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A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers

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Bibliographische Detailangaben
Zeitschriftentitel: Cancer Epidemiology, Biomarkers & Prevention
Personen und Körperschaften: Ding, Yuan C., McGuffog, Lesley, Healey, Sue, Friedman, Eitan, Laitman, Yael, Paluch–Shimon, Shani-, Kaufman, Bella, Liljegren, Annelie, Lindblom, Annika, Olsson, Håkan, Kristoffersson, Ulf, Stenmark-Askmalm, Marie, Melin, Beatrice, Domchek, Susan M., Nathanson, Katherine L., Rebbeck, Timothy R., Jakubowska, Anna, Lubinski, Jan, Jaworska, Katarzyna, Durda, Katarzyna, Gronwald, Jacek, Huzarski, Tomasz, Cybulski, Cezary, Byrski, Tomasz, Osorio, Ana, Cajal, Teresa Ramóny, Stavropoulou, Alexandra V., Benítez, Javier, Hamann, Ute, Rookus, Matti, Aalfs, Cora M., de Lange, Judith L., Meijers-Heijboer, Hanne E.J., Oosterwijk, Jan C., van Asperen, Christi J., Gómez García, Encarna B., Hoogerbrugge, Nicoline, Jager, Agnes, van der Luijt, Rob B., Easton, Douglas F., Peock, Susan, Frost, Debra, Ellis, Steve D., Platte, Radka, Fineberg, Elena, Evans, D. Gareth, Lalloo, Fiona, Izatt, Louise, Eeles, Ros, Adlard, Julian, Davidson, Rosemarie, Eccles, Diana, Cole, Trevor, Cook, Jackie, Brewer, Carole, Tischkowitz, Marc, Godwin, Andrew K., Pathak, Harsh, Stoppa-Lyonnet, Dominique, Sinilnikova, Olga M., Mazoyer, Sylvie, Barjhoux, Laure, Léoné, Mélanie, Gauthier-Villars, Marion, Caux-Moncoutier, Virginie, de Pauw, Antoine, Hardouin, Agnès, Berthet, Pascaline, Dreyfus, Hélène, Ferrer, Sandra Fert, Collonge-Rame, Marie-Agnès, Sokolowska, Johanna, Buys, Saundra, Daly, Mary, Miron, Alex, Terry, Mary Beth, Chung, Wendy, John, Esther M., Southey, Melissa, Goldgar, David, Singer, Christian F., Tea, Muy-Kheng Maria, Gschwantler-Kaulich, Daphne, Fink-Retter, Anneliese, Hansen, Thomas V.O., Ejlertsen, Bent, Johannsson, Oskar T., Offit, Kenneth, Sarrel, Kara, Gaudet, Mia M., Vijai, Joseph, Robson, Mark, Piedmonte, Marion R., Andrews, Lesley, Cohn, David, DeMars, Leslie R., DiSilvestro, Paul, Rodriguez, Gustavo, Toland, Amanda Ewart, Montagna, Marco, Agata, Simona, Imyanitov, Evgeny, Isaacs, Claudine, Janavicius, Ramunas, Lazaro, Conxi, Blanco, Ignacio, Ramus, Susan J., Sucheston, Lara, Karlan, Beth Y., Gross, Jenny, Ganz, Patricia A., Beattie, Mary S., Schmutzler, Rita K., Wappenschmidt, Barbara, Meindl, Alfons, Arnold, Norbert, Niederacher, Dieter, Preisler-Adams, Sabine, Gadzicki, Dorotehea, Varon-Mateeva, Raymonda, Deissler, Helmut, Gehrig, Andrea, Sutter, Christian, Kast, Karin, Nevanlinna, Heli, Aittomäki, Kristiina, Simard, Jacques, Spurdle, Amanda B., Beesley, Jonathan, Chen, Xiaoqing, Tomlinson, Gail E., Weitzel, Jeffrey, Garber, Judy E., Olopade, Olufunmilayo I., Rubinstein, Wendy S., Tung, Nadine, Blum, Joanne L., Narod, Steven A., Brummel, Sean, Gillen, Daniel L., Lindor, Noralane, Fredericksen, Zachary, Pankratz, Vernon S., Couch, Fergus J., Radice, Paolo, Peterlongo, Paolo, Greene, Mark H., Loud, Jennifer T., Mai, Phuong L., Andrulis, Irene L., Glendon, Gord, Ozcelik, Hilmi, Gerdes, Anne-Marie, Thomassen, Mads, Jensen, Uffe Birk, Skytte, Anne-Bine, Caligo, Maria A., Lee, Andrew, Chenevix-Trench, Georgia, Antoniou, Antonis C., Neuhausen, Susan L.
In: Cancer Epidemiology, Biomarkers & Prevention, 21, 2012, 8, S. 1362-1370
Format: E-Article
Sprache: Englisch
veröffentlicht:
American Association for Cancer Research (AACR)
Schlagwörter:
author_facet Ding, Yuan C.
McGuffog, Lesley
Healey, Sue
Friedman, Eitan
Laitman, Yael
Paluch–Shimon, Shani-
Kaufman, Bella
Liljegren, Annelie
Lindblom, Annika
Olsson, Håkan
Kristoffersson, Ulf
Stenmark-Askmalm, Marie
Melin, Beatrice
Domchek, Susan M.
Nathanson, Katherine L.
Rebbeck, Timothy R.
Jakubowska, Anna
Lubinski, Jan
Jaworska, Katarzyna
Durda, Katarzyna
Gronwald, Jacek
Huzarski, Tomasz
Cybulski, Cezary
Byrski, Tomasz
Osorio, Ana
Cajal, Teresa Ramóny
Stavropoulou, Alexandra V.
Benítez, Javier
Hamann, Ute
Rookus, Matti
Aalfs, Cora M.
de Lange, Judith L.
Meijers-Heijboer, Hanne E.J.
Oosterwijk, Jan C.
van Asperen, Christi J.
Gómez García, Encarna B.
Hoogerbrugge, Nicoline
Jager, Agnes
van der Luijt, Rob B.
Easton, Douglas F.
Peock, Susan
Frost, Debra
Ellis, Steve D.
Platte, Radka
Fineberg, Elena
Evans, D. Gareth
Lalloo, Fiona
Izatt, Louise
Eeles, Ros
Adlard, Julian
Davidson, Rosemarie
Eccles, Diana
Cole, Trevor
Cook, Jackie
Brewer, Carole
Tischkowitz, Marc
Godwin, Andrew K.
Pathak, Harsh
Stoppa-Lyonnet, Dominique
Sinilnikova, Olga M.
Mazoyer, Sylvie
Barjhoux, Laure
Léoné, Mélanie
Gauthier-Villars, Marion
Caux-Moncoutier, Virginie
de Pauw, Antoine
Hardouin, Agnès
Berthet, Pascaline
Dreyfus, Hélène
Ferrer, Sandra Fert
Collonge-Rame, Marie-Agnès
Sokolowska, Johanna
Buys, Saundra
Daly, Mary
Miron, Alex
Terry, Mary Beth
Chung, Wendy
John, Esther M.
Southey, Melissa
Goldgar, David
Singer, Christian F.
Tea, Muy-Kheng Maria
Gschwantler-Kaulich, Daphne
Fink-Retter, Anneliese
Hansen, Thomas V.O.
Ejlertsen, Bent
Johannsson, Oskar T.
