Eintrag weiter verarbeiten
Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris
Gespeichert in:
Zeitschriftentitel: | Mediators of Inflammation |
---|---|
Personen und Körperschaften: | , , , , , , , |
In: | Mediators of Inflammation, 2017, 2017, S. 1-9 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
Hindawi Limited
|
Schlagwörter: |
author_facet |
Timoteo, Rodolfo Pessato da Silva, Marcos Vinicius Miguel, Camila Botelho Silva, Djalma Alexandre Alves Catarino, Jonatas Da Silva Rodrigues Junior, Virmondes Sales-Campos, Helioswilton Freire Oliveira, Carlo Jose Timoteo, Rodolfo Pessato da Silva, Marcos Vinicius Miguel, Camila Botelho Silva, Djalma Alexandre Alves Catarino, Jonatas Da Silva Rodrigues Junior, Virmondes Sales-Campos, Helioswilton Freire Oliveira, Carlo Jose |
---|---|
author |
Timoteo, Rodolfo Pessato da Silva, Marcos Vinicius Miguel, Camila Botelho Silva, Djalma Alexandre Alves Catarino, Jonatas Da Silva Rodrigues Junior, Virmondes Sales-Campos, Helioswilton Freire Oliveira, Carlo Jose |
spellingShingle |
Timoteo, Rodolfo Pessato da Silva, Marcos Vinicius Miguel, Camila Botelho Silva, Djalma Alexandre Alves Catarino, Jonatas Da Silva Rodrigues Junior, Virmondes Sales-Campos, Helioswilton Freire Oliveira, Carlo Jose Mediators of Inflammation Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris Cell Biology Immunology |
author_sort |
timoteo, rodolfo pessato |
spelling |
Timoteo, Rodolfo Pessato da Silva, Marcos Vinicius Miguel, Camila Botelho Silva, Djalma Alexandre Alves Catarino, Jonatas Da Silva Rodrigues Junior, Virmondes Sales-Campos, Helioswilton Freire Oliveira, Carlo Jose 0962-9351 1466-1861 Hindawi Limited Cell Biology Immunology http://dx.doi.org/10.1155/2017/7151285 <jats:p>Pemphigus vulgaris (PV) is an autoimmune disease characterized by the presence of IgG autoantibodies against desmoglein-3. Despite the variety of findings, the chemokine and cytokine profiles that characterize the immune response in the disease are still poorly explored. Thus, 20 PV patients and 20 controls were grouped according to gender, ethnicity, place of residence, and clinical parameters of the disease. Then, the levels of chemokines and of Th1/Th2/Th17/Treg/Th9/Th22-related cytokines were assessed in the serum. PV patients had higher levels of inflammatory Th1/Th17 cytokines (IFN-<jats:italic>γ</jats:italic>, IL-17, and IL-23), as well as higher levels of CXCL8 and reduced levels of Th1/Th2-related chemokines (IP-10 and CCL11). However, no differences in the levels of IL-2, IL-6, TNF-<jats:italic>α</jats:italic>, IL-1<jats:italic>β</jats:italic>, IL-4, IL-9, IL-12, TGF-<jats:italic>β</jats:italic>, IL-33, MCP-1, RANTES, and MIP-1<jats:italic>α</jats:italic> were found between PV patients and their control counterparts. Furthermore, PV patients with skin lesions had higher serum levels of IL-6 and CXCL8 when compared to PV patients without lesions. Taken together, our findings describe the role of cytokines and chemokines associated with Th1/Th17 immune response in PV patients. Finally, these data are important for better understanding of the immune aspects that control disease outcome, and they may also provide important information about why patients develop autoantibodies against desmogleins.</jats:p> Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris Mediators of Inflammation |
doi_str_mv |
10.1155/2017/7151285 |
facet_avail |
Online Free |
finc_class_facet |
Biologie Medizin |
format |
ElectronicArticle |
fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1NS8yMDE3LzcxNTEyODU |
id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1NS8yMDE3LzcxNTEyODU |
institution |
DE-Gla1 DE-Zi4 DE-15 DE-Rs1 DE-Pl11 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 |
imprint |
Hindawi Limited, 2017 |
imprint_str_mv |
Hindawi Limited, 2017 |
issn |
0962-9351 1466-1861 |
issn_str_mv |
0962-9351 1466-1861 |
language |
English |
mega_collection |
Hindawi Limited (CrossRef) |
match_str |
timoteo2017th1th17relatedcytokinesandchemokinesandtheirimplicationsinthepathogenesisofpemphigusvulgaris |
publishDateSort |
2017 |
publisher |
Hindawi Limited |
recordtype |
ai |
record_format |
ai |
series |
Mediators of Inflammation |
source_id |
49 |
title |
Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris |
title_unstemmed |
Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris |
title_full |
Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris |
title_fullStr |
Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris |
title_full_unstemmed |
Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris |
title_short |
Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris |
title_sort |
th1/th17-related cytokines and chemokines and their implications in the pathogenesis of pemphigus vulgaris |
topic |
Cell Biology Immunology |
