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Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study
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| Zeitschriftentitel: | Cancer Epidemiology, Biomarkers & Prevention |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| In: | Cancer Epidemiology, Biomarkers & Prevention, 20, 2011, 12, S. 2532-2540 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Association for Cancer Research (AACR)
|
| Schlagwörter: |
| author_facet |
Rinaldi, Sabina Plummer, Martyn Biessy, Carine Castellsagué, Xavier Overvad, Kim Krüger Kjær, Susanne Tjønneland, Anne Clavel-Chapelon, Françoise Chabbert-Buffet, Nathalie Mesrine, Sylvie Lukanova, Annekatrin Kaaks, Rudolf Weikert, Cornelia Boeing, Heiner Trichopoulou, Antonia Lagiou, Pagona Trichopoulos, Dimitrios Palli, Domenico Agnoli, Claudia Tumino, Rosario Vineis, Paolo Panico, Salvatore Bueno-de-Mesquita, Bas van Kranen, Henk J. Peeters, Petra HM. Bakken, Kjersti Lund, Eiliv Gram, Inger Torhild Rodríguez, Laudina Bosch, F Xavier Sánchez, Maria-José Dorronsoro, Miren Navarro, Carmen Gurrea, Aurelio Barricarte Kjellberg, Lennart Dillner, Joakim Manjer, Jonas Butt, Salma Khaw, Kay-Tee Wareham, Nicholas Allen, Naomi E. Travis, Ruth Romieu, Isabelle Ferrari, Pietro Riboli, Elio Franceschi, Silvia Rinaldi, Sabina Plummer, Martyn Biessy, Carine Castellsagué, Xavier Overvad, Kim Krüger Kjær, Susanne Tjønneland, Anne Clavel-Chapelon, Françoise Chabbert-Buffet, Nathalie Mesrine, Sylvie Lukanova, Annekatrin Kaaks, Rudolf Weikert, Cornelia Boeing, Heiner Trichopoulou, Antonia Lagiou, Pagona Trichopoulos, Dimitrios Palli, Domenico Agnoli, Claudia Tumino, Rosario Vineis, Paolo Panico, Salvatore Bueno-de-Mesquita, Bas van Kranen, Henk J. Peeters, Petra HM. Bakken, Kjersti Lund, Eiliv Gram, Inger Torhild Rodríguez, Laudina Bosch, F Xavier Sánchez, Maria-José Dorronsoro, Miren Navarro, Carmen Gurrea, Aurelio Barricarte Kjellberg, Lennart Dillner, Joakim Manjer, Jonas Butt, Salma Khaw, Kay-Tee Wareham, Nicholas Allen, Naomi E. Travis, Ruth Romieu, Isabelle Ferrari, Pietro Riboli, Elio Franceschi, Silvia |
|---|---|
| author |
Rinaldi, Sabina Plummer, Martyn Biessy, Carine Castellsagué, Xavier Overvad, Kim Krüger Kjær, Susanne Tjønneland, Anne Clavel-Chapelon, Françoise Chabbert-Buffet, Nathalie Mesrine, Sylvie Lukanova, Annekatrin Kaaks, Rudolf Weikert, Cornelia Boeing, Heiner Trichopoulou, Antonia Lagiou, Pagona Trichopoulos, Dimitrios Palli, Domenico Agnoli, Claudia Tumino, Rosario Vineis, Paolo Panico, Salvatore Bueno-de-Mesquita, Bas van Kranen, Henk J. Peeters, Petra HM. Bakken, Kjersti Lund, Eiliv Gram, Inger Torhild Rodríguez, Laudina Bosch, F Xavier Sánchez, Maria-José Dorronsoro, Miren Navarro, Carmen Gurrea, Aurelio Barricarte Kjellberg, Lennart Dillner, Joakim Manjer, Jonas Butt, Salma Khaw, Kay-Tee Wareham, Nicholas Allen, Naomi E. Travis, Ruth Romieu, Isabelle Ferrari, Pietro Riboli, Elio Franceschi, Silvia |
| spellingShingle |
Rinaldi, Sabina Plummer, Martyn Biessy, Carine Castellsagué, Xavier Overvad, Kim Krüger Kjær, Susanne Tjønneland, Anne Clavel-Chapelon, Françoise Chabbert-Buffet, Nathalie Mesrine, Sylvie Lukanova, Annekatrin Kaaks, Rudolf Weikert, Cornelia Boeing, Heiner Trichopoulou, Antonia Lagiou, Pagona Trichopoulos, Dimitrios Palli, Domenico Agnoli, Claudia Tumino, Rosario Vineis, Paolo Panico, Salvatore Bueno-de-Mesquita, Bas van Kranen, Henk J. Peeters, Petra HM. Bakken, Kjersti Lund, Eiliv Gram, Inger Torhild Rodríguez, Laudina Bosch, F Xavier Sánchez, Maria-José Dorronsoro, Miren Navarro, Carmen Gurrea, Aurelio Barricarte Kjellberg, Lennart Dillner, Joakim Manjer, Jonas Butt, Salma Khaw, Kay-Tee Wareham, Nicholas Allen, Naomi E. Travis, Ruth Romieu, Isabelle Ferrari, Pietro Riboli, Elio Franceschi, Silvia Cancer Epidemiology, Biomarkers & Prevention Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study Oncology Epidemiology |
