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Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

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Bibliographische Detailangaben
Zeitschriftentitel: Cancer Epidemiology, Biomarkers & Prevention
Personen und Körperschaften: Peterlongo, Paolo, Chang-Claude, Jenny, Moysich, Kirsten B., Rudolph, Anja, Schmutzler, Rita K., Simard, Jacques, Soucy, Penny, Eeles, Rosalind A., Easton, Douglas F., Hamann, Ute, Wilkening, Stefan, Chen, Bowang, Rookus, Matti A., Schmidt, Marjanka K., van der Baan, Frederieke H., Spurdle, Amanda B., Walker, Logan C., Lose, Felicity, Maia, Ana-Teresa, Montagna, Marco, Matricardi, Laura, Lubinski, Jan, Jakubowska, Anna, Gómez Garcia, Encarna B., Olopade, Olufunmilayo I., Nussbaum, Robert L., Nathanson, Katherine L., Domchek, Susan M., Rebbeck, Timothy R., Arun, Banu K., Karlan, Beth Y., Orsulic, Sandra, Lester, Jenny, Chung, Wendy K., Miron, Alex, Southey, Melissa C., Goldgar, David E., Buys, Saundra S., Janavicius, Ramunas, Dorfling, Cecilia M., van Rensburg, Elizabeth J., Ding, Yuan Chun, Neuhausen, Susan L., Hansen, Thomas V.O., Gerdes, Anne-Marie, Ejlertsen, Bent, Jønson, Lars, Osorio, Ana, Martínez-Bouzas, Cristina, Benitez, Javier, Conway, Edye E., Blazer, Kathleen R., Weitzel, Jeffrey N., Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Scuvera, Giulietta, Barile, Monica, Ficarazzi, Filomena, Mariette, Frederique, Fortuzzi, Stefano, Viel, Alessandra, Giannini, Giuseppe, Papi, Laura, Martayan, Aline, Tibiletti, Maria Grazia, Radice, Paolo, Vratimos, Athanassios, Fostira, Florentia, Garber, Judy E., Donaldson, Alan, Brewer, Carole, Foo, Claire, Evans, D. Gareth R., Frost, Debra, Eccles, Diana, Brady, Angela, Cook, Jackie, Tischkowitz, Marc, Adlard, Julian, Barwell, Julian, Walker, Lisa, Izatt, Louise, Side, Lucy E., Kennedy, M. John, Rogers, Mark T., Porteous, Mary E., Morrison, Patrick J., Platte, Radka, Davidson, Rosemarie, Hodgson, Shirley V., Ellis, Steve, Cole, Trevor, Godwin, Andrew K., Claes, Kathleen, Van Maerken, Tom, Meindl, Alfons, Gehrig, Andrea, Sutter, Christian, Engel, Christoph, Niederacher, Dieter, Steinemann, Doris, Plendl, Hansjoerg, Kast, Karin, Rhiem, Kerstin, Ditsch, Nina, Arnold, Norbert, Varon-Mateeva, Raymonda, Wappenschmidt, Barbara, Wang-Gohrke, Shan, Bressac-de Paillerets, Brigitte, Buecher, Bruno, Delnatte, Capucine, Houdayer, Claude, Stoppa-Lyonnet, Dominique, Damiola, Francesca, Coupier, Isabelle, Barjhoux, Laure, Venat-Bouvet, Laurence, Golmard, Lisa, Boutry-Kryza, Nadia, Sinilnikova, Olga M., Caron, Olivier, Pujol, Pascal, Mazoyer, Sylvie, Belotti, Muriel, Piedmonte, Marion, Friedlander, Michael L., Rodriguez, Gustavo C., Copeland, Larry J., de la Hoya, Miguel, Segura, Pedro Perez, Nevanlinna, Heli, Aittomäki, Kristiina, van Os, Theo A.M., Meijers-Heijboer, Hanne E.J., van der Hout, Annemarie H., Vreeswijk, Maaike P.G., Hoogerbrugge, Nicoline, Ausems, Margreet G.E.M., van Doorn, Helena C., Collée, J. Margriet, Olah, Edith, Diez, Orland, Blanco, Ignacio, Lazaro, Conxi, Brunet, Joan, Feliubadalo, Lidia, Cybulski, Cezary, Gronwald, Jacek, Durda, Katarzyna, Jaworska-Bieniek, Katarzyna, Sukiennicki, Grzegorz, Arason, Adalgeir, Chiquette, Jocelyne, Teixeira, Manuel R., Olswold, Curtis, Couch, Fergus J., Lindor, Noralane M., Wang, Xianshu, Szabo, Csilla I., Offit, Kenneth, Corines, Marina, Jacobs, Lauren, Robson, Mark E., Zhang, Liying, Joseph, Vijai, Berger, Andreas, Singer, Christian F., Rappaport, Christine, Kaulich, Daphne Geschwantler, Pfeiler, Georg, Tea, Muy-Kheng M., Phelan, Catherine M., Greene, Mark H., Mai, Phuong L., Rennert, Gad, Mulligan, Anna Marie, Glendon, Gord, Tchatchou, Sandrine, Andrulis, Irene L., Toland, Amanda Ewart, Bojesen, Anders, Pedersen, Inge Sokilde, Thomassen, Mads, Jensen, Uffe Birk, Laitman, Yael, Rantala, Johanna, von Wachenfeldt, Anna, Ehrencrona, Hans, Askmalm, Marie Stenmark, Borg, Åke, Kuchenbaecker, Karoline B., McGuffog, Lesley, Barrowdale, Daniel, Healey, Sue, Lee, Andrew, Pharoah, Paul D.P., Chenevix-Trench, Georgia, Antoniou, Antonis C., Friedman, Eitan
In: Cancer Epidemiology, Biomarkers & Prevention, 24, 2015, 1, S. 308-316
Format: E-Article
Sprache: Englisch
veröffentlicht:
American Association for Cancer Research (AACR)
Schlagwörter:
author_facet Peterlongo, Paolo
Chang-Claude, Jenny
Moysich, Kirsten B.
Rudolph, Anja
Schmutzler, Rita K.
Simard, Jacques
Soucy, Penny
Eeles, Rosalind A.
Easton, Douglas F.
Hamann, Ute
Wilkening, Stefan
Chen, Bowang
Rookus, Matti A.
Schmidt, Marjanka K.
van der Baan, Frederieke H.
Spurdle, Amanda B.
Walker, Logan C.
Lose, Felicity
Maia, Ana-Teresa
Montagna, Marco
Matricardi, Laura
Lubinski, Jan
Jakubowska, Anna
Gómez Garcia, Encarna B.
Olopade, Olufunmilayo I.
Nussbaum, Robert L.
Nathanson, Katherine L.
Domchek, Susan M.
Rebbeck, Timothy R.
Arun, Banu K.
Karlan, Beth Y.
Orsulic, Sandra
Lester, Jenny
Chung, Wendy K.
Miron, Alex
Southey, Melissa C.
Goldgar, David E.
Buys, Saundra S.
Janavicius, Ramunas
Dorfling, Cecilia M.
van Rensburg, Elizabeth J.
Ding, Yuan Chun
Neuhausen, Susan L.
Hansen, Thomas V.O.
Gerdes, Anne-Marie
Ejlertsen, Bent
Jønson, Lars
Osorio, Ana
Martínez-Bouzas, Cristina
Benitez, Javier
Conway, Edye E.
Blazer, Kathleen R.
Weitzel, Jeffrey N.
Manoukian, Siranoush
Peissel, Bernard
Zaffaroni, Daniela
Scuvera, Giulietta
Barile, Monica
Ficarazzi, Filomena
Mariette, Frederique
Fortuzzi, Stefano
Viel, Alessandra
Giannini, Giuseppe
Papi, Laura
Martayan, Aline
Tibiletti, Maria Grazia
Radice, Paolo
Vratimos, Athanassios
Fostira, Florentia
Garber, Judy E.
Donaldson, Alan
Brewer, Carole
Foo, Claire
Evans, D. Gareth R.
Frost, Debra
Eccles, Diana
Brady, Angela
Cook, Jackie
Tischkowitz, Marc
Adlard, Julian
Barwell, Julian
Walker, Lisa
Izatt, Louise
Side, Lucy E.
Kennedy, M. John
Rogers, Mark T.
Porteous, Mary E.
Morrison, Patrick J.
Platte, Radka
Davidson, Rosemarie
Hodgson, Shirley V.
Ellis, Steve
Cole, Trevor
Godwin, Andrew K.
