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Contribution of Transcriptomics to Systems-Level Understanding of MethanogenicArchaea
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| Zeitschriftentitel: | Archaea |
|---|---|
| Personen und Körperschaften: | , |
| In: | Archaea, 2013, 2013, S. 1-11 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Hindawi Limited
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Browne, Patrick D. Cadillo-Quiroz, Hinsby Browne, Patrick D. Cadillo-Quiroz, Hinsby |
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Browne, Patrick D. Cadillo-Quiroz, Hinsby |
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Browne, Patrick D. Cadillo-Quiroz, Hinsby Archaea Contribution of Transcriptomics to Systems-Level Understanding of MethanogenicArchaea Ecology, Evolution, Behavior and Systematics Physiology Microbiology |
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browne, patrick d. |
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Browne, Patrick D. Cadillo-Quiroz, Hinsby 1472-3646 1472-3654 Hindawi Limited Ecology, Evolution, Behavior and Systematics Physiology Microbiology http://dx.doi.org/10.1155/2013/586369 <jats:p>Methane-producing<jats:italic>Archaea</jats:italic>are of interest due to their contribution to atmospheric change and for their roles in technological applications including waste treatment and biofuel production. Although restricted to anaerobic environments, methanogens are found in a wide variety of habitats, where they commonly live in syntrophic relationships with bacterial partners. Owing to tight thermodynamic constraints of methanogenesis alone or in syntrophic metabolism, methanogens must carefully regulate their catabolic pathways including the regulation of RNA transcripts. The transcriptome is a dynamic and important control point in microbial systems. This paper assesses the impact of mRNA (transcriptome) studies on the understanding of methanogenesis with special consideration given to how methanogenesis is regulated to cope with nutrient limitation, environmental variability, and interactions with syntrophic partners. In comparison with traditional microarray-based transcriptome analyses, next-generation high-throughput RNA sequencing is greatly advantageous in assessing transcription start sites, the extent of 5′ untranslated regions, operonic structure, and the presence of small RNAs. We are still in the early stages of understanding RNA regulation but it is already clear that determinants beyond transcript abundance are highly relevant to the lifestyles of methanogens, requiring further study.</jats:p> Contribution of Transcriptomics to Systems-Level Understanding of Methanogenic<i>Archaea</i> Archaea |
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Contribution of Transcriptomics to Systems-Level Understanding of MethanogenicArchaea |
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Contribution of Transcriptomics to Systems-Level Understanding of MethanogenicArchaea |
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Contribution of Transcriptomics to Systems-Level Understanding of MethanogenicArchaea |
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Contribution of Transcriptomics to Systems-Level Understanding of MethanogenicArchaea |
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Contribution of Transcriptomics to Systems-Level Understanding of MethanogenicArchaea |
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Contribution of Transcriptomics to Systems-Level Understanding of MethanogenicArchaea |
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contribution of transcriptomics to systems-level understanding of methanogenic<i>archaea</i> |
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Ecology, Evolution, Behavior and Systematics Physiology Microbiology |
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http://dx.doi.org/10.1155/2013/586369 |
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2013 |
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1-11 |
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<jats:p>Methane-producing<jats:italic>Archaea</jats:italic>are of interest due to their contribution to atmospheric change and for their roles in technological applications including waste treatment and biofuel production. Although restricted to anaerobic environments, methanogens are found in a wide variety of habitats, where they commonly live in syntrophic relationships with bacterial partners. Owing to tight thermodynamic constraints of methanogenesis alone or in syntrophic metabolism, methanogens must carefully regulate their catabolic pathways including the regulation of RNA transcripts. The transcriptome is a dynamic and important control point in microbial systems. This paper assesses the impact of mRNA (transcriptome) studies on the understanding of methanogenesis with special consideration given to how methanogenesis is regulated to cope with nutrient limitation, environmental variability, and interactions with syntrophic partners. In comparison with traditional microarray-based transcriptome analyses, next-generation high-throughput RNA sequencing is greatly advantageous in assessing transcription start sites, the extent of 5′ untranslated regions, operonic structure, and the presence of small RNAs. We are still in the early stages of understanding RNA regulation but it is already clear that determinants beyond transcript abundance are highly relevant to the lifestyles of methanogens, requiring further study.</jats:p> |