| author_sort |
rinaldi, sabina |
| spelling |
Rinaldi, Sabina Plummer, Martyn Biessy, Carine Castellsagué, Xavier Overvad, Kim Krüger Kjær, Susanne Tjønneland, Anne Clavel-Chapelon, Françoise Chabbert-Buffet, Nathalie Mesrine, Sylvie Lukanova, Annekatrin Kaaks, Rudolf Weikert, Cornelia Boeing, Heiner Trichopoulou, Antonia Lagiou, Pagona Trichopoulos, Dimitrios Palli, Domenico Agnoli, Claudia Tumino, Rosario Vineis, Paolo Panico, Salvatore Bueno-de-Mesquita, Bas van Kranen, Henk J. Peeters, Petra HM. Bakken, Kjersti Lund, Eiliv Gram, Inger Torhild Rodríguez, Laudina Bosch, F Xavier Sánchez, Maria-José Dorronsoro, Miren Navarro, Carmen Gurrea, Aurelio Barricarte Kjellberg, Lennart Dillner, Joakim Manjer, Jonas Butt, Salma Khaw, Kay-Tee Wareham, Nicholas Allen, Naomi E. Travis, Ruth Romieu, Isabelle Ferrari, Pietro Riboli, Elio Franceschi, Silvia 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-11-0753 <jats:title>Abstract</jats:title> <jats:p>Background: Epidemiologic data and animal models suggest that, despite the predominant role of human papillomavirus infection, sex steroid hormones are also involved in the etiology of invasive cervical carcinoma (ICC).</jats:p> <jats:p>Methods: Ninety-nine ICC cases, 121 cervical intraepithelial neoplasia grade 3 (CIN3) cases and 2 control women matched with each case for center, age, menopausal status and blood collection–related variables, were identified in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Circulating levels of testosterone (T) and estradiol (E2); dehydroepiandrosterone sulfate (DHEAS); progesterone (premenopausal women); and sex hormone–binding globulin (SHBG) were measured using immunoassays. Levels of free (f) T and E2 were calculated from absolute concentrations of T, E2, and SHBG. Odds ratios (ORs) and 95% confidence intervals (CI) were computed using regularized conditional logistic regression.</jats:p> <jats:p>Results: Among premenopausal women, associations with ICC were observed for fT (OR for highest vs. lowest tertile = 5.16, 95% CI, 1.50–20.1). SHBG level was associated with a significant downward trend in ICC risk. T, E2, fE2, and DHEAS showed nonsignificant positive association with ICC. Progesterone was uninfluential. Among postmenopausal women, associations with ICC were found for T (OR = 3.14; 95% CI, 1.21–9.37), whereas E2 and fT showed nonsignificant positive association. SHBG level was unrelated to ICC risk in postmenopausal women. No associations between any hormone and CIN3 were detected in either pre- or postmenopausal women.</jats:p> <jats:p>Conclusions: Our findings suggest for the first time that T and possibly E2 may be involved in the etiology of ICC.</jats:p> <jats:p>Impact: The responsiveness of cervical tumors to hormone modulators is worth exploring. Cancer Epidemiol Biomarkers Prev; 20(12); 2532–40. ©2011 AACR.</jats:p> Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study Cancer Epidemiology, Biomarkers & Prevention |
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Cancer Epidemiology, Biomarkers & Prevention |
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| title |
Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study |
| title_unstemmed |
Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study |
| title_full |
Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study |
| title_fullStr |
Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study |
| title_full_unstemmed |
Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study |
