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Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein KinaseIn VivoandIn Vitro
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| Zeitschriftentitel: | Evidence-Based Complementary and Alternative Medicine |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , |
| In: | Evidence-Based Complementary and Alternative Medicine, 2013, 2013, S. 1-14 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Hindawi Limited
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| Schlagwörter: |
| author_facet |
Feng, Qin Gou, Xiao-jun Meng, Sheng-xi Huang, Cheng Zhang, Yu-quan Tang, Ya-jun Wang, Wen-jing Xu, Lin Peng, Jing-hua Hu, Yi-yang Feng, Qin Gou, Xiao-jun Meng, Sheng-xi Huang, Cheng Zhang, Yu-quan Tang, Ya-jun Wang, Wen-jing Xu, Lin Peng, Jing-hua Hu, Yi-yang |
|---|---|
| author |
Feng, Qin Gou, Xiao-jun Meng, Sheng-xi Huang, Cheng Zhang, Yu-quan Tang, Ya-jun Wang, Wen-jing Xu, Lin Peng, Jing-hua Hu, Yi-yang |
| spellingShingle |
Feng, Qin Gou, Xiao-jun Meng, Sheng-xi Huang, Cheng Zhang, Yu-quan Tang, Ya-jun Wang, Wen-jing Xu, Lin Peng, Jing-hua Hu, Yi-yang Evidence-Based Complementary and Alternative Medicine Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein KinaseIn VivoandIn Vitro Complementary and alternative medicine |
| author_sort |
feng, qin |
| spelling |
Feng, Qin Gou, Xiao-jun Meng, Sheng-xi Huang, Cheng Zhang, Yu-quan Tang, Ya-jun Wang, Wen-jing Xu, Lin Peng, Jing-hua Hu, Yi-yang 1741-427X 1741-4288 Hindawi Limited Complementary and alternative medicine http://dx.doi.org/10.1155/2013/184358 <jats:p>Qushi Huayu Decoction (QHD), a Chinese herbal formula, has been proven effective on alleviating nonalcoholic fatty liver disease (NAFLD) in human and rats. The present study was conducted to investigate whether QHD could inhibit hepatic lipid accumulation by activating AMP-activated protein kinase (AMPK)<jats:italic>in vivo</jats:italic>and<jats:italic>in vitro</jats:italic>. Nonalcoholic fatty liver (NAFL) model was duplicated with high-fat diet in rats and with free fatty acid (FFA) in L02 cells. In<jats:italic>in vivo</jats:italic>experimental condition, QHD significantly decreased the accumulation of fatty droplets in livers, lowered low-density lipoprotein cholesterol (LDL-c), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels in serum. Moreover, QHD supplementation reversed the HFD-induced decrease in the phosphorylation levels of AMPK and acetyl-CoA carboxylase (ACC) and decreased hepatic nuclear protein expression of sterol regulatory element-binding protein-1 (SREBP-1) and carbohydrate-responsive element-binding protein (ChREBP) in the liver. In<jats:italic>in vitro</jats:italic>, QHD-containing serum decreased the cellular TG content and alleviated the accumulation of fatty droplets in L02 cells. QHD supplementation reversed the FFA-induced decrease in the phosphorylation levels of AMPK and ACC and decreased the hepatic nuclear protein expression of SREBP-1 and ChREBP. Overall results suggest that QHD has significant effect on inhibiting hepatic lipid accumulation via AMPK pathway<jats:italic>in vivo</jats:italic>and<jats:italic>in vitro</jats:italic>.</jats:p> Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein Kinase<i>In Vivo</i>and<i>In Vitro</i> Evidence-Based Complementary and Alternative Medicine |
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10.1155/2013/184358 |
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Hindawi Limited, 2013 |
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Hindawi Limited, 2013 |
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1741-427X 1741-4288 |
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Evidence-Based Complementary and Alternative Medicine |
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| title |
Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein KinaseIn VivoandIn Vitro |
| title_unstemmed |
Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein KinaseIn VivoandIn Vitro |
| title_full |
Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein KinaseIn VivoandIn Vitro |