Claes, Kathleen
Van Maerken, Tom
Meindl, Alfons
Gehrig, Andrea
Sutter, Christian
Engel, Christoph
Niederacher, Dieter
Steinemann, Doris
Plendl, Hansjoerg
Kast, Karin
Rhiem, Kerstin
Ditsch, Nina
Arnold, Norbert
Varon-Mateeva, Raymonda
Wappenschmidt, Barbara
Wang-Gohrke, Shan
Bressac-de Paillerets, Brigitte
Buecher, Bruno
Delnatte, Capucine
Houdayer, Claude
Stoppa-Lyonnet, Dominique
Damiola, Francesca
Coupier, Isabelle
Barjhoux, Laure
Venat-Bouvet, Laurence
Golmard, Lisa
Boutry-Kryza, Nadia
Sinilnikova, Olga M.
Caron, Olivier
Pujol, Pascal
Mazoyer, Sylvie
Belotti, Muriel
Piedmonte, Marion
Friedlander, Michael L.
Rodriguez, Gustavo C.
Copeland, Larry J.
de la Hoya, Miguel
Segura, Pedro Perez
Nevanlinna, Heli
Aittomäki, Kristiina
van Os, Theo A.M.
Meijers-Heijboer, Hanne E.J.
van der Hout, Annemarie H.
Vreeswijk, Maaike P.G.
Hoogerbrugge, Nicoline
Ausems, Margreet G.E.M.
van Doorn, Helena C.
Collée, J. Margriet
Olah, Edith
Diez, Orland
Blanco, Ignacio
Lazaro, Conxi
Brunet, Joan
Feliubadalo, Lidia
Cybulski, Cezary
Gronwald, Jacek
Durda, Katarzyna
Jaworska-Bieniek, Katarzyna
Sukiennicki, Grzegorz
Arason, Adalgeir
Chiquette, Jocelyne
Teixeira, Manuel R.
Olswold, Curtis
Couch, Fergus J.
Lindor, Noralane M.
Wang, Xianshu
Szabo, Csilla I.
Offit, Kenneth
Corines, Marina
Jacobs, Lauren
Robson, Mark E.
Zhang, Liying
Joseph, Vijai
Berger, Andreas
Singer, Christian F.
Rappaport, Christine
Kaulich, Daphne Geschwantler
Pfeiler, Georg
Tea, Muy-Kheng M.
Phelan, Catherine M.
Greene, Mark H.
Mai, Phuong L.
Rennert, Gad
Mulligan, Anna Marie
Glendon, Gord
Tchatchou, Sandrine
Andrulis, Irene L.
Toland, Amanda Ewart
Bojesen, Anders
Pedersen, Inge Sokilde
Thomassen, Mads
Jensen, Uffe Birk
Laitman, Yael
Rantala, Johanna
von Wachenfeldt, Anna
Ehrencrona, Hans
Askmalm, Marie Stenmark
Borg, Åke
Kuchenbaecker, Karoline B.
McGuffog, Lesley
Barrowdale, Daniel
Healey, Sue
Lee, Andrew
Pharoah, Paul D.P.
Chenevix-Trench, Georgia
Antoniou, Antonis C.
Friedman, Eitan
Peterlongo, Paolo
Chang-Claude, Jenny
Moysich, Kirsten B.
Rudolph, Anja
Schmutzler, Rita K.
Simard, Jacques
Soucy, Penny
Eeles, Rosalind A.
Easton, Douglas F.
Hamann, Ute
Wilkening, Stefan
Chen, Bowang
Rookus, Matti A.
Schmidt, Marjanka K.
van der Baan, Frederieke H.
Spurdle, Amanda B.
Walker, Logan C.
Lose, Felicity
Maia, Ana-Teresa
Montagna, Marco
Matricardi, Laura
Lubinski, Jan
Jakubowska, Anna
Gómez Garcia, Encarna B.
Olopade, Olufunmilayo I.
Nussbaum, Robert L.
Nathanson, Katherine L.
Domchek, Susan M.
Rebbeck, Timothy R.
Arun, Banu K.
Karlan, Beth Y.
Orsulic, Sandra
Lester, Jenny
Chung, Wendy K.
Miron, Alex
Southey, Melissa C.
Goldgar, David E.
Buys, Saundra S.
Janavicius, Ramunas
Dorfling, Cecilia M.
van Rensburg, Elizabeth J.
Ding, Yuan Chun
Neuhausen, Susan L.
Hansen, Thomas V.O.
Gerdes, Anne-Marie
Ejlertsen, Bent
Jønson, Lars
Osorio, Ana
Martínez-Bouzas, Cristina
Benitez, Javier
Conway, Edye E.
Blazer, Kathleen R.
Weitzel, Jeffrey N.
Manoukian, Siranoush
Peissel, Bernard
Zaffaroni, Daniela
Scuvera, Giulietta
Barile, Monica
Ficarazzi, Filomena
Mariette, Frederique
Fortuzzi, Stefano
Viel, Alessandra
Giannini, Giuseppe
Papi, Laura
Martayan, Aline
Tibiletti, Maria Grazia
Radice, Paolo
Vratimos, Athanassios
Fostira, Florentia
Garber, Judy E.
Donaldson, Alan
Brewer, Carole
Foo, Claire
Evans, D. Gareth R.
Frost, Debra
Eccles, Diana
Brady, Angela
Cook, Jackie
Tischkowitz, Marc
Adlard, Julian
Barwell, Julian
Walker, Lisa
Izatt, Louise
Side, Lucy E.
Kennedy, M. John
Rogers, Mark T.
Porteous, Mary E.
Morrison, Patrick J.
Platte, Radka
Davidson, Rosemarie
Hodgson, Shirley V.
Ellis, Steve
Cole, Trevor
Godwin, Andrew K.
Claes, Kathleen
Van Maerken, Tom
Meindl, Alfons
Gehrig, Andrea
Sutter, Christian
Engel, Christoph
Niederacher, Dieter
Steinemann, Doris
Plendl, Hansjoerg
Kast, Karin
Rhiem, Kerstin
Ditsch, Nina
Arnold, Norbert
Varon-Mateeva, Raymonda
Wappenschmidt, Barbara
Wang-Gohrke, Shan
Bressac-de Paillerets, Brigitte
Buecher, Bruno
Delnatte, Capucine
Houdayer, Claude
Stoppa-Lyonnet, Dominique
Damiola, Francesca
Coupier, Isabelle
Barjhoux, Laure
Venat-Bouvet, Laurence
Golmard, Lisa
Boutry-Kryza, Nadia
Sinilnikova, Olga M.
Caron, Olivier
Pujol, Pascal
Mazoyer, Sylvie
Belotti, Muriel
Piedmonte, Marion
Friedlander, Michael L.
Rodriguez, Gustavo C.
Copeland, Larry J.
de la Hoya, Miguel
Segura, Pedro Perez
Nevanlinna, Heli
Aittomäki, Kristiina
van Os, Theo A.M.
Meijers-Heijboer, Hanne E.J.
van der Hout, Annemarie H.
Vreeswijk, Maaike P.G.
Hoogerbrugge, Nicoline
Ausems, Margreet G.E.M.
van Doorn, Helena C.
Collée, J. Margriet
Olah, Edith
Diez, Orland
Blanco, Ignacio
Lazaro, Conxi
Brunet, Joan
Feliubadalo, Lidia
Cybulski, Cezary
Gronwald, Jacek
Durda, Katarzyna
Jaworska-Bieniek, Katarzyna
Sukiennicki, Grzegorz
Arason, Adalgeir
Chiquette, Jocelyne
Teixeira, Manuel R.
Olswold, Curtis
Couch, Fergus J.
Lindor, Noralane M.
Wang, Xianshu
Szabo, Csilla I.
Offit, Kenneth
Corines, Marina
Jacobs, Lauren
Robson, Mark E.
Zhang, Liying
Joseph, Vijai
Berger, Andreas
Singer, Christian F.
Rappaport, Christine
Kaulich, Daphne Geschwantler
Pfeiler, Georg
Tea, Muy-Kheng M.
Phelan, Catherine M.
Greene, Mark H.
Mai, Phuong L.
Rennert, Gad
Mulligan, Anna Marie
Glendon, Gord
Tchatchou, Sandrine
Andrulis, Irene L.