Offit, Kenneth
Sarrel, Kara
Gaudet, Mia M.
Vijai, Joseph
Robson, Mark
Piedmonte, Marion R.
Andrews, Lesley
Cohn, David
DeMars, Leslie R.
DiSilvestro, Paul
Rodriguez, Gustavo
Toland, Amanda Ewart
Montagna, Marco
Agata, Simona
Imyanitov, Evgeny
Isaacs, Claudine
Janavicius, Ramunas
Lazaro, Conxi
Blanco, Ignacio
Ramus, Susan J.
Sucheston, Lara
Karlan, Beth Y.
Gross, Jenny
Ganz, Patricia A.
Beattie, Mary S.
Schmutzler, Rita K.
Wappenschmidt, Barbara
Meindl, Alfons
Arnold, Norbert
Niederacher, Dieter
Preisler-Adams, Sabine
Gadzicki, Dorotehea
Varon-Mateeva, Raymonda
Deissler, Helmut
Gehrig, Andrea
Sutter, Christian
Kast, Karin
Nevanlinna, Heli
Aittomäki, Kristiina
Simard, Jacques
Spurdle, Amanda B.
Beesley, Jonathan
Chen, Xiaoqing
Tomlinson, Gail E.
Weitzel, Jeffrey
Garber, Judy E.
Olopade, Olufunmilayo I.
Rubinstein, Wendy S.
Tung, Nadine
Blum, Joanne L.
Narod, Steven A.
Brummel, Sean
Gillen, Daniel L.
Lindor, Noralane
Fredericksen, Zachary
Pankratz, Vernon S.
Couch, Fergus J.
Radice, Paolo
Peterlongo, Paolo
Greene, Mark H.
Loud, Jennifer T.
Mai, Phuong L.
Andrulis, Irene L.
Glendon, Gord
Ozcelik, Hilmi
Gerdes, Anne-Marie
Thomassen, Mads
Jensen, Uffe Birk
Skytte, Anne-Bine
Caligo, Maria A.
Lee, Andrew
Chenevix-Trench, Georgia
Antoniou, Antonis C.
Neuhausen, Susan L.
Ding, Yuan C.
McGuffog, Lesley
Healey, Sue
Friedman, Eitan
Laitman, Yael
Paluch–Shimon, Shani-
Kaufman, Bella
Liljegren, Annelie
Lindblom, Annika
Olsson, Håkan
Kristoffersson, Ulf
Stenmark-Askmalm, Marie
Melin, Beatrice
Domchek, Susan M.
Nathanson, Katherine L.
Rebbeck, Timothy R.
Jakubowska, Anna
Lubinski, Jan
Jaworska, Katarzyna
Durda, Katarzyna
Gronwald, Jacek
Huzarski, Tomasz
Cybulski, Cezary
Byrski, Tomasz
Osorio, Ana
Cajal, Teresa Ramóny
Stavropoulou, Alexandra V.
Benítez, Javier
Hamann, Ute
Rookus, Matti
Aalfs, Cora M.
de Lange, Judith L.
Meijers-Heijboer, Hanne E.J.
Oosterwijk, Jan C.
van Asperen, Christi J.
Gómez García, Encarna B.
Hoogerbrugge, Nicoline
Jager, Agnes
van der Luijt, Rob B.
Easton, Douglas F.
Peock, Susan
Frost, Debra
Ellis, Steve D.
Platte, Radka
Fineberg, Elena
Evans, D. Gareth
Lalloo, Fiona
Izatt, Louise
Eeles, Ros
Adlard, Julian
Davidson, Rosemarie
Eccles, Diana
Cole, Trevor
Cook, Jackie
Brewer, Carole
Tischkowitz, Marc
Godwin, Andrew K.
Pathak, Harsh
Stoppa-Lyonnet, Dominique
Sinilnikova, Olga M.
Mazoyer, Sylvie
Barjhoux, Laure
Léoné, Mélanie
Gauthier-Villars, Marion
Caux-Moncoutier, Virginie
de Pauw, Antoine
Hardouin, Agnès
Berthet, Pascaline
Dreyfus, Hélène
Ferrer, Sandra Fert
Collonge-Rame, Marie-Agnès
Sokolowska, Johanna
Buys, Saundra
Daly, Mary
Miron, Alex
Terry, Mary Beth
Chung, Wendy
John, Esther M.
Southey, Melissa
Goldgar, David
Singer, Christian F.
Tea, Muy-Kheng Maria
Gschwantler-Kaulich, Daphne
Fink-Retter, Anneliese
Hansen, Thomas V.O.
Ejlertsen, Bent
Johannsson, Oskar T.
Offit, Kenneth
Sarrel, Kara
Gaudet, Mia M.
Vijai, Joseph
Robson, Mark
Piedmonte, Marion R.
Andrews, Lesley
Cohn, David
DeMars, Leslie R.
DiSilvestro, Paul
Rodriguez, Gustavo
Toland, Amanda Ewart
Montagna, Marco
Agata, Simona
Imyanitov, Evgeny
Isaacs, Claudine
Janavicius, Ramunas
Lazaro, Conxi
Blanco, Ignacio
Ramus, Susan J.
Sucheston, Lara
Karlan, Beth Y.
Gross, Jenny
Ganz, Patricia A.
Beattie, Mary S.
Schmutzler, Rita K.
Wappenschmidt, Barbara
Meindl, Alfons
Arnold, Norbert
Niederacher, Dieter
Preisler-Adams, Sabine
Gadzicki, Dorotehea
Varon-Mateeva, Raymonda
Deissler, Helmut
Gehrig, Andrea
Sutter, Christian
Kast, Karin
Nevanlinna, Heli
Aittomäki, Kristiina
Simard, Jacques
Spurdle, Amanda B.
Beesley, Jonathan
Chen, Xiaoqing
Tomlinson, Gail E.
Weitzel, Jeffrey
Garber, Judy E.
Olopade, Olufunmilayo I.
Rubinstein, Wendy S.
Tung, Nadine
Blum, Joanne L.
Narod, Steven A.
Brummel, Sean
Gillen, Daniel L.
Lindor, Noralane
Fredericksen, Zachary
Pankratz, Vernon S.
Couch, Fergus J.
Radice, Paolo
Peterlongo, Paolo
Greene, Mark H.
Loud, Jennifer T.
Mai, Phuong L.
Andrulis, Irene L.
Glendon, Gord
Ozcelik, Hilmi
Gerdes, Anne-Marie
Thomassen, Mads
Jensen, Uffe Birk
Skytte, Anne-Bine
Caligo, Maria A.
Lee, Andrew
Chenevix-Trench, Georgia
Antoniou, Antonis C.
Neuhausen, Susan L.
author Ding, Yuan C.
McGuffog, Lesley
Healey, Sue
Friedman, Eitan
Laitman, Yael
Paluch–Shimon, Shani-
Kaufman, Bella
Liljegren, Annelie
Lindblom, Annika
Olsson, Håkan
Kristoffersson, Ulf
Stenmark-Askmalm, Marie
Melin, Beatrice
Domchek, Susan M.
Nathanson, Katherine L.
Rebbeck, Timothy R.
Jakubowska, Anna
Lubinski, Jan
Jaworska, Katarzyna
Durda, Katarzyna
Gronwald, Jacek
Huzarski, Tomasz
Cybulski, Cezary
Byrski, Tomasz
Osorio, Ana
Cajal, Teresa Ramóny
Stavropoulou, Alexandra V.