| title_fullStr |
Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein KinaseIn VivoandIn Vitro |
| title_full_unstemmed |
Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein KinaseIn VivoandIn Vitro |
| title_short |
Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein KinaseIn VivoandIn Vitro |
| title_sort |
qushi huayu decoction inhibits hepatic lipid accumulation by activating amp-activated protein kinase<i>in vivo</i>and<i>in vitro</i> |
| topic |
Complementary and alternative medicine |
| url |
http://dx.doi.org/10.1155/2013/184358 |
| publishDate |
2013 |
| physical |
1-14 |
| description |
<jats:p>Qushi Huayu Decoction (QHD), a Chinese herbal formula, has been proven effective on alleviating nonalcoholic fatty liver disease (NAFLD) in human and rats. The present study was conducted to investigate whether QHD could inhibit hepatic lipid accumulation by activating AMP-activated protein kinase (AMPK)<jats:italic>in vivo</jats:italic>and<jats:italic>in vitro</jats:italic>. Nonalcoholic fatty liver (NAFL) model was duplicated with high-fat diet in rats and with free fatty acid (FFA) in L02 cells. In<jats:italic>in vivo</jats:italic>experimental condition, QHD significantly decreased the accumulation of fatty droplets in livers, lowered low-density lipoprotein cholesterol (LDL-c), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels in serum. Moreover, QHD supplementation reversed the HFD-induced decrease in the phosphorylation levels of AMPK and acetyl-CoA carboxylase (ACC) and decreased hepatic nuclear protein expression of sterol regulatory element-binding protein-1 (SREBP-1) and carbohydrate-responsive element-binding protein (ChREBP) in the liver. In<jats:italic>in vitro</jats:italic>, QHD-containing serum decreased the cellular TG content and alleviated the accumulation of fatty droplets in L02 cells. QHD supplementation reversed the FFA-induced decrease in the phosphorylation levels of AMPK and ACC and decreased the hepatic nuclear protein expression of SREBP-1 and ChREBP. Overall results suggest that QHD has significant effect on inhibiting hepatic lipid accumulation via AMPK pathway<jats:italic>in vivo</jats:italic>and<jats:italic>in vitro</jats:italic>.</jats:p> |
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| author | Feng, Qin, Gou, Xiao-jun, Meng, Sheng-xi, Huang, Cheng, Zhang, Yu-quan, Tang, Ya-jun, Wang, Wen-jing, Xu, Lin, Peng, Jing-hua, Hu, Yi-yang |
| author_facet | Feng, Qin, Gou, Xiao-jun, Meng, Sheng-xi, Huang, Cheng, Zhang, Yu-quan, Tang, Ya-jun, Wang, Wen-jing, Xu, Lin, Peng, Jing-hua, Hu, Yi-yang, Feng, Qin, Gou, Xiao-jun, Meng, Sheng-xi, Huang, Cheng, Zhang, Yu-quan, Tang, Ya-jun, Wang, Wen-jing, Xu, Lin, Peng, Jing-hua, Hu, Yi-yang |
| author_sort | feng, qin |
| container_start_page | 1 |
| container_title | Evidence-Based Complementary and Alternative Medicine |
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| description | <jats:p>Qushi Huayu Decoction (QHD), a Chinese herbal formula, has been proven effective on alleviating nonalcoholic fatty liver disease (NAFLD) in human and rats. The present study was conducted to investigate whether QHD could inhibit hepatic lipid accumulation by activating AMP-activated protein kinase (AMPK)<jats:italic>in vivo</jats:italic>and<jats:italic>in vitro</jats:italic>. Nonalcoholic fatty liver (NAFL) model was duplicated with high-fat diet in rats and with free fatty acid (FFA) in L02 cells. In<jats:italic>in vivo</jats:italic>experimental condition, QHD significantly decreased the accumulation of fatty droplets in livers, lowered low-density lipoprotein cholesterol (LDL-c), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels in serum. Moreover, QHD supplementation reversed the HFD-induced decrease in the phosphorylation levels of AMPK and acetyl-CoA carboxylase (ACC) and decreased hepatic nuclear protein expression of sterol regulatory element-binding protein-1 (SREBP-1) and carbohydrate-responsive element-binding protein (ChREBP) in the liver. In<jats:italic>in vitro</jats:italic>, QHD-containing serum decreased the cellular TG content and alleviated the accumulation of fatty droplets in L02 cells. QHD supplementation reversed the FFA-induced decrease in the phosphorylation levels of AMPK and ACC and decreased the hepatic nuclear protein expression of SREBP-1 and ChREBP. Overall results suggest that QHD has significant effect on inhibiting hepatic lipid accumulation via AMPK pathway<jats:italic>in vivo</jats:italic>and<jats:italic>in vitro</jats:italic>.</jats:p> |
