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The Association of Gastric Cancer Risk with Plasma Folate, Cobalamin, and Methylenetetrahydrofolate Reductase Polymorphisms in the European Prospective Investigation into Cancer an...
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| Zeitschriftentitel: | Cancer Epidemiology, Biomarkers & Prevention |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| In: | Cancer Epidemiology, Biomarkers & Prevention, 16, 2007, 11, S. 2416-2424 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Association for Cancer Research (AACR)
|
| Schlagwörter: |
| author_facet |
Vollset, Stein Emil Igland, Jannicke Jenab, Mazda Fredriksen, Åse Meyer, Klaus Eussen, Simone Gjessing, Håkon K. Ueland, Per Magne Pera, Guillem Sala, Núria Agudo, Antonio Capella, Gabriel Del Giudice, Giuseppe Palli, Domenico Boeing, Heiner Weikert, Cornelia Bueno-de-Mesquita, H. Bas Carneiro, Fátima Pala, Valeria Vineis, Paolo Tumino, Rosario Panico, Salvatore Berglund, Göran Manjer, Jonas Stenling, Roger Hallmans, Göran Martínez, Carmen Dorronsoro, Miren Barricarte, Aurelio Navarro, Carmen Quirós, José R. Allen, Naomi Key, Timothy J. Bingham, Sheila Linseisen, Jakob Kaaks, Rudolf Overvad, Kim Tjønneland, Anne Büchner, Frederike L. Peeters, Petra H.M. Numans, Mattijs E. Clavel-Chapelon, Françoise Boutron-Ruault, Marie-Christine Trichopoulou, Antonia Lund, Eiliv Slimani, Nadia Ferrari, Pietro Riboli, Elio González, Carlos A. Vollset, Stein Emil Igland, Jannicke Jenab, Mazda Fredriksen, Åse Meyer, Klaus Eussen, Simone Gjessing, Håkon K. Ueland, Per Magne Pera, Guillem Sala, Núria Agudo, Antonio Capella, Gabriel Del Giudice, Giuseppe Palli, Domenico Boeing, Heiner Weikert, Cornelia Bueno-de-Mesquita, H. Bas Carneiro, Fátima Pala, Valeria Vineis, Paolo Tumino, Rosario Panico, Salvatore Berglund, Göran Manjer, Jonas Stenling, Roger Hallmans, Göran Martínez, Carmen Dorronsoro, Miren Barricarte, Aurelio Navarro, Carmen Quirós, José R. Allen, Naomi Key, Timothy J. Bingham, Sheila Linseisen, Jakob Kaaks, Rudolf Overvad, Kim Tjønneland, Anne Büchner, Frederike L. Peeters, Petra H.M. Numans, Mattijs E. Clavel-Chapelon, Françoise Boutron-Ruault, Marie-Christine Trichopoulou, Antonia Lund, Eiliv Slimani, Nadia Ferrari, Pietro Riboli, Elio González, Carlos A. |
|---|---|
| author |
Vollset, Stein Emil Igland, Jannicke Jenab, Mazda Fredriksen, Åse Meyer, Klaus Eussen, Simone Gjessing, Håkon K. Ueland, Per Magne Pera, Guillem Sala, Núria Agudo, Antonio Capella, Gabriel Del Giudice, Giuseppe Palli, Domenico Boeing, Heiner Weikert, Cornelia Bueno-de-Mesquita, H. Bas Carneiro, Fátima Pala, Valeria Vineis, Paolo Tumino, Rosario Panico, Salvatore Berglund, Göran Manjer, Jonas Stenling, Roger Hallmans, Göran Martínez, Carmen Dorronsoro, Miren Barricarte, Aurelio Navarro, Carmen Quirós, José R. Allen, Naomi Key, Timothy J. Bingham, Sheila Linseisen, Jakob Kaaks, Rudolf Overvad, Kim Tjønneland, Anne Büchner, Frederike L. Peeters, Petra H.M. Numans, Mattijs E. Clavel-Chapelon, Françoise Boutron-Ruault, Marie-Christine Trichopoulou, Antonia Lund, Eiliv Slimani, Nadia Ferrari, Pietro Riboli, Elio González, Carlos A. |
| spellingShingle |
