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The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma
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| Zeitschriftentitel: | Cancer Research |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , |
| In: | Cancer Research, 78, 2018, 11, S. 2839-2851 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Association for Cancer Research (AACR)
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| Schlagwörter: |
| author_facet |
Qiu, Mantang Xia, Wenjia Chen, Rui Wang, Siwei Xu, Youtao Ma, Zhifei Xu, Weizhang Zhang, Erbao Wang, Jie Fang, Tian Hu, Jingwen Dong, Gaochao Yin, Rong Wang, Jun Xu, Lin Qiu, Mantang Xia, Wenjia Chen, Rui Wang, Siwei Xu, Youtao Ma, Zhifei Xu, Weizhang Zhang, Erbao Wang, Jie Fang, Tian Hu, Jingwen Dong, Gaochao Yin, Rong Wang, Jun Xu, Lin |
|---|---|
| author |
Qiu, Mantang Xia, Wenjia Chen, Rui Wang, Siwei Xu, Youtao Ma, Zhifei Xu, Weizhang Zhang, Erbao Wang, Jie Fang, Tian Hu, Jingwen Dong, Gaochao Yin, Rong Wang, Jun Xu, Lin |
| spellingShingle |
Qiu, Mantang Xia, Wenjia Chen, Rui Wang, Siwei Xu, Youtao Ma, Zhifei Xu, Weizhang Zhang, Erbao Wang, Jie Fang, Tian Hu, Jingwen Dong, Gaochao Yin, Rong Wang, Jun Xu, Lin Cancer Research The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma Cancer Research Oncology |
| author_sort |
qiu, mantang |
| spelling |
Qiu, Mantang Xia, Wenjia Chen, Rui Wang, Siwei Xu, Youtao Ma, Zhifei Xu, Weizhang Zhang, Erbao Wang, Jie Fang, Tian Hu, Jingwen Dong, Gaochao Yin, Rong Wang, Jun Xu, Lin 0008-5472 1538-7445 American Association for Cancer Research (AACR) Cancer Research Oncology http://dx.doi.org/10.1158/0008-5472.can-17-2808 <jats:title>Abstract</jats:title> <jats:p>Somatic copy number variations (CNV) may drive cancer progression through both coding and noncoding transcripts. However, noncoding transcripts resulting from CNV are largely unknown, especially for circular RNAs. By integrating bioinformatics analyses of alerted circRNAs and focal CNV in lung adenocarcinoma, we identify a proto-oncogenic circular RNA (circPRKCI) from the 3q26.2 amplicon, one of the most frequent genomic aberrations in multiple cancers. circPRKCI was overexpressed in lung adenocarcinoma tissues, in part due to amplification of the 3q26.2 locus, and promoted proliferation and tumorigenesis of lung adenocarcinoma. circPRKCI functioned as a sponge for both miR-545 and miR-589 and abrogated their suppression of the protumorigenic transcription factor E2F7. Intratumor injection of cholesterol-conjugated siRNA specifically targeting circPRKCI inhibited tumor growth in a patient-derived lung adenocarcinoma xenograft model. In summary, circPRKCI is crucial for tumorigenesis and may serve as a potential therapeutic target in patients with lung adenocarcinoma.</jats:p> <jats:p>Significance: These findings reveal high expression of the circular RNA circPRKCI drives lung adenocarcinoma tumorigenesis. Cancer Res; 78(11); 2839–51. ©2018 AACR.</jats:p> The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma Cancer Research |
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10.1158/0008-5472.can-17-2808 |
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American Association for Cancer Research (AACR), 2018 |
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American Association for Cancer Research (AACR), 2018 |
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0008-5472 1538-7445 |
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| title |
The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma |
| title_unstemmed |
The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma |
| title_full |
The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma |
| title_fullStr |
The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma |
| title_full_unstemmed |
The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma |
| title_short |
The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma |
| title_sort |
the circular rna circprkci promotes tumor growth in lung adenocarcinoma |
| topic |
Cancer Research Oncology |
| url |
http://dx.doi.org/10.1158/0008-5472.can-17-2808 |
| publishDate |
2018 |
| physical |
2839-2851 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>Somatic copy number variations (CNV) may drive cancer progression through both coding and noncoding transcripts. However, noncoding transcripts resulting from CNV are largely unknown, especially for circular RNAs. By integrating bioinformatics analyses of alerted circRNAs and focal CNV in lung adenocarcinoma, we identify a proto-oncogenic circular RNA (circPRKCI) from the 3q26.2 amplicon, one of the most frequent genomic aberrations in multiple cancers. circPRKCI was overexpressed in lung adenocarcinoma tissues, in part due to amplification of the 3q26.2 locus, and promoted proliferation and tumorigenesis of lung adenocarcinoma. circPRKCI functioned as a sponge for both miR-545 and miR-589 and abrogated their suppression of the protumorigenic transcription factor E2F7. Intratumor injection of cholesterol-conjugated siRNA specifically targeting circPRKCI inhibited tumor growth in a patient-derived lung adenocarcinoma xenograft model. In summary, circPRKCI is crucial for tumorigenesis and may serve as a potential therapeutic target in patients with lung adenocarcinoma.</jats:p>