Toland, Amanda Ewart
Bojesen, Anders
Pedersen, Inge Sokilde
Thomassen, Mads
Jensen, Uffe Birk
Laitman, Yael
Rantala, Johanna
von Wachenfeldt, Anna
Ehrencrona, Hans
Askmalm, Marie Stenmark
Borg, Åke
Kuchenbaecker, Karoline B.
McGuffog, Lesley
Barrowdale, Daniel
Healey, Sue
Lee, Andrew
Pharoah, Paul D.P.
Chenevix-Trench, Georgia
Antoniou, Antonis C.
Friedman, Eitan
author Peterlongo, Paolo
Chang-Claude, Jenny
Moysich, Kirsten B.
Rudolph, Anja
Schmutzler, Rita K.
Simard, Jacques
Soucy, Penny
Eeles, Rosalind A.
Easton, Douglas F.
Hamann, Ute
Wilkening, Stefan
Chen, Bowang
Rookus, Matti A.
Schmidt, Marjanka K.
van der Baan, Frederieke H.
Spurdle, Amanda B.
Walker, Logan C.
Lose, Felicity
Maia, Ana-Teresa
Montagna, Marco
Matricardi, Laura
Lubinski, Jan
Jakubowska, Anna
Gómez Garcia, Encarna B.
Olopade, Olufunmilayo I.
Nussbaum, Robert L.
Nathanson, Katherine L.
Domchek, Susan M.
Rebbeck, Timothy R.
Arun, Banu K.
Karlan, Beth Y.
Orsulic, Sandra
Lester, Jenny
Chung, Wendy K.
Miron, Alex
Southey, Melissa C.
Goldgar, David E.
Buys, Saundra S.
Janavicius, Ramunas
Dorfling, Cecilia M.
van Rensburg, Elizabeth J.
Ding, Yuan Chun
Neuhausen, Susan L.
Hansen, Thomas V.O.
Gerdes, Anne-Marie
Ejlertsen, Bent
Jønson, Lars
Osorio, Ana
Martínez-Bouzas, Cristina
Benitez, Javier
Conway, Edye E.
Blazer, Kathleen R.
Weitzel, Jeffrey N.
Manoukian, Siranoush
Peissel, Bernard
Zaffaroni, Daniela
Scuvera, Giulietta
Barile, Monica
Ficarazzi, Filomena
Mariette, Frederique
Fortuzzi, Stefano
Viel, Alessandra
Giannini, Giuseppe
Papi, Laura
Martayan, Aline
Tibiletti, Maria Grazia
Radice, Paolo
Vratimos, Athanassios
Fostira, Florentia
Garber, Judy E.
Donaldson, Alan
Brewer, Carole
Foo, Claire
Evans, D. Gareth R.
Frost, Debra
Eccles, Diana
Brady, Angela
Cook, Jackie
Tischkowitz, Marc
Adlard, Julian
Barwell, Julian
Walker, Lisa
Izatt, Louise
Side, Lucy E.
Kennedy, M. John
Rogers, Mark T.
Porteous, Mary E.
Morrison, Patrick J.
Platte, Radka
Davidson, Rosemarie
Hodgson, Shirley V.
Ellis, Steve
Cole, Trevor
Godwin, Andrew K.
Claes, Kathleen
Van Maerken, Tom
Meindl, Alfons
Gehrig, Andrea
Sutter, Christian
Engel, Christoph
Niederacher, Dieter
Steinemann, Doris
Plendl, Hansjoerg
Kast, Karin
Rhiem, Kerstin
Ditsch, Nina
Arnold, Norbert
Varon-Mateeva, Raymonda
Wappenschmidt, Barbara
Wang-Gohrke, Shan
Bressac-de Paillerets, Brigitte
Buecher, Bruno
Delnatte, Capucine
Houdayer, Claude
Stoppa-Lyonnet, Dominique
Damiola, Francesca
Coupier, Isabelle
Barjhoux, Laure
Venat-Bouvet, Laurence
Golmard, Lisa
Boutry-Kryza, Nadia
Sinilnikova, Olga M.
Caron, Olivier
Pujol, Pascal
Mazoyer, Sylvie
Belotti, Muriel
Piedmonte, Marion
Friedlander, Michael L.
Rodriguez, Gustavo C.
Copeland, Larry J.
de la Hoya, Miguel
Segura, Pedro Perez
Nevanlinna, Heli
Aittomäki, Kristiina
van Os, Theo A.M.
Meijers-Heijboer, Hanne E.J.
van der Hout, Annemarie H.
Vreeswijk, Maaike P.G.
Hoogerbrugge, Nicoline
Ausems, Margreet G.E.M.
van Doorn, Helena C.
Collée, J. Margriet
Olah, Edith
Diez, Orland
Blanco, Ignacio
Lazaro, Conxi
Brunet, Joan
Feliubadalo, Lidia
Cybulski, Cezary
Gronwald, Jacek
Durda, Katarzyna
Jaworska-Bieniek, Katarzyna
Sukiennicki, Grzegorz
Arason, Adalgeir
Chiquette, Jocelyne
Teixeira, Manuel R.
Olswold, Curtis
Couch, Fergus J.
Lindor, Noralane M.
Wang, Xianshu
Szabo, Csilla I.
Offit, Kenneth
Corines, Marina
Jacobs, Lauren
Robson, Mark E.
Zhang, Liying
Joseph, Vijai
Berger, Andreas
Singer, Christian F.
Rappaport, Christine
Kaulich, Daphne Geschwantler
Pfeiler, Georg
Tea, Muy-Kheng M.
Phelan, Catherine M.
Greene, Mark H.
Mai, Phuong L.
Rennert, Gad
Mulligan, Anna Marie
Glendon, Gord
Tchatchou, Sandrine
Andrulis, Irene L.
Toland, Amanda Ewart
Bojesen, Anders
Pedersen, Inge Sokilde
Thomassen, Mads
Jensen, Uffe Birk
Laitman, Yael
Rantala, Johanna
von Wachenfeldt, Anna
Ehrencrona, Hans
Askmalm, Marie Stenmark
Borg, Åke
Kuchenbaecker, Karoline B.
McGuffog, Lesley
Barrowdale, Daniel
Healey, Sue
Lee, Andrew
Pharoah, Paul D.P.
Chenevix-Trench, Georgia
Antoniou, Antonis C.
Friedman, Eitan
spellingShingle Peterlongo, Paolo
Chang-Claude, Jenny
Moysich, Kirsten B.
Rudolph, Anja
Schmutzler, Rita K.
Simard, Jacques
Soucy, Penny
Eeles, Rosalind A.
Easton, Douglas F.
Hamann, Ute
Wilkening, Stefan
Chen, Bowang
Rookus, Matti A.
Schmidt, Marjanka K.
van der Baan, Frederieke H.
Spurdle, Amanda B.
Walker, Logan C.
Lose, Felicity
Maia, Ana-Teresa
Montagna, Marco
Matricardi, Laura
Lubinski, Jan
Jakubowska, Anna
Gómez Garcia, Encarna B.
Olopade, Olufunmilayo I.
Nussbaum, Robert L.
Nathanson, Katherine L.
Domchek, Susan M.
Rebbeck, Timothy R.
Arun, Banu K.
Karlan, Beth Y.
Orsulic, Sandra
Lester, Jenny
Chung, Wendy K.
Miron, Alex
Southey, Melissa C.
Goldgar, David E.
Buys, Saundra S.
Janavicius, Ramunas
Dorfling, Cecilia M.
van Rensburg, Elizabeth J.
Ding, Yuan Chun
Neuhausen, Susan L.
Hansen, Thomas V.O.
Gerdes, Anne-Marie
Ejlertsen, Bent
Jønson, Lars
Osorio, Ana
Martínez-Bouzas, Cristina
Benitez, Javier
Conway, Edye E.
Blazer, Kathleen R.
Weitzel, Jeffrey N.
Manoukian, Siranoush
Peissel, Bernard
Zaffaroni, Daniela
Scuvera, Giulietta
Barile, Monica
Ficarazzi, Filomena
Mariette, Frederique
Fortuzzi, Stefano
Viel, Alessandra
Giannini, Giuseppe
Papi, Laura
Martayan, Aline
Tibiletti, Maria Grazia
Radice, Paolo
Vratimos, Athanassios
Fostira, Florentia
Garber, Judy E.
Donaldson, Alan
Brewer, Carole
Foo, Claire
Evans, D. Gareth R.
Frost, Debra
Eccles, Diana
Brady, Angela
Cook, Jackie
Tischkowitz, Marc
Adlard, Julian
Barwell, Julian
Walker, Lisa
Izatt, Louise
Side, Lucy E.