Vollset, Stein Emil Igland, Jannicke Jenab, Mazda Fredriksen, Åse Meyer, Klaus Eussen, Simone Gjessing, Håkon K. Ueland, Per Magne Pera, Guillem Sala, Núria Agudo, Antonio Capella, Gabriel Del Giudice, Giuseppe Palli, Domenico Boeing, Heiner Weikert, Cornelia Bueno-de-Mesquita, H. Bas Carneiro, Fátima Pala, Valeria Vineis, Paolo Tumino, Rosario Panico, Salvatore Berglund, Göran Manjer, Jonas Stenling, Roger Hallmans, Göran Martínez, Carmen Dorronsoro, Miren Barricarte, Aurelio Navarro, Carmen Quirós, José R. Allen, Naomi Key, Timothy J. Bingham, Sheila Linseisen, Jakob Kaaks, Rudolf Overvad, Kim Tjønneland, Anne Büchner, Frederike L. Peeters, Petra H.M. Numans, Mattijs E. Clavel-Chapelon, Françoise Boutron-Ruault, Marie-Christine Trichopoulou, Antonia Lund, Eiliv Slimani, Nadia Ferrari, Pietro Riboli, Elio González, Carlos A. Cancer Epidemiology, Biomarkers & Prevention The Association of Gastric Cancer Risk with Plasma Folate, Cobalamin, and Methylenetetrahydrofolate Reductase Polymorphisms in the European Prospective Investigation into Cancer and Nutrition Oncology Epidemiology |
| author_sort |
vollset, stein emil |
| spelling |
Vollset, Stein Emil Igland, Jannicke Jenab, Mazda Fredriksen, Åse Meyer, Klaus Eussen, Simone Gjessing, Håkon K. Ueland, Per Magne Pera, Guillem Sala, Núria Agudo, Antonio Capella, Gabriel Del Giudice, Giuseppe Palli, Domenico Boeing, Heiner Weikert, Cornelia Bueno-de-Mesquita, H. Bas Carneiro, Fátima Pala, Valeria Vineis, Paolo Tumino, Rosario Panico, Salvatore Berglund, Göran Manjer, Jonas Stenling, Roger Hallmans, Göran Martínez, Carmen Dorronsoro, Miren Barricarte, Aurelio Navarro, Carmen Quirós, José R. Allen, Naomi Key, Timothy J. Bingham, Sheila Linseisen, Jakob Kaaks, Rudolf Overvad, Kim Tjønneland, Anne Büchner, Frederike L. Peeters, Petra H.M. Numans, Mattijs E. Clavel-Chapelon, Françoise Boutron-Ruault, Marie-Christine Trichopoulou, Antonia Lund, Eiliv Slimani, Nadia Ferrari, Pietro Riboli, Elio González, Carlos A. 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-07-0256 <jats:title>Abstract</jats:title> <jats:p>Previous studies have shown inconsistent associations of folate intake and polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene with gastric cancer risk. Our nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort is the first prospective study of blood folate levels and gastric cancer. Gastric cancer cases (n = 247) and controls (n = 631) were matched for study center, age, sex, and time of blood donation. Two common single nucleotide polymorphisms of the MTHFR gene were determined, as were plasma concentrations of folate, cobalamin (vitamin B12), total homocysteine, and methylmalonic acid (cobalamin deficiency marker) in prediagnostic plasma. Risk measures were calculated with conditional logistic regression. Although no relations were observed between plasma folate or total homocysteine concentrations and gastric cancer, we observed a trend toward lower risk of gastric cancer with increasing cobalamin concentrations (odds ratio, 0.79 per SD increase in cobalamin; P = 0.01). Further analyses showed that the inverse association between cobalamin and gastric cancer was confined to cancer cases with low pepsinogen A levels (marker of severe chronic atrophic gastritis) at the time of blood sampling. The 677 C→T MTHFR polymorphism was not associated with gastric cancer, but we observed an increased risk with the variant genotype of the 1298 A→C polymorphism (odds ratio, 1.47 for CC versus AA; P = 0.04). In conclusion, we found no evidence of a role of folate in gastric cancer etiology. However, we observed increased gastric cancer risk at low cobalamin levels that was most likely due to compromised cobalamin status in atrophic gastritis preceding gastric cancer. (Cancer Epidemiol Biomarkers Prev 2007;16(11):2416–24)</jats:p> The Association of Gastric Cancer Risk with Plasma Folate, Cobalamin, and <i>Methylenetetrahydrofolate Reductase</i> Polymorphisms in the European Prospective Investigation into Cancer and Nutrition Cancer Epidemiology, Biomarkers & Prevention |
