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Jacalin Has Chemopreventive Effects on Colon Cancer Development
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| Zeitschriftentitel: | BioMed Research International |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | BioMed Research International, 2017, 2017, S. 1-10 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Hindawi Limited
|
| Schlagwörter: |
| author_facet |
Geraldino, Thais Herrero Modiano, Patricia Veronez, Luciana Chain Flória-Santos, Milena Garcia, Sergio Britto Pereira-da-Silva, Gabriela Geraldino, Thais Herrero Modiano, Patricia Veronez, Luciana Chain Flória-Santos, Milena Garcia, Sergio Britto Pereira-da-Silva, Gabriela |
|---|---|
| author |
Geraldino, Thais Herrero Modiano, Patricia Veronez, Luciana Chain Flória-Santos, Milena Garcia, Sergio Britto Pereira-da-Silva, Gabriela |
| spellingShingle |
Geraldino, Thais Herrero Modiano, Patricia Veronez, Luciana Chain Flória-Santos, Milena Garcia, Sergio Britto Pereira-da-Silva, Gabriela BioMed Research International Jacalin Has Chemopreventive Effects on Colon Cancer Development General Immunology and Microbiology General Biochemistry, Genetics and Molecular Biology General Medicine |
| author_sort |
geraldino, thais herrero |
| spelling |
Geraldino, Thais Herrero Modiano, Patricia Veronez, Luciana Chain Flória-Santos, Milena Garcia, Sergio Britto Pereira-da-Silva, Gabriela 2314-6133 2314-6141 Hindawi Limited General Immunology and Microbiology General Biochemistry, Genetics and Molecular Biology General Medicine http://dx.doi.org/10.1155/2017/4614357 <jats:p>Colorectal cancer, which is one of the most common causes of cancer-related deaths worldwide, has a slow natural history that provides a great opportunity for prevention strategies. Plant-derived natural products have received considerable attention because of their inherent colorectal cancer chemopreventive effects. The plant lectin jacalin specifically recognizes the tumor-associated Thomsen-Friedenreich antigen and has antiproliferative effects on human colon cancer cells, highlighting its potential antitumor activity. To evaluate jacalin’s potential application in colorectal cancer chemoprevention, we studied its effects on the early stages of carcinogenesis. Balb/c mice were given 4 intrarectal deposits of 0.1 ml solution of Methyl-N′-Nitro-N-Nitroso-Guanidine (5 mg/ml) twice a week (with a 3-day interval) for 2 weeks. Starting 2 weeks before carcinogen administration, animals were treated orally with jacalin (0.5 and 25 <jats:italic>μ</jats:italic>g) three times a week (on alternate weekdays) for 10 weeks. We show that jacalin treatment reduced the number of preneoplastic lesions in carcinogen-exposed mice. This anticarcinogenic activity was associated with decreased colonic epithelial cell proliferation and stromal COX-2 expression and with increased intestinal production of TNF-<jats:italic>α</jats:italic>. Our results demonstrate that jacalin is able to modulate the early stages of colon carcinogenesis and emphasize its promising chemopreventive activity in colorectal cancer.</jats:p> Jacalin Has Chemopreventive Effects on Colon Cancer Development BioMed Research International |
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| title |
Jacalin Has Chemopreventive Effects on Colon Cancer Development |
| title_unstemmed |
Jacalin Has Chemopreventive Effects on Colon Cancer Development |
| title_full |
Jacalin Has Chemopreventive Effects on Colon Cancer Development |
| title_fullStr |
Jacalin Has Chemopreventive Effects on Colon Cancer Development |
| title_full_unstemmed |
Jacalin Has Chemopreventive Effects on Colon Cancer Development |
| title_short |
Jacalin Has Chemopreventive Effects on Colon Cancer Development |
| title_sort |
jacalin has chemopreventive effects on colon cancer development |
| topic |
General Immunology and Microbiology General Biochemistry, Genetics and Molecular Biology General Medicine |
| url |
http://dx.doi.org/10.1155/2017/4614357 |
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2017 |
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1-10 |
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<jats:p>Colorectal cancer, which is one of the most common causes of cancer-related deaths worldwide, has a slow natural history that provides a great opportunity for prevention strategies. Plant-derived natural products have received considerable attention because of their inherent colorectal cancer chemopreventive effects. The plant lectin jacalin specifically recognizes the tumor-associated Thomsen-Friedenreich antigen and has antiproliferative effects on human colon cancer cells, highlighting its potential antitumor activity. To evaluate jacalin’s potential application in colorectal cancer chemoprevention, we studied its effects on the early stages of carcinogenesis. Balb/c mice were given 4 intrarectal deposits of 0.1 ml solution of Methyl-N′-Nitro-N-Nitroso-Guanidine (5 mg/ml) twice a week (with a 3-day interval) for 2 weeks. Starting 2 weeks before carcinogen administration, animals were treated orally with jacalin (0.5 and 25 <jats:italic>μ</jats:italic>g) three times a week (on alternate weekdays) for 10 weeks. We show that jacalin treatment reduced the number of preneoplastic lesions in carcinogen-exposed mice. This anticarcinogenic activity was associated with decreased colonic epithelial cell proliferation and stromal COX-2 expression and with increased intestinal production of TNF-<jats:italic>α</jats:italic>. Our results demonstrate that jacalin is able to modulate the early stages of colon carcinogenesis and emphasize its promising chemopreventive activity in colorectal cancer.</jats:p> |