Kennedy, M. John
Rogers, Mark T.
Porteous, Mary E.
Morrison, Patrick J.
Platte, Radka
Davidson, Rosemarie
Hodgson, Shirley V.
Ellis, Steve
Cole, Trevor
Godwin, Andrew K.
Claes, Kathleen
Van Maerken, Tom
Meindl, Alfons
Gehrig, Andrea
Sutter, Christian
Engel, Christoph
Niederacher, Dieter
Steinemann, Doris
Plendl, Hansjoerg
Kast, Karin
Rhiem, Kerstin
Ditsch, Nina
Arnold, Norbert
Varon-Mateeva, Raymonda
Wappenschmidt, Barbara
Wang-Gohrke, Shan
Bressac-de Paillerets, Brigitte
Buecher, Bruno
Delnatte, Capucine
Houdayer, Claude
Stoppa-Lyonnet, Dominique
Damiola, Francesca
Coupier, Isabelle
Barjhoux, Laure
Venat-Bouvet, Laurence
Golmard, Lisa
Boutry-Kryza, Nadia
Sinilnikova, Olga M.
Caron, Olivier
Pujol, Pascal
Mazoyer, Sylvie
Belotti, Muriel
Piedmonte, Marion
Friedlander, Michael L.
Rodriguez, Gustavo C.
Copeland, Larry J.
de la Hoya, Miguel
Segura, Pedro Perez
Nevanlinna, Heli
Aittomäki, Kristiina
van Os, Theo A.M.
Meijers-Heijboer, Hanne E.J.
van der Hout, Annemarie H.
Vreeswijk, Maaike P.G.
Hoogerbrugge, Nicoline
Ausems, Margreet G.E.M.
van Doorn, Helena C.
Collée, J. Margriet
Olah, Edith
Diez, Orland
Blanco, Ignacio
Lazaro, Conxi
Brunet, Joan
Feliubadalo, Lidia
Cybulski, Cezary
Gronwald, Jacek
Durda, Katarzyna
Jaworska-Bieniek, Katarzyna
Sukiennicki, Grzegorz
Arason, Adalgeir
Chiquette, Jocelyne
Teixeira, Manuel R.
Olswold, Curtis
Couch, Fergus J.
Lindor, Noralane M.
Wang, Xianshu
Szabo, Csilla I.
Offit, Kenneth
Corines, Marina
Jacobs, Lauren
Robson, Mark E.
Zhang, Liying
Joseph, Vijai
Berger, Andreas
Singer, Christian F.
Rappaport, Christine
Kaulich, Daphne Geschwantler
Pfeiler, Georg
Tea, Muy-Kheng M.
Phelan, Catherine M.
Greene, Mark H.
Mai, Phuong L.
Rennert, Gad
Mulligan, Anna Marie
Glendon, Gord
Tchatchou, Sandrine
Andrulis, Irene L.
Toland, Amanda Ewart
Bojesen, Anders
Pedersen, Inge Sokilde
Thomassen, Mads
Jensen, Uffe Birk
Laitman, Yael
Rantala, Johanna
von Wachenfeldt, Anna
Ehrencrona, Hans
Askmalm, Marie Stenmark
Borg, Åke
Kuchenbaecker, Karoline B.
McGuffog, Lesley
Barrowdale, Daniel
Healey, Sue
Lee, Andrew
Pharoah, Paul D.P.
Chenevix-Trench, Georgia
Antoniou, Antonis C.
Friedman, Eitan
Cancer Epidemiology, Biomarkers & Prevention
Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
Oncology
Epidemiology
author_sort peterlongo, paolo
spelling Peterlongo, Paolo Chang-Claude, Jenny Moysich, Kirsten B. Rudolph, Anja Schmutzler, Rita K. Simard, Jacques Soucy, Penny Eeles, Rosalind A. Easton, Douglas F. Hamann, Ute Wilkening, Stefan Chen, Bowang Rookus, Matti A. Schmidt, Marjanka K. van der Baan, Frederieke H. Spurdle, Amanda B. Walker, Logan C. Lose, Felicity Maia, Ana-Teresa Montagna, Marco Matricardi, Laura Lubinski, Jan Jakubowska, Anna Gómez Garcia, Encarna B. Olopade, Olufunmilayo I. Nussbaum, Robert L. Nathanson, Katherine L. Domchek, Susan M. Rebbeck, Timothy R. Arun, Banu K. Karlan, Beth Y. Orsulic, Sandra Lester, Jenny Chung, Wendy K. Miron, Alex Southey, Melissa C. Goldgar, David E. Buys, Saundra S. Janavicius, Ramunas Dorfling, Cecilia M. van Rensburg, Elizabeth J. Ding, Yuan Chun Neuhausen, Susan L. Hansen, Thomas V.O. Gerdes, Anne-Marie Ejlertsen, Bent Jønson, Lars Osorio, Ana Martínez-Bouzas, Cristina Benitez, Javier Conway, Edye E. Blazer, Kathleen R. Weitzel, Jeffrey N. Manoukian, Siranoush Peissel, Bernard Zaffaroni, Daniela Scuvera, Giulietta Barile, Monica Ficarazzi, Filomena Mariette, Frederique Fortuzzi, Stefano Viel, Alessandra Giannini, Giuseppe Papi, Laura Martayan, Aline Tibiletti, Maria Grazia Radice, Paolo Vratimos, Athanassios Fostira, Florentia Garber, Judy E. Donaldson, Alan Brewer, Carole Foo, Claire Evans, D. Gareth R. Frost, Debra Eccles, Diana Brady, Angela Cook, Jackie Tischkowitz, Marc Adlard, Julian Barwell, Julian Walker, Lisa Izatt, Louise Side, Lucy E. Kennedy, M. John Rogers, Mark T. Porteous, Mary E. Morrison, Patrick J. Platte, Radka Davidson, Rosemarie Hodgson, Shirley V. Ellis, Steve Cole, Trevor Godwin, Andrew K. Claes, Kathleen Van Maerken, Tom Meindl, Alfons Gehrig, Andrea Sutter, Christian Engel, Christoph Niederacher, Dieter Steinemann, Doris Plendl, Hansjoerg Kast, Karin Rhiem, Kerstin Ditsch, Nina Arnold, Norbert Varon-Mateeva, Raymonda Wappenschmidt, Barbara Wang-Gohrke, Shan Bressac-de Paillerets, Brigitte Buecher, Bruno Delnatte, Capucine Houdayer, Claude Stoppa-Lyonnet, Dominique Damiola, Francesca Coupier, Isabelle Barjhoux, Laure Venat-Bouvet, Laurence Golmard, Lisa Boutry-Kryza, Nadia Sinilnikova, Olga M. Caron, Olivier Pujol, Pascal Mazoyer, Sylvie Belotti, Muriel Piedmonte, Marion Friedlander, Michael L. Rodriguez, Gustavo C. Copeland, Larry J. de la Hoya, Miguel Segura, Pedro Perez Nevanlinna, Heli Aittomäki, Kristiina van Os, Theo A.M. Meijers-Heijboer, Hanne E.J. van der Hout, Annemarie H. Vreeswijk, Maaike P.G. Hoogerbrugge, Nicoline Ausems, Margreet G.E.M. van Doorn, Helena C. Collée, J. Margriet Olah, Edith Diez, Orland Blanco, Ignacio Lazaro, Conxi Brunet, Joan Feliubadalo, Lidia Cybulski, Cezary Gronwald, Jacek Durda, Katarzyna Jaworska-Bieniek, Katarzyna Sukiennicki, Grzegorz Arason, Adalgeir Chiquette, Jocelyne Teixeira, Manuel R. Olswold, Curtis Couch, Fergus J. Lindor, Noralane M. Wang, Xianshu Szabo, Csilla I. Offit, Kenneth Corines, Marina Jacobs, Lauren Robson, Mark E. Zhang, Liying Joseph, Vijai Berger, Andreas Singer, Christian F. Rappaport, Christine Kaulich, Daphne Geschwantler Pfeiler, Georg Tea, Muy-Kheng M. Phelan, Catherine M. Greene, Mark H. Mai, Phuong L. Rennert, Gad Mulligan, Anna Marie Glendon, Gord Tchatchou, Sandrine Andrulis, Irene L. Toland, Amanda Ewart Bojesen, Anders Pedersen, Inge Sokilde Thomassen, Mads Jensen, Uffe Birk Laitman, Yael Rantala, Johanna von Wachenfeldt, Anna Ehrencrona, Hans Askmalm, Marie Stenmark Borg, Åke Kuchenbaecker, Karoline B. McGuffog, Lesley Barrowdale, Daniel Healey, Sue Lee, Andrew Pharoah, Paul D.P. Chenevix-Trench, Georgia Antoniou, Antonis C. Friedman, Eitan 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-14-0532 <jats:title>Abstract</jats:title> <jats:p>Background:BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and nongenetic modifying factors. In this study, we evaluated the putative role of variants in many candidate modifier genes.</jats:p> <jats:p>Methods: Genotyping data from 15,252 BRCA1 and 8,211 BRCA2 mutation carriers, for known variants (n = 3,248) located within or around 445 candidate genes, were available through the iCOGS custom-designed array. Breast and ovarian cancer association analysis was performed within a retrospective cohort approach.</jats:p> <jats:p>Results: The observed P values of association ranged between 0.005 and 1.000. None of the variants was significantly associated with breast or ovarian cancer risk in either BRCA1 or BRCA2 mutation carriers, after multiple testing adjustments.</jats:p> <jats:p>Conclusion: There is little evidence that any of the evaluated candidate variants act as modifiers of breast and/or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers.</jats:p> <jats:p>Impact: Genome-wide association studies have been more successful at identifying genetic modifiers of BRCA1/2 penetrance than candidate gene studies. Cancer Epidemiol Biomarkers Prev; 24(1); 308–16. ©2014 AACR.</jats:p> Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in <i>BRCA1</i> and <i>BRCA2</i> Mutation Carriers Cancer Epidemiology, Biomarkers & Prevention