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| title |
The Association of Gastric Cancer Risk with Plasma Folate, Cobalamin, and Methylenetetrahydrofolate Reductase Polymorphisms in the European Prospective Investigation into Cancer and Nutrition |
| title_unstemmed |
The Association of Gastric Cancer Risk with Plasma Folate, Cobalamin, and Methylenetetrahydrofolate Reductase Polymorphisms in the European Prospective Investigation into Cancer and Nutrition |
| title_full |
The Association of Gastric Cancer Risk with Plasma Folate, Cobalamin, and Methylenetetrahydrofolate Reductase Polymorphisms in the European Prospective Investigation into Cancer and Nutrition |
| title_fullStr |
The Association of Gastric Cancer Risk with Plasma Folate, Cobalamin, and Methylenetetrahydrofolate Reductase Polymorphisms in the European Prospective Investigation into Cancer and Nutrition |
| title_full_unstemmed |
The Association of Gastric Cancer Risk with Plasma Folate, Cobalamin, and Methylenetetrahydrofolate Reductase Polymorphisms in the European Prospective Investigation into Cancer and Nutrition |
| title_short |
The Association of Gastric Cancer Risk with Plasma Folate, Cobalamin, and Methylenetetrahydrofolate Reductase Polymorphisms in the European Prospective Investigation into Cancer and Nutrition |
| title_sort |
the association of gastric cancer risk with plasma folate, cobalamin, and <i>methylenetetrahydrofolate reductase</i> polymorphisms in the european prospective investigation into cancer and nutrition |
| topic |
Oncology Epidemiology |
| url |
http://dx.doi.org/10.1158/1055-9965.epi-07-0256 |
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2007 |
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2416-2424 |
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<jats:title>Abstract</jats:title>
<jats:p>Previous studies have shown inconsistent associations of folate intake and polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene with gastric cancer risk. Our nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort is the first prospective study of blood folate levels and gastric cancer. Gastric cancer cases (n = 247) and controls (n = 631) were matched for study center, age, sex, and time of blood donation. Two common single nucleotide polymorphisms of the MTHFR gene were determined, as were plasma concentrations of folate, cobalamin (vitamin B12), total homocysteine, and methylmalonic acid (cobalamin deficiency marker) in prediagnostic plasma. Risk measures were calculated with conditional logistic regression. Although no relations were observed between plasma folate or total homocysteine concentrations and gastric cancer, we observed a trend toward lower risk of gastric cancer with increasing cobalamin concentrations (odds ratio, 0.79 per SD increase in cobalamin; P = 0.01). Further analyses showed that the inverse association between cobalamin and gastric cancer was confined to cancer cases with low pepsinogen A levels (marker of severe chronic atrophic gastritis) at the time of blood sampling. The 677 C→T MTHFR polymorphism was not associated with gastric cancer, but we observed an increased risk with the variant genotype of the 1298 A→C polymorphism (odds ratio, 1.47 for CC versus AA; P = 0.04). In conclusion, we found no evidence of a role of folate in gastric cancer etiology. However, we observed increased gastric cancer risk at low cobalamin levels that was most likely due to compromised cobalamin status in atrophic gastritis preceding gastric cancer. (Cancer Epidemiol Biomarkers Prev 2007;16(11):2416–24)</jats:p> |