Benítez, Javier
Hamann, Ute
Rookus, Matti
Aalfs, Cora M.
de Lange, Judith L.
Meijers-Heijboer, Hanne E.J.
Oosterwijk, Jan C.
van Asperen, Christi J.
Gómez García, Encarna B.
Hoogerbrugge, Nicoline
Jager, Agnes
van der Luijt, Rob B.
Easton, Douglas F.
Peock, Susan
Frost, Debra
Ellis, Steve D.
Platte, Radka
Fineberg, Elena
Evans, D. Gareth
Lalloo, Fiona
Izatt, Louise
Eeles, Ros
Adlard, Julian
Davidson, Rosemarie
Eccles, Diana
Cole, Trevor
Cook, Jackie
Brewer, Carole
Tischkowitz, Marc
Godwin, Andrew K.
Pathak, Harsh
Stoppa-Lyonnet, Dominique
Sinilnikova, Olga M.
Mazoyer, Sylvie
Barjhoux, Laure
Léoné, Mélanie
Gauthier-Villars, Marion
Caux-Moncoutier, Virginie
de Pauw, Antoine
Hardouin, Agnès
Berthet, Pascaline
Dreyfus, Hélène
Ferrer, Sandra Fert
Collonge-Rame, Marie-Agnès
Sokolowska, Johanna
Buys, Saundra
Daly, Mary
Miron, Alex
Terry, Mary Beth
Chung, Wendy
John, Esther M.
Southey, Melissa
Goldgar, David
Singer, Christian F.
Tea, Muy-Kheng Maria
Gschwantler-Kaulich, Daphne
Fink-Retter, Anneliese
Hansen, Thomas V.O.
Ejlertsen, Bent
Johannsson, Oskar T.
Offit, Kenneth
Sarrel, Kara
Gaudet, Mia M.
Vijai, Joseph
Robson, Mark
Piedmonte, Marion R.
Andrews, Lesley
Cohn, David
DeMars, Leslie R.
DiSilvestro, Paul
Rodriguez, Gustavo
Toland, Amanda Ewart
Montagna, Marco
Agata, Simona
Imyanitov, Evgeny
Isaacs, Claudine
Janavicius, Ramunas
Lazaro, Conxi
Blanco, Ignacio
Ramus, Susan J.
Sucheston, Lara
Karlan, Beth Y.
Gross, Jenny
Ganz, Patricia A.
Beattie, Mary S.
Schmutzler, Rita K.
Wappenschmidt, Barbara
Meindl, Alfons
Arnold, Norbert
Niederacher, Dieter
Preisler-Adams, Sabine
Gadzicki, Dorotehea
Varon-Mateeva, Raymonda
Deissler, Helmut
Gehrig, Andrea
Sutter, Christian
Kast, Karin
Nevanlinna, Heli
Aittomäki, Kristiina
Simard, Jacques
Spurdle, Amanda B.
Beesley, Jonathan
Chen, Xiaoqing
Tomlinson, Gail E.
Weitzel, Jeffrey
Garber, Judy E.
Olopade, Olufunmilayo I.
Rubinstein, Wendy S.
Tung, Nadine
Blum, Joanne L.
Narod, Steven A.
Brummel, Sean
Gillen, Daniel L.
Lindor, Noralane
Fredericksen, Zachary
Pankratz, Vernon S.
Couch, Fergus J.
Radice, Paolo
Peterlongo, Paolo
Greene, Mark H.
Loud, Jennifer T.
Mai, Phuong L.
Andrulis, Irene L.
Glendon, Gord
Ozcelik, Hilmi
Gerdes, Anne-Marie
Thomassen, Mads
Jensen, Uffe Birk
Skytte, Anne-Bine
Caligo, Maria A.
Lee, Andrew
Chenevix-Trench, Georgia
Antoniou, Antonis C.
Neuhausen, Susan L.
spellingShingle Ding, Yuan C.
McGuffog, Lesley
Healey, Sue
Friedman, Eitan
Laitman, Yael
Paluch–Shimon, Shani-
Kaufman, Bella
Liljegren, Annelie
Lindblom, Annika
Olsson, Håkan
Kristoffersson, Ulf
Stenmark-Askmalm, Marie
Melin, Beatrice
Domchek, Susan M.
Nathanson, Katherine L.
Rebbeck, Timothy R.
Jakubowska, Anna
Lubinski, Jan
Jaworska, Katarzyna
Durda, Katarzyna
Gronwald, Jacek
Huzarski, Tomasz
Cybulski, Cezary
Byrski, Tomasz
Osorio, Ana
Cajal, Teresa Ramóny
Stavropoulou, Alexandra V.
Benítez, Javier
Hamann, Ute
Rookus, Matti
Aalfs, Cora M.
de Lange, Judith L.
Meijers-Heijboer, Hanne E.J.
Oosterwijk, Jan C.
van Asperen, Christi J.
Gómez García, Encarna B.
Hoogerbrugge, Nicoline
Jager, Agnes
van der Luijt, Rob B.
Easton, Douglas F.
Peock, Susan
Frost, Debra
Ellis, Steve D.
Platte, Radka
Fineberg, Elena
Evans, D. Gareth
Lalloo, Fiona
Izatt, Louise
Eeles, Ros
Adlard, Julian
Davidson, Rosemarie
Eccles, Diana
Cole, Trevor
Cook, Jackie
Brewer, Carole
Tischkowitz, Marc
Godwin, Andrew K.
Pathak, Harsh
Stoppa-Lyonnet, Dominique
Sinilnikova, Olga M.
Mazoyer, Sylvie
Barjhoux, Laure
Léoné, Mélanie
Gauthier-Villars, Marion
Caux-Moncoutier, Virginie
de Pauw, Antoine
Hardouin, Agnès
Berthet, Pascaline
Dreyfus, Hélène
Ferrer, Sandra Fert
Collonge-Rame, Marie-Agnès
Sokolowska, Johanna
Buys, Saundra
Daly, Mary
Miron, Alex
Terry, Mary Beth
Chung, Wendy
John, Esther M.
Southey, Melissa
Goldgar, David
Singer, Christian F.
Tea, Muy-Kheng Maria
Gschwantler-Kaulich, Daphne
Fink-Retter, Anneliese
Hansen, Thomas V.O.
Ejlertsen, Bent
Johannsson, Oskar T.
Offit, Kenneth
Sarrel, Kara
Gaudet, Mia M.
Vijai, Joseph
Robson, Mark
Piedmonte, Marion R.
Andrews, Lesley
Cohn, David
DeMars, Leslie R.
DiSilvestro, Paul
Rodriguez, Gustavo
Toland, Amanda Ewart
Montagna, Marco
Agata, Simona
Imyanitov, Evgeny
Isaacs, Claudine
Janavicius, Ramunas
Lazaro, Conxi
Blanco, Ignacio
Ramus, Susan J.
Sucheston, Lara
Karlan, Beth Y.
Gross, Jenny
Ganz, Patricia A.
Beattie, Mary S.
Schmutzler, Rita K.
Wappenschmidt, Barbara
Meindl, Alfons
Arnold, Norbert
Niederacher, Dieter
Preisler-Adams, Sabine
Gadzicki, Dorotehea
Varon-Mateeva, Raymonda
Deissler, Helmut
Gehrig, Andrea
Sutter, Christian
Kast, Karin
Nevanlinna, Heli
Aittomäki, Kristiina
Simard, Jacques
Spurdle, Amanda B.
