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Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel
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| Zeitschriftentitel: | International Journal of Biomaterials |
|---|---|
| Personen und Körperschaften: | , , |
| In: | International Journal of Biomaterials, 2017, 2017, S. 1-7 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Hindawi Limited
|
| Schlagwörter: |
| author_facet |
Nguyen, Thi Lan Nguyen, Thi Hiep Nguyen, Dai Hai Nguyen, Thi Lan Nguyen, Thi Hiep Nguyen, Dai Hai |
|---|---|
| author |
Nguyen, Thi Lan Nguyen, Thi Hiep Nguyen, Dai Hai |
| spellingShingle |
Nguyen, Thi Lan Nguyen, Thi Hiep Nguyen, Dai Hai International Journal of Biomaterials Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel Biomedical Engineering Biomaterials |
| author_sort |
nguyen, thi lan |
| spelling |
Nguyen, Thi Lan Nguyen, Thi Hiep Nguyen, Dai Hai 1687-8787 1687-8795 Hindawi Limited Biomedical Engineering Biomaterials http://dx.doi.org/10.1155/2017/8234712 <jats:p>The formulation of a potential delivery system based on liposomes (Lips) formulated from soy lecithin (SL) for paclitaxel (PTX) was achieved (PTX-Lips). At first, PTX-Lips were prepared by thin film method using SL and cholesterol and then were characterized for their physiochemical properties (particle size, polydispersity index, zeta potential, and morphology). The results indicated that PTX-Lips were spherical in shape with a dynamic light scattering (DLS) particle size of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mn fontstyle="italic">131</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle="italic">30.5</mml:mn></mml:math> nm. Besides, PTX was efficiently encapsulated in Lips, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mn fontstyle="italic">94.5</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle="italic">3.2</mml:mn></mml:math>% for drug loading efficiency, and slowly released up to 96 h, compared with free PTX. More importantly, cell proliferation kit I (MTT) assay data showed that Lips were biocompatible nanocarriers, and in addition the incorporation of PTX into Lips has been proven successful in reducing the toxicity of PTX. As a result, development of Lips using SL may offer a stable delivery system and promising properties for loading and sustained release of PTX in cancer therapy.</jats:p> Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel International Journal of Biomaterials |
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International Journal of Biomaterials |
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| title |
Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel |
| title_unstemmed |
Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel |
| title_full |
Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel |
| title_fullStr |
Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel |
| title_full_unstemmed |
Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel |
| title_short |
Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel |
| title_sort |
development and in vitro evaluation of liposomes using soy lecithin to encapsulate paclitaxel |
| topic |
Biomedical Engineering Biomaterials |
| url |
http://dx.doi.org/10.1155/2017/8234712 |
| publishDate |
2017 |
| physical |
1-7 |
| description |
<jats:p>The formulation of a potential delivery system based on liposomes (Lips) formulated from soy lecithin (SL) for paclitaxel (PTX) was achieved (PTX-Lips). At first, PTX-Lips were prepared by thin film method using SL and cholesterol and then were characterized for their physiochemical properties (particle size, polydispersity index, zeta potential, and morphology). The results indicated that PTX-Lips were spherical in shape with a dynamic light scattering (DLS) particle size of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mn fontstyle="italic">131</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle="italic">30.5</mml:mn></mml:math> nm. Besides, PTX was efficiently encapsulated in Lips, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mn fontstyle="italic">94.5</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle="italic">3.2</mml:mn></mml:math>% for drug loading efficiency, and slowly released up to 96 h, compared with free PTX. More importantly, cell proliferation kit I (MTT) assay data showed that Lips were biocompatible nanocarriers, and in addition the incorporation of PTX into Lips has been proven successful in reducing the toxicity of PTX. As a result, development of Lips using SL may offer a stable delivery system and promising properties for loading and sustained release of PTX in cancer therapy.</jats:p> |
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| author | Nguyen, Thi Lan, Nguyen, Thi Hiep, Nguyen, Dai Hai |
| author_facet | Nguyen, Thi Lan, Nguyen, Thi Hiep, Nguyen, Dai Hai, Nguyen, Thi Lan, Nguyen, Thi Hiep, Nguyen, Dai Hai |
| author_sort | nguyen, thi lan |
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| container_title | International Journal of Biomaterials |
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| description | <jats:p>The formulation of a potential delivery system based on liposomes (Lips) formulated from soy lecithin (SL) for paclitaxel (PTX) was achieved (PTX-Lips). At first, PTX-Lips were prepared by thin film method using SL and cholesterol and then were characterized for their physiochemical properties (particle size, polydispersity index, zeta potential, and morphology). The results indicated that PTX-Lips were spherical in shape with a dynamic light scattering (DLS) particle size of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mn fontstyle="italic">131</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle="italic">30.5</mml:mn></mml:math> nm. Besides, PTX was efficiently encapsulated in Lips, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mn fontstyle="italic">94.5</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle="italic">3.2</mml:mn></mml:math>% for drug loading efficiency, and slowly released up to 96 h, compared with free PTX. More importantly, cell proliferation kit I (MTT) assay data showed that Lips were biocompatible nanocarriers, and in addition the incorporation of PTX into Lips has been proven successful in reducing the toxicity of PTX. As a result, development of Lips using SL may offer a stable delivery system and promising properties for loading and sustained release of PTX in cancer therapy.</jats:p> |
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| spelling | Nguyen, Thi Lan Nguyen, Thi Hiep Nguyen, Dai Hai 1687-8787 1687-8795 Hindawi Limited Biomedical Engineering Biomaterials http://dx.doi.org/10.1155/2017/8234712 <jats:p>The formulation of a potential delivery system based on liposomes (Lips) formulated from soy lecithin (SL) for paclitaxel (PTX) was achieved (PTX-Lips). At first, PTX-Lips were prepared by thin film method using SL and cholesterol and then were characterized for their physiochemical properties (particle size, polydispersity index, zeta potential, and morphology). The results indicated that PTX-Lips were spherical in shape with a dynamic light scattering (DLS) particle size of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mn fontstyle="italic">131</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle="italic">30.5</mml:mn></mml:math> nm. Besides, PTX was efficiently encapsulated in Lips, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mn fontstyle="italic">94.5</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle="italic">3.2</mml:mn></mml:math>% for drug loading efficiency, and slowly released up to 96 h, compared with free PTX. More importantly, cell proliferation kit I (MTT) assay data showed that Lips were biocompatible nanocarriers, and in addition the incorporation of PTX into Lips has been proven successful in reducing the toxicity of PTX. As a result, development of Lips using SL may offer a stable delivery system and promising properties for loading and sustained release of PTX in cancer therapy.</jats:p> Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel International Journal of Biomaterials |
| spellingShingle | Nguyen, Thi Lan, Nguyen, Thi Hiep, Nguyen, Dai Hai, International Journal of Biomaterials, Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel, Biomedical Engineering, Biomaterials |
| title | Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel |
| title_full | Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel |
| title_fullStr | Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel |
| title_full_unstemmed | Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel |
| title_short | Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel |
| title_sort | development and in vitro evaluation of liposomes using soy lecithin to encapsulate paclitaxel |
| title_unstemmed | Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel |
| topic | Biomedical Engineering, Biomaterials |
| url | http://dx.doi.org/10.1155/2017/8234712 |