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| author | Vollset, Stein Emil, Igland, Jannicke, Jenab, Mazda, Fredriksen, Åse, Meyer, Klaus, Eussen, Simone, Gjessing, Håkon K., Ueland, Per Magne, Pera, Guillem, Sala, Núria, Agudo, Antonio, Capella, Gabriel, Del Giudice, Giuseppe, Palli, Domenico, Boeing, Heiner, Weikert, Cornelia, Bueno-de-Mesquita, H. Bas, Carneiro, Fátima, Pala, Valeria, Vineis, Paolo, Tumino, Rosario, Panico, Salvatore, Berglund, Göran, Manjer, Jonas, Stenling, Roger, Hallmans, Göran, Martínez, Carmen, Dorronsoro, Miren, Barricarte, Aurelio, Navarro, Carmen, Quirós, José R., Allen, Naomi, Key, Timothy J., Bingham, Sheila, Linseisen, Jakob, Kaaks, Rudolf, Overvad, Kim, Tjønneland, Anne, Büchner, Frederike L., Peeters, Petra H.M., Numans, Mattijs E., Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Trichopoulou, Antonia, Lund, Eiliv, Slimani, Nadia, Ferrari, Pietro, Riboli, Elio, González, Carlos A. |
| author_facet | Vollset, Stein Emil, Igland, Jannicke, Jenab, Mazda, Fredriksen, Åse, Meyer, Klaus, Eussen, Simone, Gjessing, Håkon K., Ueland, Per Magne, Pera, Guillem, Sala, Núria, Agudo, Antonio, Capella, Gabriel, Del Giudice, Giuseppe, Palli, Domenico, Boeing, Heiner, Weikert, Cornelia, Bueno-de-Mesquita, H. Bas, Carneiro, Fátima, Pala, Valeria, Vineis, Paolo, Tumino, Rosario, Panico, Salvatore, Berglund, Göran, Manjer, Jonas, Stenling, Roger, Hallmans, Göran, Martínez, Carmen, Dorronsoro, Miren, Barricarte, Aurelio, Navarro, Carmen, Quirós, José R., Allen, Naomi, Key, Timothy J., Bingham, Sheila, Linseisen, Jakob, Kaaks, Rudolf, Overvad, Kim, Tjønneland, Anne, Büchner, Frederike L., Peeters, Petra H.M., Numans, Mattijs E., Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Trichopoulou, Antonia, Lund, Eiliv, Slimani, Nadia, Ferrari, Pietro, Riboli, Elio, González, Carlos A., Vollset, Stein Emil, Igland, Jannicke, Jenab, Mazda, Fredriksen, Åse, Meyer, Klaus, Eussen, Simone, Gjessing, Håkon K., Ueland, Per Magne, Pera, Guillem, Sala, Núria, Agudo, Antonio, Capella, Gabriel, Del Giudice, Giuseppe, Palli, Domenico, Boeing, Heiner, Weikert, Cornelia, Bueno-de-Mesquita, H. Bas, Carneiro, Fátima, Pala, Valeria, Vineis, Paolo, Tumino, Rosario, Panico, Salvatore, Berglund, Göran, Manjer, Jonas, Stenling, Roger, Hallmans, Göran, Martínez, Carmen, Dorronsoro, Miren, Barricarte, Aurelio, Navarro, Carmen, Quirós, José R., Allen, Naomi, Key, Timothy J., Bingham, Sheila, Linseisen, Jakob, Kaaks, Rudolf, Overvad, Kim, Tjønneland, Anne, Büchner, Frederike L., Peeters, Petra H.M., Numans, Mattijs E., Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Trichopoulou, Antonia, Lund, Eiliv, Slimani, Nadia, Ferrari, Pietro, Riboli, Elio, González, Carlos A. |
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| description | <jats:title>Abstract</jats:title> <jats:p>Previous studies have shown inconsistent associations of folate intake and polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene with gastric cancer risk. Our nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort is the first prospective study of blood folate levels and gastric cancer. Gastric cancer cases (n = 247) and controls (n = 631) were matched for study center, age, sex, and time of blood donation. Two common single