Beesley, Jonathan
Chen, Xiaoqing
Tomlinson, Gail E.
Weitzel, Jeffrey
Garber, Judy E.
Olopade, Olufunmilayo I.
Rubinstein, Wendy S.
Tung, Nadine
Blum, Joanne L.
Narod, Steven A.
Brummel, Sean
Gillen, Daniel L.
Lindor, Noralane
Fredericksen, Zachary
Pankratz, Vernon S.
Couch, Fergus J.
Radice, Paolo
Peterlongo, Paolo
Greene, Mark H.
Loud, Jennifer T.
Mai, Phuong L.
Andrulis, Irene L.
Glendon, Gord
Ozcelik, Hilmi
Gerdes, Anne-Marie
Thomassen, Mads
Jensen, Uffe Birk
Skytte, Anne-Bine
Caligo, Maria A.
Lee, Andrew
Chenevix-Trench, Georgia
Antoniou, Antonis C.
Neuhausen, Susan L.
Cancer Epidemiology, Biomarkers & Prevention
A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers
Oncology
Epidemiology
author_sort ding, yuan c.
spelling Ding, Yuan C. McGuffog, Lesley Healey, Sue Friedman, Eitan Laitman, Yael Paluch–Shimon, Shani- Kaufman, Bella Liljegren, Annelie Lindblom, Annika Olsson, Håkan Kristoffersson, Ulf Stenmark-Askmalm, Marie Melin, Beatrice Domchek, Susan M. Nathanson, Katherine L. Rebbeck, Timothy R. Jakubowska, Anna Lubinski, Jan Jaworska, Katarzyna Durda, Katarzyna Gronwald, Jacek Huzarski, Tomasz Cybulski, Cezary Byrski, Tomasz Osorio, Ana Cajal, Teresa Ramóny Stavropoulou, Alexandra V. Benítez, Javier Hamann, Ute Rookus, Matti Aalfs, Cora M. de Lange, Judith L. Meijers-Heijboer, Hanne E.J. Oosterwijk, Jan C. van Asperen, Christi J. Gómez García, Encarna B. Hoogerbrugge, Nicoline Jager, Agnes van der Luijt, Rob B. Easton, Douglas F. Peock, Susan Frost, Debra Ellis, Steve D. Platte, Radka Fineberg, Elena Evans, D. Gareth Lalloo, Fiona Izatt, Louise Eeles, Ros Adlard, Julian Davidson, Rosemarie Eccles, Diana Cole, Trevor Cook, Jackie Brewer, Carole Tischkowitz, Marc Godwin, Andrew K. Pathak, Harsh Stoppa-Lyonnet, Dominique Sinilnikova, Olga M. Mazoyer, Sylvie Barjhoux, Laure Léoné, Mélanie Gauthier-Villars, Marion Caux-Moncoutier, Virginie de Pauw, Antoine Hardouin, Agnès Berthet, Pascaline Dreyfus, Hélène Ferrer, Sandra Fert Collonge-Rame, Marie-Agnès Sokolowska, Johanna Buys, Saundra Daly, Mary Miron, Alex Terry, Mary Beth Chung, Wendy John, Esther M. Southey, Melissa Goldgar, David Singer, Christian F. Tea, Muy-Kheng Maria Gschwantler-Kaulich, Daphne Fink-Retter, Anneliese Hansen, Thomas V.O. Ejlertsen, Bent Johannsson, Oskar T. Offit, Kenneth Sarrel, Kara Gaudet, Mia M. Vijai, Joseph Robson, Mark Piedmonte, Marion R. Andrews, Lesley Cohn, David DeMars, Leslie R. DiSilvestro, Paul Rodriguez, Gustavo Toland, Amanda Ewart Montagna, Marco Agata, Simona Imyanitov, Evgeny Isaacs, Claudine Janavicius, Ramunas Lazaro, Conxi Blanco, Ignacio Ramus, Susan J. Sucheston, Lara Karlan, Beth Y. Gross, Jenny Ganz, Patricia A. Beattie, Mary S. Schmutzler, Rita K. Wappenschmidt, Barbara Meindl, Alfons Arnold, Norbert Niederacher, Dieter Preisler-Adams, Sabine Gadzicki, Dorotehea Varon-Mateeva, Raymonda Deissler, Helmut Gehrig, Andrea Sutter, Christian Kast, Karin Nevanlinna, Heli Aittomäki, Kristiina Simard, Jacques Spurdle, Amanda B. Beesley, Jonathan Chen, Xiaoqing Tomlinson, Gail E. Weitzel, Jeffrey Garber, Judy E. Olopade, Olufunmilayo I. Rubinstein, Wendy S. Tung, Nadine Blum, Joanne L. Narod, Steven A. Brummel, Sean Gillen, Daniel L. Lindor, Noralane Fredericksen, Zachary Pankratz, Vernon S. Couch, Fergus J. Radice, Paolo Peterlongo, Paolo Greene, Mark H. Loud, Jennifer T. Mai, Phuong L. Andrulis, Irene L. Glendon, Gord Ozcelik, Hilmi Gerdes, Anne-Marie Thomassen, Mads Jensen, Uffe Birk Skytte, Anne-Bine Caligo, Maria A. Lee, Andrew Chenevix-Trench, Georgia Antoniou, Antonis C. Neuhausen, Susan L. 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-12-0229 <jats:title>Abstract</jats:title> <jats:p>Background: We previously reported significant associations between genetic variants in insulin receptor substrate 1 (IRS1) and breast cancer risk in women carrying BRCA1 mutations. The objectives of this study were to investigate whether the IRS1 variants modified ovarian cancer risk and were associated with breast cancer risk in a larger cohort of BRCA1 and BRCA2 mutation carriers.</jats:p> <jats:p>Methods:IRS1 rs1801123, rs1330645, and rs1801278 were genotyped in samples from 36 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Data were analyzed by a retrospective cohort approach modeling the associations with breast and ovarian cancer risks simultaneously. Analyses were stratified by BRCA1 and BRCA2 status and mutation class in BRCA1 carriers.</jats:p> <jats:p>Results: Rs1801278 (Gly972Arg) was associated with ovarian cancer risk for both BRCA1 (HR, 1.43; 95% confidence interval (CI), 1.06–1.92; P = 0.019) and BRCA2 mutation carriers (HR, 2.21; 95% CI, 1.39–3.52, P = 0.0008). For BRCA1 mutation carriers, the breast cancer risk was higher in carriers with class II mutations than class I mutations (class II HR, 1.86; 95% CI, 1.28–2.70; class I HR, 0.86; 95%CI, 0.69–1.09; Pdifference, 0.0006). Rs13306465 was associated with ovarian cancer risk in BRCA1 class II mutation carriers (HR, 2.42; P = 0.03).</jats:p> <jats:p>Conclusion: The IRS1 Gly972Arg single-nucleotide polymorphism, which affects insulin-like growth factor and insulin signaling, modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers and breast cancer risk in BRCA1 class II mutation carriers.</jats:p> <jats:p>Impact: These findings may prove useful for risk prediction for breast and ovarian cancers in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev; 21(8); 1362–70. ©2012 AACR.</jats:p> A Nonsynonymous Polymorphism in <i>IRS1</i> Modifies Risk of Developing Breast and Ovarian Cancers in <i>BRCA1</i> and Ovarian Cancer in <i>BRCA2</i> Mutation Carriers Cancer Epidemiology, Biomarkers & Prevention
