mads Jensen, Uffe Birk Skytte, Anne-Bine Caligo, Maria A. Lee, Andrew Chenevix-Trench, Georgia Antoniou, Antonis C. Neuhausen, Susan L. 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-12-0229 <jats:title>Abstract</jats:title> <jats:p>Background: We previously reported significant associations between genetic variants in insulin receptor substrate 1 (IRS1) and breast cancer risk in women carrying BRCA1 mutations. The objectives of this study were to investigate whether the IRS1 variants modified ovarian cancer risk and were associated with breast cancer risk in a larger cohort of BRCA1 and BRCA2 mutation carriers.</jats:p> <jats:p>Methods:IRS1 rs1801123, rs1330645, and rs1801278 were genotyped in samples from 36 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Data were analyzed by a retrospective cohort approach modeling the associations with breast and ovarian cancer risks simultaneously. Analyses were stratified by BRCA1 and BRCA2 status and mutation class in BRCA1 carriers.</jats:p> <jats:p>Results: Rs1801278 (Gly972Arg) was associated with ovarian cancer risk for both BRCA1 (HR, 1.43; 95% confidence interval (CI), 1.06–1.92; P = 0.019) and BRCA2 mutation carriers (HR, 2.21; 95% CI, 1.39–3.52, P = 0.0008). For BRCA1 mutation carriers, the breast cancer risk was higher in carriers with class II mutations than class I mutations (class II HR, 1.86; 95% CI, 1.28–2.70; class I HR, 0.86; 95%CI, 0.69–1.09; Pdifference, 0.0006). Rs13306465 was associated with ovarian cancer risk in BRCA1 class II mutation carriers (HR, 2.42; P = 0.03).</jats:p> <jats:p>Conclusion: The IRS1 Gly972Arg single-nucleotide polymorphism, which affects insulin-like growth factor and insulin signaling, modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers and breast cancer risk in BRCA1 class II mutation carriers.</jats:p> <jats:p>Impact: These findings may prove useful for risk prediction for breast and ovarian cancers in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev; 21(8); 1362–70. ©2012 AACR.</jats:p> A Nonsynonymous Polymorphism in <i>IRS1</i> Modifies Risk of Developing Breast and Ovarian Cancers in <i>BRCA1</i> and Ovarian Cancer in <i>BRCA2</i> Mutation Carriers Cancer Epidemiology, Biomarkers & Prevention |
doi_str_mv |
10.1158/1055-9965.epi-12-0229 |
facet_avail |
Online Free |
finc_class_facet |
Medizin |
format |
ElectronicArticle |
fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1OC8xMDU1LTk5NjUuZXBpLTEyLTAyMjk |
id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1OC8xMDU1LTk5NjUuZXBpLTEyLTAyMjk |
institution |
DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 |
imprint |
American Association for Cancer Research (AACR), 2012 |
imprint_str_mv |
American Association for Cancer Research (AACR), 2012 |
issn |
1538-7755 1055-9965 |
issn_str_mv |
1538-7755 1055-9965 |
language |
English |
mega_collection |
American Association for Cancer Research (AACR) (CrossRef) |
match_str |
ding2012anonsynonymouspolymorphisminirs1modifiesriskofdevelopingbreastandovariancancersinbrca1andovariancancerinbrca2mutationcarriers |
publishDateSort |
2012 |
publisher |
American Association for Cancer Research (AACR) |
recordtype |
ai |
record_format |
ai |
series |
Cancer Epidemiology, Biomarkers & Prevention |
source_id |
49 |
title |
A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers |
title_unstemmed |
A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers |
title_full |
A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers |
title_fullStr |
A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers |
title_full_unstemmed |
