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Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
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Zeitschriftentitel: | Cancer Epidemiology, Biomarkers & Prevention |
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In: | Cancer Epidemiology, Biomarkers & Prevention, 24, 2015, 1, S. 308-316 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
American Association for Cancer Research (AACR)
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Schlagwörter: |
author_facet |
Peterlongo, Paolo Chang-Claude, Jenny Moysich, Kirsten B. Rudolph, Anja Schmutzler, Rita K. Simard, Jacques Soucy, Penny Eeles, Rosalind A. Easton, Douglas F. Hamann, Ute Wilkening, Stefan Chen, Bowang Rookus, Matti A. Schmidt, Marjanka K. van der Baan, Frederieke H. Spurdle, Amanda B. Walker, Logan C. Lose, Felicity Maia, Ana-Teresa Montagna, Marco Matricardi, Laura Lubinski, Jan Jakubowska, Anna Gómez Garcia, Encarna B. Olopade, Olufunmilayo I. Nussbaum, Robert L. Nathanson, Katherine L. Domchek, Susan M. Rebbeck, Timothy R. Arun, Banu K. Karlan, Beth Y. Orsulic, Sandra Lester, Jenny Chung, Wendy K. Miron, Alex Southey, Melissa C. Goldgar, David E. Buys, Saundra S. Janavicius, Ramunas Dorfling, Cecilia M. van Rensburg, Elizabeth J. Ding, Yuan Chun Neuhausen, Susan L. Hansen, Thomas V.O. Gerdes, Anne-Marie Ejlertsen, Bent Jønson, Lars Osorio, Ana Martínez-Bouzas, Cristina Benitez, Javier Conway, Edye E. Blazer, Kathleen R. Weitzel, Jeffrey N. Manoukian, Siranoush Peissel, Bernard Zaffaroni, Daniela Scuvera, Giulietta Barile, Monica Ficarazzi, Filomena Mariette, Frederique Fortuzzi, Stefano Viel, Alessandra Giannini, Giuseppe Papi, Laura Martayan, Aline Tibiletti, Maria Grazia Radice, Paolo Vratimos, Athanassios Fostira, Florentia Garber, Judy E. Donaldson, Alan Brewer, Carole Foo, Claire Evans, D. Gareth R. Frost, Debra Eccles, Diana Brady, Angela Cook, Jackie Tischkowitz, Marc Adlard, Julian Barwell, Julian Walker, Lisa Izatt, Louise Side, Lucy E. Kennedy, M. John Rogers, Mark T. Porteous, Mary E. Morrison, Patrick J. Platte, Radka Davidson, Rosemarie Hodgson, Shirley V. Ellis, Steve Cole, Trevor Godwin, Andrew K. Claes, Kathleen Van Maerken, Tom Meindl, Alfons Gehrig, Andrea Sutter, Christian Engel, Christoph Niederacher, Dieter Steinemann, Doris Plendl, Hansjoerg Kast, Karin Rhiem, Kerstin Ditsch, Nina Arnold, Norbert Varon-Mateeva, Raymonda Wappenschmidt, Barbara Wang-Gohrke, Shan Bressac-de Paillerets, Brigitte Buecher, Bruno Delnatte, Capucine Houdayer, Claude Stoppa-Lyonnet, Dominique Damiola, Francesca Coupier, Isabelle Barjhoux, Laure Venat-Bouvet, Laurence Golmard, Lisa Boutry-Kryza, Nadia Sinilnikova, Olga M. Caron, Olivier Pujol, Pascal Mazoyer, Sylvie Belotti, Muriel Piedmonte, Marion Friedlander, Michael L. Rodriguez, Gustavo C. Copeland, Larry J. de la Hoya, Miguel Segura, Pedro Perez Nevanlinna, Heli Aittomäki, Kristiina van Os, Theo A.M. Meijers-Heijboer, Hanne E.J. van der Hout, Annemarie H. Vreeswijk, Maaike P.G. Hoogerbrugge, Nicoline Ausems, Margreet G.E.M. van Doorn, Helena C. Collée, J. Margriet Olah, Edith Diez, Orland Blanco, Ignacio Lazaro, Conxi Brunet, Joan Feliubadalo, Lidia Cybulski, Cezary Gronwald, Jacek Durda, Katarzyna Jaworska-Bieniek, Katarzyna Sukiennicki, Grzegorz Arason, Adalgeir Chiquette, Jocelyne Teixeira, Manuel R. Olswold, Curtis Couch, Fergus J. Lindor, Noralane M. Wang, Xianshu Szabo, Csilla I. Offit, Kenneth Corines, Marina Jacobs, Lauren Robson, Mark E. Zhang, Liying Joseph, Vijai Berger, Andreas Singer, Christian F. Rappaport, Christine Kaulich, Daphne Geschwantler Pfeiler, Georg Tea, Muy-Kheng M. Phelan, Catherine M. Greene, Mark H. Mai, Phuong L. Rennert, Gad Mulligan, Anna Marie Glendon, Gord Tchatchou, Sandrine Andrulis, Irene L. Toland, Amanda Ewart Bojesen, Anders Pedersen, Inge Sokilde Thomassen, Mads Jensen, Uffe Birk Laitman, Yael Rantala, Johanna von Wachenfeldt, Anna Ehrencrona, Hans Askmalm, Marie Stenmark Borg, Åke Kuchenbaecker, Karoline B. McGuffog, Lesley Barrowdale, Daniel Healey, Sue Lee, Andrew Pharoah, Paul D.P. Chenevix-Trench, Georgia Antoniou, Antonis C. Friedman, Eitan Peterlongo, Paolo Chang-Claude, Jenny Moysich, Kirsten B. Rudolph, Anja Schmutzler, Rita K. Simard, Jacques Soucy, Penny Eeles, Rosalind A. Easton, Douglas F. Hamann, Ute Wilkening, Stefan Chen, Bowang Rookus, Matti A. Schmidt, Marjanka K. van der Baan, Frederieke H. Spurdle, Amanda B. Walker, Logan C. Lose, Felicity Maia, Ana-Teresa Montagna, Marco Matricardi, Laura Lubinski, Jan Jakubowska, Anna Gómez Garcia, Encarna B. Olopade, Olufunmilayo I. Nussbaum, Robert L. Nathanson, Katherine L. Domchek, Susan M. Rebbeck, Timothy R. Arun, Banu K. Karlan, Beth Y. Orsulic, Sandra Lester, Jenny Chung, Wendy K. Miron, Alex Southey, Melissa C. Goldgar, David E. Buys, Saundra S. Janavicius, Ramunas Dorfling, Cecilia M. van Rensburg, Elizabeth J. Ding, Yuan Chun Neuhausen, Susan L. Hansen, Thomas V.O. Gerdes, Anne-Marie Ejlertsen, Bent Jønson, Lars Osorio, Ana Martínez-Bouzas, Cristina Benitez, Javier Conway, Edye E. Blazer, Kathleen R. Weitzel, Jeffrey N. Manoukian, Siranoush Peissel, Bernard Zaffaroni, Daniela Scuvera, Giulietta Barile, Monica Ficarazzi, Filomena Mariette, Frederique Fortuzzi, Stefano Viel, Alessandra Giannini, Giuseppe Papi, Laura Martayan, Aline Tibiletti, Maria Grazia Radice, Paolo Vratimos, Athanassios Fostira, Florentia Garber, Judy E. Donaldson, Alan Brewer, Carole Foo, Claire Evans, D. Gareth R. Frost, Debra Eccles, Diana Brady, Angela Cook, Jackie Tischkowitz, Marc Adlard, Julian Barwell, Julian Walker, Lisa Izatt, Louise Side, Lucy E. Kennedy, M. John Rogers, Mark T. Porteous, Mary E. Morrison, Patrick J. Platte, Radka Davidson, Rosemarie Hodgson, Shirley V. Ellis, Steve Cole, Trevor Godwin, Andrew K. Claes, Kathleen Van Maerken, Tom Meindl, Alfons Gehrig, Andrea Sutter, Christian Engel, Christoph Niederacher, Dieter Steinemann, Doris