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Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina
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| Zeitschriftentitel: | BioMed Research International |
|---|---|
| Personen und Körperschaften: | , , |
| In: | BioMed Research International, 2017, 2017, S. 1-8 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Hindawi Limited
|
| Schlagwörter: |
| author_facet |
Yao, Wei Gao, Yuxia Wan, Zheng Yao, Wei Gao, Yuxia Wan, Zheng |
|---|---|
| author |
Yao, Wei Gao, Yuxia Wan, Zheng |
| spellingShingle |
Yao, Wei Gao, Yuxia Wan, Zheng BioMed Research International Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina General Immunology and Microbiology General Biochemistry, Genetics and Molecular Biology General Medicine |
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yao, wei |
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Yao, Wei Gao, Yuxia Wan, Zheng 2314-6133 2314-6141 Hindawi Limited General Immunology and Microbiology General Biochemistry, Genetics and Molecular Biology General Medicine http://dx.doi.org/10.1155/2017/7657306 <jats:p>Although statistical evidence is clear regarding the dangerousness of unstable angina (UA), a form of coronary heart disease (CHD) characterised by high mortality and morbidity globally, it is important to recognise that diagnostic precision for the condition is unfavourable. In the present research, to gain insight into candidate biomarkers, the author draws on<jats:sup>1</jats:sup>H NMR-based serum metabolic profiling to analyze the unstable angina pectoris (UAP) metabolic signatures; this constitutes an effective way to produce medical diagnosis. 101 unstable angina pectoris patients and 132 healthy controls were enrolled and 22 serum samples from each group were analyzed. Effective separation was noted regarding the UAP and control groups, and, for the former group considered in relation to their counterpart, the serum concentrations of Lac, m-I, lipid, VLDL, 3-HB, and LDL were higher whereas the concentrations of Thr, Cr, Cho, PC/GPC, Glu, Gln, Lys, HDL, Ile, Leu, and Val were lower. The conclusion drawn in view of the results is that the plasma metabolomics examined by<jats:sup>1</jats:sup>H NMR displayed promise for biomarker identification for UA. In addition to this, the analysis illuminated the metabolic processes of UA.</jats:p> Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina BioMed Research International |
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| title |
Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina |
| title_unstemmed |
Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina |
| title_full |
Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina |
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Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina |
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Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina |
| title_short |
Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina |
| title_sort |
serum metabolomics profiling to identify biomarkers for unstable angina |
| topic |
General Immunology and Microbiology General Biochemistry, Genetics and Molecular Biology General Medicine |
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http://dx.doi.org/10.1155/2017/7657306 |
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2017 |
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1-8 |
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<jats:p>Although statistical evidence is clear regarding the dangerousness of unstable angina (UA), a form of coronary heart disease (CHD) characterised by high mortality and morbidity globally, it is important to recognise that diagnostic precision for the condition is unfavourable. In the present research, to gain insight into candidate biomarkers, the author draws on<jats:sup>1</jats:sup>H NMR-based serum metabolic profiling to analyze the unstable angina pectoris (UAP) metabolic signatures; this constitutes an effective way to produce medical diagnosis. 101 unstable angina pectoris patients and 132 healthy controls were enrolled and 22 serum samples from each group were analyzed. Effective separation was noted regarding the UAP and control groups, and, for the former group considered in relation to their counterpart, the serum concentrations of Lac, m-I, lipid, VLDL, 3-HB, and LDL were higher whereas the concentrations of Thr, Cr, Cho, PC/GPC, Glu, Gln, Lys, HDL, Ile, Leu, and Val were lower. The conclusion drawn in view of the results is that the plasma metabolomics examined by<jats:sup>1</jats:sup>H NMR displayed promise for biomarker identification for UA. In addition to this, the analysis illuminated the metabolic processes of UA.</jats:p> |
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| description | <jats:p>Although statistical evidence is clear regarding the dangerousness of unstable angina (UA), a form of coronary heart disease (CHD) characterised by high mortality and morbidity globally, it is important to recognise that diagnostic precision for the condition is unfavourable. In the present research, to gain insight into candidate biomarkers, the author draws on<jats:sup>1</jats:sup>H NMR-based serum metabolic profiling to analyze the unstable angina pectoris (UAP) metabolic signatures; this constitutes an effective way to produce medical diagnosis. 101 unstable angina pectoris patients and 132 healthy controls were enrolled and 22 serum samples from each group were analyzed. Effective separation was noted regarding the UAP and control groups, and, for the former group considered in relation to their counterpart, the serum concentrations of Lac, m-I, lipid, VLDL, 3-HB, and LDL were higher whereas the concentrations of Thr, Cr, Cho, PC/GPC, Glu, Gln, Lys, HDL, Ile, Leu, and Val were lower. The conclusion drawn in view of the results is that the plasma metabolomics examined by<jats:sup>1</jats:sup>H NMR displayed promise for biomarker identification for UA. In addition to this, the analysis illuminated the metabolic processes of UA.</jats:p> |
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| spelling | Yao, Wei Gao, Yuxia Wan, Zheng 2314-6133 2314-6141 Hindawi Limited General Immunology and Microbiology General Biochemistry, Genetics and Molecular Biology General Medicine http://dx.doi.org/10.1155/2017/7657306 <jats:p>Although statistical evidence is clear regarding the dangerousness of unstable angina (UA), a form of coronary heart disease (CHD) characterised by high mortality and morbidity globally, it is important to recognise that diagnostic precision for the condition is unfavourable. In the present research, to gain insight into candidate biomarkers, the author draws on<jats:sup>1</jats:sup>H NMR-based serum metabolic profiling to analyze the unstable angina pectoris (UAP) metabolic signatures; this constitutes an effective way to produce medical diagnosis. 101 unstable angina pectoris patients and 132 healthy controls were enrolled and 22 serum samples from each group were analyzed. Effective separation was noted regarding the UAP and control groups, and, for the former group considered in relation to their counterpart, the serum concentrations of Lac, m-I, lipid, VLDL, 3-HB, and LDL were higher whereas the concentrations of Thr, Cr, Cho, PC/GPC, Glu, Gln, Lys, HDL, Ile, Leu, and Val were lower. The conclusion drawn in view of the results is that the plasma metabolomics examined by<jats:sup>1</jats:sup>H NMR displayed promise for biomarker identification for UA. In addition to this, the analysis illuminated the metabolic processes of UA.</jats:p> Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina BioMed Research International |
| spellingShingle | Yao, Wei, Gao, Yuxia, Wan, Zheng, BioMed Research International, Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina, General Immunology and Microbiology, General Biochemistry, Genetics and Molecular Biology, General Medicine |
| title | Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina |
| title_full | Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina |
| title_fullStr | Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina |
| title_full_unstemmed | Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina |
| title_short | Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina |
| title_sort | serum metabolomics profiling to identify biomarkers for unstable angina |
| title_unstemmed | Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina |
| topic | General Immunology and Microbiology, General Biochemistry, Genetics and Molecular Biology, General Medicine |
| url | http://dx.doi.org/10.1155/2017/7657306 |