A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers |
title_short |
A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers |
title_sort |
a nonsynonymous polymorphism in <i>irs1</i> modifies risk of developing breast and ovarian cancers in <i>brca1</i> and ovarian cancer in <i>brca2</i> mutation carriers |
topic |
Oncology Epidemiology |
url |
http://dx.doi.org/10.1158/1055-9965.epi-12-0229 |
publishDate |
2012 |
physical |
1362-1370 |
description |
<jats:title>Abstract</jats:title>
<jats:p>Background: We previously reported significant associations between genetic variants in insulin receptor substrate 1 (IRS1) and breast cancer risk in women carrying BRCA1 mutations. The objectives of this study were to investigate whether the IRS1 variants modified ovarian cancer risk and were associated with breast cancer risk in a larger cohort of BRCA1 and BRCA2 mutation carriers.</jats:p>
<jats:p>Methods:IRS1 rs1801123, rs1330645, and rs1801278 were genotyped in samples from 36 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Data were analyzed by a retrospective cohort approach modeling the associations with breast and ovarian cancer risks simultaneously. Analyses were stratified by BRCA1 and BRCA2 status and mutation class in BRCA1 carriers.</jats:p>
<jats:p>Results: Rs1801278 (Gly972Arg) was associated with ovarian cancer risk for both BRCA1 (HR, 1.43; 95% confidence interval (CI), 1.06–1.92; P = 0.019) and BRCA2 mutation carriers (HR, 2.21; 95% CI, 1.39–3.52, P = 0.0008). For BRCA1 mutation carriers, the breast cancer risk was higher in carriers with class II mutations than class I mutations (class II HR, 1.86; 95% CI, 1.28–2.70; class I HR, 0.86; 95%CI, 0.69–1.09; Pdifference, 0.0006). Rs13306465 was associated with ovarian cancer risk in BRCA1 class II mutation carriers (HR, 2.42; P = 0.03).</jats:p>
<jats:p>Conclusion: The IRS1 Gly972Arg single-nucleotide polymorphism, which affects insulin-like growth factor and insulin signaling, modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers and breast cancer risk in BRCA1 class II mutation carriers.</jats:p>
<jats:p>Impact: These findings may prove useful for risk prediction for breast and ovarian cancers in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev; 21(8); 1362–70. ©2012 AACR.</jats:p> |
container_issue |
8 |
container_start_page |
1362 |
container_title |
Cancer Epidemiology, Biomarkers & Prevention |
container_volume |
21 |
format_de105 |
Article, E-Article |
format_de14 |
Article, E-Article |
format_de15 |
Article, E-Article |
format_de520 |
Article, E-Article |
format_de540 |
Article, E-Article |
format_dech1 |
Article, E-Article |
format_ded117 |
Article, E-Article |
format_degla1 |
E-Article |
format_del152 |
Buch |
format_del189 |
Article, E-Article |
format_dezi4 |
Article |
format_dezwi2 |
Article, E-Article |
format_finc |
Article, E-Article |
format_nrw |
Article, E-Article |
_version_ |
1792342284232032259 |
geogr_code |
not assigned |
last_indexed |
2024-03-01T16:32:32.471Z |
geogr_code_person |
not assigned |
openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=A+Nonsynonymous+Polymorphism+in+IRS1+Modifies+Risk+of+Developing+Breast+and+Ovarian+Cancers+in+BRCA1+and+Ovarian+Cancer+in+BRCA2+Mutation+Carriers&rft.date=2012-08-01&genre=article&issn=1538-7755&volume=21&issue=8&spage=1362&epage=1370&pages=1362-1370&jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&atitle=A+Nonsynonymous+Polymorphism+in+%3Ci%3EIRS1%3C%2Fi%3E+Modifies+Risk+of+Developing+Breast+and+Ovarian+Cancers+in+%3Ci%3EBRCA1%3C%2Fi%3E+and+Ovarian+Cancer+in+%3Ci%3EBRCA2%3C%2Fi%3E+Mutation+Carriers&aulast=Neuhausen&aufirst=Susan+L.&rft_id=info%3Adoi%2F10.1158%2F1055-9965.epi-12-0229&rft.language%5B0%5D=eng |