<jats:p>Significance: These findings reveal high expression of the circular RNA circPRKCI drives lung adenocarcinoma tumorigenesis. Cancer Res; 78(11); 2839–51. ©2018 AACR.</jats:p> |
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| author | Qiu, Mantang, Xia, Wenjia, Chen, Rui, Wang, Siwei, Xu, Youtao, Ma, Zhifei, Xu, Weizhang, Zhang, Erbao, Wang, Jie, Fang, Tian, Hu, Jingwen, Dong, Gaochao, Yin, Rong, Wang, Jun, Xu, Lin |
| author_facet | Qiu, Mantang, Xia, Wenjia, Chen, Rui, Wang, Siwei, Xu, Youtao, Ma, Zhifei, Xu, Weizhang, Zhang, Erbao, Wang, Jie, Fang, Tian, Hu, Jingwen, Dong, Gaochao, Yin, Rong, Wang, Jun, Xu, Lin, Qiu, Mantang, Xia, Wenjia, Chen, Rui, Wang, Siwei, Xu, Youtao, Ma, Zhifei, Xu, Weizhang, Zhang, Erbao, Wang, Jie, Fang, Tian, Hu, Jingwen, Dong, Gaochao, Yin, Rong, Wang, Jun, Xu, Lin |
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| description | <jats:title>Abstract</jats:title> <jats:p>Somatic copy number variations (CNV) may drive cancer progression through both coding and noncoding transcripts. However, noncoding transcripts resulting from CNV are largely unknown, especially for circular RNAs. By integrating bioinformatics analyses of alerted circRNAs and focal CNV in lung adenocarcinoma, we identify a proto-oncogenic circular RNA (circPRKCI) from the 3q26.2 amplicon, one of the most frequent genomic aberrations in multiple cancers. circPRKCI was overexpressed in lung adenocarcinoma tissues, in part due to amplification of the 3q26.2 locus, and promoted proliferation and tumorigenesis of lung adenocarcinoma. circPRKCI functioned as a sponge for both miR-545 and miR-589 and abrogated their suppression of the protumorigenic transcription factor E2F7. Intratumor injection of cholesterol-conjugated siRNA specifically targeting circPRKCI inhibited tumor growth in a patient-derived lung adenocarcinoma xenograft model. In summary, circPRKCI is crucial for tumorigenesis and may serve as a potential therapeutic target in patients with lung adenocarcinoma.</jats:p> <jats:p>Significance: These findings reveal high expression of the circular RNA circPRKCI drives lung adenocarcinoma tumorigenesis. Cancer Res; 78(11); 2839–51. ©2018 AACR.</jats:p> |
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| spelling | Qiu, Mantang Xia, Wenjia Chen, Rui Wang, Siwei Xu, Youtao Ma, Zhifei Xu, Weizhang Zhang, Erbao Wang, Jie Fang, Tian Hu, Jingwen Dong, Gaochao Yin, Rong Wang, Jun Xu, Lin 0008-5472 1538-7445 American Association for Cancer Research (AACR) Cancer Research Oncology http://dx.doi.org/10.1158/0008-5472.can-17-2808 <jats:title>Abstract</jats:title> <jats:p>Somatic copy number variations (CNV) may drive cancer progression through both coding and noncoding transcripts. However, noncoding transcripts resulting from CNV are largely unknown, especially for circular RNAs. By integrating bioinformatics analyses of alerted circRNAs and focal CNV in lung adenocarcinoma, we identify a proto-oncogenic circular RNA (circPRKCI) from the 3q26.2 amplicon, one of the most frequent genomic aberrations in multiple cancers. circPRKCI was overexpressed in lung adenocarcinoma tissues, in part due to amplification of the 3q26.2 locus, and promoted proliferation and tumorigenesis of lung adenocarcinoma. circPRKCI functioned as a sponge for both miR-545 and miR-589 and abrogated their suppression of the protumorigenic transcription factor E2F7. Intratumor injection of cholesterol-conjugated siRNA specifically targeting circPRKCI inhibited tumor growth in a patient-derived lung adenocarcinoma xenograft model. In summary, circPRKCI is crucial for tumorigenesis and may serve as a potential therapeutic target in patients with lung adenocarcinoma.</jats:p> <jats:p>Significance: These findings reveal high expression of the circular RNA circPRKCI drives lung adenocarcinoma tumorigenesis. Cancer Res; 78(11); 2839–51. ©2018 AACR.</jats:p> The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma Cancer Research |
| spellingShingle | Qiu, Mantang, Xia, Wenjia, Chen, Rui, Wang, Siwei, Xu, Youtao, Ma, Zhifei, Xu, Weizhang, Zhang, Erbao, Wang, Jie, Fang, Tian, Hu, Jingwen, Dong, Gaochao, Yin, Rong, Wang, Jun, Xu, Lin, Cancer Research, The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma, Cancer Research, Oncology |
| title | The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma |
| title_full | The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma |
| title_fullStr | The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma |
| title_full_unstemmed | The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma |
| title_short | The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma |
| title_sort | the circular rna circprkci promotes tumor growth in lung adenocarcinoma |
| title_unstemmed | The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.1158/0008-5472.can-17-2808 |