url |
http://dx.doi.org/10.1155/2017/7151285 |
publishDate |
2017 |
physical |
1-9 |
description |
<jats:p>Pemphigus vulgaris (PV) is an autoimmune disease characterized by the presence of IgG autoantibodies against desmoglein-3. Despite the variety of findings, the chemokine and cytokine profiles that characterize the immune response in the disease are still poorly explored. Thus, 20 PV patients and 20 controls were grouped according to gender, ethnicity, place of residence, and clinical parameters of the disease. Then, the levels of chemokines and of Th1/Th2/Th17/Treg/Th9/Th22-related cytokines were assessed in the serum. PV patients had higher levels of inflammatory Th1/Th17 cytokines (IFN-<jats:italic>γ</jats:italic>, IL-17, and IL-23), as well as higher levels of CXCL8 and reduced levels of Th1/Th2-related chemokines (IP-10 and CCL11). However, no differences in the levels of IL-2, IL-6, TNF-<jats:italic>α</jats:italic>, IL-1<jats:italic>β</jats:italic>, IL-4, IL-9, IL-12, TGF-<jats:italic>β</jats:italic>, IL-33, MCP-1, RANTES, and MIP-1<jats:italic>α</jats:italic> were found between PV patients and their control counterparts. Furthermore, PV patients with skin lesions had higher serum levels of IL-6 and CXCL8 when compared to PV patients without lesions. Taken together, our findings describe the role of cytokines and chemokines associated with Th1/Th17 immune response in PV patients. Finally, these data are important for better understanding of the immune aspects that control disease outcome, and they may also provide important information about why patients develop autoantibodies against desmogleins.</jats:p> |
container_start_page |
1 |
container_title |
Mediators of Inflammation |
container_volume |
2017 |
format_de105 |
Article, E-Article |
format_de14 |
Article, E-Article |
format_de15 |
Article, E-Article |
format_de520 |
Article, E-Article |
format_de540 |
Article, E-Article |
format_dech1 |
Article, E-Article |
format_ded117 |
Article, E-Article |
format_degla1 |
E-Article |
format_del152 |
Buch |
format_del189 |
Article, E-Article |
format_dezi4 |
Article |
format_dezwi2 |
Article, E-Article |
format_finc |
Article, E-Article |
format_nrw |
Article, E-Article |
_version_ |
1792342808067047431 |
geogr_code |
not assigned |
last_indexed |
2024-03-01T16:41:41.954Z |
geogr_code_person |
not assigned |
openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Th1%2FTh17-Related+Cytokines+and+Chemokines+and+Their+Implications+in+the+Pathogenesis+of+Pemphigus+Vulgaris&rft.date=2017-01-01&genre=article&issn=1466-1861&volume=2017&spage=1&epage=9&pages=1-9&jtitle=Mediators+of+Inflammation&atitle=Th1%2FTh17-Related+Cytokines+and+Chemokines+and+Their+Implications+in+the+Pathogenesis+of+Pemphigus+Vulgaris&aulast=Freire+Oliveira&aufirst=Carlo+Jose&rft_id=info%3Adoi%2F10.1155%2F2017%2F7151285&rft.language%5B0%5D=eng |
SOLR | |
_version_ | 1792342808067047431 |
author | Timoteo, Rodolfo Pessato, da Silva, Marcos Vinicius, Miguel, Camila Botelho, Silva, Djalma Alexandre Alves, Catarino, Jonatas Da Silva, Rodrigues Junior, Virmondes, Sales-Campos, Helioswilton, Freire Oliveira, Carlo Jose |
author_facet | Timoteo, Rodolfo Pessato, da Silva, Marcos Vinicius, Miguel, Camila Botelho, Silva, Djalma Alexandre Alves, Catarino, Jonatas Da Silva, Rodrigues Junior, Virmondes, Sales-Campos, Helioswilton, Freire Oliveira, Carlo Jose, Timoteo, Rodolfo Pessato, da Silva, Marcos Vinicius, Miguel, Camila Botelho, Silva, Djalma Alexandre Alves, Catarino, Jonatas Da Silva, Rodrigues Junior, Virmondes, Sales-Campos, Helioswilton, Freire Oliveira, Carlo Jose |
author_sort | timoteo, rodolfo pessato |
container_start_page | 1 |
container_title | Mediators of Inflammation |
container_volume | 2017 |
description | <jats:p>Pemphigus vulgaris (PV) is an autoimmune disease characterized by the presence of IgG autoantibodies against desmoglein-3. Despite the variety of findings, the chemokine and cytokine profiles that characterize the immune response in the disease are still poorly explored. Thus, 20 PV patients and 20 controls were grouped according to gender, ethnicity, place of residence, and clinical parameters of the disease. Then, the levels of chemokines and of Th1/Th2/Th17/Treg/Th9/Th22-related cytokines were assessed in the serum. PV patients had higher levels of inflammatory Th1/Th17 cytokines (IFN-<jats:italic>γ</jats:italic>, IL-17, and IL-23), as well as higher levels of CXCL8 and reduced levels of Th1/Th2-related chemokines (IP-10 and CCL11). However, no differences in the levels of IL-2, IL-6, TNF-<jats:italic>α</jats:italic>, IL-1<jats:italic>β</jats:italic>, IL-4, IL-9, IL-12, TGF-<jats:italic>β</jats:italic>, IL-33, MCP-1, RANTES, and MIP-1<jats:italic>α</jats:italic> were found between PV patients and their control counterparts. Furthermore, PV patients with skin lesions had higher serum levels of IL-6 and CXCL8 when compared to PV patients without lesions. Taken together, our findings describe the role of cytokines and chemokines associated with Th1/Th17 immune response in PV patients. Finally, these data are important for better understanding of the immune aspects that control disease outcome, and they may also provide important information about why patients develop autoantibodies against desmogleins.</jats:p> |