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title A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers
title_unstemmed A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers
title_full A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers
title_fullStr A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers
title_full_unstemmed A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers
title_short A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers
title_sort a nonsynonymous polymorphism in <i>irs1</i> modifies risk of developing breast and ovarian cancers in <i>brca1</i> and ovarian cancer in <i>brca2</i> mutation carriers
topic Oncology
Epidemiology
url http://dx.doi.org/10.1158/1055-9965.epi-12-0229
publishDate 2012
physical 1362-1370
description <jats:title>Abstract</jats:title> <jats:p>Background: We previously reported significant associations between genetic variants in insulin receptor substrate 1 (IRS1) and breast cancer risk in women carrying BRCA1 mutations. The objectives of this study were to investigate whether the IRS1 variants modified ovarian cancer risk and were associated with breast cancer risk in a larger cohort of BRCA1 and BRCA2 mutation carriers.</jats:p> <jats:p>Methods:IRS1 rs1801123, rs1330645, and rs1801278 were genotyped in samples from 36 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Data were analyzed by a retrospective cohort approach modeling the associations with breast and ovarian cancer risks simultaneously. Analyses were stratified by BRCA1 and BRCA2 status and mutation class in BRCA1 carriers.</jats:p> <jats:p>Results: Rs1801278 (Gly972Arg) was associated with ovarian cancer risk for both BRCA1 (HR, 1.43; 95% confidence interval (CI), 1.06–1.92; P = 0.019) and BRCA2 mutation carriers (HR, 2.21; 95% CI, 1.39–3.52, P = 0.0008). For BRCA1 mutation carriers, the breast cancer risk was higher in carriers with class II mutations than class I mutations (class II HR, 1.86; 95% CI, 1.28–2.70; class I HR, 0.86; 95%CI, 0.69–1.09; Pdifference, 0.0006). Rs13306465 was associated with ovarian cancer risk in BRCA1 class II mutation carriers (HR, 2.42; P = 0.03).</jats:p> <jats:p>Conclusion: The IRS1 Gly972Arg single-nucleotide polymorphism, which affects insulin-like growth factor and insulin signaling, modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers and breast cancer risk in BRCA1 class II mutation carriers.</jats:p> <jats:p>Impact: These findings may prove useful for risk prediction for breast and ovarian cancers in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev; 21(8); 1362–70. ©2012 AACR.</jats:p>
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author Ding, Yuan C., McGuffog, Lesley, Healey, Sue, Friedman, Eitan, Laitman, Yael, Paluch–Shimon, Shani-, Kaufman, Bella, Liljegren, Annelie, Lindblom, Annika, Olsson, Håkan, Kristoffersson, Ulf, Stenmark-Askmalm, Marie, Melin, Beatrice, Domchek, Susan M., Nathanson, Katherine L., Rebbeck, Timothy R., Jakubowska, Anna, Lubinski, Jan, Jaworska, Katarzyna, Durda, Katarzyna, Gronwald, Jacek, Huzarski, Tomasz, Cybulski, Cezary, Byrski, Tomasz, Osorio, Ana, Cajal, Teresa Ramóny, Stavropoulou, Alexandra V., Benítez, Javier, Hamann, Ute, Rookus, Matti, Aalfs, Cora M., de Lange, Judith L., Meijers-Heijboer, Hanne E.J., Oosterwijk, Jan C., van Asperen, Christi J., Gómez García, Encarna B., Hoogerbrugge, Nicoline, Jager, Agnes, van der Luijt, Rob B., Easton, Douglas F., Peock, Susan, Frost, Debra, Ellis, Steve D., Platte, Radka, Fineberg, Elena, Evans, D. Gareth, Lalloo, Fiona, Izatt, Louise, Eeles, Ros, Adlard, Julian, Davidson, Rosemarie, Eccles, Diana, Cole, Trevor, Cook, Jackie, Brewer, Carole, Tischkowitz, Marc, Godwin, Andrew K., Pathak, Harsh, Stoppa-Lyonnet, Dominique, Sinilnikova, Olga M., Mazoyer, Sylvie, Barjhoux, Laure, Léoné, Mélanie, Gauthier-Villars, Marion, Caux-Moncoutier, Virginie, de Pauw, Antoine, Hardouin, Agnès, Berthet, Pascaline, Dreyfus, Hélène, Ferrer, Sandra Fert, Collonge-Rame, Marie-Agnès, Sokolowska, Johanna, Buys, Saundra, Daly, Mary, Miron, Alex, Terry, Mary Beth, Chung, Wendy, John, Esther M., Southey, Melissa, Goldgar, David, Singer, Christian F., Tea, Muy-Kheng Maria, Gschwantler-Kaulich, Daphne, Fink-Retter, Anneliese, Hansen, Thomas V.O., Ejlertsen, Bent, Johannsson, Oskar T., Offit, Kenneth, Sarrel, Kara, Gaudet, Mia M., Vijai, Joseph, Robson, Mark, Piedmonte, Marion R., Andrews, Lesley, Cohn, David, DeMars, Leslie R., DiSilvestro, Paul, Rodriguez, Gustavo, Toland, Amanda Ewart, Montagna, Marco, Agata, Simona, Imyanitov, Evgeny, Isaacs, Claudine, Janavicius, Ramunas, Lazaro, Conxi, Blanco, Ignacio, Ramus, Susan J., Sucheston, Lara, Karlan, Beth Y., Gross, Jenny, Ganz, Patricia A., Beattie, Mary S., Schmutzler, Rita K., Wappenschmidt, Barbara, Meindl, Alfons, Arnold, Norbert, Niederacher, Dieter, Preisler-Adams, Sabine, Gadzicki, Dorotehea, Varon-Mateeva, Raymonda, Deissler, Helmut, Gehrig, Andrea, Sutter, Christian, Kast, Karin, Nevanlinna, Heli, Aittomäki, Kristiina, Simard, Jacques, Spurdle, Amanda B., Beesley, Jonathan, Chen, Xiaoqing, Tomlinson, Gail E., Weitzel, Jeffrey, Garber, Judy E., Olopade, Olufunmilayo I., Rubinstein, Wendy S., Tung, Nadine, Blum, Joanne L., Narod, Steven A., Brummel, Sean, Gillen, Daniel L., Lindor, Noralane, Fredericksen, Zachary, Pankratz, Vernon S., Couch, Fergus J., Radice, Paolo, Peterlongo, Paolo, Greene, Mark H., Loud, Jennifer T., Mai, Phuong L., Andrulis, Irene L., Glendon, Gord, Ozcelik, Hilmi, Gerdes, Anne-Marie, Thomassen, Mads, Jensen, Uffe Birk, Skytte, Anne-Bine, Caligo, Maria A., Lee, Andrew, Chenevix-Trench, Georgia, Antoniou, Antonis C., Neuhausen, Susan L.