SOLR | |
_version_ | 1792342284232032259 |
author | Ding, Yuan C., McGuffog, Lesley, Healey, Sue, Friedman, Eitan, Laitman, Yael, Paluch–Shimon, Shani-, Kaufman, Bella, Liljegren, Annelie, Lindblom, Annika, Olsson, Håkan, Kristoffersson, Ulf, Stenmark-Askmalm, Marie, Melin, Beatrice, Domchek, Susan M., Nathanson, Katherine L., Rebbeck, Timothy R., Jakubowska, Anna, Lubinski, Jan, Jaworska, Katarzyna, Durda, Katarzyna, Gronwald, Jacek, Huzarski, Tomasz, Cybulski, Cezary, Byrski, Tomasz, Osorio, Ana, Cajal, Teresa Ramóny, Stavropoulou, Alexandra V., Benítez, Javier, Hamann, Ute, Rookus, Matti, Aalfs, Cora M., de Lange, Judith L., Meijers-Heijboer, Hanne E.J., Oosterwijk, Jan C., van Asperen, Christi J., Gómez García, Encarna B., Hoogerbrugge, Nicoline, Jager, Agnes, van der Luijt, Rob B., Easton, Douglas F., Peock, Susan, Frost, Debra, Ellis, Steve D., Platte, Radka, Fineberg, Elena, Evans, D. Gareth, Lalloo, Fiona, Izatt, Louise, Eeles, Ros, Adlard, Julian, Davidson, Rosemarie, Eccles, Diana, Cole, Trevor, Cook, Jackie, Brewer, Carole, Tischkowitz, Marc, Godwin, Andrew K., Pathak, Harsh, Stoppa-Lyonnet, Dominique, Sinilnikova, Olga M., Mazoyer, Sylvie, Barjhoux, Laure, Léoné, Mélanie, Gauthier-Villars, Marion, Caux-Moncoutier, Virginie, de Pauw, Antoine, Hardouin, Agnès, Berthet, Pascaline, Dreyfus, Hélène, Ferrer, Sandra Fert, Collonge-Rame, Marie-Agnès, Sokolowska, Johanna, Buys, Saundra, Daly, Mary, Miron, Alex, Terry, Mary Beth, Chung, Wendy, John, Esther M., Southey, Melissa, Goldgar, David, Singer, Christian F., Tea, Muy-Kheng Maria, Gschwantler-Kaulich, Daphne, Fink-Retter, Anneliese, Hansen, Thomas V.O., Ejlertsen, Bent, Johannsson, Oskar T., Offit, Kenneth, Sarrel, Kara, Gaudet, Mia M., Vijai, Joseph, Robson, Mark, Piedmonte, Marion R., Andrews, Lesley, Cohn, David, DeMars, Leslie R., DiSilvestro, Paul, Rodriguez, Gustavo, Toland, Amanda Ewart, Montagna, Marco, Agata, Simona, Imyanitov, Evgeny, Isaacs, Claudine, Janavicius, Ramunas, Lazaro, Conxi, Blanco, Ignacio, Ramus, Susan J., Sucheston, Lara, Karlan, Beth Y., Gross, Jenny, Ganz, Patricia A., Beattie, Mary S., Schmutzler, Rita K., Wappenschmidt, Barbara, Meindl, Alfons, Arnold, Norbert, Niederacher, Dieter, Preisler-Adams, Sabine, Gadzicki, Dorotehea, Varon-Mateeva, Raymonda, Deissler, Helmut, Gehrig, Andrea, Sutter, Christian, Kast, Karin, Nevanlinna, Heli, Aittomäki, Kristiina, Simard, Jacques, Spurdle, Amanda B., Beesley, Jonathan, Chen, Xiaoqing, Tomlinson, Gail E., Weitzel, Jeffrey, Garber, Judy E., Olopade, Olufunmilayo I., Rubinstein, Wendy S., Tung, Nadine, Blum, Joanne L., Narod, Steven A., Brummel, Sean, Gillen, Daniel L., Lindor, Noralane, Fredericksen, Zachary, Pankratz, Vernon S., Couch, Fergus J., Radice, Paolo, Peterlongo, Paolo, Greene, Mark H., Loud, Jennifer T., Mai, Phuong L., Andrulis, Irene L., Glendon, Gord, Ozcelik, Hilmi, Gerdes, Anne-Marie, Thomassen, Mads, Jensen, Uffe Birk, Skytte, Anne-Bine, Caligo, Maria A., Lee, Andrew, Chenevix-Trench, Georgia, Antoniou, Antonis C., Neuhausen, Susan L. |
