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Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells:Rubus suavissimusLeaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affectin...
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| Zeitschriftentitel: | Evidence-Based Complementary and Alternative Medicine |
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| Personen und Körperschaften: | , , , , , , , |
| In: | Evidence-Based Complementary and Alternative Medicine, 2016, 2016, S. 1-9 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Hindawi Limited
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| Schlagwörter: |
| author_facet |
Takahashi, Tomohiro Sugawara, Wataru Takiguchi, Yuya Takizawa, Kento Nakabayashi, Ami Nakamura, Mitsuo Nagano-Ito, Michiyo Ichikawa, Shinichi Takahashi, Tomohiro Sugawara, Wataru Takiguchi, Yuya Takizawa, Kento Nakabayashi, Ami Nakamura, Mitsuo Nagano-Ito, Michiyo Ichikawa, Shinichi |
|---|---|
| author |
Takahashi, Tomohiro Sugawara, Wataru Takiguchi, Yuya Takizawa, Kento Nakabayashi, Ami Nakamura, Mitsuo Nagano-Ito, Michiyo Ichikawa, Shinichi |
| spellingShingle |
Takahashi, Tomohiro Sugawara, Wataru Takiguchi, Yuya Takizawa, Kento Nakabayashi, Ami Nakamura, Mitsuo Nagano-Ito, Michiyo Ichikawa, Shinichi Evidence-Based Complementary and Alternative Medicine Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells:Rubus suavissimusLeaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells Complementary and alternative medicine |
| author_sort |
takahashi, tomohiro |
| spelling |
Takahashi, Tomohiro Sugawara, Wataru Takiguchi, Yuya Takizawa, Kento Nakabayashi, Ami Nakamura, Mitsuo Nagano-Ito, Michiyo Ichikawa, Shinichi 1741-427X 1741-4288 Hindawi Limited Complementary and alternative medicine http://dx.doi.org/10.1155/2016/4282758 <jats:p>Fatty liver disease is a condition in which abnormally large numbers of lipid droplets accumulate in liver cells. Fatty liver disease induces inflammation under conditions of oxidative stress and may result in cancer. To identify plants that protect against fatty liver disease, we examined the inhibitory effects of plant extracts on lipid droplet formation in mouse hepatoma cells. A screen of 98 water extracts of plants revealed 4 extracts with inhibitory effects. One of these extracts,<jats:italic>Rubus suavissimus</jats:italic>S. Lee (Tien-cha or Chinese sweet tea) leaf extract, which showed strong inhibitory effects, was tested in a mouse fatty liver model. In these mouse experiments, intake of the plant extract significantly protected mice against fatty liver disease without affecting body weight gain. Our results suggest that RSE directly affects liver cells and protects them from fatty liver disease.</jats:p> Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells:<i>Rubus suavissimus</i>Leaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells Evidence-Based Complementary and Alternative Medicine |
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Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells:Rubus suavissimusLeaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells |
| title_unstemmed |
Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells:Rubus suavissimusLeaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells |
| title_full |
Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells:Rubus suavissimusLeaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells |
| title_fullStr |
Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells:Rubus suavissimusLeaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells |
| title_full_unstemmed |
Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells:Rubus suavissimusLeaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells |
| title_short |
Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells:Rubus suavissimusLeaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells |
| title_sort |
identification of plants that inhibit lipid droplet formation in liver cells:<i>rubus suavissimus</i>leaf extract protects mice from high-fat diet-induced fatty liver by directly affecting liver cells |
| topic |
Complementary and alternative medicine |
| url |
http://dx.doi.org/10.1155/2016/4282758 |
| publishDate |
2016 |
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1-9 |
| description |
<jats:p>Fatty liver disease is a condition in which abnormally large numbers of lipid droplets accumulate in liver cells. Fatty liver disease induces inflammation under conditions of oxidative stress and may result in cancer. To identify plants that protect against fatty liver disease, we examined the inhibitory effects of plant extracts on lipid droplet formation in mouse hepatoma cells. A screen of 98 water extracts of plants revealed 4 extracts with inhibitory effects. One of these extracts,<jats:italic>Rubus suavissimus</jats:italic>S. Lee (Tien-cha or Chinese sweet tea) leaf extract, which showed strong inhibitory effects, was tested in a mouse fatty liver model. In these mouse experiments, intake of the plant extract significantly protected mice against fatty liver disease without affecting body weight gain. Our results suggest that RSE directly affects liver cells and protects them from fatty liver disease.</jats:p> |
