Eintrag weiter verarbeiten
A Fermented Whole Grain Prevents Lipopolysaccharides-Induced Dysfunction in Human Endothelial Progenitor Cells
Gespeichert in:
| Zeitschriftentitel: | Oxidative Medicine and Cellular Longevity |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Oxidative Medicine and Cellular Longevity, 2017, 2017, S. 1-13 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Hindawi Limited
|
| Schlagwörter: |
| author_facet |
Giusti, Laura Gabriele, Morena Penno, Giuseppe Garofolo, Monia Longo, Vincenzo Del Prato, Stefano Lucchesi, Daniela Pucci, Laura Giusti, Laura Gabriele, Morena Penno, Giuseppe Garofolo, Monia Longo, Vincenzo Del Prato, Stefano Lucchesi, Daniela Pucci, Laura |
|---|---|
| author |
Giusti, Laura Gabriele, Morena Penno, Giuseppe Garofolo, Monia Longo, Vincenzo Del Prato, Stefano Lucchesi, Daniela Pucci, Laura |
| spellingShingle |
Giusti, Laura Gabriele, Morena Penno, Giuseppe Garofolo, Monia Longo, Vincenzo Del Prato, Stefano Lucchesi, Daniela Pucci, Laura Oxidative Medicine and Cellular Longevity A Fermented Whole Grain Prevents Lipopolysaccharides-Induced Dysfunction in Human Endothelial Progenitor Cells Cell Biology Aging General Medicine Biochemistry |
| author_sort |
giusti, laura |
| spelling |
Giusti, Laura Gabriele, Morena Penno, Giuseppe Garofolo, Monia Longo, Vincenzo Del Prato, Stefano Lucchesi, Daniela Pucci, Laura 1942-0900 1942-0994 Hindawi Limited Cell Biology Aging General Medicine Biochemistry http://dx.doi.org/10.1155/2017/1026268 <jats:p>Endogenous and exogenous signals derived by the gut microbiota such as lipopolysaccharides (LPS) orchestrate inflammatory responses contributing to development of the endothelial dysfunction associated with atherosclerosis in obesity, metabolic syndrome, and diabetes. Endothelial progenitor cells (EPCs), bone marrow derived stem cells, promote recovery of damaged endothelium playing a pivotal role in cardiovascular repair. Since healthy nutrition improves EPCs functions, we evaluated the effect of a fermented grain, Lisosan G (LG), on early EPCs exposed to LPS. The potential protective effect of LG against LPS-induced alterations was evaluated as cell viability, adhesiveness, ROS production, gene expression, and NF-kB signaling pathway activation. Our results showed that LPS treatment did not affect EPCs viability and adhesiveness but induced endothelial alterations via activation of NF-kB signaling. LG protects EPCs from inflammation as well as from LPS-induced oxidative and endoplasmic reticulum (ER) stress reducing ROS levels, downregulating proinflammatory and proapoptotic factors, and strengthening antioxidant defense. Moreover, LG pretreatment prevented NF-kB translocation from the cytoplasm into the nucleus caused by LPS exposure. In human EPCs, LPS increases ROS and upregulates proinflammatory tone, proapoptotic factors, and antioxidants. LG protects EPCs exposed to LPS reducing ROS, downregulating proinflammatory and proapoptotic factors, and strengthening antioxidant defenses possibly by inhibiting NF-<jats:italic>κ</jats:italic>B nuclear translocation.</jats:p> A Fermented Whole Grain Prevents Lipopolysaccharides-Induced Dysfunction in Human Endothelial Progenitor Cells Oxidative Medicine and Cellular Longevity |
| doi_str_mv |
10.1155/2017/1026268 |
| facet_avail |
Online Free |
| finc_class_facet |
Biologie Chemie und Pharmazie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1NS8yMDE3LzEwMjYyNjg |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1NS8yMDE3LzEwMjYyNjg |
| institution |
DE-Brt1 DE-D161 DE-Zwi2 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 |
| imprint |
Hindawi Limited, 2017 |
| imprint_str_mv |
Hindawi Limited, 2017 |
| issn |
1942-0900 1942-0994 |
| issn_str_mv |
1942-0900 1942-0994 |
| language |
English |
| mega_collection |
Hindawi Limited (CrossRef) |
| match_str |
giusti2017afermentedwholegrainpreventslipopolysaccharidesinduceddysfunctioninhumanendothelialprogenitorcells |
| publishDateSort |
2017 |
| publisher |
Hindawi Limited |
| recordtype |
ai |
| record_format |
ai |
| series |
Oxidative Medicine and Cellular Longevity |
| source_id |
49 |
| title |
A Fermented Whole Grain Prevents Lipopolysaccharides-Induced Dysfunction in Human Endothelial Progenitor Cells |
| title_unstemmed |
A Fermented Whole Grain Prevents Lipopolysaccharides-Induced Dysfunction in Human Endothelial Progenitor Cells |
| title_full |
A Fermented Whole Grain Prevents Lipopolysaccharides-Induced Dysfunction in Human Endothelial Progenitor Cells |
| title_fullStr |
A Fermented Whole Grain Prevents Lipopolysaccharides-Induced Dysfunction in Human Endothelial Progenitor Cells |
| title_full_unstemmed |