| title_short |
Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study |
| title_sort |
endogenous sex steroids and risk of cervical carcinoma: results from the epic study |
| topic |
Oncology Epidemiology |
| url |
http://dx.doi.org/10.1158/1055-9965.epi-11-0753 |
| publishDate |
2011 |
| physical |
2532-2540 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>Background: Epidemiologic data and animal models suggest that, despite the predominant role of human papillomavirus infection, sex steroid hormones are also involved in the etiology of invasive cervical carcinoma (ICC).</jats:p>
<jats:p>Methods: Ninety-nine ICC cases, 121 cervical intraepithelial neoplasia grade 3 (CIN3) cases and 2 control women matched with each case for center, age, menopausal status and blood collection–related variables, were identified in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Circulating levels of testosterone (T) and estradiol (E2); dehydroepiandrosterone sulfate (DHEAS); progesterone (premenopausal women); and sex hormone–binding globulin (SHBG) were measured using immunoassays. Levels of free (f) T and E2 were calculated from absolute concentrations of T, E2, and SHBG. Odds ratios (ORs) and 95% confidence intervals (CI) were computed using regularized conditional logistic regression.</jats:p>
<jats:p>Results: Among premenopausal women, associations with ICC were observed for fT (OR for highest vs. lowest tertile = 5.16, 95% CI, 1.50–20.1). SHBG level was associated with a significant downward trend in ICC risk. T, E2, fE2, and DHEAS showed nonsignificant positive association with ICC. Progesterone was uninfluential. Among postmenopausal women, associations with ICC were found for T (OR = 3.14; 95% CI, 1.21–9.37), whereas E2 and fT showed nonsignificant positive association. SHBG level was unrelated to ICC risk in postmenopausal women. No associations between any hormone and CIN3 were detected in either pre- or postmenopausal women.</jats:p>
<jats:p>Conclusions: Our findings suggest for the first time that T and possibly E2 may be involved in the etiology of ICC.</jats:p>
<jats:p>Impact: The responsiveness of cervical tumors to hormone modulators is worth exploring. Cancer Epidemiol Biomarkers Prev; 20(12); 2532–40. ©2011 AACR.</jats:p> |
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| author | Rinaldi, Sabina, Plummer, Martyn, Biessy, Carine, Castellsagué, Xavier, Overvad, Kim, Krüger Kjær, Susanne, Tjønneland, Anne, Clavel-Chapelon, Françoise, Chabbert-Buffet, Nathalie, Mesrine, Sylvie, Lukanova, Annekatrin, Kaaks, Rudolf, Weikert, Cornelia, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Bueno-de-Mesquita, Bas, van Kranen, Henk J., Peeters, Petra HM., Bakken, Kjersti, Lund, Eiliv, Gram, Inger Torhild, Rodríguez, Laudina, Bosch, F Xavier, Sánchez, Maria-José, Dorronsoro, Miren, Navarro, Carmen, Gurrea, Aurelio Barricarte, Kjellberg, Lennart, Dillner, Joakim, Manjer, Jonas, Butt, Salma, Khaw, Kay-Tee, Wareham, Nicholas, Allen, Naomi E., Travis, Ruth, Romieu, Isabelle, Ferrari, Pietro, Riboli, Elio, Franceschi, Silvia |
| author_facet | Rinaldi, Sabina, Plummer, Martyn, Biessy, Carine, Castellsagué, Xavier, Overvad, Kim, Krüger Kjær, Susanne, Tjønneland, Anne, Clavel-Chapelon, Françoise, Chabbert-Buffet, Nathalie, Mesrine, Sylvie, Lukanova, Annekatrin, Kaaks, Rudolf, Weikert, Cornelia, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Bueno-de-Mesquita, Bas, van Kranen, Henk J., Peeters, Petra HM., Bakken, Kjersti, Lund, Eiliv, Gram, Inger Torhild, Rodríguez, Laudina, Bosch, F Xavier, Sánchez, Maria-José, Dorronsoro, Miren, Navarro, Carmen, Gurrea, Aurelio Barricarte, Kjellberg, Lennart, Dillner, Joakim, Manjer, Jonas, Butt, Salma, Khaw, Kay-Tee, Wareham, Nicholas, Allen, Naomi