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| author | Takahashi, Tomohiro, Sugawara, Wataru, Takiguchi, Yuya, Takizawa, Kento, Nakabayashi, Ami, Nakamura, Mitsuo, Nagano-Ito, Michiyo, Ichikawa, Shinichi |
| author_facet | Takahashi, Tomohiro, Sugawara, Wataru, Takiguchi, Yuya, Takizawa, Kento, Nakabayashi, Ami, Nakamura, Mitsuo, Nagano-Ito, Michiyo, Ichikawa, Shinichi, Takahashi, Tomohiro, Sugawara, Wataru, Takiguchi, Yuya, Takizawa, Kento, Nakabayashi, Ami, Nakamura, Mitsuo, Nagano-Ito, Michiyo, Ichikawa, Shinichi |
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| container_title | Evidence-Based Complementary and Alternative Medicine |
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| description | <jats:p>Fatty liver disease is a condition in which abnormally large numbers of lipid droplets accumulate in liver cells. Fatty liver disease induces inflammation under conditions of oxidative stress and may result in cancer. To identify plants that protect against fatty liver disease, we examined the inhibitory effects of plant extracts on lipid droplet formation in mouse hepatoma cells. A screen of 98 water extracts of plants revealed 4 extracts with inhibitory effects. One of these extracts,<jats:italic>Rubus suavissimus</jats:italic>S. Lee (Tien-cha or Chinese sweet tea) leaf extract, which showed strong inhibitory effects, was tested in a mouse fatty liver model. In these mouse experiments, intake of the plant extract significantly protected mice against fatty liver disease without affecting body weight gain. Our results suggest that RSE directly affects liver cells and protects them from fatty liver disease.</jats:p> |
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| spelling | Takahashi, Tomohiro Sugawara, Wataru Takiguchi, Yuya Takizawa, Kento Nakabayashi, Ami Nakamura, Mitsuo Nagano-Ito, Michiyo Ichikawa, Shinichi 1741-427X 1741-4288 Hindawi Limited Complementary and alternative medicine http://dx.doi.org/10.1155/2016/4282758 <jats:p>Fatty liver disease is a condition in which abnormally large numbers of lipid droplets accumulate in liver cells. Fatty liver disease induces inflammation under conditions of oxidative stress and may result in cancer. To identify plants that protect against fatty liver disease, we examined the inhibitory effects of plant extracts on lipid droplet formation in mouse hepatoma cells. A screen of 98 water extracts of plants revealed 4 extracts with inhibitory effects. One of these extracts,<jats:italic>Rubus suavissimus</jats:italic>S. Lee (Tien-cha or Chinese sweet tea) leaf extract, which showed strong inhibitory effects, was tested in a mouse fatty liver model. In these mouse experiments, intake of the plant extract significantly protected mice against fatty liver disease without affecting body weight gain. Our results suggest that RSE directly affects liver cells and protects them from fatty liver disease.</jats:p> Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells:<i>Rubus suavissimus</i>Leaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells Evidence-Based Complementary and Alternative Medicine |
| spellingShingle | Takahashi, Tomohiro, Sugawara, Wataru, Takiguchi, Yuya, Takizawa, Kento, Nakabayashi, Ami, Nakamura, Mitsuo, Nagano-Ito, Michiyo, Ichikawa, Shinichi, Evidence-Based Complementary and Alternative Medicine, Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells:Rubus suavissimusLeaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells, Complementary and alternative medicine |
| title | Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells:Rubus suavissimusLeaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells |
| title_full | Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells:Rubus suavissimusLeaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells |
| title_fullStr | Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells:Rubus suavissimusLeaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells |
| title_full_unstemmed | Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells:Rubus suavissimusLeaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells |
| title_short | Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells:Rubus suavissimusLeaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells |
| title_sort | identification of plants that inhibit lipid droplet formation in liver cells:<i>rubus suavissimus</i>leaf extract protects mice from high-fat diet-induced fatty liver by directly affecting liver cells |
| title_unstemmed | Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells:Rubus suavissimusLeaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells |
| topic | Complementary and alternative medicine |
| url | http://dx.doi.org/10.1155/2016/4282758 |