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BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage
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| Zeitschriftentitel: | Oxidative Medicine and Cellular Longevity |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , |
| In: | Oxidative Medicine and Cellular Longevity, 2017, 2017, S. 1-10 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Hindawi Limited
|
| Schlagwörter: |
| author_facet |
Qin, Li-xia Tan, Jie-qiong Zhang, Hai-nan Rizwana, Kousar Lu, Jia-hong Tang, Jian-guang Jiang, Bo Shen, Xiang-min Guo, Ji-feng Tang, Bei-sha Tan, Li-ming Wang, Chun-yu Qin, Li-xia Tan, Jie-qiong Zhang, Hai-nan Rizwana, Kousar Lu, Jia-hong Tang, Jian-guang Jiang, Bo Shen, Xiang-min Guo, Ji-feng Tang, Bei-sha Tan, Li-ming Wang, Chun-yu |
|---|---|
| author |
Qin, Li-xia Tan, Jie-qiong Zhang, Hai-nan Rizwana, Kousar Lu, Jia-hong Tang, Jian-guang Jiang, Bo Shen, Xiang-min Guo, Ji-feng Tang, Bei-sha Tan, Li-ming Wang, Chun-yu |
| spellingShingle |
Qin, Li-xia Tan, Jie-qiong Zhang, Hai-nan Rizwana, Kousar Lu, Jia-hong Tang, Jian-guang Jiang, Bo Shen, Xiang-min Guo, Ji-feng Tang, Bei-sha Tan, Li-ming Wang, Chun-yu Oxidative Medicine and Cellular Longevity BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage Cell Biology Aging General Medicine Biochemistry |
| author_sort |
qin, li-xia |
| spelling |
Qin, Li-xia Tan, Jie-qiong Zhang, Hai-nan Rizwana, Kousar Lu, Jia-hong Tang, Jian-guang Jiang, Bo Shen, Xiang-min Guo, Ji-feng Tang, Bei-sha Tan, Li-ming Wang, Chun-yu 1942-0900 1942-0994 Hindawi Limited Cell Biology Aging General Medicine Biochemistry http://dx.doi.org/10.1155/2017/5094934 <jats:p>Loss-of-function mutations in gene encoding DJ-1 contribute to the pathogenesis of autosomal recessive early-onset familial forms of Parkinson’s disease (PD). DJ-1 is a multifunctional protein and plays a protective role against oxidative stress-induced mitochondrial damage and cell death, but the exact mechanism underlying this is not yet clearly understood. Here, using coimmunoprecipitation (Co-IP) and immunofluorescence methods, we prove that Bcl-2-associated athanogene 5 (BAG5), a BAG family member, interacts with DJ-1 in mammalian cells. Moreover, we show that BAG5 could decrease stability of DJ-1 and weaken its role in mitochondrial protection probably by influencing dimerization in stress condition. Our study reveals the relationship of BAG5 and DJ-1 suggesting a potential role for BAG5 in the pathogenesis of PD through its functional interactions with DJ-1.</jats:p> BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage Oxidative Medicine and Cellular Longevity |
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10.1155/2017/5094934 |
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Hindawi Limited, 2017 |
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Oxidative Medicine and Cellular Longevity |
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| title |
BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage |
| title_unstemmed |
BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage |
| title_full |
BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage |
| title_fullStr |
BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage |
| title_full_unstemmed |
BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage |
| title_short |
BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage |
| title_sort |
bag5 interacts with dj-1 and inhibits the neuroprotective effects of dj-1 to combat mitochondrial oxidative damage |
| topic |
Cell Biology Aging General Medicine Biochemistry |
| url |
http://dx.doi.org/10.1155/2017/5094934 |
| publishDate |
2017 |
| physical |
1-10 |
| description |
<jats:p>Loss-of-function mutations in gene encoding DJ-1 contribute to the pathogenesis of autosomal recessive early-onset familial forms of Parkinson’s disease (PD). DJ-1 is a multifunctional protein and plays a protective role against oxidative stress-induced mitochondrial damage and cell death, but the exact mechanism underlying this is not yet clearly understood. Here, using coimmunoprecipitation (Co-IP) and immunofluorescence methods, we prove that Bcl-2-associated athanogene 5 (BAG5), a BAG family member, interacts with DJ-1 in mammalian cells. Moreover, we show that BAG5 could decrease stability of DJ-1 and weaken its role in mitochondrial protection probably by influencing dimerization in stress condition. Our study reveals the relationship of BAG5 and DJ-1 suggesting a potential role for BAG5 in the pathogenesis of PD through its functional interactions with DJ-1.</jats:p> |