Plendl, Hansjoerg Kast, Karin Rhiem, Kerstin Ditsch, Nina Arnold, Norbert Varon-Mateeva, Raymonda Wappenschmidt, Barbara Wang-Gohrke, Shan Bressac-de Paillerets, Brigitte Buecher, Bruno Delnatte, Capucine Houdayer, Claude Stoppa-Lyonnet, Dominique Damiola, Francesca Coupier, Isabelle Barjhoux, Laure Venat-Bouvet, Laurence Golmard, Lisa Boutry-Kryza, Nadia Sinilnikova, Olga M. Caron, Olivier Pujol, Pascal Mazoyer, Sylvie Belotti, Muriel Piedmonte, Marion Friedlander, Michael L. Rodriguez, Gustavo C. Copeland, Larry J. de la Hoya, Miguel Segura, Pedro Perez Nevanlinna, Heli Aittomäki, Kristiina van Os, Theo A.M. Meijers-Heijboer, Hanne E.J. van der Hout, Annemarie H. Vreeswijk, Maaike P.G. Hoogerbrugge, Nicoline Ausems, Margreet G.E.M. van Doorn, Helena C. Collée, J. Margriet Olah, Edith Diez, Orland Blanco, Ignacio Lazaro, Conxi Brunet, Joan Feliubadalo, Lidia Cybulski, Cezary Gronwald, Jacek Durda, Katarzyna Jaworska-Bieniek, Katarzyna Sukiennicki, Grzegorz Arason, Adalgeir Chiquette, Jocelyne Teixeira, Manuel R. Olswold, Curtis Couch, Fergus J. Lindor, Noralane M. Wang, Xianshu Szabo, Csilla I. Offit, Kenneth Corines, Marina Jacobs, Lauren Robson, Mark E. Zhang, Liying Joseph, Vijai Berger, Andreas Singer, Christian F. Rappaport, Christine Kaulich, Daphne Geschwantler Pfeiler, Georg Tea, Muy-Kheng M. Phelan, Catherine M. Greene, Mark H. Mai, Phuong L. Rennert, Gad Mulligan, Anna Marie Glendon, Gord Tchatchou, Sandrine Andrulis, Irene L. Toland, Amanda Ewart Bojesen, Anders Pedersen, Inge Sokilde Thomassen, Mads Jensen, Uffe Birk Laitman, Yael Rantala, Johanna von Wachenfeldt, Anna Ehrencrona, Hans Askmalm, Marie Stenmark Borg, Åke Kuchenbaecker, Karoline B. McGuffog, Lesley Barrowdale, Daniel Healey, Sue Lee, Andrew Pharoah, Paul D.P. Chenevix-Trench, Georgia Antoniou, Antonis C. Friedman, Eitan |
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author |
Peterlongo, Paolo Chang-Claude, Jenny Moysich, Kirsten B. Rudolph, Anja Schmutzler, Rita K. Simard, Jacques Soucy, Penny Eeles, Rosalind A. Easton, Douglas F. Hamann, Ute Wilkening, Stefan Chen, Bowang Rookus, Matti A. Schmidt, Marjanka K. van der Baan, Frederieke H. Spurdle, Amanda B. Walker, Logan C. Lose, Felicity Maia, Ana-Teresa Montagna, Marco Matricardi, Laura Lubinski, Jan Jakubowska, Anna Gómez Garcia, Encarna B. Olopade, Olufunmilayo I. Nussbaum, Robert L. Nathanson, Katherine L. Domchek, Susan M. Rebbeck, Timothy R. Arun, Banu K. Karlan, Beth Y. Orsulic, Sandra Lester, Jenny Chung, Wendy K. Miron, Alex Southey, Melissa C. Goldgar, David E. Buys, Saundra S. Janavicius, Ramunas Dorfling, Cecilia M. van Rensburg, Elizabeth J. Ding, Yuan Chun Neuhausen, Susan L. Hansen, Thomas V.O. Gerdes, Anne-Marie Ejlertsen, Bent Jønson, Lars Osorio, Ana Martínez-Bouzas, Cristina Benitez, Javier Conway, Edye E. Blazer, Kathleen R. Weitzel, Jeffrey N. Manoukian, Siranoush Peissel, Bernard Zaffaroni, Daniela Scuvera, Giulietta Barile, Monica Ficarazzi, Filomena Mariette, Frederique Fortuzzi, Stefano Viel, Alessandra Giannini, Giuseppe Papi, Laura Martayan, Aline Tibiletti, Maria Grazia Radice, Paolo Vratimos, Athanassios Fostira, Florentia Garber, Judy E. Donaldson, Alan Brewer, Carole Foo, Claire Evans, D. Gareth R. Frost, Debra Eccles, Diana Brady, Angela Cook, Jackie Tischkowitz, Marc Adlard, Julian Barwell, Julian Walker, Lisa Izatt, Louise Side, Lucy E. Kennedy, M. John Rogers, Mark T. Porteous, Mary E. Morrison, Patrick J. Platte, Radka Davidson, Rosemarie Hodgson, Shirley V. Ellis, Steve Cole, Trevor Godwin, Andrew K. Claes, Kathleen Van Maerken, Tom Meindl, Alfons Gehrig, Andrea Sutter, Christian Engel, Christoph Niederacher, Dieter Steinemann, Doris Plendl, Hansjoerg Kast, Karin Rhiem, Kerstin Ditsch, Nina Arnold, Norbert Varon-Mateeva, Raymonda Wappenschmidt, Barbara Wang-Gohrke, Shan Bressac-de Paillerets, Brigitte Buecher, Bruno Delnatte, Capucine Houdayer, Claude Stoppa-Lyonnet, Dominique Damiola, Francesca Coupier, Isabelle Barjhoux, Laure Venat-Bouvet, Laurence Golmard, Lisa Boutry-Kryza, Nadia Sinilnikova, Olga M. Caron, Olivier Pujol, Pascal Mazoyer, Sylvie Belotti, Muriel Piedmonte, Marion Friedlander, Michael L. Rodriguez, Gustavo C. Copeland, Larry J. de la Hoya, Miguel Segura, Pedro Perez Nevanlinna, Heli Aittomäki, Kristiina van Os, Theo A.M. Meijers-Heijboer, Hanne E.J. van der Hout, Annemarie H. Vreeswijk, Maaike P.G. Hoogerbrugge, Nicoline Ausems, Margreet G.E.M. van Doorn, Helena C. Collée, J. Margriet Olah, Edith Diez, Orland Blanco, Ignacio Lazaro, Conxi Brunet, Joan Feliubadalo, Lidia Cybulski, Cezary Gronwald, Jacek Durda, Katarzyna Jaworska-Bieniek, Katarzyna Sukiennicki, Grzegorz Arason, Adalgeir Chiquette, Jocelyne Teixeira, Manuel R. Olswold, Curtis Couch, Fergus J. Lindor, Noralane M. Wang, Xianshu Szabo, Csilla I. Offit, Kenneth Corines, Marina Jacobs, Lauren Robson, Mark E. Zhang, Liying Joseph, Vijai Berger, Andreas Singer, Christian F. Rappaport, Christine Kaulich, Daphne Geschwantler Pfeiler, Georg Tea, Muy-Kheng M. Phelan, Catherine M. Greene, Mark H. Mai, Phuong L. Rennert, Gad Mulligan, Anna Marie Glendon, Gord Tchatchou, Sandrine Andrulis, Irene L. Toland, Amanda Ewart Bojesen, Anders Pedersen, Inge Sokilde Thomassen, Mads Jensen, Uffe Birk Laitman, Yael Rantala, Johanna von Wachenfeldt, Anna Ehrencrona, Hans Askmalm, Marie Stenmark Borg, Åke Kuchenbaecker, Karoline B. McGuffog, Lesley Barrowdale, Daniel Healey, Sue Lee, Andrew Pharoah, Paul D.P. Chenevix-Trench, Georgia Antoniou, Antonis C. Friedman, Eitan |
spellingShingle |