author_facet | Ding, Yuan C., McGuffog, Lesley, Healey, Sue, Friedman, Eitan, Laitman, Yael, Paluch–Shimon, Shani-, Kaufman, Bella, Liljegren, Annelie, Lindblom, Annika, Olsson, Håkan, Kristoffersson, Ulf, Stenmark-Askmalm, Marie, Melin, Beatrice, Domchek, Susan M., Nathanson, Katherine L., Rebbeck, Timothy R., Jakubowska, Anna, Lubinski, Jan, Jaworska, Katarzyna, Durda, Katarzyna, Gronwald, Jacek, Huzarski, Tomasz, Cybulski, Cezary, Byrski, Tomasz, Osorio, Ana, Cajal, Teresa Ramóny, Stavropoulou, Alexandra V., Benítez, Javier, Hamann, Ute, Rookus, Matti, Aalfs, Cora M., de Lange, Judith L., Meijers-Heijboer, Hanne E.J., Oosterwijk, Jan C., van Asperen, Christi J., Gómez García, Encarna B., Hoogerbrugge, Nicoline, Jager, Agnes, van der Luijt, Rob B., Easton, Douglas F., Peock, Susan, Frost, Debra, Ellis, Steve D., Platte, Radka, Fineberg, Elena, Evans, D. Gareth, Lalloo, Fiona, Izatt, Louise, Eeles, Ros, Adlard, Julian, Davidson, Rosemarie, Eccles, Diana, Cole, Trevor, Cook, Jackie, Brewer, Carole, Tischkowitz, Marc, Godwin, Andrew K., Pathak, Harsh, Stoppa-Lyonnet, Dominique, Sinilnikova, Olga M., Mazoyer, Sylvie, Barjhoux, Laure, Léoné, Mélanie, Gauthier-Villars, Marion, Caux-Moncoutier, Virginie, de Pauw, Antoine, Hardouin, Agnès, Berthet, Pascaline, Dreyfus, Hélène, Ferrer, Sandra Fert, Collonge-Rame, Marie-Agnès, Sokolowska, Johanna, Buys, Saundra, Daly, Mary, Miron, Alex, Terry, Mary Beth, Chung, Wendy, John, Esther M., Southey, Melissa, Goldgar, David, Singer, Christian F., Tea, Muy-Kheng Maria, Gschwantler-Kaulich, Daphne, Fink-Retter, Anneliese, Hansen, Thomas V.O., Ejlertsen, Bent, Johannsson, Oskar T., Offit, Kenneth, Sarrel, Kara, Gaudet, Mia M., Vijai, Joseph, Robson, Mark, Piedmonte, Marion R., Andrews, Lesley, Cohn, David, DeMars, Leslie R., DiSilvestro, Paul, Rodriguez, Gustavo, Toland, Amanda Ewart, Montagna, Marco, Agata, Simona, Imyanitov, Evgeny, Isaacs, Claudine, Janavicius, Ramunas, Lazaro, Conxi, Blanco, Ignacio, Ramus, Susan J., Sucheston, Lara, Karlan, Beth Y., Gross, Jenny, Ganz, Patricia A., Beattie, Mary S., Schmutzler, Rita K., Wappenschmidt, Barbara, Meindl, Alfons, Arnold, Norbert, Niederacher, Dieter, Preisler-Adams, Sabine, Gadzicki, Dorotehea, Varon-Mateeva, Raymonda, Deissler, Helmut, Gehrig, Andrea, Sutter, Christian, Kast, Karin, Nevanlinna, Heli, Aittomäki, Kristiina, Simard, Jacques, Spurdle, Amanda B., Beesley, Jonathan, Chen, Xiaoqing, Tomlinson, Gail E., Weitzel, Jeffrey, Garber, Judy E., Olopade, Olufunmilayo I., Rubinstein, Wendy S., Tung, Nadine, Blum, Joanne L., Narod, Steven A., Brummel, Sean, Gillen, Daniel L., Lindor, Noralane, Fredericksen, Zachary, Pankratz, Vernon S., Couch, Fergus J., Radice, Paolo, Peterlongo, Paolo, Greene, Mark H., Loud, Jennifer T., Mai, Phuong L., Andrulis, Irene L., Glendon, Gord, Ozcelik, Hilmi, Gerdes, Anne-Marie, Thomassen, Mads, Jensen, Uffe Birk, Skytte, Anne-Bine, Caligo, Maria A., Lee, Andrew, Chenevix-Trench, Georgia, Antoniou, Antonis C., Neuhausen, Susan L., Ding, Yuan C., McGuffog, Lesley, Healey, Sue, Friedman, Eitan, Laitman, Yael, Paluch–Shimon, Shani-, Kaufman, Bella, Liljegren, Annelie, Lindblom, Annika, Olsson, Håkan, Kristoffersson, Ulf, Stenmark-Askmalm, Marie, Melin, Beatrice, Domchek, Susan M., Nathanson, Katherine L., Rebbeck, Timothy R., Jakubowska, Anna, Lubinski, Jan, Jaworska, Katarzyna, Durda, Katarzyna, Gronwald, Jacek, Huzarski, Tomasz, Cybulski, Cezary, Byrski, Tomasz, Osorio, Ana, Cajal, Teresa Ramóny, Stavropoulou, Alexandra V., Benítez, Javier, Hamann, Ute, Rookus, Matti, Aalfs, Cora M., de Lange, Judith L., Meijers-Heijboer, Hanne E.J., Oosterwijk, Jan C., van Asperen, Christi J., Gómez García, Encarna B., Hoogerbrugge, Nicoline, Jager, Agnes, van der Luijt, Rob B., Easton, Douglas F., Peock, Susan, Frost, Debra, Ellis, Steve D., Platte, Radka, Fineberg, Elena, Evans, D. Gareth, Lalloo, Fiona, Izatt, Louise, Eeles, Ros, Adlard, Julian, Davidson, Rosemarie, Eccles, Diana, Cole, Trevor, Cook, Jackie, Brewer, Carole, Tischkowitz, Marc, Godwin, Andrew