A Fermented Whole Grain Prevents Lipopolysaccharides-Induced Dysfunction in Human Endothelial Progenitor Cells |
| title_short |
A Fermented Whole Grain Prevents Lipopolysaccharides-Induced Dysfunction in Human Endothelial Progenitor Cells |
| title_sort |
a fermented whole grain prevents lipopolysaccharides-induced dysfunction in human endothelial progenitor cells |
| topic |
Cell Biology Aging General Medicine Biochemistry |
| url |
http://dx.doi.org/10.1155/2017/1026268 |
| publishDate |
2017 |
| physical |
1-13 |
| description |
<jats:p>Endogenous and exogenous signals derived by the gut microbiota such as lipopolysaccharides (LPS) orchestrate inflammatory responses contributing to development of the endothelial dysfunction associated with atherosclerosis in obesity, metabolic syndrome, and diabetes. Endothelial progenitor cells (EPCs), bone marrow derived stem cells, promote recovery of damaged endothelium playing a pivotal role in cardiovascular repair. Since healthy nutrition improves EPCs functions, we evaluated the effect of a fermented grain, Lisosan G (LG), on early EPCs exposed to LPS. The potential protective effect of LG against LPS-induced alterations was evaluated as cell viability, adhesiveness, ROS production, gene expression, and NF-kB signaling pathway activation. Our results showed that LPS treatment did not affect EPCs viability and adhesiveness but induced endothelial alterations via activation of NF-kB signaling. LG protects EPCs from inflammation as well as from LPS-induced oxidative and endoplasmic reticulum (ER) stress reducing ROS levels, downregulating proinflammatory and proapoptotic factors, and strengthening antioxidant defense. Moreover, LG pretreatment prevented NF-kB translocation from the cytoplasm into the nucleus caused by LPS exposure. In human EPCs, LPS increases ROS and upregulates proinflammatory tone, proapoptotic factors, and antioxidants. LG protects EPCs exposed to LPS reducing ROS, downregulating proinflammatory and proapoptotic factors, and strengthening antioxidant defenses possibly by inhibiting NF-<jats:italic>κ</jats:italic>B nuclear translocation.</jats:p> |
| container_start_page |
1 |
| container_title |
Oxidative Medicine and Cellular Longevity |
| container_volume |
2017 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792342562277687304 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T16:37:31.33Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=A+Fermented+Whole+Grain+Prevents+Lipopolysaccharides-Induced+Dysfunction+in+Human+Endothelial+Progenitor+Cells&rft.date=2017-01-01&genre=article&issn=1942-0994&volume=2017&spage=1&epage=13&pages=1-13&jtitle=Oxidative+Medicine+and+Cellular+Longevity&atitle=A+Fermented+Whole+Grain+Prevents+Lipopolysaccharides-Induced+Dysfunction+in+Human+Endothelial+Progenitor+Cells&aulast=Pucci&aufirst=Laura&rft_id=info%3Adoi%2F10.1155%2F2017%2F1026268&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792342562277687304 |
| author | Giusti, Laura, Gabriele, Morena, Penno, Giuseppe, Garofolo, Monia, Longo, Vincenzo, Del Prato, Stefano, Lucchesi, Daniela, Pucci, Laura |
| author_facet | Giusti, Laura, Gabriele, Morena, Penno, Giuseppe, Garofolo, Monia, Longo, Vincenzo, Del Prato, Stefano, Lucchesi, Daniela, Pucci, Laura, Giusti, Laura, Gabriele, Morena, Penno, Giuseppe, Garofolo, Monia, Longo, Vincenzo, Del Prato, Stefano, Lucchesi, Daniela, Pucci, Laura |
| author_sort | giusti, laura |
| container_start_page | 1 |
| container_title | Oxidative Medicine and Cellular Longevity |
| container_volume | 2017 |
| description | <jats:p>Endogenous and exogenous signals derived by the gut microbiota such as lipopolysaccharides (LPS) orchestrate inflammatory responses contributing to development of the endothelial dysfunction associated with atherosclerosis in obesity, metabolic syndrome, and diabetes. Endothelial progenitor cells (EPCs), bone marrow derived stem cells, promote recovery of damaged endothelium playing a pivotal role in cardiovascular repair. Since healthy nutrition improves EPCs functions, we evaluated the effect of a fermented grain, Lisosan G (LG), on early EPCs exposed to LPS. The potential protective effect of LG against LPS-induced alterations was evaluated as cell viability, adhesiveness, ROS production, gene expression, and NF-kB signaling pathway activation. Our results showed that LPS treatment did not affect EPCs viability and adhesiveness but induced endothelial alterations via activation of NF-kB signaling. LG protects EPCs from inflammation as well as from LPS-induced oxidative and endoplasmic reticulum (ER) stress reducing ROS levels, downregulating proinflammatory and proapoptotic factors, and strengthening antioxidant defense. Moreover, LG pretreatment prevented NF-kB translocation from the cytoplasm into the nucleus caused by LPS exposure. In human EPCs, LPS increases ROS and upregulates proinflammatory tone, proapoptotic factors, and antioxidants. LG protects EPCs exposed to LPS reducing ROS, downregulating proinflammatory and proapoptotic factors, and strengthening antioxidant defenses possibly by inhibiting NF-<jats:italic>κ</jats:italic>B nuclear translocation.</jats:p> |