Peterlongo, Paolo Chang-Claude, Jenny Moysich, Kirsten B. Rudolph, Anja Schmutzler, Rita K. Simard, Jacques Soucy, Penny Eeles, Rosalind A. Easton, Douglas F. Hamann, Ute Wilkening, Stefan Chen, Bowang Rookus, Matti A. Schmidt, Marjanka K. van der Baan, Frederieke H. Spurdle, Amanda B. Walker, Logan C. Lose, Felicity Maia, Ana-Teresa Montagna, Marco Matricardi, Laura Lubinski, Jan Jakubowska, Anna Gómez Garcia, Encarna B. Olopade, Olufunmilayo I. Nussbaum, Robert L. Nathanson, Katherine L. Domchek, Susan M. Rebbeck, Timothy R. Arun, Banu K. Karlan, Beth Y. Orsulic, Sandra Lester, Jenny Chung, Wendy K. Miron, Alex Southey, Melissa C. Goldgar, David E. Buys, Saundra S. Janavicius, Ramunas Dorfling, Cecilia M. van Rensburg, Elizabeth J. Ding, Yuan Chun Neuhausen, Susan L. Hansen, Thomas V.O. Gerdes, Anne-Marie Ejlertsen, Bent Jønson, Lars Osorio, Ana Martínez-Bouzas, Cristina Benitez, Javier Conway, Edye E. Blazer, Kathleen R. Weitzel, Jeffrey N. Manoukian, Siranoush Peissel, Bernard Zaffaroni, Daniela Scuvera, Giulietta Barile, Monica Ficarazzi, Filomena Mariette, Frederique Fortuzzi, Stefano Viel, Alessandra Giannini, Giuseppe Papi, Laura Martayan, Aline Tibiletti, Maria Grazia Radice, Paolo Vratimos, Athanassios Fostira, Florentia Garber, Judy E. Donaldson, Alan Brewer, Carole Foo, Claire Evans, D. Gareth R. Frost, Debra Eccles, Diana Brady, Angela Cook, Jackie Tischkowitz, Marc Adlard, Julian Barwell, Julian Walker, Lisa Izatt, Louise Side, Lucy E. Kennedy, M. John Rogers, Mark T. Porteous, Mary E. Morrison, Patrick J. Platte, Radka Davidson, Rosemarie Hodgson, Shirley V. Ellis, Steve Cole, Trevor Godwin, Andrew K. Claes, Kathleen Van Maerken, Tom Meindl, Alfons Gehrig, Andrea Sutter, Christian Engel, Christoph Niederacher, Dieter Steinemann, Doris Plendl, Hansjoerg Kast, Karin Rhiem, Kerstin Ditsch, Nina Arnold, Norbert Varon-Mateeva, Raymonda Wappenschmidt, Barbara Wang-Gohrke, Shan Bressac-de Paillerets, Brigitte Buecher, Bruno Delnatte, Capucine Houdayer, Claude Stoppa-Lyonnet, Dominique Damiola, Francesca Coupier, Isabelle Barjhoux, Laure Venat-Bouvet, Laurence Golmard, Lisa Boutry-Kryza, Nadia Sinilnikova, Olga M. Caron, Olivier Pujol, Pascal Mazoyer, Sylvie Belotti, Muriel Piedmonte, Marion Friedlander, Michael L. Rodriguez, Gustavo C. Copeland, Larry J. de la Hoya, Miguel Segura, Pedro Perez Nevanlinna, Heli Aittomäki, Kristiina van Os, Theo A.M. Meijers-Heijboer, Hanne E.J. van der Hout, Annemarie H. Vreeswijk, Maaike P.G. Hoogerbrugge, Nicoline Ausems, Margreet G.E.M. van Doorn, Helena C. Collée, J. Margriet Olah, Edith Diez, Orland Blanco, Ignacio Lazaro, Conxi Brunet, Joan Feliubadalo, Lidia Cybulski, Cezary Gronwald, Jacek Durda, Katarzyna Jaworska-Bieniek, Katarzyna Sukiennicki, Grzegorz Arason, Adalgeir Chiquette, Jocelyne Teixeira, Manuel R. Olswold, Curtis Couch, Fergus J. Lindor, Noralane M. Wang, Xianshu Szabo, Csilla I. Offit, Kenneth Corines, Marina Jacobs, Lauren Robson, Mark E. Zhang, Liying Joseph, Vijai Berger, Andreas Singer, Christian F. Rappaport, Christine Kaulich, Daphne Geschwantler Pfeiler, Georg Tea, Muy-Kheng M. Phelan, Catherine M. Greene, Mark H. Mai, Phuong L. Rennert, Gad Mulligan, Anna Marie Glendon, Gord Tchatchou, Sandrine Andrulis, Irene L. Toland, Amanda Ewart Bojesen, Anders Pedersen, Inge Sokilde Thomassen, Mads Jensen, Uffe Birk Laitman, Yael Rantala, Johanna von Wachenfeldt, Anna Ehrencrona, Hans Askmalm, Marie Stenmark Borg, Åke Kuchenbaecker, Karoline B. McGuffog, Lesley Barrowdale, Daniel Healey, Sue Lee, Andrew Pharoah, Paul D.P. Chenevix-Trench, Georgia Antoniou, Antonis C. Friedman, Eitan Cancer Epidemiology, Biomarkers & Prevention Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers Oncology Epidemiology |
author_sort |
peterlongo, paolo |
spelling |
Peterlongo, Paolo Chang-Claude, Jenny Moysich, Kirsten B. Rudolph, Anja Schmutzler, Rita K. Simard, Jacques Soucy, Penny Eeles, Rosalind A. Easton, Douglas F. Hamann, Ute Wilkening, Stefan Chen, Bowang Rookus, Matti A. Schmidt, Marjanka K. van der Baan, Frederieke H. Spurdle, Amanda B. Walker, Logan C. Lose, Felicity Maia, Ana-Teresa Montagna, Marco Matricardi, Laura Lubinski, Jan Jakubowska, Anna Gómez Garcia, Encarna B. Olopade, Olufunmilayo I. Nussbaum, Robert L. Nathanson, Katherine L. Domchek, Susan M. Rebbeck, Timothy R. Arun, Banu K. Karlan, Beth Y. Orsulic, Sandra Lester, Jenny Chung, Wendy K. Miron, Alex Southey, Melissa C. Goldgar, David E. Buys, Saundra S. Janavicius, Ramunas Dorfling, Cecilia M. van Rensburg, Elizabeth J. Ding, Yuan Chun Neuhausen, Susan L. Hansen, Thomas V.O. Gerdes, Anne-Marie Ejlertsen, Bent Jønson, Lars Osorio, Ana Martínez-Bouzas, Cristina Benitez, Javier Conway, Edye E. Blazer, Kathleen R. Weitzel, Jeffrey N. Manoukian, Siranoush Peissel, Bernard Zaffaroni, Daniela Scuvera, Giulietta Barile, Monica Ficarazzi, Filomena Mariette, Frederique Fortuzzi, Stefano Viel, Alessandra Giannini, Giuseppe Papi, Laura Martayan, Aline Tibiletti, Maria Grazia Radice, Paolo Vratimos, Athanassios Fostira, Florentia Garber, Judy E. Donaldson, Alan Brewer, Carole Foo, Claire Evans, D. Gareth R. Frost, Debra Eccles, Diana Brady, Angela Cook, Jackie Tischkowitz, Marc Adlard, Julian Barwell, Julian Walker, Lisa Izatt, Louise Side, Lucy E. Kennedy, M. John Rogers, Mark T. Porteous, Mary E. Morrison, Patrick J. Platte, Radka Davidson, Rosemarie Hodgson, Shirley V. Ellis, Steve Cole, Trevor Godwin, Andrew K. Claes, Kathleen Van Maerken, Tom Meindl, Alfons Gehrig, Andrea Sutter, Christian Engel, Christoph Niederacher, Dieter Steinemann, Doris Plendl, Hansjoerg Kast, Karin Rhiem, Kerstin Ditsch, Nina Arnold, Norbert Varon-Mateeva, Raymonda Wappenschmidt, Barbara Wang-Gohrke, Shan Bressac-de Paillerets, Brigitte Buecher, Bruno Delnatte, Capucine Houdayer, Claude Stoppa-Lyonnet, Dominique Damiola, Francesca Coupier, Isabelle Barjhoux, Laure Venat-Bouvet, Laurence Golmard, Lisa Boutry-Kryza, Nadia Sinilnikova, Olga M. Caron, Olivier Pujol, Pascal Mazoyer, Sylvie Belotti, Muriel Piedmonte, Marion Friedlander, Michael L. Rodriguez, Gustavo C. Copeland, Larry J. de la Hoya, Miguel Segura, Pedro Perez Nevanlinna, Heli Aittomäki, Kristiina van Os, Theo A.M. Meijers-Heijboer, Hanne E.J. van der Hout, Annemarie H. Vreeswijk, Maaike P.G. Hoogerbrugge, Nicoline Ausems, Margreet G.E.M. van Doorn, Helena C. Collée, J. Margriet Olah, Edith Diez, Orland