K., Pathak, Harsh, Stoppa-Lyonnet, Dominique, Sinilnikova, Olga M., Mazoyer, Sylvie, Barjhoux, Laure, Léoné, Mélanie, Gauthier-Villars, Marion, Caux-Moncoutier, Virginie, de Pauw, Antoine, Hardouin, Agnès, Berthet, Pascaline, Dreyfus, Hélène, Ferrer, Sandra Fert, Collonge-Rame, Marie-Agnès, Sokolowska, Johanna, Buys, Saundra, Daly, Mary, Miron, Alex, Terry, Mary Beth, Chung, Wendy, John, Esther M., Southey, Melissa, Goldgar, David, Singer, Christian F., Tea, Muy-Kheng Maria, Gschwantler-Kaulich, Daphne, Fink-Retter, Anneliese, Hansen, Thomas V.O., Ejlertsen, Bent, Johannsson, Oskar T., Offit, Kenneth, Sarrel, Kara, Gaudet, Mia M., Vijai, Joseph, Robson, Mark, Piedmonte, Marion R., Andrews, Lesley, Cohn, David, DeMars, Leslie R., DiSilvestro, Paul, Rodriguez, Gustavo, Toland, Amanda Ewart, Montagna, Marco, Agata, Simona, Imyanitov, Evgeny, Isaacs, Claudine, Janavicius, Ramunas, Lazaro, Conxi, Blanco, Ignacio, Ramus, Susan J., Sucheston, Lara, Karlan, Beth Y., Gross, Jenny, Ganz, Patricia A., Beattie, Mary S., Schmutzler, Rita K., Wappenschmidt, Barbara, Meindl, Alfons, Arnold, Norbert, Niederacher, Dieter, Preisler-Adams, Sabine, Gadzicki, Dorotehea, Varon-Mateeva, Raymonda, Deissler, Helmut, Gehrig, Andrea, Sutter, Christian, Kast, Karin, Nevanlinna, Heli, Aittomäki, Kristiina, Simard, Jacques, Spurdle, Amanda B., Beesley, Jonathan, Chen, Xiaoqing, Tomlinson, Gail E., Weitzel, Jeffrey, Garber, Judy E., Olopade, Olufunmilayo I., Rubinstein, Wendy S., Tung, Nadine, Blum, Joanne L., Narod, Steven A., Brummel, Sean, Gillen, Daniel L., Lindor, Noralane, Fredericksen, Zachary, Pankratz, Vernon S., Couch, Fergus J., Radice, Paolo, Peterlongo, Paolo, Greene, Mark H., Loud, Jennifer T., Mai, Phuong L., Andrulis, Irene L., Glendon, Gord, Ozcelik, Hilmi, Gerdes, Anne-Marie, Thomassen, Mads, Jensen, Uffe Birk, Skytte, Anne-Bine, Caligo, Maria A., Lee, Andrew, Chenevix-Trench, Georgia, Antoniou, Antonis C., Neuhausen, Susan L. |
author_sort | ding, yuan c. |
container_issue | 8 |
container_start_page | 1362 |
container_title | Cancer Epidemiology, Biomarkers & Prevention |
container_volume | 21 |
description | <jats:title>Abstract</jats:title> <jats:p>Background: We previously reported significant associations between genetic variants in insulin receptor substrate 1 (IRS1) and breast cancer risk in women carrying BRCA1 mutations. The objectives of this study were to investigate whether the IRS1 variants modified ovarian cancer risk and were associated with breast cancer risk in a larger cohort of BRCA1 and BRCA2 mutation carriers.</jats:p> <jats:p>Methods:IRS1 rs1801123, rs1330645, and rs1801278 were genotyped in samples from 36 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Data were analyzed by a retrospective cohort approach modeling the associations with breast and ovarian cancer risks simultaneously. Analyses were stratified by BRCA1 and BRCA2 status and mutation class in BRCA1 carriers.</jats:p> <jats:p>Results: Rs1801278 (Gly972Arg) was associated with ovarian cancer risk for both BRCA1 (HR, 1.43; 95% confidence interval (CI), 1.06–1.92; P = 0.019) and BRCA2 mutation carriers (HR, 2.21; 95% CI, 1.39–3.52, P = 0.0008). For BRCA1 mutation carriers, the breast cancer risk was higher in carriers with class II mutations than class I mutations (class II HR, 1.86; 95% CI, 1.28–2.70; class I HR, 0.86; 95%CI, 0.69–1.09; Pdifference, 0.0006). Rs13306465 was associated with ovarian cancer risk in BRCA1 class II mutation carriers (HR, 2.42; P = 0.03).</jats:p> <jats:p>Conclusion: The IRS1 Gly972Arg single-nucleotide polymorphism, which affects insulin-like growth factor and insulin signaling, modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers and breast cancer risk in BRCA1 class II mutation carriers.</jats:p> <jats:p>Impact: These findings may prove useful for risk prediction for breast and ovarian cancers in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev; 21(8); 1362–70. ©2012 AACR.</jats:p> |