author_facet Ding, Yuan C., McGuffog, Lesley, Healey, Sue, Friedman, Eitan, Laitman, Yael, Paluch–Shimon, Shani-, Kaufman, Bella, Liljegren, Annelie, Lindblom, Annika, Olsson, Håkan, Kristoffersson, Ulf, Stenmark-Askmalm, Marie, Melin, Beatrice, Domchek, Susan M., Nathanson, Katherine L., Rebbeck, Timothy R., Jakubowska, Anna, Lubinski, Jan, Jaworska, Katarzyna, Durda, Katarzyna, Gronwald, Jacek, Huzarski, Tomasz, Cybulski, Cezary, Byrski, Tomasz, Osorio, Ana, Cajal, Teresa Ramóny, Stavropoulou, Alexandra V., Benítez, Javier, Hamann, Ute, Rookus, Matti, Aalfs, Cora M., de Lange, Judith L., Meijers-Heijboer, Hanne E.J., Oosterwijk, Jan C., van Asperen, Christi J., Gómez García, Encarna B., Hoogerbrugge, Nicoline, Jager, Agnes, van der Luijt, Rob B., Easton, Douglas F., Peock, Susan, Frost, Debra, Ellis, Steve D., Platte, Radka, Fineberg, Elena, Evans, D. Gareth, Lalloo, Fiona, Izatt, Louise, Eeles, Ros, Adlard, Julian, Davidson, Rosemarie, Eccles, Diana, Cole, Trevor, Cook, Jackie, Brewer, Carole, Tischkowitz, Marc, Godwin, Andrew K., Pathak, Harsh, Stoppa-Lyonnet, Dominique, Sinilnikova, Olga M., Mazoyer, Sylvie, Barjhoux, Laure, Léoné, Mélanie, Gauthier-Villars, Marion, Caux-Moncoutier, Virginie, de Pauw, Antoine, Hardouin, Agnès, Berthet, Pascaline, Dreyfus, Hélène, Ferrer, Sandra Fert, Collonge-Rame, Marie-Agnès, Sokolowska, Johanna, Buys, Saundra, Daly, Mary, Miron, Alex, Terry, Mary Beth, Chung, Wendy, John, Esther M., Southey, Melissa, Goldgar, David, Singer, Christian F., Tea, Muy-Kheng Maria, Gschwantler-Kaulich, Daphne, Fink-Retter, Anneliese, Hansen, Thomas V.O., Ejlertsen, Bent, Johannsson, Oskar T., Offit, Kenneth, Sarrel, Kara, Gaudet, Mia M., Vijai, Joseph, Robson, Mark, Piedmonte, Marion R., Andrews, Lesley, Cohn, David, DeMars, Leslie R., DiSilvestro, Paul, Rodriguez, Gustavo, Toland, Amanda Ewart, Montagna, Marco, Agata, Simona, Imyanitov, Evgeny, Isaacs, Claudine, Janavicius, Ramunas, Lazaro, Conxi, Blanco, Ignacio, Ramus, Susan J., Sucheston, Lara, Karlan, Beth Y., Gross, Jenny, Ganz, Patricia A., Beattie, Mary S., Schmutzler, Rita K., Wappenschmidt, Barbara, Meindl, Alfons, Arnold, Norbert, Niederacher, Dieter, Preisler-Adams, Sabine, Gadzicki, Dorotehea, Varon-Mateeva, Raymonda, Deissler, Helmut, Gehrig, Andrea, Sutter, Christian, Kast, Karin, Nevanlinna, Heli, Aittomäki, Kristiina, Simard, Jacques, Spurdle, Amanda B., Beesley, Jonathan, Chen, Xiaoqing, Tomlinson, Gail E., Weitzel, Jeffrey, Garber, Judy E., Olopade, Olufunmilayo I., Rubinstein, Wendy S., Tung, Nadine, Blum, Joanne L., Narod, Steven A., Brummel, Sean, Gillen, Daniel L., Lindor, Noralane, Fredericksen, Zachary, Pankratz, Vernon S., Couch, Fergus J., Radice, Paolo, Peterlongo, Paolo, Greene, Mark H., Loud, Jennifer T., Mai, Phuong L., Andrulis, Irene L., Glendon, Gord, Ozcelik, Hilmi, Gerdes, Anne-Marie, Thomassen, Mads, Jensen, Uffe Birk, Skytte, Anne-Bine, Caligo, Maria A., Lee, Andrew, Chenevix-Trench, Georgia, Antoniou, Antonis C., Neuhausen, Susan L., Ding, Yuan C., McGuffog, Lesley, Healey, Sue, Friedman, Eitan, Laitman, Yael, Paluch–Shimon, Shani-, Kaufman, Bella, Liljegren, Annelie, Lindblom, Annika, Olsson, Håkan, Kristoffersson, Ulf, Stenmark-Askmalm, Marie, Melin, Beatrice, Domchek, Susan M., Nathanson, Katherine L., Rebbeck, Timothy R., Jakubowska, Anna, Lubinski, Jan, Jaworska, Katarzyna, Durda, Katarzyna, Gronwald, Jacek, Huzarski, Tomasz, Cybulski, Cezary, Byrski, Tomasz, Osorio, Ana, Cajal, Teresa Ramóny, Stavropoulou, Alexandra V., Benítez, Javier, Hamann, Ute, Rookus, Matti, Aalfs, Cora M., de Lange, Judith L., Meijers-Heijboer, Hanne E.J., Oosterwijk, Jan C., van Asperen, Christi J., Gómez García, Encarna B., Hoogerbrugge, Nicoline, Jager, Agnes, van der Luijt, Rob B., Easton, Douglas F., Peock, Susan, Frost, Debra, Ellis, Steve D., Platte, Radka, Fineberg, Elena, Evans, D. Gareth, Lalloo, Fiona, Izatt, Louise, Eeles, Ros, Adlard, Julian, Davidson, Rosemarie, Eccles, Diana, Cole, Trevor, Cook, Jackie, Brewer, Carole, Tischkowitz, Marc, Godwin, Andrew K., Pathak, Harsh, Stoppa-Lyonnet, Dominique, Sinilnikova, Olga M., Mazoyer, Sylvie, Barjhoux, Laure, Léoné, Mélanie, Gauthier-Villars, Marion, Caux-Moncoutier, Virginie, de Pauw, Antoine, Hardouin, Agnès, Berthet, Pascaline, Dreyfus, Hélène, Ferrer, Sandra Fert, Collonge-Rame, Marie-Agnès, Sokolowska, Johanna, Buys, Saundra, Daly, Mary, Miron, Alex, Terry, Mary Beth, Chung, Wendy, John, Esther M., Southey, Melissa, Goldgar, David, Singer, Christian F., Tea, Muy-Kheng Maria, Gschwantler-Kaulich, Daphne, Fink-Retter, Anneliese, Hansen, Thomas V.O., Ejlertsen, Bent, Johannsson, Oskar T., Offit, Kenneth, Sarrel, Kara, Gaudet, Mia M., Vijai, Joseph, Robson, Mark, Piedmonte, Marion R., Andrews, Lesley, Cohn, David, DeMars, Leslie R., DiSilvestro, Paul, Rodriguez, Gustavo, Toland, Amanda Ewart, Montagna, Marco, Agata, Simona, Imyanitov, Evgeny, Isaacs, Claudine, Janavicius, Ramunas, Lazaro, Conxi, Blanco, Ignacio, Ramus, Susan J., Sucheston, Lara, Karlan, Beth Y., Gross, Jenny, Ganz, Patricia A., Beattie, Mary S., Schmutzler, Rita K., Wappenschmidt, Barbara, Meindl, Alfons, Arnold, Norbert, Niederacher, Dieter, Preisler-Adams, Sabine, Gadzicki, Dorotehea, Varon-Mateeva, Raymonda, Deissler, Helmut, Gehrig, Andrea, Sutter, Christian, Kast, Karin, Nevanlinna, Heli, Aittomäki, Kristiina, Simard, Jacques, Spurdle, Amanda B., Beesley, Jonathan, Chen, Xiaoqing, Tomlinson, Gail E., Weitzel, Jeffrey, Garber, Judy E., Olopade, Olufunmilayo I., Rubinstein, Wendy S., Tung, Nadine, Blum, Joanne L., Narod, Steven A., Brummel, Sean, Gillen, Daniel L., Lindor, Noralane, Fredericksen, Zachary, Pankratz, Vernon S., Couch, Fergus J., Radice, Paolo, Peterlongo, Paolo, Greene, Mark H., Loud, Jennifer T., Mai, Phuong L., Andrulis, Irene L., Glendon, Gord, Ozcelik, Hilmi, Gerdes, Anne-Marie, Thomassen, Mads, Jensen, Uffe Birk, Skytte, Anne-Bine, Caligo, Maria A., Lee, Andrew, Chenevix-Trench, Georgia, Antoniou, Antonis C., Neuhausen, Susan L.