E., Travis, Ruth, Romieu, Isabelle, Ferrari, Pietro, Riboli, Elio, Franceschi, Silvia, Rinaldi, Sabina, Plummer, Martyn, Biessy, Carine, Castellsagué, Xavier, Overvad, Kim, Krüger Kjær, Susanne, Tjønneland, Anne, Clavel-Chapelon, Françoise, Chabbert-Buffet, Nathalie, Mesrine, Sylvie, Lukanova, Annekatrin, Kaaks, Rudolf, Weikert, Cornelia, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Bueno-de-Mesquita, Bas, van Kranen, Henk J., Peeters, Petra HM., Bakken, Kjersti, Lund, Eiliv, Gram, Inger Torhild, Rodríguez, Laudina, Bosch, F Xavier, Sánchez, Maria-José, Dorronsoro, Miren, Navarro, Carmen, Gurrea, Aurelio Barricarte, Kjellberg, Lennart, Dillner, Joakim, Manjer, Jonas, Butt, Salma, Khaw, Kay-Tee, Wareham, Nicholas, Allen, Naomi E., Travis, Ruth, Romieu, Isabelle, Ferrari, Pietro, Riboli, Elio, Franceschi, Silvia |
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| description | <jats:title>Abstract</jats:title> <jats:p>Background: Epidemiologic data and animal models suggest that, despite the predominant role of human papillomavirus infection, sex steroid hormones are also involved in the etiology of invasive cervical carcinoma (ICC).</jats:p> <jats:p>Methods: Ninety-nine ICC cases, 121 cervical intraepithelial neoplasia grade 3 (CIN3) cases and 2 control women matched with each case for center, age, menopausal status and blood collection–related variables, were identified in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Circulating levels of testosterone (T) and estradiol (E2); dehydroepiandrosterone sulfate (DHEAS); progesterone (premenopausal women); and sex hormone–binding globulin (SHBG) were measured using immunoassays. Levels of free (f) T and E2 were calculated from absolute concentrations of T, E2, and SHBG. Odds ratios (ORs) and 95% confidence intervals (CI) were computed using regularized conditional logistic regression.</jats:p> <jats:p>Results: Among premenopausal women, associations with ICC were observed for fT (OR for highest vs. lowest tertile = 5.16, 95% CI, 1.50–20.1). SHBG level was associated with a significant downward trend in ICC risk. T, E2, fE2, and DHEAS showed nonsignificant positive association with ICC. Progesterone was uninfluential. Among postmenopausal women, associations with ICC were found for T (OR = 3.14; 95% CI, 1.21–9.37), whereas E2 and fT showed nonsignificant positive association. SHBG level was unrelated to ICC risk in postmenopausal women. No associations between any hormone and CIN3 were detected in either pre- or postmenopausal women.</jats:p> <jats:p>Conclusions: Our findings suggest for the first time that T and possibly E2 may be involved in the etiology of ICC.</jats:p> <jats:p>Impact: The responsiveness of cervical tumors to hormone modulators is worth exploring. Cancer Epidemiol Biomarkers Prev; 20(12); 2532–40. ©2011 AACR.</jats:p> |
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| spelling | Rinaldi, Sabina Plummer, Martyn Biessy, Carine Castellsagué, Xavier Overvad, Kim Krüger Kjær, Susanne Tjønneland, Anne Clavel-Chapelon, Françoise Chabbert-Buffet, Nathalie Mesrine, Sylvie Lukanova, Annekatrin Kaaks, Rudolf Weikert, Cornelia Boeing, Heiner Trichopoulou, Antonia Lagiou, Pagona Trichopoulos, Dimitrios Palli, Domenico Agnoli, Claudia Tumino, Rosario Vineis, Paolo Panico, Salvatore Bueno-de-Mesquita, Bas van Kranen, Henk J. Peeters, Petra HM. Bakken, Kjersti Lund, Eiliv Gram, Inger Torhild Rodríguez, Laudina Bosch, F Xavier Sánchez, Maria-José Dorronsoro, Miren Navarro, Carmen Gurrea, Aurelio Barricarte Kjellberg, Lennart Dillner, Joakim Manjer, Jonas Butt, Salma Khaw, Kay-Tee Wareham, Nicholas Allen, Naomi E. Travis, Ruth Romieu, Isabelle Ferrari, Pietro Riboli, Elio Franceschi, Silvia 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-11-0753 <jats:title>Abstract</jats:title> <jats:p>Background: Epidemiologic data and animal models suggest that, despite the predominant role of human papillomavirus infection, sex steroid hormones are also involved in the etiology of invasive cervical carcinoma (ICC).