Blanco, Ignacio Lazaro, Conxi Brunet, Joan Feliubadalo, Lidia Cybulski, Cezary Gronwald, Jacek Durda, Katarzyna Jaworska-Bieniek, Katarzyna Sukiennicki, Grzegorz Arason, Adalgeir Chiquette, Jocelyne Teixeira, Manuel R. Olswold, Curtis Couch, Fergus J. Lindor, Noralane M. Wang, Xianshu Szabo, Csilla I. Offit, Kenneth Corines, Marina Jacobs, Lauren Robson, Mark E. Zhang, Liying Joseph, Vijai Berger, Andreas Singer, Christian F. Rappaport, Christine Kaulich, Daphne Geschwantler Pfeiler, Georg Tea, Muy-Kheng M. Phelan, Catherine M. Greene, Mark H. Mai, Phuong L. Rennert, Gad Mulligan, Anna Marie Glendon, Gord Tchatchou, Sandrine Andrulis, Irene L. Toland, Amanda Ewart Bojesen, Anders Pedersen, Inge Sokilde Thomassen, Mads Jensen, Uffe Birk Laitman, Yael Rantala, Johanna von Wachenfeldt, Anna Ehrencrona, Hans Askmalm, Marie Stenmark Borg, Åke Kuchenbaecker, Karoline B. McGuffog, Lesley Barrowdale, Daniel Healey, Sue Lee, Andrew Pharoah, Paul D.P. Chenevix-Trench, Georgia Antoniou, Antonis C. Friedman, Eitan 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-14-0532 <jats:title>Abstract</jats:title> <jats:p>Background:BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and nongenetic modifying factors. In this study, we evaluated the putative role of variants in many candidate modifier genes.</jats:p> <jats:p>Methods: Genotyping data from 15,252 BRCA1 and 8,211 BRCA2 mutation carriers, for known variants (n = 3,248) located within or around 445 candidate genes, were available through the iCOGS custom-designed array. Breast and ovarian cancer association analysis was performed within a retrospective cohort approach.</jats:p> <jats:p>Results: The observed P values of association ranged between 0.005 and 1.000. None of the variants was significantly associated with breast or ovarian cancer risk in either BRCA1 or BRCA2 mutation carriers, after multiple testing adjustments.</jats:p> <jats:p>Conclusion: There is little evidence that any of the evaluated candidate variants act as modifiers of breast and/or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers.</jats:p> <jats:p>Impact: Genome-wide association studies have been more successful at identifying genetic modifiers of BRCA1/2 penetrance than candidate gene studies. Cancer Epidemiol Biomarkers Prev; 24(1); 308–16. ©2014 AACR.</jats:p> Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in <i>BRCA1</i> and <i>BRCA2</i> Mutation Carriers Cancer Epidemiology, Biomarkers & Prevention |
doi_str_mv |
10.1158/1055-9965.epi-14-0532 |
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Online Free |
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Medizin |
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ElectronicArticle |
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ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1OC8xMDU1LTk5NjUuZXBpLTE0LTA1MzI |
institution |
DE-D275 DE-Bn3 DE-Brt1 DE-D161 DE-Zwi2 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 |
imprint |
American Association for Cancer Research (AACR), 2015 |
imprint_str_mv |
American Association for Cancer Research (AACR), 2015 |
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1055-9965 1538-7755 |
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1055-9965 1538-7755 |
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English |
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American Association for Cancer Research (AACR) (CrossRef) |
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peterlongo2015candidategeneticmodifiersforbreastandovariancancerriskinbrca1andbrca2mutationcarriers |
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2015 |
publisher |
American Association for Cancer Research (AACR) |
recordtype |
ai |
record_format |
ai |
series |
Cancer Epidemiology, Biomarkers & Prevention |
source_id |
49 |
title |
Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers |
title_unstemmed |
Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers |
title_full |
Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers |
title_fullStr |
Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers |
title_full_unstemmed |
Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers |
title_short |
Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers |
title_sort |
candidate genetic modifiers for breast and ovarian cancer risk in <i>brca1</i> and <i>brca2</i> mutation carriers |
topic |
Oncology Epidemiology |
url |
http://dx.doi.org/10.1158/1055-9965.epi-14-0532 |
publishDate |
2015 |
physical |
308-316 |
description |
<jats:title>Abstract</jats:title>
<jats:p>Background:BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and nongenetic modifying factors. In this study, we evaluated the putative role of variants in many candidate modifier genes.</jats:p>
<jats:p>Methods: Genotyping data from 15,252 BRCA1 and 8,211 BRCA2 mutation carriers, for known variants (n = 3,248) located within or around 445 candidate genes, were available through the iCOGS custom-designed array. Breast and ovarian cancer association analysis was performed within a retrospective cohort approach.</jats:p>
<jats:p>Results: The observed P values of association ranged between 0.005 and 1.000. None of the variants was significantly associated with breast or ovarian cancer risk in either BRCA1 or BRCA2 mutation carriers, after multiple testing adjustments.</jats:p>
<jats:p>Conclusion: There is little evidence that any of the evaluated candidate variants act as modifiers of breast and/or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers.</jats:p>
<jats:p>Impact: Genome-wide association studies have been more successful at identifying genetic modifiers of BRCA1/2 penetrance than candidate gene studies. Cancer Epidemiol Biomarkers Prev; 24(1); 308–16. ©2014 AACR.</jats:p> |
