Eintrag weiter verarbeiten
Effect of Complexation with Arabinogalactan on Pharmacokinetics of “Guest” Drugs in Rats: For Example, Warfarin
Gespeichert in:
| Zeitschriftentitel: | BioMed Research International |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | BioMed Research International, 2013, 2013, S. 1-4 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Hindawi Limited
|
| Schlagwörter: |
| author_facet |
Khvostov, Mikhail V. Chernonosov, Alexander A. Tolstikova, Tatjana G. Kasakin, Marat F. Fedorova, Olga S. Dushkin, Alexander V. Khvostov, Mikhail V. Chernonosov, Alexander A. Tolstikova, Tatjana G. Kasakin, Marat F. Fedorova, Olga S. Dushkin, Alexander V. |
|---|---|
| author |
Khvostov, Mikhail V. Chernonosov, Alexander A. Tolstikova, Tatjana G. Kasakin, Marat F. Fedorova, Olga S. Dushkin, Alexander V. |
| spellingShingle |
Khvostov, Mikhail V. Chernonosov, Alexander A. Tolstikova, Tatjana G. Kasakin, Marat F. Fedorova, Olga S. Dushkin, Alexander V. BioMed Research International Effect of Complexation with Arabinogalactan on Pharmacokinetics of “Guest” Drugs in Rats: For Example, Warfarin General Immunology and Microbiology General Biochemistry, Genetics and Molecular Biology General Medicine |
| author_sort |
khvostov, mikhail v. |
| spelling |
Khvostov, Mikhail V. Chernonosov, Alexander A. Tolstikova, Tatjana G. Kasakin, Marat F. Fedorova, Olga S. Dushkin, Alexander V. 2314-6133 2314-6141 Hindawi Limited General Immunology and Microbiology General Biochemistry, Genetics and Molecular Biology General Medicine http://dx.doi.org/10.1155/2013/156381 <jats:p>A pharmacokinetic study of the warfarin (WF) : arabinogalactan (AG) complex with the 1 : 10 mass ratio after its intragastric introduction to Wistar rats at a dose of 5 mg/kg (WF dose in the complex was 0.5 mg/kg) once a day for three days was conducted. It was found that<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mi>C</mml:mi><mml:mrow><mml:mtext>max</mml:mtext></mml:mrow></mml:msub></mml:mrow></mml:math>,<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:msub><mml:mrow><mml:mi>T</mml:mi></mml:mrow><mml:mrow><mml:mn mathvariant="normal">1</mml:mn><mml:mo>/</mml:mo><mml:mn mathvariant="normal">2</mml:mn></mml:mrow></mml:msub><mml:mi mathvariant="normal" /></mml:math>, and AUC of WF in the complex form were lower than after the introduction of blank WF at the same dose, but its elimination (Cl, MRT) was much faster. Significant accumulation (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M3"><mml:mrow><mml:msub><mml:mi>C</mml:mi><mml:mrow><mml:mtext>min</mml:mtext></mml:mrow></mml:msub></mml:mrow></mml:math>) and an abrupt increase in plasma concentration after the third introduction were observed for blank WF, whereas the complex showed a much more moderate increase in concentration at this point. However, despite obvious differences in pharmacokinetic parameters, the efficacies of both agents were virtually identical; the complex differed from blank WF by only 15%. This value is rather insignificant and does not impair its anticoagulant activity. Thus, we can conclude that introduction of the WF : AG complex is safe in terms of reduction of the bleeding risk and accumulation.</jats:p> Effect of Complexation with Arabinogalactan on Pharmacokinetics of “Guest” Drugs in Rats: For Example, Warfarin BioMed Research International |
| doi_str_mv |
10.1155/2013/156381 |
| facet_avail |
Online Free |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1NS8yMDEzLzE1NjM4MQ |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1NS8yMDEzLzE1NjM4MQ |
| institution |
DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 |
| imprint |
Hindawi Limited, 2013 |
| imprint_str_mv |
Hindawi Limited, 2013 |
| issn |
2314-6133 2314-6141 |
| issn_str_mv |
2314-6133 2314-6141 |
| language |
English |
| mega_collection |
Hindawi Limited (CrossRef) |
| match_str |
khvostov2013effectofcomplexationwitharabinogalactanonpharmacokineticsofguestdrugsinratsforexamplewarfarin |
| publishDateSort |
2013 |
| publisher |
Hindawi Limited |
| recordtype |
ai |
| record_format |
ai |
| series |
BioMed Research International |
| source_id |
49 |
| title |
Effect of Complexation with Arabinogalactan on Pharmacokinetics of “Guest” Drugs in Rats: For Example, Warfarin |
| title_unstemmed |
Effect of Complexation with Arabinogalactan on Pharmacokinetics of “Guest” Drugs in Rats: For Example, Warfarin |
| title_full |
Effect of Complexation with Arabinogalactan on Pharmacokinetics of “Guest” Drugs in Rats: For Example, Warfarin |
| title_fullStr |
Effect of Complexation with Arabinogalactan on Pharmacokinetics of “Guest” Drugs in Rats: For Example, Warfarin |
| title_full_unstemmed |
Effect of Complexation with Arabinogalactan on Pharmacokinetics of “Guest” Drugs in Rats: For Example, Warfarin |
