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Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration
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| Zeitschriftentitel: | The Scientific World Journal |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | The Scientific World Journal, 2017, 2017, S. 1-25 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Hindawi Limited
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| Schlagwörter: |
| author_facet |
Ribeiro, José Carlos Viana Vieira, Rodrigo Silveira Melo, Iracema Matos Araújo, Vilana Maria Adriano Lima, Vilma Ribeiro, José Carlos Viana Vieira, Rodrigo Silveira Melo, Iracema Matos Araújo, Vilana Maria Adriano Lima, Vilma |
|---|---|
| author |
Ribeiro, José Carlos Viana Vieira, Rodrigo Silveira Melo, Iracema Matos Araújo, Vilana Maria Adriano Lima, Vilma |
| spellingShingle |
Ribeiro, José Carlos Viana Vieira, Rodrigo Silveira Melo, Iracema Matos Araújo, Vilana Maria Adriano Lima, Vilma The Scientific World Journal Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration General Environmental Science General Biochemistry, Genetics and Molecular Biology General Medicine |
| author_sort |
ribeiro, josé carlos viana |
| spelling |
Ribeiro, José Carlos Viana Vieira, Rodrigo Silveira Melo, Iracema Matos Araújo, Vilana Maria Adriano Lima, Vilma 2356-6140 1537-744X Hindawi Limited General Environmental Science General Biochemistry, Genetics and Molecular Biology General Medicine http://dx.doi.org/10.1155/2017/8639898 <jats:p>Chitosan is a naturally occurring polysaccharide obtained from chitin, present in abundance in the exoskeletons of crustaceans and insects. It has aroused great interest as a biomaterial for tissue engineering on account of its biocompatibility and biodegradation and its affinity for biomolecules. A significant number of research groups have investigated the application of chitosan as scaffolds for tissue regeneration. However, there is a wide variability in terms of physicochemical characteristics of chitosan used in some studies and its combinations with other biomaterials, making it difficult to compare results and standardize its properties. The current systematic review of literature on the use of chitosan for tissue regeneration consisted of a study of 478 articles in the PubMed database, which resulted, after applying inclusion criteria, in the selection of 61 catalogued, critically analysed works. The results demonstrated the effectiveness of chitosan-based biomaterials in 93.4% of the studies reviewed, whether or not combined with cells and growth factors, in the regeneration of various types of tissues in animals. However, the absence of clinical studies in humans, the inadequate experimental designs, and the lack of information concerning chitosan’s characteristics limit the reproducibility and relevance of studies and the clinical applicability of chitosan.</jats:p> Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration The Scientific World Journal |
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| title |
Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration |
| title_unstemmed |
Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration |
| title_full |
Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration |
| title_fullStr |
Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration |
| title_full_unstemmed |
Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration |
| title_short |
Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration |
| title_sort |
versatility of chitosan-based biomaterials and their use as scaffolds for tissue regeneration |
| topic |
General Environmental Science General Biochemistry, Genetics and Molecular Biology General Medicine |
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http://dx.doi.org/10.1155/2017/8639898 |
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2017 |
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1-25 |
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<jats:p>Chitosan is a naturally occurring polysaccharide obtained from chitin, present in abundance in the exoskeletons of crustaceans and insects. It has aroused great interest as a biomaterial for tissue engineering on account of its biocompatibility and biodegradation and its affinity for biomolecules. A significant number of research groups have investigated the application of chitosan as scaffolds for tissue regeneration. However, there is a wide variability in terms of physicochemical characteristics of chitosan used in some studies and its combinations with other biomaterials, making it difficult to compare results and standardize its properties. The current systematic review of literature on the use of chitosan for tissue regeneration consisted of a study of 478 articles in the PubMed database, which resulted, after applying inclusion criteria, in the selection of 61 catalogued, critically analysed works. The results demonstrated the effectiveness of chitosan-based biomaterials in 93.4% of the studies reviewed, whether or not combined with cells and growth factors, in the regeneration of various types of tissues in animals. However, the absence of clinical studies in humans, the inadequate experimental designs, and the lack of information concerning chitosan’s characteristics limit the reproducibility and relevance of studies and the clinical applicability of chitosan.</jats:p> |
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| description | <jats:p>Chitosan is a naturally occurring polysaccharide obtained from chitin, present in abundance in the exoskeletons of crustaceans and insects. It has aroused great interest as a biomaterial for tissue engineering on account of its biocompatibility and biodegradation and its affinity for biomolecules. A significant number of research groups have investigated the application of chitosan as scaffolds for tissue regeneration. However, there is a wide variability in terms of physicochemical characteristics of chitosan used in some studies and its combinations with other biomaterials, making it difficult to compare results and standardize its properties. The current systematic review of literature on the use of chitosan for tissue regeneration consisted of a study of 478 articles in the PubMed database, which resulted, after applying inclusion criteria, in the selection of 61 catalogued, critically analysed works. The results demonstrated the effectiveness of chitosan-based biomaterials in 93.4% of the studies reviewed, whether or not combined with cells and growth factors, in the regeneration of various types of tissues in animals. However, the absence of clinical studies in humans, the inadequate experimental designs, and the lack of information concerning chitosan’s characteristics limit the reproducibility and relevance of studies and the clinical applicability of chitosan.</jats:p> |
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| spelling | Ribeiro, José Carlos Viana Vieira, Rodrigo Silveira Melo, Iracema Matos Araújo, Vilana Maria Adriano Lima, Vilma 2356-6140 1537-744X Hindawi Limited General Environmental Science General Biochemistry, Genetics and Molecular Biology General Medicine http://dx.doi.org/10.1155/2017/8639898 <jats:p>Chitosan is a naturally occurring polysaccharide obtained from chitin, present in abundance in the exoskeletons of crustaceans and insects. It has aroused great interest as a biomaterial for tissue engineering on account of its biocompatibility and biodegradation and its affinity for biomolecules. A significant number of research groups have investigated the application of chitosan as scaffolds for tissue regeneration. However, there is a wide variability in terms of physicochemical characteristics of chitosan used in some studies and its combinations with other biomaterials, making it difficult to compare results and standardize its properties. The current systematic review of literature on the use of chitosan for tissue regeneration consisted of a study of 478 articles in the PubMed database, which resulted, after applying inclusion criteria, in the selection of 61 catalogued, critically analysed works. The results demonstrated the effectiveness of chitosan-based biomaterials in 93.4% of the studies reviewed, whether or not combined with cells and growth factors, in the regeneration of various types of tissues in animals. However, the absence of clinical studies in humans, the inadequate experimental designs, and the lack of information concerning chitosan’s characteristics limit the reproducibility and relevance of studies and the clinical applicability of chitosan.</jats:p> Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration The Scientific World Journal |
| spellingShingle | Ribeiro, José Carlos Viana, Vieira, Rodrigo Silveira, Melo, Iracema Matos, Araújo, Vilana Maria Adriano, Lima, Vilma, The Scientific World Journal, Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration, General Environmental Science, General Biochemistry, Genetics and Molecular Biology, General Medicine |
| title | Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration |
| title_full | Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration |
| title_fullStr | Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration |
| title_full_unstemmed | Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration |
| title_short | Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration |
| title_sort | versatility of chitosan-based biomaterials and their use as scaffolds for tissue regeneration |
| title_unstemmed | Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration |
| topic | General Environmental Science, General Biochemistry, Genetics and Molecular Biology, General Medicine |
| url | http://dx.doi.org/10.1155/2017/8639898 |