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author | Peterlongo, Paolo, Chang-Claude, Jenny, Moysich, Kirsten B., Rudolph, Anja, Schmutzler, Rita K., Simard, Jacques, Soucy, Penny, Eeles, Rosalind A., Easton, Douglas F., Hamann, Ute, Wilkening, Stefan, Chen, Bowang, Rookus, Matti A., Schmidt, Marjanka K., van der Baan, Frederieke H., Spurdle, Amanda B., Walker, Logan C., Lose, Felicity, Maia, Ana-Teresa, Montagna, Marco, Matricardi, Laura, Lubinski, Jan, Jakubowska, Anna, Gómez Garcia, Encarna B., Olopade, Olufunmilayo I., Nussbaum, Robert L., Nathanson, Katherine L., Domchek, Susan M., Rebbeck, Timothy R., Arun, Banu K., Karlan, Beth Y., Orsulic, Sandra, Lester, Jenny, Chung, Wendy K., Miron, Alex, Southey, Melissa C., Goldgar, David E., Buys, Saundra S., Janavicius, Ramunas, Dorfling, Cecilia M., van Rensburg, Elizabeth J., Ding, Yuan Chun, Neuhausen, Susan L., Hansen, Thomas V.O., Gerdes, Anne-Marie, Ejlertsen, Bent, Jønson, Lars, Osorio, Ana, Martínez-Bouzas, Cristina, Benitez, Javier, Conway, Edye E., Blazer, Kathleen R., Weitzel, Jeffrey N., Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Scuvera, Giulietta, Barile, Monica, Ficarazzi, Filomena, Mariette, Frederique, Fortuzzi, Stefano, Viel, Alessandra, Giannini, Giuseppe, Papi, Laura, Martayan, Aline, Tibiletti, Maria Grazia, Radice, Paolo, Vratimos, Athanassios, Fostira, Florentia, Garber, Judy E., Donaldson, Alan, Brewer, Carole, Foo, Claire, Evans, D. Gareth R., Frost, Debra, Eccles, Diana, Brady, Angela, Cook, Jackie, Tischkowitz, Marc, Adlard, Julian, Barwell, Julian, Walker, Lisa, Izatt, Louise, Side, Lucy E., Kennedy, M. John, Rogers, Mark T., Porteous, Mary E., Morrison, Patrick J., Platte, Radka, Davidson, Rosemarie, Hodgson, Shirley V., Ellis, Steve, Cole, Trevor, Godwin, Andrew K., Claes, Kathleen, Van Maerken, Tom, Meindl, Alfons, Gehrig, Andrea, Sutter, Christian, Engel, Christoph, Niederacher, Dieter, Steinemann, Doris, Plendl, Hansjoerg, Kast, Karin, Rhiem, Kerstin, Ditsch, Nina, Arnold, Norbert, Varon-Mateeva, Raymonda, Wappenschmidt, Barbara, Wang-Gohrke, Shan, Bressac-de Paillerets, Brigitte, Buecher, Bruno, Delnatte, Capucine, Houdayer, Claude, Stoppa-Lyonnet, Dominique, Damiola, Francesca, Coupier, Isabelle, Barjhoux, Laure, Venat-Bouvet, Laurence, Golmard, Lisa, Boutry-Kryza, Nadia, Sinilnikova, Olga M., Caron, Olivier, Pujol, Pascal, Mazoyer, Sylvie, Belotti, Muriel, Piedmonte, Marion, Friedlander, Michael L., Rodriguez, Gustavo C., Copeland, Larry J., de la Hoya, Miguel, Segura, Pedro Perez, Nevanlinna, Heli, Aittomäki, Kristiina, van Os, Theo A.M., Meijers-Heijboer, Hanne E.J., van der Hout, Annemarie H., Vreeswijk, Maaike P.G., Hoogerbrugge, Nicoline, Ausems, Margreet G.E.M., van Doorn, Helena C., Collée, J. Margriet, Olah, Edith, Diez, Orland, Blanco, Ignacio, Lazaro, Conxi, Brunet, Joan, Feliubadalo, Lidia, Cybulski, Cezary, Gronwald, Jacek, Durda, Katarzyna, Jaworska-Bieniek, Katarzyna, Sukiennicki, Grzegorz, Arason, Adalgeir, Chiquette, Jocelyne, Teixeira, Manuel R., Olswold, Curtis, Couch, Fergus J., Lindor, Noralane M., Wang, Xianshu, Szabo, Csilla I., Offit, Kenneth, Corines, Marina, Jacobs, Lauren, Robson, Mark E., Zhang, Liying, Joseph, Vijai, Berger, Andreas, Singer, Christian F., Rappaport, Christine, Kaulich, Daphne Geschwantler, Pfeiler, Georg, Tea, Muy-Kheng M., Phelan, Catherine M., Greene, Mark H., Mai, Phuong L., Rennert, Gad, Mulligan, Anna Marie, Glendon, Gord, Tchatchou, Sandrine, Andrulis, Irene L., Toland, Amanda Ewart, Bojesen, Anders, Pedersen, Inge Sokilde, Thomassen, Mads, Jensen, Uffe Birk, Laitman, Yael, Rantala, Johanna, von Wachenfeldt, Anna, Ehrencrona, Hans, Askmalm, Marie Stenmark, Borg, Åke, Kuchenbaecker, Karoline B., McGuffog, Lesley, Barrowdale, Daniel, Healey, Sue, Lee, Andrew, Pharoah, Paul D.P., Chenevix-Trench, Georgia, Antoniou, Antonis C., Friedman, Eitan |
author_facet | Peterlongo, Paolo, Chang-Claude, Jenny, Moysich, Kirsten B., Rudolph, Anja, Schmutzler, Rita K., Simard, Jacques, Soucy, Penny, Eeles, Rosalind A., Easton, Douglas F., Hamann, Ute, Wilkening, Stefan, Chen, Bowang, Rookus, Matti A., Schmidt, Marjanka K., van der Baan, Frederieke H., Spurdle, Amanda B., Walker, Logan C., Lose, Felicity, Maia, Ana-Teresa, Montagna, Marco, Matricardi, Laura, Lubinski, Jan, Jakubowska, Anna, Gómez Garcia, Encarna B., Olopade, Olufunmilayo I., Nussbaum, Robert L., Nathanson, Katherine L., Domchek, Susan M., Rebbeck, Timothy R., Arun, Banu K., Karlan, Beth Y., Orsulic, Sandra, Lester, Jenny, Chung, Wendy K., Miron, Alex, Southey, Melissa C., Goldgar, David E., Buys, Saundra S., Janavicius, Ramunas, Dorfling, Cecilia M., van Rensburg, Elizabeth J., Ding, Yuan Chun, Neuhausen, Susan L., Hansen, Thomas V.O., Gerdes, Anne-Marie, Ejlertsen, Bent, Jønson, Lars, Osorio, Ana, Martínez-Bouzas, Cristina, Benitez, Javier, Conway, Edye E., Blazer, Kathleen R., Weitzel, Jeffrey N., Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Scuvera, Giulietta, Barile, Monica, Ficarazzi, Filomena, Mariette, Frederique, Fortuzzi, Stefano, Viel, Alessandra, Giannini, Giuseppe, Papi, Laura, Martayan, Aline, Tibiletti, Maria Grazia, Radice, Paolo, Vratimos, Athanassios, Fostira, Florentia, Garber, Judy E., Donaldson, Alan, Brewer, Carole, Foo, Claire, Evans, D. Gareth R., Frost, Debra, Eccles, Diana, Brady, Angela, Cook, Jackie, Tischkowitz, Marc, Adlard, Julian, Barwell, Julian, Walker, Lisa, Izatt, Louise, Side, Lucy E., Kennedy, M. John, Rogers, Mark T., Porteous, Mary E., Morrison, Patrick J., Platte, Radka, Davidson, Rosemarie, Hodgson, Shirley V., Ellis, Steve, Cole, Trevor, Godwin, Andrew K., Claes, Kathleen, Van Maerken, Tom, Meindl, Alfons, Gehrig, Andrea, Sutter, Christian, Engel, Christoph, Niederacher, Dieter, Steinemann, Doris, Plendl, Hansjoerg, Kast, Karin, Rhiem, Kerstin, Ditsch, Nina, Arnold, Norbert, Varon-Mateeva, Raymonda, Wappenschmidt, Barbara, Wang-Gohrke, Shan, Bressac-de Paillerets, Brigitte, Buecher, Bruno, Delnatte, Capucine, Houdayer, Claude, Stoppa-Lyonnet, Dominique, Damiola, Francesca, Coupier, Isabelle, Barjhoux, Laure, Venat-Bouvet, Laurence, Golmard, Lisa, Boutry-Kryza, Nadia, Sinilnikova, Olga