</jats:p> <jats:p>Methods: Ninety-nine ICC cases, 121 cervical intraepithelial neoplasia grade 3 (CIN3) cases and 2 control women matched with each case for center, age, menopausal status and blood collection–related variables, were identified in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Circulating levels of testosterone (T) and estradiol (E2); dehydroepiandrosterone sulfate (DHEAS); progesterone (premenopausal women); and sex hormone–binding globulin (SHBG) were measured using immunoassays. Levels of free (f) T and E2 were calculated from absolute concentrations of T, E2, and SHBG. Odds ratios (ORs) and 95% confidence intervals (CI) were computed using regularized conditional logistic regression.</jats:p> <jats:p>Results: Among premenopausal women, associations with ICC were observed for fT (OR for highest vs. lowest tertile = 5.16, 95% CI, 1.50–20.1). SHBG level was associated with a significant downward trend in ICC risk. T, E2, fE2, and DHEAS showed nonsignificant positive association with ICC. Progesterone was uninfluential. Among postmenopausal women, associations with ICC were found for T (OR = 3.14; 95% CI, 1.21–9.37), whereas E2 and fT showed nonsignificant positive association. SHBG level was unrelated to ICC risk in postmenopausal women. No associations between any hormone and CIN3 were detected in either pre- or postmenopausal women.</jats:p> <jats:p>Conclusions: Our findings suggest for the first time that T and possibly E2 may be involved in the etiology of ICC.</jats:p> <jats:p>Impact: The responsiveness of cervical tumors to hormone modulators is worth exploring. Cancer Epidemiol Biomarkers Prev; 20(12); 2532–40. ©2011 AACR.</jats:p> Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study Cancer Epidemiology, Biomarkers & Prevention |
| spellingShingle | Rinaldi, Sabina, Plummer, Martyn, Biessy, Carine, Castellsagué, Xavier, Overvad, Kim, Krüger Kjær, Susanne, Tjønneland, Anne, Clavel-Chapelon, Françoise, Chabbert-Buffet, Nathalie, Mesrine, Sylvie, Lukanova, Annekatrin, Kaaks, Rudolf, Weikert, Cornelia, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Bueno-de-Mesquita, Bas, van Kranen, Henk J., Peeters, Petra HM., Bakken, Kjersti, Lund, Eiliv, Gram, Inger Torhild, Rodríguez, Laudina, Bosch, F Xavier, Sánchez, Maria-José, Dorronsoro, Miren, Navarro, Carmen, Gurrea, Aurelio Barricarte, Kjellberg, Lennart, Dillner, Joakim, Manjer, Jonas, Butt, Salma, Khaw, Kay-Tee, Wareham, Nicholas, Allen, Naomi E., Travis, Ruth, Romieu, Isabelle, Ferrari, Pietro, Riboli, Elio, Franceschi, Silvia, Cancer Epidemiology, Biomarkers & Prevention, Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study, Oncology, Epidemiology |
| title | Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study |
| title_full | Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study |
| title_fullStr | Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study |
| title_full_unstemmed | Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study |
| title_short | Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study |
| title_sort | endogenous sex steroids and risk of cervical carcinoma: results from the epic study |
| title_unstemmed | Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study |
| topic | Oncology, Epidemiology |
| url | http://dx.doi.org/10.1158/1055-9965.epi-11-0753 |