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series Cancer Epidemiology, Biomarkers & Prevention
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title Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
title_unstemmed Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
title_full Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
title_fullStr Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
title_full_unstemmed Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
title_short Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
title_sort candidate genetic modifiers for breast and ovarian cancer risk in <i>brca1</i> and <i>brca2</i> mutation carriers
topic Oncology
Epidemiology
url http://dx.doi.org/10.1158/1055-9965.epi-14-0532
publishDate 2015
physical 308-316
description <jats:title>Abstract</jats:title> <jats:p>Background:BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and nongenetic modifying factors. In this study, we evaluated the putative role of variants in many candidate modifier genes.</jats:p> <jats:p>Methods: Genotyping data from 15,252 BRCA1 and 8,211 BRCA2 mutation carriers, for known variants (n = 3,248) located within or around 445 candidate genes, were available through the iCOGS custom-designed array. Breast and ovarian cancer association analysis was performed within a retrospective cohort approach.</jats:p> <jats:p>Results: The observed P values of association ranged between 0.005 and 1.000. None of the variants was significantly associated with breast or ovarian cancer risk in either BRCA1 or BRCA2 mutation carriers, after multiple testing adjustments.</jats:p> <jats:p>Conclusion: There is little evidence that any of the evaluated candidate variants act as modifiers of breast and/or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers.</jats:p> <jats:p>Impact: Genome-wide association studies have been more successful at identifying genetic modifiers of BRCA1/2 penetrance than candidate gene studies. Cancer Epidemiol Biomarkers Prev; 24(1); 308–16. ©2014 AACR.</jats:p>
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author Peterlongo, Paolo, Chang-Claude, Jenny, Moysich, Kirsten B., Rudolph, Anja, Schmutzler, Rita K., Simard, Jacques, Soucy, Penny, Eeles, Rosalind A., Easton, Douglas F., Hamann, Ute, Wilkening, Stefan, Chen, Bowang, Rookus, Matti A., Schmidt, Marjanka K., van der Baan, Frederieke H., Spurdle, Amanda B., Walker, Logan C., Lose, Felicity, Maia, Ana-Teresa, Montagna, Marco, Matricardi, Laura, Lubinski, Jan, Jakubowska, Anna, Gómez Garcia, Encarna B., Olopade, Olufunmilayo I., Nussbaum, Robert L., Nathanson, Katherine L., Domchek, Susan M., Rebbeck, Timothy R., Arun, Banu K., Karlan, Beth Y., Orsulic, Sandra, Lester, Jenny, Chung, Wendy K., Miron, Alex, Southey, Melissa C., Goldgar, David E., Buys, Saundra S., Janavicius, Ramunas, Dorfling, Cecilia M., van Rensburg, Elizabeth J., Ding, Yuan Chun, Neuhausen, Susan L., Hansen, Thomas V.O., Gerdes, Anne-Marie, Ejlertsen, Bent, Jønson, Lars, Osorio, Ana, Martínez-Bouzas, Cristina, Benitez, Javier, Conway, Edye E., Blazer, Kathleen R., Weitzel, Jeffrey N., Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Scuvera, Giulietta, Barile, Monica, Ficarazzi, Filomena, Mariette, Frederique, Fortuzzi, Stefano, Viel, Alessandra, Giannini, Giuseppe, Papi, Laura, Martayan, Aline, Tibiletti, Maria Grazia, Radice, Paolo, Vratimos, Athanassios, Fostira, Florentia, Garber, Judy E., Donaldson, Alan, Brewer, Carole, Foo, Claire, Evans, D. Gareth R., Frost, Debra, Eccles, Diana, Brady, Angela, Cook, Jackie, Tischkowitz, Marc, Adlard, Julian, Barwell, Julian, Walker, Lisa, Izatt, Louise, Side, Lucy E., Kennedy, M. John, Rogers, Mark T., Porteous, Mary E., Morrison, Patrick J., Platte, Radka, Davidson, Rosemarie, Hodgson, Shirley V., Ellis, Steve, Cole, Trevor, Godwin, Andrew K., Claes, Kathleen, Van Maerken, Tom, Meindl, Alfons, Gehrig, Andrea, Sutter, Christian, Engel, Christoph, Niederacher, Dieter, Steinemann, Doris, Plendl, Hansjoerg, Kast, Karin, Rhiem, Kerstin, Ditsch, Nina, Arnold, Norbert, Varon-Mateeva, Raymonda, Wappenschmidt, Barbara, Wang-Gohrke, Shan, Bressac-de Paillerets, Brigitte, Buecher, Bruno, Delnatte, Capucine, Houdayer, Claude, Stoppa-Lyonnet, Dominique, Damiola, Francesca, Coupier, Isabelle, Barjhoux, Laure, Venat-Bouvet, Laurence, Golmard, Lisa, Boutry-Kryza, Nadia, Sinilnikova, Olga M., Caron, Olivier, Pujol, Pascal, Mazoyer, Sylvie, Belotti, Muriel, Piedmonte, Marion, Friedlander, Michael L., Rodriguez, Gustavo C., Copeland, Larry J., de la Hoya, Miguel, Segura, Pedro Perez, Nevanlinna, Heli, Aittomäki, Kristiina, van Os, Theo A.M., Meijers-Heijboer, Hanne E.J., van der Hout, Annemarie H., Vreeswijk, Maaike P.G., Hoogerbrugge, Nicoline, Ausems, Margreet G.E.M., van Doorn, Helena C., Collée, J. Margriet, Olah, Edith, Diez, Orland, Blanco, Ignacio, Lazaro, Conxi, Brunet, Joan, Feliubadalo, Lidia, Cybulski, Cezary, Gronwald, Jacek, Durda, Katarzyna, Jaworska-Bieniek, Katarzyna, Sukiennicki, Grzegorz, Arason, Adalgeir, Chiquette, Jocelyne, Teixeira, Manuel R., Olswold, Curtis, Couch, Fergus J., Lindor, Noralane M., Wang, Xianshu, Szabo, Csilla I., Offit, Kenneth, Corines, Marina, Jacobs, Lauren, Robson, Mark E., Zhang, Liying, Joseph, Vijai, Berger, Andreas, Singer, Christian F., Rappaport, Christine, Kaulich, Daphne Geschwantler, Pfeiler, Georg, Tea, Muy-Kheng M., Phelan, Catherine M., Greene, Mark H., Mai, Phuong L., Rennert, Gad, Mulligan, Anna Marie, Glendon, Gord, Tchatchou, Sandrine, Andrulis, Irene L., Toland, Amanda Ewart, Bojesen, Anders, Pedersen, Inge Sokilde, Thomassen, Mads, Jensen, Uffe Birk, Laitman, Yael, Rantala, Johanna, von Wachenfeldt, Anna, Ehrencrona, Hans, Askmalm, Marie Stenmark, Borg, Åke, Kuchenbaecker, Karoline B., McGuffog, Lesley, Barrowdale, Daniel, Healey, Sue, Lee, Andrew, Pharoah, Paul D.P., Chenevix-Trench, Georgia, Antoniou, Antonis C., Friedman, Eitan