M., Caron, Olivier, Pujol, Pascal, Mazoyer, Sylvie, Belotti, Muriel, Piedmonte, Marion, Friedlander, Michael L., Rodriguez, Gustavo C., Copeland, Larry J., de la Hoya, Miguel, Segura, Pedro Perez, Nevanlinna, Heli, Aittomäki, Kristiina, van Os, Theo A.M., Meijers-Heijboer, Hanne E.J., van der Hout, Annemarie H., Vreeswijk, Maaike P.G., Hoogerbrugge, Nicoline, Ausems, Margreet G.E.M., van Doorn, Helena C., Collée, J. Margriet, Olah, Edith, Diez, Orland, Blanco, Ignacio, Lazaro, Conxi, Brunet, Joan, Feliubadalo, Lidia, Cybulski, Cezary, Gronwald, Jacek, Durda, Katarzyna, Jaworska-Bieniek, Katarzyna, Sukiennicki, Grzegorz, Arason, Adalgeir, Chiquette, Jocelyne, Teixeira, Manuel R., Olswold, Curtis, Couch, Fergus J., Lindor, Noralane M., Wang, Xianshu, Szabo, Csilla I., Offit, Kenneth, Corines, Marina, Jacobs, Lauren, Robson, Mark E., Zhang, Liying, Joseph, Vijai, Berger, Andreas, Singer, Christian F., Rappaport, Christine, Kaulich, Daphne Geschwantler, Pfeiler, Georg, Tea, Muy-Kheng M., Phelan, Catherine M., Greene, Mark H., Mai, Phuong L., Rennert, Gad, Mulligan, Anna Marie, Glendon, Gord, Tchatchou, Sandrine, Andrulis, Irene L., Toland, Amanda Ewart, Bojesen, Anders, Pedersen, Inge Sokilde, Thomassen, Mads, Jensen, Uffe Birk, Laitman, Yael, Rantala, Johanna, von Wachenfeldt, Anna, Ehrencrona, Hans, Askmalm, Marie Stenmark, Borg, Åke, Kuchenbaecker, Karoline B., McGuffog, Lesley, Barrowdale, Daniel, Healey, Sue, Lee, Andrew, Pharoah, Paul D.P., Chenevix-Trench, Georgia, Antoniou, Antonis C., Friedman, Eitan, Peterlongo, Paolo, Chang-Claude, Jenny, Moysich, Kirsten B., Rudolph, Anja, Schmutzler, Rita K., Simard, Jacques, Soucy, Penny, Eeles, Rosalind A., Easton, Douglas F., Hamann, Ute, Wilkening, Stefan, Chen, Bowang, Rookus, Matti A., Schmidt, Marjanka K., van der Baan, Frederieke H., Spurdle, Amanda B., Walker, Logan C., Lose, Felicity, Maia, Ana-Teresa, Montagna, Marco, Matricardi, Laura, Lubinski, Jan, Jakubowska, Anna, Gómez Garcia, Encarna B., Olopade, Olufunmilayo I., Nussbaum, Robert L., Nathanson, Katherine L., Domchek, Susan M., Rebbeck, Timothy R., Arun, Banu K., Karlan, Beth Y., Orsulic, Sandra, Lester, Jenny, Chung, Wendy K., Miron, Alex, Southey, Melissa C., Goldgar, David E., Buys, Saundra S., Janavicius, Ramunas, Dorfling, Cecilia M., van Rensburg, Elizabeth J., Ding, Yuan Chun, Neuhausen, Susan L., Hansen, Thomas V.O., Gerdes, Anne-Marie, Ejlertsen, Bent, Jønson, Lars, Osorio, Ana, Martínez-Bouzas, Cristina, Benitez, Javier, Conway, Edye E., Blazer, Kathleen R., Weitzel, Jeffrey N., Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Scuvera, Giulietta, Barile, Monica, Ficarazzi, Filomena, Mariette, Frederique, Fortuzzi, Stefano, Viel, Alessandra, Giannini, Giuseppe, Papi, Laura, Martayan, Aline, Tibiletti, Maria Grazia, Radice, Paolo, Vratimos, Athanassios, Fostira, Florentia, Garber, Judy E., Donaldson, Alan, Brewer, Carole, Foo, Claire, Evans, D. Gareth R., Frost, Debra, Eccles, Diana, Brady, Angela, Cook, Jackie, Tischkowitz, Marc, Adlard, Julian, Barwell, Julian, Walker, Lisa, Izatt, Louise, Side, Lucy E., Kennedy, M. John, Rogers, Mark T., Porteous, Mary E., Morrison, Patrick J., Platte, Radka, Davidson, Rosemarie, Hodgson, Shirley V., Ellis, Steve, Cole, Trevor, Godwin, Andrew K., Claes, Kathleen, Van Maerken, Tom, Meindl, Alfons, Gehrig, Andrea, Sutter, Christian, Engel, Christoph, Niederacher, Dieter, Steinemann, Doris, Plendl, Hansjoerg, Kast, Karin, Rhiem, Kerstin, Ditsch, Nina, Arnold, Norbert, Varon-Mateeva, Raymonda, Wappenschmidt, Barbara, Wang-Gohrke, Shan, Bressac-de Paillerets, Brigitte, Buecher, Bruno, Delnatte, Capucine, Houdayer, Claude, Stoppa-Lyonnet, Dominique, Damiola, Francesca, Coupier, Isabelle, Barjhoux, Laure, Venat-Bouvet, Laurence, Golmard, Lisa, Boutry-Kryza, Nadia, Sinilnikova, Olga M., Caron, Olivier, Pujol, Pascal, Mazoyer, Sylvie, Belotti, Muriel, Piedmonte, Marion, Friedlander, Michael L., Rodriguez, Gustavo C., Copeland, Larry J., de la Hoya, Miguel, Segura, Pedro Perez, Nevanlinna, Heli, Aittomäki, Kristiina, van Os, Theo A.M., Meijers-Heijboer, Hanne E.J., van der Hout, Annemarie H., Vreeswijk, Maaike P.G., Hoogerbrugge, Nicoline, Ausems, Margreet G.E.M., van Doorn, Helena C., Collée, J. Margriet, Olah, Edith, Diez, Orland, Blanco, Ignacio, Lazaro, Conxi, Brunet, Joan, Feliubadalo, Lidia, Cybulski, Cezary, Gronwald, Jacek, Durda, Katarzyna, Jaworska-Bieniek, Katarzyna, Sukiennicki, Grzegorz, Arason, Adalgeir, Chiquette, Jocelyne, Teixeira, Manuel R., Olswold, Curtis, Couch, Fergus J., Lindor, Noralane M., Wang, Xianshu, Szabo, Csilla I., Offit, Kenneth, Corines, Marina, Jacobs, Lauren, Robson, Mark E., Zhang, Liying, Joseph, Vijai, Berger, Andreas, Singer, Christian F., Rappaport, Christine, Kaulich, Daphne Geschwantler, Pfeiler, Georg, Tea, Muy-Kheng M., Phelan, Catherine M., Greene, Mark H., Mai, Phuong L., Rennert, Gad, Mulligan, Anna Marie, Glendon, Gord, Tchatchou, Sandrine, Andrulis, Irene L., Toland, Amanda Ewart, Bojesen, Anders, Pedersen, Inge Sokilde, Thomassen, Mads, Jensen, Uffe Birk, Laitman, Yael, Rantala, Johanna, von Wachenfeldt, Anna, Ehrencrona, Hans, Askmalm, Marie Stenmark, Borg, Åke, Kuchenbaecker, Karoline B., McGuffog, Lesley, Barrowdale, Daniel, Healey, Sue, Lee, Andrew, Pharoah, Paul D.P., Chenevix-Trench, Georgia, Antoniou, Antonis C., Friedman, Eitan |
author_sort | peterlongo, paolo |
container_issue | 1 |
container_start_page | 308 |
container_title | Cancer Epidemiology, Biomarkers & Prevention |
container_volume | 24 |