nucleotide polymorphisms of the MTHFR gene were determined, as were plasma concentrations of folate, cobalamin (vitamin B12), total homocysteine, and methylmalonic acid (cobalamin deficiency marker) in prediagnostic plasma. Risk measures were calculated with conditional logistic regression. Although no relations were observed between plasma folate or total homocysteine concentrations and gastric cancer, we observed a trend toward lower risk of gastric cancer with increasing cobalamin concentrations (odds ratio, 0.79 per SD increase in cobalamin; P = 0.01). Further analyses showed that the inverse association between cobalamin and gastric cancer was confined to cancer cases with low pepsinogen A levels (marker of severe chronic atrophic gastritis) at the time of blood sampling. The 677 C→T MTHFR polymorphism was not associated with gastric cancer, but we observed an increased risk with the variant genotype of the 1298 A→C polymorphism (odds ratio, 1.47 for CC versus AA; P = 0.04). In conclusion, we found no evidence of a role of folate in gastric cancer etiology. However, we observed increased gastric cancer risk at low cobalamin levels that was most likely due to compromised cobalamin status in atrophic gastritis preceding gastric cancer. (Cancer Epidemiol Biomarkers Prev 2007;16(11):2416–24)</jats:p> |
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| spelling | Vollset, Stein Emil Igland, Jannicke Jenab, Mazda Fredriksen, Åse Meyer, Klaus Eussen, Simone Gjessing, Håkon K. Ueland, Per Magne Pera, Guillem Sala, Núria Agudo, Antonio Capella, Gabriel Del Giudice, Giuseppe Palli, Domenico Boeing, Heiner Weikert, Cornelia Bueno-de-Mesquita, H. Bas Carneiro, Fátima Pala, Valeria Vineis, Paolo Tumino, Rosario Panico, Salvatore Berglund, Göran Manjer, Jonas Stenling, Roger Hallmans, Göran Martínez, Carmen Dorronsoro, Miren Barricarte, Aurelio Navarro, Carmen Quirós, José R. Allen, Naomi Key, Timothy J. Bingham, Sheila Linseisen, Jakob Kaaks, Rudolf Overvad, Kim Tjønneland, Anne Büchner, Frederike L. Peeters, Petra H.M. Numans, Mattijs E. Clavel-Chapelon, Françoise Boutron-Ruault, Marie-Christine Trichopoulou, Antonia Lund, Eiliv Slimani, Nadia Ferrari, Pietro Riboli, Elio González, Carlos A. 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-07-0256 <jats:title>Abstract</jats:title> <jats:p>Previous studies have shown inconsistent associations of folate intake and polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene with gastric cancer risk. Our nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort is the first prospective study of blood folate levels and gastric cancer. Gastric cancer cases (n = 247) and controls (n = 631) were matched for study center, age, sex, and time of blood donation. Two common single nucleotide polymorphisms of the MTHFR gene were determined, as were plasma concentrations of folate, cobalamin (vitamin B12), total homocysteine, and methylmalonic acid (cobalamin deficiency marker) in prediagnostic plasma. Risk measures were calculated with conditional logistic regression. Although no relations were observed between plasma folate or total homocysteine concentrations and gastric cancer, we observed a trend toward lower risk of gastric cancer with increasing cobalamin concentrations (odds ratio, 0.79 per SD increase in cobalamin; P = 0.01). Further analyses showed that the inverse association between cobalamin and gastric cancer was confined to cancer cases with low pepsinogen A levels (marker of severe chronic atrophic gastritis) at the time