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| author | Qin, Li-xia, Tan, Jie-qiong, Zhang, Hai-nan, Rizwana, Kousar, Lu, Jia-hong, Tang, Jian-guang, Jiang, Bo, Shen, Xiang-min, Guo, Ji-feng, Tang, Bei-sha, Tan, Li-ming, Wang, Chun-yu |
| author_facet | Qin, Li-xia, Tan, Jie-qiong, Zhang, Hai-nan, Rizwana, Kousar, Lu, Jia-hong, Tang, Jian-guang, Jiang, Bo, Shen, Xiang-min, Guo, Ji-feng, Tang, Bei-sha, Tan, Li-ming, Wang, Chun-yu, Qin, Li-xia, Tan, Jie-qiong, Zhang, Hai-nan, Rizwana, Kousar, Lu, Jia-hong, Tang, Jian-guang, Jiang, Bo, Shen, Xiang-min, Guo, Ji-feng, Tang, Bei-sha, Tan, Li-ming, Wang, Chun-yu |
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| container_title | Oxidative Medicine and Cellular Longevity |
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| description | <jats:p>Loss-of-function mutations in gene encoding DJ-1 contribute to the pathogenesis of autosomal recessive early-onset familial forms of Parkinson’s disease (PD). DJ-1 is a multifunctional protein and plays a protective role against oxidative stress-induced mitochondrial damage and cell death, but the exact mechanism underlying this is not yet clearly understood. Here, using coimmunoprecipitation (Co-IP) and immunofluorescence methods, we prove that Bcl-2-associated athanogene 5 (BAG5), a BAG family member, interacts with DJ-1 in mammalian cells. Moreover, we show that BAG5 could decrease stability of DJ-1 and weaken its role in mitochondrial protection probably by influencing dimerization in stress condition. Our study reveals the relationship of BAG5 and DJ-1 suggesting a potential role for BAG5 in the pathogenesis of PD through its functional interactions with DJ-1.</jats:p> |
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| series | Oxidative Medicine and Cellular Longevity |
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| spelling | Qin, Li-xia Tan, Jie-qiong Zhang, Hai-nan Rizwana, Kousar Lu, Jia-hong Tang, Jian-guang Jiang, Bo Shen, Xiang-min Guo, Ji-feng Tang, Bei-sha Tan, Li-ming Wang, Chun-yu 1942-0900 1942-0994 Hindawi Limited Cell Biology Aging General Medicine Biochemistry http://dx.doi.org/10.1155/2017/5094934 <jats:p>Loss-of-function mutations in gene encoding DJ-1 contribute to the pathogenesis of autosomal recessive early-onset familial forms of Parkinson’s disease (PD). DJ-1 is a multifunctional protein and plays a protective role against oxidative stress-induced mitochondrial damage and cell death, but the exact mechanism underlying this is not yet clearly understood. Here, using coimmunoprecipitation (Co-IP) and immunofluorescence methods, we prove that Bcl-2-associated athanogene 5 (BAG5), a BAG family member, interacts with DJ-1 in mammalian cells. Moreover, we show that BAG5 could decrease stability of DJ-1 and weaken its role in mitochondrial protection probably by influencing dimerization in stress condition. Our study reveals the relationship of BAG5 and DJ-1 suggesting a potential role for BAG5 in the pathogenesis of PD through its functional interactions with DJ-1.</jats:p> BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage Oxidative Medicine and Cellular Longevity |
| spellingShingle | Qin, Li-xia, Tan, Jie-qiong, Zhang, Hai-nan, Rizwana, Kousar, Lu, Jia-hong, Tang, Jian-guang, Jiang, Bo, Shen, Xiang-min, Guo, Ji-feng, Tang, Bei-sha, Tan, Li-ming, Wang, Chun-yu, Oxidative Medicine and Cellular Longevity, BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage, Cell Biology, Aging, General Medicine, Biochemistry |
| title | BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage |
| title_full | BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage |
| title_fullStr | BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage |
| title_full_unstemmed | BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage |
| title_short | BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage |
| title_sort | bag5 interacts with dj-1 and inhibits the neuroprotective effects of dj-1 to combat mitochondrial oxidative damage |
| title_unstemmed | BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage |
| topic | Cell Biology, Aging, General Medicine, Biochemistry |
| url | http://dx.doi.org/10.1155/2017/5094934 |