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| institution | DE-Pl11, DE-Rs1, DE-14, DE-105, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Zi4, DE-Gla1, DE-15 |
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| series | Evidence-Based Complementary and Alternative Medicine |
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| spelling | Feng, Qin Gou, Xiao-jun Meng, Sheng-xi Huang, Cheng Zhang, Yu-quan Tang, Ya-jun Wang, Wen-jing Xu, Lin Peng, Jing-hua Hu, Yi-yang 1741-427X 1741-4288 Hindawi Limited Complementary and alternative medicine http://dx.doi.org/10.1155/2013/184358 <jats:p>Qushi Huayu Decoction (QHD), a Chinese herbal formula, has been proven effective on alleviating nonalcoholic fatty liver disease (NAFLD) in human and rats. The present study was conducted to investigate whether QHD could inhibit hepatic lipid accumulation by activating AMP-activated protein kinase (AMPK)<jats:italic>in vivo</jats:italic>and<jats:italic>in vitro</jats:italic>. Nonalcoholic fatty liver (NAFL) model was duplicated with high-fat diet in rats and with free fatty acid (FFA) in L02 cells. In<jats:italic>in vivo</jats:italic>experimental condition, QHD significantly decreased the accumulation of fatty droplets in livers, lowered low-density lipoprotein cholesterol (LDL-c), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels in serum. Moreover, QHD supplementation reversed the HFD-induced decrease in the phosphorylation levels of AMPK and acetyl-CoA carboxylase (ACC) and decreased hepatic nuclear protein expression of sterol regulatory element-binding protein-1 (SREBP-1) and carbohydrate-responsive element-binding protein (ChREBP) in the liver. In<jats:italic>in vitro</jats:italic>, QHD-containing serum decreased the cellular TG content and alleviated the accumulation of fatty droplets in L02 cells. QHD supplementation reversed the FFA-induced decrease in the phosphorylation levels of AMPK and ACC and decreased the hepatic nuclear protein expression of SREBP-1 and ChREBP. Overall results suggest that QHD has significant effect on inhibiting hepatic lipid accumulation via AMPK pathway<jats:italic>in vivo</jats:italic>and<jats:italic>in vitro</jats:italic>.</jats:p> Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein Kinase<i>In Vivo</i>and<i>In Vitro</i> Evidence-Based Complementary and Alternative Medicine |
| spellingShingle | Feng, Qin, Gou, Xiao-jun, Meng, Sheng-xi, Huang, Cheng, Zhang, Yu-quan, Tang, Ya-jun, Wang, Wen-jing, Xu, Lin, Peng, Jing-hua, Hu, Yi-yang, Evidence-Based Complementary and Alternative Medicine, Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein KinaseIn VivoandIn Vitro, Complementary and alternative medicine |
| title | Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein KinaseIn VivoandIn Vitro |
| title_full | Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein KinaseIn VivoandIn Vitro |
| title_fullStr | Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein KinaseIn VivoandIn Vitro |
| title_full_unstemmed | Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein KinaseIn VivoandIn Vitro |
| title_short | Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein KinaseIn VivoandIn Vitro |
| title_sort | qushi huayu decoction inhibits hepatic lipid accumulation by activating amp-activated protein kinase<i>in vivo</i>and<i>in vitro</i> |
| title_unstemmed | Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein KinaseIn VivoandIn Vitro |
| topic | Complementary and alternative medicine |
| url | http://dx.doi.org/10.1155/2013/184358 |