author_sort ding, yuan c.
container_issue 8
container_start_page 1362
container_title Cancer Epidemiology, Biomarkers & Prevention
container_volume 21
description <jats:title>Abstract</jats:title> <jats:p>Background: We previously reported significant associations between genetic variants in insulin receptor substrate 1 (IRS1) and breast cancer risk in women carrying BRCA1 mutations. The objectives of this study were to investigate whether the IRS1 variants modified ovarian cancer risk and were associated with breast cancer risk in a larger cohort of BRCA1 and BRCA2 mutation carriers.</jats:p> <jats:p>Methods:IRS1 rs1801123, rs1330645, and rs1801278 were genotyped in samples from 36 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Data were analyzed by a retrospective cohort approach modeling the associations with breast and ovarian cancer risks simultaneously. Analyses were stratified by BRCA1 and BRCA2 status and mutation class in BRCA1 carriers.</jats:p> <jats:p>Results: Rs1801278 (Gly972Arg) was associated with ovarian cancer risk for both BRCA1 (HR, 1.43; 95% confidence interval (CI), 1.06–1.92; P = 0.019) and BRCA2 mutation carriers (HR, 2.21; 95% CI, 1.39–3.52, P = 0.0008). For BRCA1 mutation carriers, the breast cancer risk was higher in carriers with class II mutations than class I mutations (class II HR, 1.86; 95% CI, 1.28–2.70; class I HR, 0.86; 95%CI, 0.69–1.09; Pdifference, 0.0006). Rs13306465 was associated with ovarian cancer risk in BRCA1 class II mutation carriers (HR, 2.42; P = 0.03).</jats:p> <jats:p>Conclusion: The IRS1 Gly972Arg single-nucleotide polymorphism, which affects insulin-like growth factor and insulin signaling, modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers and breast cancer risk in BRCA1 class II mutation carriers.</jats:p> <jats:p>Impact: These findings may prove useful for risk prediction for breast and ovarian cancers in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev; 21(8); 1362–70. ©2012 AACR.</jats:p>
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imprint_str_mv American Association for Cancer Research (AACR), 2012
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spelling Ding, Yuan C. McGuffog, Lesley Healey, Sue Friedman, Eitan Laitman, Yael Paluch–Shimon, Shani- Kaufman, Bella Liljegren, Annelie Lindblom, Annika Olsson, Håkan Kristoffersson, Ulf Stenmark-Askmalm, Marie Melin, Beatrice Domchek, Susan M. Nathanson, Katherine L. Rebbeck, Timothy R. Jakubowska, Anna Lubinski, Jan Jaworska, Katarzyna Durda, Katarzyna Gronwald, Jacek Huzarski, Tomasz Cybulski, Cezary Byrski, Tomasz Osorio, Ana Cajal, Teresa Ramóny Stavropoulou, Alexandra V. Benítez, Javier Hamann, Ute Rookus, Matti Aalfs, Cora M. de Lange, Judith L. Meijers-Heijboer, Hanne E.J. Oosterwijk, Jan C. van Asperen, Christi J. Gómez García, Encarna B. Hoogerbrugge, Nicoline Jager, Agnes van der Luijt, Rob B. Easton, Douglas F. Peock, Susan Frost, Debra Ellis, Steve D. Platte, Radka Fineberg, Elena Evans, D. Gareth Lalloo, Fiona Izatt, Louise Eeles, Ros Adlard, Julian Davidson, Rosemarie Eccles, Diana Cole, Trevor Cook, Jackie Brewer, Carole Tischkowitz, Marc Godwin, Andrew K. Pathak, Harsh Stoppa-Lyonnet, Dominique Sinilnikova, Olga M. Mazoyer, Sylvie Barjhoux, Laure Léoné, Mélanie Gauthier-Villars, Marion Caux-Moncoutier, Virginie de Pauw, Antoine Hardouin, Agnès Berthet, Pascaline Dreyfus, Hélène Ferrer, Sandra Fert Collonge-Rame, Marie-Agnès Sokolowska, Johanna Buys, Saundra Daly, Mary Miron, Alex Terry, Mary Beth Chung, Wendy John, Esther M. Southey, Melissa Goldgar, David Singer, Christian F. Tea, Muy-Kheng Maria Gschwantler-Kaulich, Daphne Fink-Retter, Anneliese Hansen, Thomas V.O. Ejlertsen, Bent Johannsson, Oskar T. Offit, Kenneth Sarrel, Kara Gaudet, Mia M. Vijai, Joseph Robson, Mark Piedmonte, Marion R. Andrews, Lesley Cohn, David DeMars, Leslie R. DiSilvestro, Paul Rodriguez, Gustavo Toland, Amanda Ewart Montagna, Marco Agata, Simona Imyanitov, Evgeny Isaacs, Claudine Janavicius, Ramunas Lazaro, Conxi Blanco, Ignacio Ramus, Susan J. Sucheston, Lara Karlan, Beth Y. Gross, Jenny Ganz, Patricia A. Beattie, Mary S. Schmutzler, Rita K. Wappenschmidt, Barbara Meindl, Alfons Arnold, Norbert Niederacher, Dieter Preisler-Adams, Sabine Gadzicki, Dorotehea Varon-Mateeva, Raymonda Deissler, Helmut Gehrig, Andrea Sutter, Christian Kast, Karin Nevanlinna, Heli Aittomäki, Kristiina Simard, Jacques Spurdle, Amanda B. Beesley, Jonathan Chen, Xiaoqing Tomlinson, Gail E. Weitzel, Jeffrey Garber, Judy E. Olopade, Olufunmilayo I. Rubinstein, Wendy S. Tung, Nadine Blum, Joanne L. Narod, Steven A. Brummel, Sean Gillen, Daniel L. Lindor, Noralane Fredericksen, Zachary Pankratz, Vernon S. Couch, Fergus J. Radice, Paolo Peterlongo, Paolo Greene, Mark H. Loud, Jennifer T. Mai, Phuong L. Andrulis, Irene L. Glendon, Gord Ozcelik, Hilmi Gerdes, Anne-Marie Thomassen, Mads Jensen, Uffe Birk Skytte, Anne-Bine Caligo, Maria A. Lee, Andrew Chenevix-Trench, Georgia Antoniou, Antonis C. Neuhausen, Susan L. 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-12-0229 <jats:title>Abstract</jats:title> <jats:p>Background: We previously reported significant associations between genetic variants in insulin receptor substrate 1 (IRS1) and breast cancer risk in women carrying BRCA1 mutations. The objectives of this study were to investigate whether the IRS1 variants modified ovarian cancer risk and were associated with breast cancer risk in a larger cohort of BRCA1 and BRCA2 mutation carriers.