| doi_str_mv | 10.1155/2017/1026268 |
| facet_avail | Online, Free |
| finc_class_facet | Biologie, Chemie und Pharmazie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1NS8yMDE3LzEwMjYyNjg |
| imprint | Hindawi Limited, 2017 |
| imprint_str_mv | Hindawi Limited, 2017 |
| institution | DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3 |
| issn | 1942-0900, 1942-0994 |
| issn_str_mv | 1942-0900, 1942-0994 |
| language | English |
| last_indexed | 2024-03-01T16:37:31.33Z |
| match_str | giusti2017afermentedwholegrainpreventslipopolysaccharidesinduceddysfunctioninhumanendothelialprogenitorcells |
| mega_collection | Hindawi Limited (CrossRef) |
| physical | 1-13 |
| publishDate | 2017 |
| publishDateSort | 2017 |
| publisher | Hindawi Limited |
| record_format | ai |
| recordtype | ai |
| series | Oxidative Medicine and Cellular Longevity |
| source_id | 49 |
| spelling | Giusti, Laura Gabriele, Morena Penno, Giuseppe Garofolo, Monia Longo, Vincenzo Del Prato, Stefano Lucchesi, Daniela Pucci, Laura 1942-0900 1942-0994 Hindawi Limited Cell Biology Aging General Medicine Biochemistry http://dx.doi.org/10.1155/2017/1026268 <jats:p>Endogenous and exogenous signals derived by the gut microbiota such as lipopolysaccharides (LPS) orchestrate inflammatory responses contributing to development of the endothelial dysfunction associated with atherosclerosis in obesity, metabolic syndrome, and diabetes. Endothelial progenitor cells (EPCs), bone marrow derived stem cells, promote recovery of damaged endothelium playing a pivotal role in cardiovascular repair. Since healthy nutrition improves EPCs functions, we evaluated the effect of a fermented grain, Lisosan G (LG), on early EPCs exposed to LPS. The potential protective effect of LG against LPS-induced alterations was evaluated as cell viability, adhesiveness, ROS production, gene expression, and NF-kB signaling pathway activation. Our results showed that LPS treatment did not affect EPCs viability and adhesiveness but induced endothelial alterations via activation of NF-kB signaling. LG protects EPCs from inflammation as well as from LPS-induced oxidative and endoplasmic reticulum (ER) stress reducing ROS levels, downregulating proinflammatory and proapoptotic factors, and strengthening antioxidant defense. Moreover, LG pretreatment prevented NF-kB translocation from the cytoplasm into the nucleus caused by LPS exposure. In human EPCs, LPS increases ROS and upregulates proinflammatory tone, proapoptotic factors, and antioxidants. LG protects EPCs exposed to LPS reducing ROS, downregulating proinflammatory and proapoptotic factors, and strengthening antioxidant defenses possibly by inhibiting NF-<jats:italic>κ</jats:italic>B nuclear translocation.</jats:p> A Fermented Whole Grain Prevents Lipopolysaccharides-Induced Dysfunction in Human Endothelial Progenitor Cells Oxidative Medicine and Cellular Longevity |
| spellingShingle | Giusti, Laura, Gabriele, Morena, Penno, Giuseppe, Garofolo, Monia, Longo, Vincenzo, Del Prato, Stefano, Lucchesi, Daniela, Pucci, Laura, Oxidative Medicine and Cellular Longevity, A Fermented Whole Grain Prevents Lipopolysaccharides-Induced Dysfunction in Human Endothelial Progenitor Cells, Cell Biology, Aging, General Medicine, Biochemistry |
| title | A Fermented Whole Grain Prevents Lipopolysaccharides-Induced Dysfunction in Human Endothelial Progenitor Cells |
| title_full | A Fermented Whole Grain Prevents Lipopolysaccharides-Induced Dysfunction in Human Endothelial Progenitor Cells |
| title_fullStr | A Fermented Whole Grain Prevents Lipopolysaccharides-Induced Dysfunction in Human Endothelial Progenitor Cells |
| title_full_unstemmed | A Fermented Whole Grain Prevents Lipopolysaccharides-Induced Dysfunction in Human Endothelial Progenitor Cells |
| title_short | A Fermented Whole Grain Prevents Lipopolysaccharides-Induced Dysfunction in Human Endothelial Progenitor Cells |
| title_sort | a fermented whole grain prevents lipopolysaccharides-induced dysfunction in human endothelial progenitor cells |
| title_unstemmed | A Fermented Whole Grain Prevents Lipopolysaccharides-Induced Dysfunction in Human Endothelial Progenitor Cells |
| topic | Cell Biology, Aging, General Medicine, Biochemistry |
| url | http://dx.doi.org/10.1155/2017/1026268 |