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| description | <jats:p>Methane-producing<jats:italic>Archaea</jats:italic>are of interest due to their contribution to atmospheric change and for their roles in technological applications including waste treatment and biofuel production. Although restricted to anaerobic environments, methanogens are found in a wide variety of habitats, where they commonly live in syntrophic relationships with bacterial partners. Owing to tight thermodynamic constraints of methanogenesis alone or in syntrophic metabolism, methanogens must carefully regulate their catabolic pathways including the regulation of RNA transcripts. The transcriptome is a dynamic and important control point in microbial systems. This paper assesses the impact of mRNA (transcriptome) studies on the understanding of methanogenesis with special consideration given to how methanogenesis is regulated to cope with nutrient limitation, environmental variability, and interactions with syntrophic partners. In comparison with traditional microarray-based transcriptome analyses, next-generation high-throughput RNA sequencing is greatly advantageous in assessing transcription start sites, the extent of 5′ untranslated regions, operonic structure, and the presence of small RNAs. We are still in the early stages of understanding RNA regulation but it is already clear that determinants beyond transcript abundance are highly relevant to the lifestyles of methanogens, requiring further study.</jats:p> |
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| spelling | Browne, Patrick D. Cadillo-Quiroz, Hinsby 1472-3646 1472-3654 Hindawi Limited Ecology, Evolution, Behavior and Systematics Physiology Microbiology http://dx.doi.org/10.1155/2013/586369 <jats:p>Methane-producing<jats:italic>Archaea</jats:italic>are of interest due to their contribution to atmospheric change and for their roles in technological applications including waste treatment and biofuel production. Although restricted to anaerobic environments, methanogens are found in a wide variety of habitats, where they commonly live in syntrophic relationships with bacterial partners. Owing to tight thermodynamic constraints of methanogenesis alone or in syntrophic metabolism, methanogens must carefully regulate their catabolic pathways including the regulation of RNA transcripts. The transcriptome is a dynamic and important control point in microbial systems. This paper assesses the impact of mRNA (transcriptome) studies on the understanding of methanogenesis with special consideration given to how methanogenesis is regulated to cope with nutrient limitation, environmental variability, and interactions with syntrophic partners. In comparison with traditional microarray-based transcriptome analyses, next-generation high-throughput RNA sequencing is greatly advantageous in assessing transcription start sites, the extent of 5′ untranslated regions, operonic structure, and the presence of small RNAs. We are still in the early stages of understanding RNA regulation but it is already clear that determinants beyond transcript abundance are highly relevant to the lifestyles of methanogens, requiring further study.</jats:p> Contribution of Transcriptomics to Systems-Level Understanding of Methanogenic<i>Archaea</i> Archaea |
| spellingShingle | Browne, Patrick D., Cadillo-Quiroz, Hinsby, Archaea, Contribution of Transcriptomics to Systems-Level Understanding of MethanogenicArchaea, Ecology, Evolution, Behavior and Systematics, Physiology, Microbiology |
| title | Contribution of Transcriptomics to Systems-Level Understanding of MethanogenicArchaea |
| title_full | Contribution of Transcriptomics to Systems-Level Understanding of MethanogenicArchaea |
| title_fullStr | Contribution of Transcriptomics to Systems-Level Understanding of MethanogenicArchaea |
| title_full_unstemmed | Contribution of Transcriptomics to Systems-Level Understanding of MethanogenicArchaea |
| title_short | Contribution of Transcriptomics to Systems-Level Understanding of MethanogenicArchaea |
| title_sort | contribution of transcriptomics to systems-level understanding of methanogenic<i>archaea</i> |
| title_unstemmed | Contribution of Transcriptomics to Systems-Level Understanding of MethanogenicArchaea |
| topic | Ecology, Evolution, Behavior and Systematics, Physiology, Microbiology |
| url | http://dx.doi.org/10.1155/2013/586369 |