| title_short |
Effect of Complexation with Arabinogalactan on Pharmacokinetics of “Guest” Drugs in Rats: For Example, Warfarin |
| title_sort |
effect of complexation with arabinogalactan on pharmacokinetics of “guest” drugs in rats: for example, warfarin |
| topic |
General Immunology and Microbiology General Biochemistry, Genetics and Molecular Biology General Medicine |
| url |
http://dx.doi.org/10.1155/2013/156381 |
| publishDate |
2013 |
| physical |
1-4 |
| description |
<jats:p>A pharmacokinetic study of the warfarin (WF) : arabinogalactan (AG) complex with the 1 : 10 mass ratio after its intragastric introduction to Wistar rats at a dose of 5 mg/kg (WF dose in the complex was 0.5 mg/kg) once a day for three days was conducted. It was found that<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mi>C</mml:mi><mml:mrow><mml:mtext>max</mml:mtext></mml:mrow></mml:msub></mml:mrow></mml:math>,<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:msub><mml:mrow><mml:mi>T</mml:mi></mml:mrow><mml:mrow><mml:mn mathvariant="normal">1</mml:mn><mml:mo>/</mml:mo><mml:mn mathvariant="normal">2</mml:mn></mml:mrow></mml:msub><mml:mi mathvariant="normal" /></mml:math>, and AUC of WF in the complex form were lower than after the introduction of blank WF at the same dose, but its elimination (Cl, MRT) was much faster. Significant accumulation (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M3"><mml:mrow><mml:msub><mml:mi>C</mml:mi><mml:mrow><mml:mtext>min</mml:mtext></mml:mrow></mml:msub></mml:mrow></mml:math>) and an abrupt increase in plasma concentration after the third introduction were observed for blank WF, whereas the complex showed a much more moderate increase in concentration at this point. However, despite obvious differences in pharmacokinetic parameters, the efficacies of both agents were virtually identical; the complex differed from blank WF by only 15%. This value is rather insignificant and does not impair its anticoagulant activity. Thus, we can conclude that introduction of the WF : AG complex is safe in terms of reduction of the bleeding risk and accumulation.</jats:p> |
| container_start_page |
1 |
| container_title |
BioMed Research International |
| container_volume |
2013 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792339735708958722 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T15:52:29.517Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Effect+of+Complexation+with+Arabinogalactan+on+Pharmacokinetics+of+%E2%80%9CGuest%E2%80%9D+Drugs+in+Rats%3A+For+Example%2C+Warfarin&rft.date=2013-01-01&genre=article&issn=2314-6141&volume=2013&spage=1&epage=4&pages=1-4&jtitle=BioMed+Research+International&atitle=Effect+of+Complexation+with+Arabinogalactan+on+Pharmacokinetics+of+%E2%80%9CGuest%E2%80%9D+Drugs+in+Rats%3A+For+Example%2C+Warfarin&aulast=Dushkin&aufirst=Alexander+V.&rft_id=info%3Adoi%2F10.1155%2F2013%2F156381&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792339735708958722 |
| author | Khvostov, Mikhail V., Chernonosov, Alexander A., Tolstikova, Tatjana G., Kasakin, Marat F., Fedorova, Olga S., Dushkin, Alexander V. |
| author_facet | Khvostov, Mikhail V., Chernonosov, Alexander A., Tolstikova, Tatjana G., Kasakin, Marat F., Fedorova, Olga S., Dushkin, Alexander V., Khvostov, Mikhail V., Chernonosov, Alexander A., Tolstikova, Tatjana G., Kasakin, Marat F., Fedorova, Olga S., Dushkin, Alexander V. |
| author_sort | khvostov, mikhail v. |
| container_start_page | 1 |
| container_title | BioMed Research International |
| container_volume | 2013 |
| description | <jats:p>A pharmacokinetic study of the warfarin (WF) : arabinogalactan (AG) complex with the 1 : 10 mass ratio after its intragastric introduction to Wistar rats at a dose of 5 mg/kg (WF dose in the complex was 0.5 mg/kg) once a day for three days was conducted. It was found that<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mi>C</mml:mi><mml:mrow><mml:mtext>max</mml:mtext></mml:mrow></mml:msub></mml:mrow></mml:math>,<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:msub><mml:mrow><mml:mi>T</mml:mi></mml:mrow><mml:mrow><mml:mn mathvariant="normal">1</mml:mn><mml:mo>/</mml:mo><mml:mn mathvariant="normal">2</mml:mn></mml:mrow></mml:msub><mml:mi mathvariant="normal" /></mml:math>, and AUC of WF in the complex form were lower than after the introduction of blank WF at the same dose, but its elimination (Cl, MRT) was much faster. Significant accumulation (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M3"><mml:mrow><mml:msub><mml:mi>C</mml:mi><mml:mrow><mml:mtext>min</mml:mtext></mml:mrow></mml:msub></mml:mrow></mml:math>) and an abrupt increase in plasma concentration after the third introduction were observed for blank WF, whereas the complex showed a much more moderate increase in concentration at this point. However, despite obvious differences in pharmacokinetic parameters, the efficacies of both agents were virtually identical; the complex differed from blank WF by only 15%. This value is rather insignificant and does not impair its anticoagulant activity. Thus, we can conclude that introduction of the WF : AG complex is safe in terms of reduction of the bleeding risk and accumulation.</jats:p> |