description | <jats:title>Abstract</jats:title> <jats:p>Background:BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and nongenetic modifying factors. In this study, we evaluated the putative role of variants in many candidate modifier genes.</jats:p> <jats:p>Methods: Genotyping data from 15,252 BRCA1 and 8,211 BRCA2 mutation carriers, for known variants (n = 3,248) located within or around 445 candidate genes, were available through the iCOGS custom-designed array. Breast and ovarian cancer association analysis was performed within a retrospective cohort approach.</jats:p> <jats:p>Results: The observed P values of association ranged between 0.005 and 1.000. None of the variants was significantly associated with breast or ovarian cancer risk in either BRCA1 or BRCA2 mutation carriers, after multiple testing adjustments.</jats:p> <jats:p>Conclusion: There is little evidence that any of the evaluated candidate variants act as modifiers of breast and/or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers.</jats:p> <jats:p>Impact: Genome-wide association studies have been more successful at identifying genetic modifiers of BRCA1/2 penetrance than candidate gene studies. Cancer Epidemiol Biomarkers Prev; 24(1); 308–16. ©2014 AACR.</jats:p> |
doi_str_mv | 10.1158/1055-9965.epi-14-0532 |
facet_avail | Online, Free |
finc_class_facet | Medizin |
format | ElectronicArticle |
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format_dech1 | Article, E-Article |
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format_dezwi2 | Article, E-Article |
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geogr_code | not assigned |
geogr_code_person | not assigned |
id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1OC8xMDU1LTk5NjUuZXBpLTE0LTA1MzI |
imprint | American Association for Cancer Research (AACR), 2015 |
imprint_str_mv | American Association for Cancer Research (AACR), 2015 |
institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
issn | 1055-9965, 1538-7755 |
issn_str_mv | 1055-9965, 1538-7755 |
language | English |
last_indexed | 2024-03-01T18:02:48.537Z |
match_str | peterlongo2015candidategeneticmodifiersforbreastandovariancancerriskinbrca1andbrca2mutationcarriers |
mega_collection | American Association for Cancer Research (AACR) (CrossRef) |
physical | 308-316 |
publishDate | 2015 |
publishDateSort | 2015 |
publisher | American Association for Cancer Research (AACR) |
record_format | ai |
recordtype | ai |
series | Cancer Epidemiology, Biomarkers & Prevention |
source_id | 49 |
spelling | Peterlongo, Paolo Chang-Claude, Jenny Moysich, Kirsten B. Rudolph, Anja Schmutzler, Rita K. Simard, Jacques Soucy, Penny Eeles, Rosalind A. Easton, Douglas F. Hamann, Ute Wilkening, Stefan Chen, Bowang Rookus, Matti A. Schmidt, Marjanka K. van der Baan, Frederieke H. Spurdle, Amanda B. Walker, Logan C. Lose, Felicity Maia, Ana-Teresa Montagna, Marco Matricardi, Laura Lubinski, Jan Jakubowska, Anna Gómez Garcia, Encarna B. Olopade, Olufunmilayo I. Nussbaum, Robert L. Nathanson, Katherine L. Domchek, Susan M. Rebbeck, Timothy R. Arun, Banu K. Karlan, Beth Y. Orsulic, Sandra Lester, Jenny Chung, Wendy K. Miron, Alex Southey, Melissa C. Goldgar, David E. Buys, Saundra S. Janavicius, Ramunas Dorfling, Cecilia M. van Rensburg, Elizabeth J. Ding, Yuan Chun Neuhausen, Susan L. Hansen, Thomas V.O. Gerdes, Anne-Marie Ejlertsen, Bent Jønson, Lars Osorio, Ana Martínez-Bouzas, Cristina Benitez, Javier Conway, Edye E. Blazer, Kathleen R. Weitzel, Jeffrey N. Manoukian, Siranoush Peissel, Bernard Zaffaroni, Daniela Scuvera, Giulietta Barile, Monica Ficarazzi, Filomena Mariette, Frederique Fortuzzi, Stefano Viel, Alessandra Giannini, Giuseppe Papi, Laura Martayan, Aline Tibiletti, Maria Grazia Radice, Paolo Vratimos, Athanassios Fostira, Florentia Garber, Judy E. Donaldson, Alan Brewer, Carole Foo, Claire Evans, D. Gareth R. Frost, Debra Eccles, Diana Brady, Angela Cook, Jackie Tischkowitz, Marc Adlard, Julian Barwell, Julian Walker, Lisa Izatt, Louise Side, Lucy E. Kennedy, M. John Rogers, Mark T. Porteous, Mary E. Morrison, Patrick J. Platte, Radka Davidson, Rosemarie Hodgson, Shirley V. Ellis, Steve Cole, Trevor Godwin, Andrew K. Claes, Kathleen Van Maerken, Tom Meindl, Alfons Gehrig, Andrea Sutter, Christian Engel, Christoph Niederacher, Dieter Steinemann, Doris Plendl, Hansjoerg Kast, Karin Rhiem, Kerstin Ditsch, Nina Arnold, Norbert Varon-Mateeva, Raymonda Wappenschmidt, Barbara Wang-Gohrke, Shan Bressac-de Paillerets, Brigitte Buecher, Bruno Delnatte, Capucine Houdayer, Claude Stoppa-Lyonnet, Dominique Damiola, Francesca Coupier, Isabelle Barjhoux, Laure Venat-Bouvet, Laurence Golmard, Lisa Boutry-Kryza, Nadia Sinilnikova, Olga M. Caron, Olivier Pujol, Pascal Mazoyer, Sylvie Belotti, Muriel Piedmonte, Marion Friedlander, Michael L. Rodriguez, Gustavo C. Copeland, Larry J. de la Hoya, Miguel Segura, Pedro Perez Nevanlinna, Heli Aittomäki, Kristiina van Os, Theo A.M. Meijers-Heijboer, Hanne E.J. van der Hout, Annemarie H. Vreeswijk, Maaike P.G. Hoogerbrugge, Nicoline Ausems, Margreet G.E.M. van Doorn, Helena C. Collée, J. Margriet Olah, Edith Diez, Orland Blanco, Ignacio Lazaro, Conxi Brunet, Joan Feliubadalo, Lidia Cybulski, Cezary Gronwald, Jacek Durda, Katarzyna Jaworska-Bieniek, Katarzyna Sukiennicki, Grzegorz Arason, Adalgeir Chiquette, Jocelyne Teixeira, Manuel R. Olswold, Curtis Couch, Fergus J. Lindor, Noralane M. Wang, Xianshu Szabo, Csilla I. Offit, Kenneth Corines, Marina Jacobs, Lauren Robson, Mark E. Zhang, Liying Joseph, Vijai Berger, Andreas Singer, Christian F. Rappaport, Christine Kaulich, Daphne Geschwantler Pfeiler, Georg Tea, Muy-Kheng M. Phelan, Catherine M. Greene, Mark H. Mai, Phuong L. Rennert, Gad Mulligan, Anna Marie Glendon, Gord Tchatchou, Sandrine Andrulis, Irene L. Toland, Amanda Ewart Bojesen, Anders Pedersen, Inge Sokilde Thomassen, Mads Jensen, Uffe Birk Laitman, Yael Rantala, Johanna von Wachenfeldt, Anna Ehrencrona, Hans Askmalm, Marie Stenmark Borg, Åke Kuchenbaecker, Karoline B. McGuffog, Lesley Barrowdale, Daniel Healey, Sue Lee, Andrew Pharoah, Paul D.P. Chenevix-Trench, Georgia Antoniou, Antonis C. Friedman, Eitan 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-14-0532 <jats:title>Abstract</jats:title> <jats:p>Background:BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and nongenetic modifying factors. In this study, we evaluated the putative role of variants in many candidate modifier genes.