</jats:p> <jats:p>Methods:IRS1 rs1801123, rs1330645, and rs1801278 were genotyped in samples from 36 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Data were analyzed by a retrospective cohort approach modeling the associations with breast and ovarian cancer risks simultaneously. Analyses were stratified by BRCA1 and BRCA2 status and mutation class in BRCA1 carriers.</jats:p> <jats:p>Results: Rs1801278 (Gly972Arg) was associated with ovarian cancer risk for both BRCA1 (HR, 1.43; 95% confidence interval (CI), 1.06–1.92; P = 0.019) and BRCA2 mutation carriers (HR, 2.21; 95% CI, 1.39–3.52, P = 0.0008). For BRCA1 mutation carriers, the breast cancer risk was higher in carriers with class II mutations than class I mutations (class II HR, 1.86; 95% CI, 1.28–2.70; class I HR, 0.86; 95%CI, 0.69–1.09; Pdifference, 0.0006). Rs13306465 was associated with ovarian cancer risk in BRCA1 class II mutation carriers (HR, 2.42; P = 0.03).</jats:p> <jats:p>Conclusion: The IRS1 Gly972Arg single-nucleotide polymorphism, which affects insulin-like growth factor and insulin signaling, modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers and breast cancer risk in BRCA1 class II mutation carriers.</jats:p> <jats:p>Impact: These findings may prove useful for risk prediction for breast and ovarian cancers in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev; 21(8); 1362–70. ©2012 AACR.</jats:p> A Nonsynonymous Polymorphism in <i>IRS1</i> Modifies Risk of Developing Breast and Ovarian Cancers in <i>BRCA1</i> and Ovarian Cancer in <i>BRCA2</i> Mutation Carriers Cancer Epidemiology, Biomarkers & Prevention
spellingShingle Ding, Yuan C., McGuffog, Lesley, Healey, Sue, Friedman, Eitan, Laitman, Yael, Paluch–Shimon, Shani-, Kaufman, Bella, Liljegren, Annelie, Lindblom, Annika, Olsson, Håkan, Kristoffersson, Ulf, Stenmark-Askmalm, Marie, Melin, Beatrice, Domchek, Susan M., Nathanson, Katherine L., Rebbeck, Timothy R., Jakubowska, Anna, Lubinski, Jan, Jaworska, Katarzyna, Durda, Katarzyna, Gronwald, Jacek, Huzarski, Tomasz, Cybulski, Cezary, Byrski, Tomasz, Osorio, Ana, Cajal, Teresa Ramóny, Stavropoulou, Alexandra V., Benítez, Javier, Hamann, Ute, Rookus, Matti, Aalfs, Cora M., de Lange, Judith L., Meijers-Heijboer, Hanne E.J., Oosterwijk, Jan C., van Asperen, Christi J., Gómez García, Encarna B., Hoogerbrugge, Nicoline, Jager, Agnes, van der Luijt, Rob B., Easton, Douglas F., Peock, Susan, Frost, Debra, Ellis, Steve D., Platte, Radka, Fineberg, Elena, Evans, D. Gareth, Lalloo, Fiona, Izatt, Louise, Eeles, Ros, Adlard, Julian, Davidson, Rosemarie, Eccles, Diana, Cole, Trevor, Cook, Jackie, Brewer, Carole, Tischkowitz, Marc, Godwin, Andrew K., Pathak, Harsh, Stoppa-Lyonnet, Dominique, Sinilnikova, Olga M., Mazoyer, Sylvie, Barjhoux, Laure, Léoné, Mélanie, Gauthier-Villars, Marion, Caux-Moncoutier, Virginie, de Pauw, Antoine, Hardouin, Agnès, Berthet, Pascaline, Dreyfus, Hélène, Ferrer, Sandra Fert, Collonge-Rame, Marie-Agnès, Sokolowska, Johanna, Buys, Saundra, Daly, Mary, Miron, Alex, Terry, Mary Beth, Chung, Wendy, John, Esther M., Southey, Melissa, Goldgar, David, Singer, Christian F., Tea, Muy-Kheng Maria, Gschwantler-Kaulich, Daphne, Fink-Retter, Anneliese, Hansen, Thomas V.O., Ejlertsen, Bent, Johannsson, Oskar T., Offit, Kenneth, Sarrel, Kara, Gaudet, Mia M., Vijai, Joseph, Robson, Mark, Piedmonte, Marion R., Andrews, Lesley, Cohn, David, DeMars, Leslie R., DiSilvestro, Paul, Rodriguez, Gustavo, Toland, Amanda Ewart, Montagna, Marco, Agata, Simona, Imyanitov, Evgeny, Isaacs, Claudine, Janavicius, Ramunas, Lazaro, Conxi, Blanco, Ignacio, Ramus, Susan J., Sucheston, Lara, Karlan, Beth Y., Gross, Jenny, Ganz, Patricia A., Beattie, Mary S., Schmutzler, Rita K., Wappenschmidt, Barbara, Meindl, Alfons, Arnold, Norbert, Niederacher, Dieter, Preisler-Adams, Sabine, Gadzicki, Dorotehea, Varon-Mateeva, Raymonda, Deissler, Helmut, Gehrig, Andrea, Sutter, Christian, Kast, Karin, Nevanlinna, Heli, Aittomäki, Kristiina, Simard, Jacques, Spurdle, Amanda B., Beesley, Jonathan, Chen, Xiaoqing, Tomlinson, Gail E., Weitzel, Jeffrey, Garber, Judy E., Olopade, Olufunmilayo I., Rubinstein, Wendy S., Tung, Nadine, Blum, Joanne L., Narod, Steven A., Brummel, Sean, Gillen, Daniel L., Lindor, Noralane, Fredericksen, Zachary, Pankratz, Vernon S., Couch, Fergus J., Radice, Paolo, Peterlongo, Paolo, Greene, Mark H., Loud, Jennifer T., Mai, Phuong L., Andrulis, Irene L., Glendon, Gord, Ozcelik, Hilmi, Gerdes, Anne-Marie, Thomassen, Mads, Jensen, Uffe Birk, Skytte, Anne-Bine, Caligo, Maria A., Lee, Andrew, Chenevix-Trench, Georgia, Antoniou, Antonis C., Neuhausen, Susan L., Cancer Epidemiology, Biomarkers & Prevention, A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers, Oncology, Epidemiology
title A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers
title_full A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers
title_fullStr A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers
title_full_unstemmed A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers
title_short A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers
title_sort a nonsynonymous polymorphism in <i>irs1</i> modifies risk of developing breast and ovarian cancers in <i>brca1</i> and ovarian cancer in <i>brca2</i> mutation carriers
title_unstemmed A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers
topic Oncology, Epidemiology
url http://dx.doi.org/10.1158/1055-9965.epi-12-0229