doi_str_mv | 10.1158/1055-9965.epi-12-0229 |
facet_avail | Online, Free |
finc_class_facet | Medizin |
format | ElectronicArticle |
format_de105 | Article, E-Article |
format_de14 | Article, E-Article |
format_de15 | Article, E-Article |
format_de520 | Article, E-Article |
format_de540 | Article, E-Article |
format_dech1 | Article, E-Article |
format_ded117 | Article, E-Article |
format_degla1 | E-Article |
format_del152 | Buch |
format_del189 | Article, E-Article |
format_dezi4 | Article |
format_dezwi2 | Article, E-Article |
format_finc | Article, E-Article |
format_nrw | Article, E-Article |
geogr_code | not assigned |
geogr_code_person | not assigned |
id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1OC8xMDU1LTk5NjUuZXBpLTEyLTAyMjk |
imprint | American Association for Cancer Research (AACR), 2012 |
imprint_str_mv | American Association for Cancer Research (AACR), 2012 |
institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
issn | 1538-7755, 1055-9965 |
issn_str_mv | 1538-7755, 1055-9965 |
language | English |
last_indexed | 2024-03-01T16:32:32.471Z |
match_str | ding2012anonsynonymouspolymorphisminirs1modifiesriskofdevelopingbreastandovariancancersinbrca1andovariancancerinbrca2mutationcarriers |
mega_collection | American Association for Cancer Research (AACR) (CrossRef) |
physical | 1362-1370 |
publishDate | 2012 |
publishDateSort | 2012 |
publisher | American Association for Cancer Research (AACR) |
record_format | ai |
recordtype | ai |
series | Cancer Epidemiology, Biomarkers & Prevention |
source_id | 49 |
spelling | Ding, Yuan C. McGuffog, Lesley Healey, Sue Friedman, Eitan Laitman, Yael Paluch–Shimon, Shani- Kaufman, Bella Liljegren, Annelie Lindblom, Annika Olsson, Håkan Kristoffersson, Ulf Stenmark-Askmalm, Marie Melin, Beatrice Domchek, Susan M. Nathanson, Katherine L. Rebbeck, Timothy R. Jakubowska, Anna Lubinski, Jan Jaworska, Katarzyna Durda, Katarzyna Gronwald, Jacek Huzarski, Tomasz Cybulski, Cezary Byrski, Tomasz Osorio, Ana Cajal, Teresa Ramóny Stavropoulou, Alexandra V. Benítez, Javier Hamann, Ute Rookus, Matti Aalfs, Cora M. de Lange, Judith L. Meijers-Heijboer, Hanne E.J. Oosterwijk, Jan C. van Asperen, Christi J. Gómez García, Encarna B. Hoogerbrugge, Nicoline Jager, Agnes van der Luijt, Rob B. Easton, Douglas F. Peock, Susan Frost, Debra Ellis, Steve D. Platte, Radka Fineberg, Elena Evans, D. Gareth Lalloo, Fiona Izatt, Louise Eeles, Ros Adlard, Julian Davidson, Rosemarie Eccles, Diana Cole, Trevor Cook, Jackie Brewer, Carole Tischkowitz, Marc Godwin, Andrew K. Pathak, Harsh Stoppa-Lyonnet, Dominique Sinilnikova, Olga M. Mazoyer, Sylvie Barjhoux, Laure Léoné, Mélanie Gauthier-Villars, Marion Caux-Moncoutier, Virginie de Pauw, Antoine Hardouin, Agnès Berthet, Pascaline Dreyfus, Hélène Ferrer, Sandra Fert Collonge-Rame, Marie-Agnès Sokolowska, Johanna Buys, Saundra Daly, Mary Miron, Alex Terry, Mary Beth Chung, Wendy John, Esther M. Southey, Melissa Goldgar, David Singer, Christian F. Tea, Muy-Kheng Maria Gschwantler-Kaulich, Daphne Fink-Retter, Anneliese Hansen, Thomas V.O. Ejlertsen, Bent Johannsson, Oskar T. Offit, Kenneth Sarrel, Kara Gaudet, Mia M. Vijai, Joseph Robson, Mark