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| author | Geraldino, Thais Herrero, Modiano, Patricia, Veronez, Luciana Chain, Flória-Santos, Milena, Garcia, Sergio Britto, Pereira-da-Silva, Gabriela |
| author_facet | Geraldino, Thais Herrero, Modiano, Patricia, Veronez, Luciana Chain, Flória-Santos, Milena, Garcia, Sergio Britto, Pereira-da-Silva, Gabriela, Geraldino, Thais Herrero, Modiano, Patricia, Veronez, Luciana Chain, Flória-Santos, Milena, Garcia, Sergio Britto, Pereira-da-Silva, Gabriela |
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| description | <jats:p>Colorectal cancer, which is one of the most common causes of cancer-related deaths worldwide, has a slow natural history that provides a great opportunity for prevention strategies. Plant-derived natural products have received considerable attention because of their inherent colorectal cancer chemopreventive effects. The plant lectin jacalin specifically recognizes the tumor-associated Thomsen-Friedenreich antigen and has antiproliferative effects on human colon cancer cells, highlighting its potential antitumor activity. To evaluate jacalin’s potential application in colorectal cancer chemoprevention, we studied its effects on the early stages of carcinogenesis. Balb/c mice were given 4 intrarectal deposits of 0.1 ml solution of Methyl-N′-Nitro-N-Nitroso-Guanidine (5 mg/ml) twice a week (with a 3-day interval) for 2 weeks. Starting 2 weeks before carcinogen administration, animals were treated orally with jacalin (0.5 and 25 <jats:italic>μ</jats:italic>g) three times a week (on alternate weekdays) for 10 weeks. We show that jacalin treatment reduced the number of preneoplastic lesions in carcinogen-exposed mice. This anticarcinogenic activity was associated with decreased colonic epithelial cell proliferation and stromal COX-2 expression and with increased intestinal production of TNF-<jats:italic>α</jats:italic>. Our results demonstrate that jacalin is able to modulate the early stages of colon carcinogenesis and emphasize its promising chemopreventive activity in colorectal cancer.</jats:p> |
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| spelling | Geraldino, Thais Herrero Modiano, Patricia Veronez, Luciana Chain Flória-Santos, Milena Garcia, Sergio Britto Pereira-da-Silva, Gabriela 2314-6133 2314-6141 Hindawi Limited General Immunology and Microbiology General Biochemistry, Genetics and Molecular Biology General Medicine http://dx.doi.org/10.1155/2017/4614357 <jats:p>Colorectal cancer, which is one of the most common causes of cancer-related deaths worldwide, has a slow natural history that provides a great opportunity for prevention strategies. Plant-derived natural products have received considerable attention because of their inherent colorectal cancer chemopreventive effects. The plant lectin jacalin specifically recognizes the tumor-associated Thomsen-Friedenreich antigen and has antiproliferative effects on human colon cancer cells, highlighting its potential antitumor activity. To evaluate jacalin’s potential application in colorectal cancer chemoprevention, we studied its effects on the early stages of carcinogenesis. Balb/c mice were given 4 intrarectal deposits of 0.1 ml solution of Methyl-N′-Nitro-N-Nitroso-Guanidine (5 mg/ml) twice a week (with a 3-day interval) for 2 weeks. Starting 2 weeks before carcinogen administration, animals were treated orally with jacalin (0.5 and 25 <jats:italic>μ</jats:italic>g) three times a week (on alternate weekdays) for 10 weeks. We show that jacalin treatment reduced the number of preneoplastic lesions in carcinogen-exposed mice. This anticarcinogenic activity was associated with decreased colonic epithelial cell proliferation and stromal COX-2 expression and with increased intestinal production of TNF-<jats:italic>α</jats:italic>. Our results demonstrate that jacalin is able to modulate the early stages of colon carcinogenesis and emphasize its promising chemopreventive activity in colorectal cancer.</jats:p> Jacalin Has Chemopreventive Effects on Colon Cancer Development BioMed Research International |
| spellingShingle | Geraldino, Thais Herrero, Modiano, Patricia, Veronez, Luciana Chain, Flória-Santos, Milena, Garcia, Sergio Britto, Pereira-da-Silva, Gabriela, BioMed Research International, Jacalin Has Chemopreventive Effects on Colon Cancer Development, General Immunology and Microbiology, General Biochemistry, Genetics and Molecular Biology, General Medicine |
| title | Jacalin Has Chemopreventive Effects on Colon Cancer Development |
| title_full | Jacalin Has Chemopreventive Effects on Colon Cancer Development |
| title_fullStr | Jacalin Has Chemopreventive Effects on Colon Cancer Development |
| title_full_unstemmed | Jacalin Has Chemopreventive Effects on Colon Cancer Development |
| title_short | Jacalin Has Chemopreventive Effects on Colon Cancer Development |
| title_sort | jacalin has chemopreventive effects on colon cancer development |
| title_unstemmed | Jacalin Has Chemopreventive Effects on Colon Cancer Development |
| topic | General Immunology and Microbiology, General Biochemistry, Genetics and Molecular Biology, General Medicine |
| url | http://dx.doi.org/10.1155/2017/4614357 |