doi_str_mv | 10.1155/2017/7151285 |
facet_avail | Online, Free |
finc_class_facet | Biologie, Medizin |
format | ElectronicArticle |
format_de105 | Article, E-Article |
format_de14 | Article, E-Article |
format_de15 | Article, E-Article |
format_de520 | Article, E-Article |
format_de540 | Article, E-Article |
format_dech1 | Article, E-Article |
format_ded117 | Article, E-Article |
format_degla1 | E-Article |
format_del152 | Buch |
format_del189 | Article, E-Article |
format_dezi4 | Article |
format_dezwi2 | Article, E-Article |
format_finc | Article, E-Article |
format_nrw | Article, E-Article |
geogr_code | not assigned |
geogr_code_person | not assigned |
id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1NS8yMDE3LzcxNTEyODU |
imprint | Hindawi Limited, 2017 |
imprint_str_mv | Hindawi Limited, 2017 |
institution | DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
issn | 0962-9351, 1466-1861 |
issn_str_mv | 0962-9351, 1466-1861 |
language | English |
last_indexed | 2024-03-01T16:41:41.954Z |
match_str | timoteo2017th1th17relatedcytokinesandchemokinesandtheirimplicationsinthepathogenesisofpemphigusvulgaris |
mega_collection | Hindawi Limited (CrossRef) |
physical | 1-9 |
publishDate | 2017 |
publishDateSort | 2017 |
publisher | Hindawi Limited |
record_format | ai |
recordtype | ai |
series | Mediators of Inflammation |
source_id | 49 |
spelling | Timoteo, Rodolfo Pessato da Silva, Marcos Vinicius Miguel, Camila Botelho Silva, Djalma Alexandre Alves Catarino, Jonatas Da Silva Rodrigues Junior, Virmondes Sales-Campos, Helioswilton Freire Oliveira, Carlo Jose 0962-9351 1466-1861 Hindawi Limited Cell Biology Immunology http://dx.doi.org/10.1155/2017/7151285 <jats:p>Pemphigus vulgaris (PV) is an autoimmune disease characterized by the presence of IgG autoantibodies against desmoglein-3. Despite the variety of findings, the chemokine and cytokine profiles that characterize the immune response in the disease are still poorly explored. Thus, 20 PV patients and 20 controls were grouped according to gender, ethnicity, place of residence, and clinical parameters of the disease. Then, the levels of chemokines and of Th1/Th2/Th17/Treg/Th9/Th22-related cytokines were assessed in the serum. PV patients had higher levels of inflammatory Th1/Th17 cytokines (IFN-<jats:italic>γ</jats:italic>, IL-17, and IL-23), as well as higher levels of CXCL8 and reduced levels of Th1/Th2-related chemokines (IP-10 and CCL11). However, no differences in the levels of IL-2, IL-6, TNF-<jats:italic>α</jats:italic>, IL-1<jats:italic>β</jats:italic>, IL-4, IL-9, IL-12, TGF-<jats:italic>β</jats:italic>, IL-33, MCP-1, RANTES, and MIP-1<jats:italic>α</jats:italic> were found between PV patients and their control counterparts. Furthermore, PV patients with skin lesions had higher serum levels of IL-6 and CXCL8 when compared to PV patients without lesions. Taken together, our findings describe the role of cytokines and chemokines associated with Th1/Th17 immune response in PV patients. Finally, these data are important for better understanding of the immune aspects that control disease outcome, and they may also provide important information about why patients develop autoantibodies against desmogleins.</jats:p> Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris Mediators of Inflammation |
spellingShingle | Timoteo, Rodolfo Pessato, da Silva, Marcos Vinicius, Miguel, Camila Botelho, Silva, Djalma Alexandre Alves, Catarino, Jonatas Da Silva, Rodrigues Junior, Virmondes, Sales-Campos, Helioswilton, Freire Oliveira, Carlo Jose, Mediators of Inflammation, Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris, Cell Biology, Immunology |
title | Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris |
title_full | Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris |
title_fullStr | Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris |
title_full_unstemmed | Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris |
title_short | Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris |
title_sort | th1/th17-related cytokines and chemokines and their implications in the pathogenesis of pemphigus vulgaris |
title_unstemmed | Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris |
topic | Cell Biology, Immunology |
url | http://dx.doi.org/10.1155/2017/7151285 |