author_facet Peterlongo, Paolo, Chang-Claude, Jenny, Moysich, Kirsten B., Rudolph, Anja, Schmutzler, Rita K., Simard, Jacques, Soucy, Penny, Eeles, Rosalind A., Easton, Douglas F., Hamann, Ute, Wilkening, Stefan, Chen, Bowang, Rookus, Matti A., Schmidt, Marjanka K., van der Baan, Frederieke H., Spurdle, Amanda B., Walker, Logan C., Lose, Felicity, Maia, Ana-Teresa, Montagna, Marco, Matricardi, Laura, Lubinski, Jan, Jakubowska, Anna, Gómez Garcia, Encarna B., Olopade, Olufunmilayo I., Nussbaum, Robert L., Nathanson, Katherine L., Domchek, Susan M., Rebbeck, Timothy R., Arun, Banu K., Karlan, Beth Y., Orsulic, Sandra, Lester, Jenny, Chung, Wendy K., Miron, Alex, Southey, Melissa C., Goldgar, David E., Buys, Saundra S., Janavicius, Ramunas, Dorfling, Cecilia M., van Rensburg, Elizabeth J., Ding, Yuan Chun, Neuhausen, Susan L., Hansen, Thomas V.O., Gerdes, Anne-Marie, Ejlertsen, Bent, Jønson, Lars, Osorio, Ana, Martínez-Bouzas, Cristina, Benitez, Javier, Conway, Edye E., Blazer, Kathleen R., Weitzel, Jeffrey N., Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Scuvera, Giulietta, Barile, Monica, Ficarazzi, Filomena, Mariette, Frederique, Fortuzzi, Stefano, Viel, Alessandra, Giannini, Giuseppe, Papi, Laura, Martayan, Aline, Tibiletti, Maria Grazia, Radice, Paolo, Vratimos, Athanassios, Fostira, Florentia, Garber, Judy E., Donaldson, Alan, Brewer, Carole, Foo, Claire, Evans, D. Gareth R., Frost, Debra, Eccles, Diana, Brady, Angela, Cook, Jackie, Tischkowitz, Marc, Adlard, Julian, Barwell, Julian, Walker, Lisa, Izatt, Louise, Side, Lucy E., Kennedy, M. John, Rogers, Mark T., Porteous, Mary E., Morrison, Patrick J., Platte, Radka, Davidson, Rosemarie, Hodgson, Shirley V., Ellis, Steve, Cole, Trevor, Godwin, Andrew K., Claes, Kathleen, Van Maerken, Tom, Meindl, Alfons, Gehrig, Andrea, Sutter, Christian, Engel, Christoph, Niederacher, Dieter, Steinemann, Doris, Plendl, Hansjoerg, Kast, Karin, Rhiem, Kerstin, Ditsch, Nina, Arnold, Norbert, Varon-Mateeva, Raymonda, Wappenschmidt, Barbara, Wang-Gohrke, Shan, Bressac-de Paillerets, Brigitte, Buecher, Bruno, Delnatte, Capucine, Houdayer, Claude, Stoppa-Lyonnet, Dominique, Damiola, Francesca, Coupier, Isabelle, Barjhoux, Laure, Venat-Bouvet, Laurence, Golmard, Lisa, Boutry-Kryza, Nadia, Sinilnikova, Olga M., Caron, Olivier, Pujol, Pascal, Mazoyer, Sylvie, Belotti, Muriel, Piedmonte, Marion, Friedlander, Michael L., Rodriguez, Gustavo C., Copeland, Larry J., de la Hoya, Miguel, Segura, Pedro Perez, Nevanlinna, Heli, Aittomäki, Kristiina, van Os, Theo A.M., Meijers-Heijboer, Hanne E.J., van der Hout, Annemarie H., Vreeswijk, Maaike P.G., Hoogerbrugge, Nicoline, Ausems, Margreet G.E.M., van Doorn, Helena C., Collée, J. Margriet, Olah, Edith, Diez, Orland, Blanco, Ignacio, Lazaro, Conxi, Brunet, Joan, Feliubadalo, Lidia, Cybulski, Cezary, Gronwald, Jacek, Durda, Katarzyna, Jaworska-Bieniek, Katarzyna, Sukiennicki, Grzegorz, Arason, Adalgeir, Chiquette, Jocelyne, Teixeira, Manuel R., Olswold, Curtis, Couch, Fergus J., Lindor, Noralane M., Wang, Xianshu, Szabo, Csilla I., Offit, Kenneth, Corines, Marina, Jacobs, Lauren, Robson, Mark E., Zhang, Liying, Joseph, Vijai, Berger, Andreas, Singer, Christian F., Rappaport, Christine, Kaulich, Daphne Geschwantler, Pfeiler, Georg, Tea, Muy-Kheng M., Phelan, Catherine M., Greene, Mark H., Mai, Phuong L., Rennert, Gad, Mulligan, Anna Marie, Glendon, Gord, Tchatchou, Sandrine, Andrulis, Irene L., Toland, Amanda Ewart, Bojesen, Anders, Pedersen, Inge Sokilde, Thomassen, Mads, Jensen, Uffe Birk, Laitman, Yael, Rantala, Johanna, von Wachenfeldt, Anna, Ehrencrona, Hans, Askmalm, Marie Stenmark, Borg, Åke, Kuchenbaecker, Karoline B., McGuffog, Lesley, Barrowdale, Daniel, Healey, Sue, Lee, Andrew, Pharoah, Paul D.P., Chenevix-Trench, Georgia, Antoniou, Antonis C., Friedman, Eitan, Peterlongo, Paolo, Chang-Claude, Jenny, Moysich, Kirsten B., Rudolph, Anja, Schmutzler, Rita K., Simard, Jacques, Soucy, Penny, Eeles, Rosalind A., Easton, Douglas F., Hamann, Ute, Wilkening, Stefan, Chen, Bowang, Rookus, Matti A., Schmidt, Marjanka K., van der Baan, Frederieke H., Spurdle, Amanda B., Walker, Logan C., Lose, Felicity, Maia, Ana-Teresa, Montagna, Marco, Matricardi, Laura, Lubinski, Jan, Jakubowska, Anna, Gómez Garcia, Encarna B., Olopade, Olufunmilayo I., Nussbaum, Robert L., Nathanson, Katherine L., Domchek, Susan M., Rebbeck, Timothy R., Arun, Banu K., Karlan, Beth Y., Orsulic, Sandra, Lester, Jenny, Chung, Wendy K., Miron, Alex, Southey, Melissa C., Goldgar, David E., Buys, Saundra S., Janavicius, Ramunas, Dorfling, Cecilia M., van Rensburg, Elizabeth J., Ding, Yuan Chun, Neuhausen, Susan L., Hansen, Thomas V.O., Gerdes, Anne-Marie, Ejlertsen, Bent, Jønson, Lars, Osorio, Ana, Martínez-Bouzas, Cristina, Benitez, Javier, Conway, Edye E., Blazer, Kathleen R., Weitzel, Jeffrey N., Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Scuvera, Giulietta, Barile, Monica, Ficarazzi, Filomena, Mariette, Frederique, Fortuzzi, Stefano, Viel, Alessandra, Giannini, Giuseppe, Papi, Laura, Martayan, Aline, Tibiletti, Maria Grazia, Radice, Paolo, Vratimos, Athanassios, Fostira, Florentia, Garber, Judy E., Donaldson, Alan, Brewer, Carole, Foo, Claire, Evans, D. Gareth R., Frost, Debra, Eccles, Diana, Brady, Angela, Cook, Jackie, Tischkowitz, Marc, Adlard, Julian, Barwell, Julian, Walker, Lisa, Izatt, Louise, Side, Lucy E., Kennedy, M. John, Rogers, Mark T., Porteous, Mary E., Morrison, Patrick J., Platte, Radka, Davidson, Rosemarie, Hodgson, Shirley V., Ellis, Steve, Cole, Trevor, Godwin, Andrew K., Claes, Kathleen, Van Maerken, Tom, Meindl, Alfons, Gehrig, Andrea, Sutter, Christian, Engel, Christoph, Niederacher, Dieter, Steinemann, Doris, Plendl, Hansjoerg, Kast, Karin, Rhiem, Kerstin, Ditsch, Nina, Arnold, Norbert, Varon-Mateeva, Raymonda, Wappenschmidt, Barbara, Wang-Gohrke, Shan, Bressac-de Paillerets, Brigitte, Buecher, Bruno, Delnatte, Capucine, Houdayer, Claude, Stoppa-Lyonnet, Dominique, Damiola, Francesca, Coupier, Isabelle, Barjhoux, Laure, Venat-Bouvet, Laurence, Golmard, Lisa, Boutry-Kryza, Nadia, Sinilnikova, Olga M., Caron, Olivier, Pujol, Pascal, Mazoyer, Sylvie, Belotti, Muriel, Piedmonte, Marion, Friedlander, Michael L., Rodriguez, Gustavo C., Copeland, Larry J., de la Hoya, Miguel, Segura, Pedro Perez, Nevanlinna, Heli, Aittomäki, Kristiina, van