</jats:p> <jats:p>Methods: Genotyping data from 15,252 BRCA1 and 8,211 BRCA2 mutation carriers, for known variants (n = 3,248) located within or around 445 candidate genes, were available through the iCOGS custom-designed array. Breast and ovarian cancer association analysis was performed within a retrospective cohort approach.</jats:p> <jats:p>Results: The observed P values of association ranged between 0.005 and 1.000. None of the variants was significantly associated with breast or ovarian cancer risk in either BRCA1 or BRCA2 mutation carriers, after multiple testing adjustments.</jats:p> <jats:p>Conclusion: There is little evidence that any of the evaluated candidate variants act as modifiers of breast and/or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers.</jats:p> <jats:p>Impact: Genome-wide association studies have been more successful at identifying genetic modifiers of BRCA1/2 penetrance than candidate gene studies. Cancer Epidemiol Biomarkers Prev; 24(1); 308–16. ©2014 AACR.</jats:p> Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in <i>BRCA1</i> and <i>BRCA2</i> Mutation Carriers Cancer Epidemiology, Biomarkers & Prevention |
spellingShingle | Peterlongo, Paolo, Chang-Claude, Jenny, Moysich, Kirsten B., Rudolph, Anja, Schmutzler, Rita K., Simard, Jacques, Soucy, Penny, Eeles, Rosalind A., Easton, Douglas F., Hamann, Ute, Wilkening, Stefan, Chen, Bowang, Rookus, Matti A., Schmidt, Marjanka K., van der Baan, Frederieke H., Spurdle, Amanda B., Walker, Logan C., Lose, Felicity, Maia, Ana-Teresa, Montagna, Marco, Matricardi, Laura, Lubinski, Jan, Jakubowska, Anna, Gómez Garcia, Encarna B., Olopade, Olufunmilayo I., Nussbaum, Robert L., Nathanson, Katherine L., Domchek, Susan M., Rebbeck, Timothy R., Arun, Banu K., Karlan, Beth Y., Orsulic, Sandra, Lester, Jenny, Chung, Wendy K., Miron, Alex, Southey, Melissa C., Goldgar, David E., Buys, Saundra S., Janavicius, Ramunas, Dorfling, Cecilia M., van Rensburg, Elizabeth J., Ding, Yuan Chun, Neuhausen, Susan L., Hansen, Thomas V.O., Gerdes, Anne-Marie, Ejlertsen, Bent, Jønson, Lars, Osorio, Ana, Martínez-Bouzas, Cristina, Benitez, Javier, Conway, Edye E., Blazer, Kathleen R., Weitzel, Jeffrey N., Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Scuvera, Giulietta, Barile, Monica, Ficarazzi, Filomena, Mariette, Frederique, Fortuzzi, Stefano, Viel, Alessandra, Giannini, Giuseppe, Papi, Laura, Martayan, Aline, Tibiletti, Maria Grazia, Radice, Paolo, Vratimos, Athanassios, Fostira, Florentia, Garber, Judy E., Donaldson, Alan, Brewer, Carole, Foo, Claire, Evans, D. Gareth R., Frost, Debra, Eccles, Diana, Brady, Angela, Cook, Jackie, Tischkowitz, Marc, Adlard, Julian, Barwell, Julian, Walker, Lisa, Izatt, Louise, Side, Lucy E., Kennedy, M. John, Rogers, Mark T., Porteous, Mary E., Morrison, Patrick J., Platte, Radka, Davidson, Rosemarie, Hodgson, Shirley V., Ellis, Steve, Cole, Trevor, Godwin, Andrew K., Claes, Kathleen, Van Maerken, Tom, Meindl, Alfons, Gehrig, Andrea, Sutter, Christian, Engel, Christoph, Niederacher, Dieter, Steinemann, Doris, Plendl, Hansjoerg, Kast, Karin, Rhiem, Kerstin, Ditsch, Nina, Arnold, Norbert, Varon-Mateeva, Raymonda, Wappenschmidt, Barbara, Wang-Gohrke, Shan, Bressac-de Paillerets, Brigitte, Buecher, Bruno, Delnatte, Capucine, Houdayer, Claude, Stoppa-Lyonnet, Dominique, Damiola, Francesca, Coupier, Isabelle, Barjhoux, Laure, Venat-Bouvet, Laurence, Golmard, Lisa, Boutry-Kryza, Nadia, Sinilnikova, Olga M., Caron, Olivier, Pujol, Pascal, Mazoyer, Sylvie, Belotti, Muriel, Piedmonte, Marion, Friedlander, Michael L., Rodriguez, Gustavo C., Copeland, Larry J., de la Hoya, Miguel, Segura, Pedro Perez, Nevanlinna, Heli, Aittomäki, Kristiina, van Os, Theo A.M., Meijers-Heijboer, Hanne E.J., van der Hout, Annemarie H., Vreeswijk, Maaike P.G., Hoogerbrugge, Nicoline, Ausems, Margreet G.E.M., van Doorn, Helena C., Collée, J. Margriet, Olah, Edith, Diez, Orland, Blanco, Ignacio, Lazaro, Conxi, Brunet, Joan, Feliubadalo, Lidia, Cybulski, Cezary, Gronwald, Jacek, Durda, Katarzyna, Jaworska-Bieniek, Katarzyna, Sukiennicki, Grzegorz, Arason, Adalgeir, Chiquette, Jocelyne, Teixeira, Manuel R., Olswold, Curtis, Couch, Fergus J., Lindor, Noralane M., Wang, Xianshu, Szabo, Csilla I., Offit, Kenneth, Corines, Marina, Jacobs, Lauren, Robson, Mark E., Zhang, Liying, Joseph, Vijai, Berger, Andreas, Singer, Christian F., Rappaport, Christine, Kaulich, Daphne Geschwantler, Pfeiler, Georg, Tea, Muy-Kheng M., Phelan, Catherine M., Greene, Mark H., Mai, Phuong L., Rennert, Gad, Mulligan, Anna Marie, Glendon, Gord, Tchatchou, Sandrine, Andrulis, Irene L., Toland, Amanda Ewart, Bojesen, Anders, Pedersen, Inge Sokilde, Thomassen, Mads, Jensen, Uffe Birk, Laitman, Yael, Rantala, Johanna, von Wachenfeldt, Anna, Ehrencrona, Hans, Askmalm, Marie Stenmark, Borg, Åke, Kuchenbaecker, Karoline B., McGuffog, Lesley, Barrowdale, Daniel, Healey, Sue, Lee, Andrew, Pharoah, Paul D.P., Chenevix-Trench, Georgia, Antoniou, Antonis C., Friedman, Eitan, Cancer Epidemiology, Biomarkers & Prevention, Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers, Oncology, Epidemiology |
title | Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers |
title_full | Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers |
title_fullStr | Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers |
title_full_unstemmed | Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers |
title_short | Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers |
title_sort | candidate genetic modifiers for breast and ovarian cancer risk in <i>brca1</i> and <i>brca2</i> mutation carriers |
title_unstemmed | Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers |
topic | Oncology, Epidemiology |
url | http://dx.doi.org/10.1158/1055-9965.epi-14-0532 |