Piedmonte, Marion R. Andrews, Lesley Cohn, David DeMars, Leslie R. DiSilvestro, Paul Rodriguez, Gustavo Toland, Amanda Ewart Montagna, Marco Agata, Simona Imyanitov, Evgeny Isaacs, Claudine Janavicius, Ramunas Lazaro, Conxi Blanco, Ignacio Ramus, Susan J. Sucheston, Lara Karlan, Beth Y. Gross, Jenny Ganz, Patricia A. Beattie, Mary S. Schmutzler, Rita K. Wappenschmidt, Barbara Meindl, Alfons Arnold, Norbert Niederacher, Dieter Preisler-Adams, Sabine Gadzicki, Dorotehea Varon-Mateeva, Raymonda Deissler, Helmut Gehrig, Andrea Sutter, Christian Kast, Karin Nevanlinna, Heli Aittomäki, Kristiina Simard, Jacques Spurdle, Amanda B. Beesley, Jonathan Chen, Xiaoqing Tomlinson, Gail E. Weitzel, Jeffrey Garber, Judy E. Olopade, Olufunmilayo I. Rubinstein, Wendy S. Tung, Nadine Blum, Joanne L. Narod, Steven A. Brummel, Sean Gillen, Daniel L. Lindor, Noralane Fredericksen, Zachary Pankratz, Vernon S. Couch, Fergus J. Radice, Paolo Peterlongo, Paolo Greene, Mark H. Loud, Jennifer T. Mai, Phuong L. Andrulis, Irene L. Glendon, Gord Ozcelik, Hilmi Gerdes, Anne-Marie Thomassen, Mads Jensen, Uffe Birk Skytte, Anne-Bine Caligo, Maria A. Lee, Andrew Chenevix-Trench, Georgia Antoniou, Antonis C. Neuhausen, Susan L. 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-12-0229 <jats:title>Abstract</jats:title> <jats:p>Background: We previously reported significant associations between genetic variants in insulin receptor substrate 1 (IRS1) and breast cancer risk in women carrying BRCA1 mutations. The objectives of this study were to investigate whether the IRS1 variants modified ovarian cancer risk and were associated with breast cancer risk in a larger cohort of BRCA1 and BRCA2 mutation carriers.</jats:p> <jats:p>Methods:IRS1 rs1801123, rs1330645, and rs1801278 were genotyped in samples from 36 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Data were analyzed by a retrospective cohort approach modeling the associations with breast and ovarian cancer risks simultaneously. Analyses were stratified by BRCA1 and BRCA2 status and mutation class in BRCA1 carriers.</jats:p> <jats:p>Results: Rs1801278 (Gly972Arg) was associated with ovarian cancer risk for both BRCA1 (HR, 1.43; 95% confidence interval (CI), 1.06–1.92; P = 0.019) and BRCA2 mutation carriers (HR, 2.21; 95% CI, 1.39–3.52, P = 0.0008). For BRCA1 mutation carriers, the breast cancer risk was higher in carriers with class II mutations than class I mutations (class II HR, 1.86; 95% CI, 1.28–2.70; class I HR, 0.86; 95%CI, 0.69–1.09; Pdifference, 0.0006). Rs13306465 was associated with ovarian cancer risk in BRCA1 class II mutation carriers (HR, 2.42; P = 0.03).</jats:p> <jats:p>Conclusion: The IRS1 Gly972Arg single-nucleotide polymorphism, which affects insulin-like growth factor and insulin signaling, modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers and breast cancer risk in BRCA1 class II mutation carriers.</jats:p> <jats:p>Impact: These findings may prove useful for risk prediction for breast and ovarian cancers in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev; 21(8); 1362–70. ©2012 AACR.</jats:p> A Nonsynonymous Polymorphism in <i>IRS1</i> Modifies Risk of Developing Breast and Ovarian Cancers in <i>BRCA1</i> and Ovarian Cancer in <i>BRCA2</i> Mutation Carriers Cancer Epidemiology, Biomarkers & Prevention |