of blood sampling. The 677 C→T MTHFR polymorphism was not associated with gastric cancer, but we observed an increased risk with the variant genotype of the 1298 A→C polymorphism (odds ratio, 1.47 for CC versus AA; P = 0.04). In conclusion, we found no evidence of a role of folate in gastric cancer etiology. However, we observed increased gastric cancer risk at low cobalamin levels that was most likely due to compromised cobalamin status in atrophic gastritis preceding gastric cancer. (Cancer Epidemiol Biomarkers Prev 2007;16(11):2416–24)</jats:p> The Association of Gastric Cancer Risk with Plasma Folate, Cobalamin, and <i>Methylenetetrahydrofolate Reductase</i> Polymorphisms in the European Prospective Investigation into Cancer and Nutrition Cancer Epidemiology, Biomarkers & Prevention |
| spellingShingle | Vollset, Stein Emil, Igland, Jannicke, Jenab, Mazda, Fredriksen, Åse, Meyer, Klaus, Eussen, Simone, Gjessing, Håkon K., Ueland, Per Magne, Pera, Guillem, Sala, Núria, Agudo, Antonio, Capella, Gabriel, Del Giudice, Giuseppe, Palli, Domenico, Boeing, Heiner, Weikert, Cornelia, Bueno-de-Mesquita, H. Bas, Carneiro, Fátima, Pala, Valeria, Vineis, Paolo, Tumino, Rosario, Panico, Salvatore, Berglund, Göran, Manjer, Jonas, Stenling, Roger, Hallmans, Göran, Martínez, Carmen, Dorronsoro, Miren, Barricarte, Aurelio, Navarro, Carmen, Quirós, José R., Allen, Naomi, Key, Timothy J., Bingham, Sheila, Linseisen, Jakob, Kaaks, Rudolf, Overvad, Kim, Tjønneland, Anne, Büchner, Frederike L., Peeters, Petra H.M., Numans, Mattijs E., Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Trichopoulou, Antonia, Lund, Eiliv, Slimani, Nadia, Ferrari, Pietro, Riboli, Elio, González, Carlos A., Cancer Epidemiology, Biomarkers & Prevention, The Association of Gastric Cancer Risk with Plasma Folate, Cobalamin, and Methylenetetrahydrofolate Reductase Polymorphisms in the European Prospective Investigation into Cancer and Nutrition, Oncology, Epidemiology |
| title | The Association of Gastric Cancer Risk with Plasma Folate, Cobalamin, and Methylenetetrahydrofolate Reductase Polymorphisms in the European Prospective Investigation into Cancer and Nutrition |
| title_full | The Association of Gastric Cancer Risk with Plasma Folate, Cobalamin, and Methylenetetrahydrofolate Reductase Polymorphisms in the European Prospective Investigation into Cancer and Nutrition |
| title_fullStr | The Association of Gastric Cancer Risk with Plasma Folate, Cobalamin, and Methylenetetrahydrofolate Reductase Polymorphisms in the European Prospective Investigation into Cancer and Nutrition |
| title_full_unstemmed | The Association of Gastric Cancer Risk with Plasma Folate, Cobalamin, and Methylenetetrahydrofolate Reductase Polymorphisms in the European Prospective Investigation into Cancer and Nutrition |
| title_short | The Association of Gastric Cancer Risk with Plasma Folate, Cobalamin, and Methylenetetrahydrofolate Reductase Polymorphisms in the European Prospective Investigation into Cancer and Nutrition |
| title_sort | the association of gastric cancer risk with plasma folate, cobalamin, and <i>methylenetetrahydrofolate reductase</i> polymorphisms in the european prospective investigation into cancer and nutrition |
| title_unstemmed | The Association of Gastric Cancer Risk with Plasma Folate, Cobalamin, and Methylenetetrahydrofolate Reductase Polymorphisms in the European Prospective Investigation into Cancer and Nutrition |
| topic | Oncology, Epidemiology |
| url | http://dx.doi.org/10.1158/1055-9965.epi-07-0256 |