Os, Theo A.M., Meijers-Heijboer, Hanne E.J., van der Hout, Annemarie H., Vreeswijk, Maaike P.G., Hoogerbrugge, Nicoline, Ausems, Margreet G.E.M., van Doorn, Helena C., Collée, J. Margriet, Olah, Edith, Diez, Orland, Blanco, Ignacio, Lazaro, Conxi, Brunet, Joan, Feliubadalo, Lidia, Cybulski, Cezary, Gronwald, Jacek, Durda, Katarzyna, Jaworska-Bieniek, Katarzyna, Sukiennicki, Grzegorz, Arason, Adalgeir, Chiquette, Jocelyne, Teixeira, Manuel R., Olswold, Curtis, Couch, Fergus J., Lindor, Noralane M., Wang, Xianshu, Szabo, Csilla I., Offit, Kenneth, Corines, Marina, Jacobs, Lauren, Robson, Mark E., Zhang, Liying, Joseph, Vijai, Berger, Andreas, Singer, Christian F., Rappaport, Christine, Kaulich, Daphne Geschwantler, Pfeiler, Georg, Tea, Muy-Kheng M., Phelan, Catherine M., Greene, Mark H., Mai, Phuong L., Rennert, Gad, Mulligan, Anna Marie, Glendon, Gord, Tchatchou, Sandrine, Andrulis, Irene L., Toland, Amanda Ewart, Bojesen, Anders, Pedersen, Inge Sokilde, Thomassen, Mads, Jensen, Uffe Birk, Laitman, Yael, Rantala, Johanna, von Wachenfeldt, Anna, Ehrencrona, Hans, Askmalm, Marie Stenmark, Borg, Åke, Kuchenbaecker, Karoline B., McGuffog, Lesley, Barrowdale, Daniel, Healey, Sue, Lee, Andrew, Pharoah, Paul D.P., Chenevix-Trench, Georgia, Antoniou, Antonis C., Friedman, Eitan
author_sort peterlongo, paolo
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container_title Cancer Epidemiology, Biomarkers & Prevention
container_volume 24
description <jats:title>Abstract</jats:title> <jats:p>Background:BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and nongenetic modifying factors. In this study, we evaluated the putative role of variants in many candidate modifier genes.</jats:p> <jats:p>Methods: Genotyping data from 15,252 BRCA1 and 8,211 BRCA2 mutation carriers, for known variants (n = 3,248) located within or around 445 candidate genes, were available through the iCOGS custom-designed array. Breast and ovarian cancer association analysis was performed within a retrospective cohort approach.</jats:p> <jats:p>Results: The observed P values of association ranged between 0.005 and 1.000. None of the variants was significantly associated with breast or ovarian cancer risk in either BRCA1 or BRCA2 mutation carriers, after multiple testing adjustments.</jats:p> <jats:p>Conclusion: There is little evidence that any of the evaluated candidate variants act as modifiers of breast and/or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers.</jats:p> <jats:p>Impact: Genome-wide association studies have been more successful at identifying genetic modifiers of BRCA1/2 penetrance than candidate gene studies. Cancer Epidemiol Biomarkers Prev; 24(1); 308–16. ©2014 AACR.</jats:p>
doi_str_mv 10.1158/1055-9965.epi-14-0532
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imprint American Association for Cancer Research (AACR), 2015
imprint_str_mv American Association for Cancer Research (AACR), 2015
institution DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229
issn 1055-9965, 1538-7755
issn_str_mv 1055-9965, 1538-7755
language English
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match_str peterlongo2015candidategeneticmodifiersforbreastandovariancancerriskinbrca1andbrca2mutationcarriers
mega_collection American Association for Cancer Research (AACR) (CrossRef)
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series Cancer Epidemiology, Biomarkers & Prevention
source_id 49
spelling Peterlongo, Paolo Chang-Claude, Jenny Moysich, Kirsten B. Rudolph, Anja Schmutzler, Rita K. Simard, Jacques Soucy, Penny Eeles, Rosalind A. Easton, Douglas F. Hamann, Ute Wilkening, Stefan Chen, Bowang Rookus, Matti A. Schmidt, Marjanka K. van der Baan, Frederieke H. Spurdle, Amanda B. Walker, Logan C. Lose, Felicity Maia, Ana-Teresa Montagna, Marco Matricardi, Laura Lubinski, Jan Jakubowska, Anna Gómez Garcia, Encarna B. Olopade, Olufunmilayo I. Nussbaum, Robert L. Nathanson, Katherine L. Domchek, Susan M. Rebbeck, Timothy R. Arun, Banu K. Karlan, Beth Y. Orsulic, Sandra Lester, Jenny Chung, Wendy K. Miron, Alex Southey, Melissa C. Goldgar, David E. Buys, Saundra S. Janavicius, Ramunas Dorfling, Cecilia M. van Rensburg, Elizabeth J. Ding, Yuan Chun Neuhausen, Susan L. Hansen, Thomas V.O. Gerdes, Anne-Marie Ejlertsen, Bent Jønson, Lars Osorio, Ana Martínez-Bouzas, Cristina Benitez, Javier Conway, Edye E. Blazer, Kathleen R. Weitzel, Jeffrey N. Manoukian, Siranoush Peissel, Bernard Zaffaroni, Daniela Scuvera, Giulietta Barile, Monica Ficarazzi, Filomena Mariette, Frederique Fortuzzi, Stefano Viel, Alessandra Giannini, Giuseppe Papi, Laura Martayan, Aline Tibiletti, Maria Grazia Radice, Paolo Vratimos, Athanassios Fostira, Florentia Garber, Judy E. Donaldson, Alan Brewer, Carole Foo, Claire Evans, D. Gareth R. Frost, Debra Eccles, Diana Brady, Angela Cook, Jackie Tischkowitz, Marc Adlard, Julian Barwell, Julian Walker, Lisa Izatt, Louise Side, Lucy E. Kennedy, M. John Rogers, Mark T. Porteous, Mary E. Morrison, Patrick J. Platte, Radka Davidson, Rosemarie Hodgson, Shirley V. Ellis, Steve Cole, Trevor Godwin, Andrew K. Claes, Kathleen Van Maerken, Tom Meindl, Alfons Gehrig, Andrea Sutter, Christian Engel, Christoph Niederacher, Dieter Steinemann, Doris Plendl, Hansjoerg Kast, Karin Rhiem, Kerstin Ditsch, Nina Arnold, Norbert Varon-Mateeva, Raymonda Wappenschmidt, Barbara Wang-Gohrke, Shan Bressac-de Paillerets, Brigitte Buecher, Bruno Delnatte, Capucine Houdayer, Claude Stoppa-Lyonnet, Dominique Damiola, Francesca Coupier, Isabelle Barjhoux, Laure Venat-Bouvet, Laurence Golmard, Lisa Boutry-Kryza, Nadia Sinilnikova, Olga M. Caron, Olivier Pujol, Pascal Mazoyer, Sylvie Belotti, Muriel Piedmonte, Marion Friedlander, Michael L. Rodriguez, Gustavo C. Copeland, Larry J. de la Hoya, Miguel Segura, Pedro Perez Nevanlinna, Heli Aittomäki, Kristiina van Os, Theo A.M. Meijers-Heijboer, Hanne E.J. van der Hout, Annemarie H. Vreeswijk, Maaike P.G. Hoogerbrugge, Nicoline Ausems, Margreet G.E.M. van Doorn, Helena C. Collée, J. Margriet Olah, Edith Diez, Orland Blanco, Ignacio Lazaro, Conxi Brunet, Joan Feliubadalo, Lidia Cybulski, Cezary Gronwald, Jacek Durda, Katarzyna Jaworska-Bieniek, Katarzyna Sukiennicki, Grzegorz Arason, Adalgeir Chiquette, Jocelyne Teixeira, Manuel R. Olswold, Curtis Couch, Fergus J. Lindor, Noralane M. Wang, Xianshu Szabo, Csilla I. Offit, Kenneth Corines, Marina Jacobs, Lauren Robson, Mark E. Zhang, Liying Joseph, Vijai Berger, Andreas Singer, Christian F. Rappaport, Christine Kaulich, Daphne Geschwantler Pfeiler, Georg Tea, Muy-Kheng M. Phelan, Catherine M. Greene, Mark H. Mai, Phuong L. Rennert, Gad Mulligan, Anna Marie Glendon, Gord Tchatchou, Sandrine Andrulis, Irene L. Toland, Amanda Ewart Bojesen, Anders Pedersen, Inge Sokilde Thomassen, Mads Jensen, Uffe Birk Laitman, Yael Rantala, Johanna von Wachenfeldt, Anna Ehrencrona, Hans Askmalm, Marie Stenmark Borg, Åke Kuchenbaecker, Karoline B. McGuffog, Lesley Barrowdale, Daniel Healey, Sue Lee, Andrew Pharoah, Paul D.P. Chenevix-Trench, Georgia Antoniou, Antonis C. Friedman, Eitan 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-14-0532 <jats:title>Abstract</jats:title> <jats:p>Background:BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and nongenetic modifying factors. In this study, we evaluated the putative role of variants in many candidate modifier genes.