| doi_str_mv | 10.1155/2013/156381 |
| facet_avail | Online, Free |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1NS8yMDEzLzE1NjM4MQ |
| imprint | Hindawi Limited, 2013 |
| imprint_str_mv | Hindawi Limited, 2013 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
| issn | 2314-6133, 2314-6141 |
| issn_str_mv | 2314-6133, 2314-6141 |
| language | English |
| last_indexed | 2024-03-01T15:52:29.517Z |
| match_str | khvostov2013effectofcomplexationwitharabinogalactanonpharmacokineticsofguestdrugsinratsforexamplewarfarin |
| mega_collection | Hindawi Limited (CrossRef) |
| physical | 1-4 |
| publishDate | 2013 |
| publishDateSort | 2013 |
| publisher | Hindawi Limited |
| record_format | ai |
| recordtype | ai |
| series | BioMed Research International |
| source_id | 49 |
| spelling | Khvostov, Mikhail V. Chernonosov, Alexander A. Tolstikova, Tatjana G. Kasakin, Marat F. Fedorova, Olga S. Dushkin, Alexander V. 2314-6133 2314-6141 Hindawi Limited General Immunology and Microbiology General Biochemistry, Genetics and Molecular Biology General Medicine http://dx.doi.org/10.1155/2013/156381 <jats:p>A pharmacokinetic study of the warfarin (WF) : arabinogalactan (AG) complex with the 1 : 10 mass ratio after its intragastric introduction to Wistar rats at a dose of 5 mg/kg (WF dose in the complex was 0.5 mg/kg) once a day for three days was conducted. It was found that<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mi>C</mml:mi><mml:mrow><mml:mtext>max</mml:mtext></mml:mrow></mml:msub></mml:mrow></mml:math>,<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:msub><mml:mrow><mml:mi>T</mml:mi></mml:mrow><mml:mrow><mml:mn mathvariant="normal">1</mml:mn><mml:mo>/</mml:mo><mml:mn mathvariant="normal">2</mml:mn></mml:mrow></mml:msub><mml:mi mathvariant="normal" /></mml:math>, and AUC of WF in the complex form were lower than after the introduction of blank WF at the same dose, but its elimination (Cl, MRT) was much faster. Significant accumulation (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M3"><mml:mrow><mml:msub><mml:mi>C</mml:mi><mml:mrow><mml:mtext>min</mml:mtext></mml:mrow></mml:msub></mml:mrow></mml:math>) and an abrupt increase in plasma concentration after the third introduction were observed for blank WF, whereas the complex showed a much more moderate increase in concentration at this point. However, despite obvious differences in pharmacokinetic parameters, the efficacies of both agents were virtually identical; the complex differed from blank WF by only 15%. This value is rather insignificant and does not impair its anticoagulant activity. Thus, we can conclude that introduction of the WF : AG complex is safe in terms of reduction of the bleeding risk and accumulation.</jats:p> Effect of Complexation with Arabinogalactan on Pharmacokinetics of “Guest” Drugs in Rats: For Example, Warfarin BioMed Research International |
| spellingShingle | Khvostov, Mikhail V., Chernonosov, Alexander A., Tolstikova, Tatjana G., Kasakin, Marat F., Fedorova, Olga S., Dushkin, Alexander V., BioMed Research International, Effect of Complexation with Arabinogalactan on Pharmacokinetics of “Guest” Drugs in Rats: For Example, Warfarin, General Immunology and Microbiology, General Biochemistry, Genetics and Molecular Biology, General Medicine |
| title | Effect of Complexation with Arabinogalactan on Pharmacokinetics of “Guest” Drugs in Rats: For Example, Warfarin |
| title_full | Effect of Complexation with Arabinogalactan on Pharmacokinetics of “Guest” Drugs in Rats: For Example, Warfarin |
| title_fullStr | Effect of Complexation with Arabinogalactan on Pharmacokinetics of “Guest” Drugs in Rats: For Example, Warfarin |
| title_full_unstemmed | Effect of Complexation with Arabinogalactan on Pharmacokinetics of “Guest” Drugs in Rats: For Example, Warfarin |
| title_short | Effect of Complexation with Arabinogalactan on Pharmacokinetics of “Guest” Drugs in Rats: For Example, Warfarin |
| title_sort | effect of complexation with arabinogalactan on pharmacokinetics of “guest” drugs in rats: for example, warfarin |
| title_unstemmed | Effect of Complexation with Arabinogalactan on Pharmacokinetics of “Guest” Drugs in Rats: For Example, Warfarin |
| topic | General Immunology and Microbiology, General Biochemistry, Genetics and Molecular Biology, General Medicine |
| url | http://dx.doi.org/10.1155/2013/156381 |