spellingShingle | Ding, Yuan C., McGuffog, Lesley, Healey, Sue, Friedman, Eitan, Laitman, Yael, Paluch–Shimon, Shani-, Kaufman, Bella, Liljegren, Annelie, Lindblom, Annika, Olsson, Håkan, Kristoffersson, Ulf, Stenmark-Askmalm, Marie, Melin, Beatrice, Domchek, Susan M., Nathanson, Katherine L., Rebbeck, Timothy R., Jakubowska, Anna, Lubinski, Jan, Jaworska, Katarzyna, Durda, Katarzyna, Gronwald, Jacek, Huzarski, Tomasz, Cybulski, Cezary, Byrski, Tomasz, Osorio, Ana, Cajal, Teresa Ramóny, Stavropoulou, Alexandra V., Benítez, Javier, Hamann, Ute, Rookus, Matti, Aalfs, Cora M., de Lange, Judith L., Meijers-Heijboer, Hanne E.J., Oosterwijk, Jan C., van Asperen, Christi J., Gómez García, Encarna B., Hoogerbrugge, Nicoline, Jager, Agnes, van der Luijt, Rob B., Easton, Douglas F., Peock, Susan, Frost, Debra, Ellis, Steve D., Platte, Radka, Fineberg, Elena, Evans, D. Gareth, Lalloo, Fiona, Izatt, Louise, Eeles, Ros, Adlard, Julian, Davidson, Rosemarie, Eccles, Diana, Cole, Trevor, Cook, Jackie, Brewer, Carole, Tischkowitz, Marc, Godwin, Andrew K., Pathak, Harsh, Stoppa-Lyonnet, Dominique, Sinilnikova, Olga M., Mazoyer, Sylvie, Barjhoux, Laure, Léoné, Mélanie, Gauthier-Villars, Marion, Caux-Moncoutier, Virginie, de Pauw, Antoine, Hardouin, Agnès, Berthet, Pascaline, Dreyfus, Hélène, Ferrer, Sandra Fert, Collonge-Rame, Marie-Agnès, Sokolowska, Johanna, Buys, Saundra, Daly, Mary, Miron, Alex, Terry, Mary Beth, Chung, Wendy, John, Esther M., Southey, Melissa, Goldgar, David, Singer, Christian F., Tea, Muy-Kheng Maria, Gschwantler-Kaulich, Daphne, Fink-Retter, Anneliese, Hansen, Thomas V.O., Ejlertsen, Bent, Johannsson, Oskar T., Offit, Kenneth, Sarrel, Kara, Gaudet, Mia M., Vijai, Joseph, Robson, Mark, Piedmonte, Marion R., Andrews, Lesley, Cohn, David, DeMars, Leslie R., DiSilvestro, Paul, Rodriguez, Gustavo, Toland, Amanda Ewart, Montagna, Marco, Agata, Simona, Imyanitov, Evgeny, Isaacs, Claudine, Janavicius, Ramunas, Lazaro, Conxi, Blanco, Ignacio, Ramus, Susan J., Sucheston, Lara, Karlan, Beth Y., Gross, Jenny, Ganz, Patricia A., Beattie, Mary S., Schmutzler, Rita K., Wappenschmidt, Barbara, Meindl, Alfons, Arnold, Norbert, Niederacher, Dieter, Preisler-Adams, Sabine, Gadzicki, Dorotehea, Varon-Mateeva, Raymonda, Deissler, Helmut, Gehrig, Andrea, Sutter, Christian, Kast, Karin, Nevanlinna, Heli, Aittomäki, Kristiina, Simard, Jacques, Spurdle, Amanda B., Beesley, Jonathan, Chen, Xiaoqing, Tomlinson, Gail E., Weitzel, Jeffrey, Garber, Judy E., Olopade, Olufunmilayo I., Rubinstein, Wendy S., Tung, Nadine, Blum, Joanne L., Narod, Steven A., Brummel, Sean, Gillen, Daniel L., Lindor, Noralane, Fredericksen, Zachary, Pankratz, Vernon S., Couch, Fergus J., Radice, Paolo, Peterlongo, Paolo, Greene, Mark H., Loud, Jennifer T., Mai, Phuong L., Andrulis, Irene L., Glendon, Gord, Ozcelik, Hilmi, Gerdes, Anne-Marie, Thomassen, Mads, Jensen, Uffe Birk, Skytte, Anne-Bine, Caligo, Maria A., Lee, Andrew, Chenevix-Trench, Georgia, Antoniou, Antonis C., Neuhausen, Susan L., Cancer Epidemiology, Biomarkers & Prevention, A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers, Oncology, Epidemiology |
title | A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers |
title_full | A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers |
title_fullStr | A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers |
title_full_unstemmed | A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers |
title_short | A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers |
title_sort | a nonsynonymous polymorphism in <i>irs1</i> modifies risk of developing breast and ovarian cancers in <i>brca1</i> and ovarian cancer in <i>brca2</i> mutation carriers |
title_unstemmed | A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers |
topic | Oncology, Epidemiology |
url | http://dx.doi.org/10.1158/1055-9965.epi-12-0229 |