</jats:p> <jats:p>Methods: Genotyping data from 15,252 BRCA1 and 8,211 BRCA2 mutation carriers, for known variants (n = 3,248) located within or around 445 candidate genes, were available through the iCOGS custom-designed array. Breast and ovarian cancer association analysis was performed within a retrospective cohort approach.</jats:p> <jats:p>Results: The observed P values of association ranged between 0.005 and 1.000. None of the variants was significantly associated with breast or ovarian cancer risk in either BRCA1 or BRCA2 mutation carriers, after multiple testing adjustments.</jats:p> <jats:p>Conclusion: There is little evidence that any of the evaluated candidate variants act as modifiers of breast and/or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers.</jats:p> <jats:p>Impact: Genome-wide association studies have been more successful at identifying genetic modifiers of BRCA1/2 penetrance than candidate gene studies. Cancer Epidemiol Biomarkers Prev; 24(1); 308–16. ©2014 AACR.</jats:p> Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in <i>BRCA1</i> and <i>BRCA2</i> Mutation Carriers Cancer Epidemiology, Biomarkers & Prevention
spellingShingle Peterlongo, Paolo, Chang-Claude, Jenny, Moysich, Kirsten B., Rudolph, Anja, Schmutzler, Rita K., Simard, Jacques, Soucy, Penny, Eeles, Rosalind A., Easton, Douglas F., Hamann, Ute, Wilkening, Stefan, Chen, Bowang, Rookus, Matti A., Schmidt, Marjanka K., van der Baan, Frederieke H., Spurdle, Amanda B., Walker, Logan C., Lose, Felicity, Maia, Ana-Teresa, Montagna, Marco, Matricardi, Laura, Lubinski, Jan, Jakubowska, Anna, Gómez Garcia, Encarna B., Olopade, Olufunmilayo I., Nussbaum, Robert L., Nathanson, Katherine L., Domchek, Susan M., Rebbeck, Timothy R., Arun, Banu K., Karlan, Beth Y., Orsulic, Sandra, Lester, Jenny, Chung, Wendy K., Miron, Alex, Southey, Melissa C., Goldgar, David E., Buys, Saundra S., Janavicius, Ramunas, Dorfling, Cecilia M., van Rensburg, Elizabeth J., Ding, Yuan Chun, Neuhausen, Susan L., Hansen, Thomas V.O., Gerdes, Anne-Marie, Ejlertsen, Bent, Jønson, Lars, Osorio, Ana, Martínez-Bouzas, Cristina, Benitez, Javier, Conway, Edye E., Blazer, Kathleen R., Weitzel, Jeffrey N., Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Scuvera, Giulietta, Barile, Monica, Ficarazzi, Filomena, Mariette, Frederique, Fortuzzi, Stefano, Viel, Alessandra, Giannini, Giuseppe, Papi, Laura, Martayan, Aline, Tibiletti, Maria Grazia, Radice, Paolo, Vratimos, Athanassios, Fostira, Florentia, Garber, Judy E., Donaldson, Alan, Brewer, Carole, Foo, Claire, Evans, D. Gareth R., Frost, Debra, Eccles, Diana, Brady, Angela, Cook, Jackie, Tischkowitz, Marc, Adlard, Julian, Barwell, Julian, Walker, Lisa, Izatt, Louise, Side, Lucy E., Kennedy, M. John, Rogers, Mark T., Porteous, Mary E., Morrison, Patrick J., Platte, Radka, Davidson, Rosemarie, Hodgson, Shirley V., Ellis, Steve, Cole, Trevor, Godwin, Andrew K., Claes, Kathleen, Van Maerken, Tom, Meindl, Alfons, Gehrig, Andrea, Sutter, Christian, Engel, Christoph, Niederacher, Dieter, Steinemann, Doris, Plendl, Hansjoerg, Kast, Karin, Rhiem, Kerstin, Ditsch, Nina, Arnold, Norbert, Varon-Mateeva, Raymonda, Wappenschmidt, Barbara, Wang-Gohrke, Shan, Bressac-de Paillerets, Brigitte, Buecher, Bruno, Delnatte, Capucine, Houdayer, Claude, Stoppa-Lyonnet, Dominique, Damiola, Francesca, Coupier, Isabelle, Barjhoux, Laure, Venat-Bouvet, Laurence, Golmard, Lisa, Boutry-Kryza, Nadia, Sinilnikova, Olga M., Caron, Olivier, Pujol, Pascal, Mazoyer, Sylvie, Belotti, Muriel, Piedmonte, Marion, Friedlander, Michael L., Rodriguez, Gustavo C., Copeland, Larry J., de la Hoya, Miguel, Segura, Pedro Perez, Nevanlinna, Heli, Aittomäki, Kristiina, van Os, Theo A.M., Meijers-Heijboer, Hanne E.J., van der Hout, Annemarie H., Vreeswijk, Maaike P.G., Hoogerbrugge, Nicoline, Ausems, Margreet G.E.M., van Doorn, Helena C., Collée, J. Margriet, Olah, Edith, Diez, Orland, Blanco, Ignacio, Lazaro, Conxi, Brunet, Joan, Feliubadalo, Lidia, Cybulski, Cezary, Gronwald, Jacek, Durda, Katarzyna, Jaworska-Bieniek, Katarzyna, Sukiennicki, Grzegorz, Arason, Adalgeir, Chiquette, Jocelyne, Teixeira, Manuel R., Olswold, Curtis, Couch, Fergus J., Lindor, Noralane M., Wang, Xianshu, Szabo, Csilla I., Offit, Kenneth, Corines, Marina, Jacobs, Lauren, Robson, Mark E., Zhang, Liying, Joseph, Vijai, Berger, Andreas, Singer, Christian F., Rappaport, Christine, Kaulich, Daphne Geschwantler, Pfeiler, Georg, Tea, Muy-Kheng M., Phelan, Catherine M., Greene, Mark H., Mai, Phuong L., Rennert, Gad, Mulligan, Anna Marie, Glendon, Gord, Tchatchou, Sandrine, Andrulis, Irene L., Toland, Amanda Ewart, Bojesen, Anders, Pedersen, Inge Sokilde, Thomassen, Mads, Jensen, Uffe Birk, Laitman, Yael, Rantala, Johanna, von Wachenfeldt, Anna, Ehrencrona, Hans, Askmalm, Marie Stenmark, Borg, Åke, Kuchenbaecker, Karoline B., McGuffog, Lesley, Barrowdale, Daniel, Healey, Sue, Lee, Andrew, Pharoah, Paul D.P., Chenevix-Trench, Georgia, Antoniou, Antonis C., Friedman, Eitan, Cancer Epidemiology, Biomarkers & Prevention, Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers, Oncology, Epidemiology
title Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
title_full Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
title_fullStr Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
title_full_unstemmed Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
title_short Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
title_sort candidate genetic modifiers for breast and ovarian cancer risk in <i>brca1</i> and <i>brca2</i> mutation carriers
title_unstemmed Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
topic Oncology, Epidemiology
url http://dx.doi.org/10.1158/1055-9965.epi-14-0532