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Renoprotective Effects ofVitex megapotamica(Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet
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| Zeitschriftentitel: | Evidence-Based Complementary and Alternative Medicine |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Evidence-Based Complementary and Alternative Medicine, 2015, 2015, S. 1-10 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Hindawi Limited
|
| Schlagwörter: |
| author_facet |
Araújo, Valdinei de Oliveira Gasparotto, Francielly Mourão Pires, Vanessa Aranega Maciel, Aline Antunes Ortmann, Caroline Flach Cardozo Junior, Euclides Lara Lourenço, Emerson Luiz Botelho Gasparotto Junior, Arquimedes Araújo, Valdinei de Oliveira Gasparotto, Francielly Mourão Pires, Vanessa Aranega Maciel, Aline Antunes Ortmann, Caroline Flach Cardozo Junior, Euclides Lara Lourenço, Emerson Luiz Botelho Gasparotto Junior, Arquimedes |
|---|---|
| author |
Araújo, Valdinei de Oliveira Gasparotto, Francielly Mourão Pires, Vanessa Aranega Maciel, Aline Antunes Ortmann, Caroline Flach Cardozo Junior, Euclides Lara Lourenço, Emerson Luiz Botelho Gasparotto Junior, Arquimedes |
| spellingShingle |
Araújo, Valdinei de Oliveira Gasparotto, Francielly Mourão Pires, Vanessa Aranega Maciel, Aline Antunes Ortmann, Caroline Flach Cardozo Junior, Euclides Lara Lourenço, Emerson Luiz Botelho Gasparotto Junior, Arquimedes Evidence-Based Complementary and Alternative Medicine Renoprotective Effects ofVitex megapotamica(Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet Complementary and alternative medicine |
| author_sort |
araújo, valdinei de oliveira |
| spelling |
Araújo, Valdinei de Oliveira Gasparotto, Francielly Mourão Pires, Vanessa Aranega Maciel, Aline Antunes Ortmann, Caroline Flach Cardozo Junior, Euclides Lara Lourenço, Emerson Luiz Botelho Gasparotto Junior, Arquimedes 1741-427X 1741-4288 Hindawi Limited Complementary and alternative medicine http://dx.doi.org/10.1155/2015/475380 <jats:p>Although<jats:italic>Vitex megapotamica</jats:italic>(Spreng.) Moldenke is used in Brazilian folk medicine as hypolipidemic drug no study has been conducted to evaluate the effects of this species in an experimental model of atherosclerosis. So, the aim of this study was to evaluate the possible renoprotective activity of methanolic extract obtained from<jats:italic>Vitex megapotamica</jats:italic>(MEVM) using C57BL/6 LDLr-null mice submitted to high fat diet (HFD). MEVM was orally administered at doses of 30, 100, and 300 mg/kg, for three weeks, starting from the 2nd week of HFD. Systolic blood pressure (SBP) and diuretic activity were measured weekly. At the end of experiments the serum lipids, atherogenic index serum (AIS), oxidative stress, and markers of renal function were determined. HFD induced a significant increase in the systolic blood pressure, dyslipidemia, increase in AIS, and lipid peroxidation accompanied by an important reduction in renal function. Treatment with MEVM was able to prevent increase in SBP, total cholesterol, triglycerides, AIS, urea, and creatinine levels in LDLr-null mice. These effects were accompanied by a significant reduction in oxidative stress and renal injury. The data reported here support the potential of<jats:italic>Vitex megapotamica</jats:italic>as candidate to be an herbal medicine used in cardiovascular or renal diseases.</jats:p> Renoprotective Effects of<i>Vitex megapotamica</i>(Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet Evidence-Based Complementary and Alternative Medicine |
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Hindawi Limited, 2015 |
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| title |
Renoprotective Effects ofVitex megapotamica(Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet |
| title_unstemmed |
Renoprotective Effects ofVitex megapotamica(Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet |
| title_full |
Renoprotective Effects ofVitex megapotamica(Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet |
| title_fullStr |
Renoprotective Effects ofVitex megapotamica(Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet |
| title_full_unstemmed |
Renoprotective Effects ofVitex megapotamica(Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet |
| title_short |
Renoprotective Effects ofVitex megapotamica(Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet |
| title_sort |
renoprotective effects of<i>vitex megapotamica</i>(spreng.) moldenke in c57bl/6 ldlr-null mice undergoing high fat diet |
| topic |
Complementary and alternative medicine |
| url |
http://dx.doi.org/10.1155/2015/475380 |
| publishDate |
2015 |
| physical |
1-10 |
| description |
<jats:p>Although<jats:italic>Vitex megapotamica</jats:italic>(Spreng.) Moldenke is used in Brazilian folk medicine as hypolipidemic drug no study has been conducted to evaluate the effects of this species in an experimental model of atherosclerosis. So, the aim of this study was to evaluate the possible renoprotective activity of methanolic extract obtained from<jats:italic>Vitex megapotamica</jats:italic>(MEVM) using C57BL/6 LDLr-null mice submitted to high fat diet (HFD). MEVM was orally administered at doses of 30, 100, and 300 mg/kg, for three weeks, starting from the 2nd week of HFD. Systolic blood pressure (SBP) and diuretic activity were measured weekly. At the end of experiments the serum lipids, atherogenic index serum (AIS), oxidative stress, and markers of renal function were determined. HFD induced a significant increase in the systolic blood pressure, dyslipidemia, increase in AIS, and lipid peroxidation accompanied by an important reduction in renal function. Treatment with MEVM was able to prevent increase in SBP, total cholesterol, triglycerides, AIS, urea, and creatinine levels in LDLr-null mice. These effects were accompanied by a significant reduction in oxidative stress and renal injury. The data reported here support the potential of<jats:italic>Vitex megapotamica</jats:italic>as candidate to be an herbal medicine used in cardiovascular or renal diseases.</jats:p> |
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| author | Araújo, Valdinei de Oliveira, Gasparotto, Francielly Mourão, Pires, Vanessa Aranega, Maciel, Aline Antunes, Ortmann, Caroline Flach, Cardozo Junior, Euclides Lara, Lourenço, Emerson Luiz Botelho, Gasparotto Junior, Arquimedes |
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| description | <jats:p>Although<jats:italic>Vitex megapotamica</jats:italic>(Spreng.) Moldenke is used in Brazilian folk medicine as hypolipidemic drug no study has been conducted to evaluate the effects of this species in an experimental model of atherosclerosis. So, the aim of this study was to evaluate the possible renoprotective activity of methanolic extract obtained from<jats:italic>Vitex megapotamica</jats:italic>(MEVM) using C57BL/6 LDLr-null mice submitted to high fat diet (HFD). MEVM was orally administered at doses of 30, 100, and 300 mg/kg, for three weeks, starting from the 2nd week of HFD. Systolic blood pressure (SBP) and diuretic activity were measured weekly. At the end of experiments the serum lipids, atherogenic index serum (AIS), oxidative stress, and markers of renal function were determined. HFD induced a significant increase in the systolic blood pressure, dyslipidemia, increase in AIS, and lipid peroxidation accompanied by an important reduction in renal function. Treatment with MEVM was able to prevent increase in SBP, total cholesterol, triglycerides, AIS, urea, and creatinine levels in LDLr-null mice. These effects were accompanied by a significant reduction in oxidative stress and renal injury. The data reported here support the potential of<jats:italic>Vitex megapotamica</jats:italic>as candidate to be an herbal medicine used in cardiovascular or renal diseases.</jats:p> |
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| spelling | Araújo, Valdinei de Oliveira Gasparotto, Francielly Mourão Pires, Vanessa Aranega Maciel, Aline Antunes Ortmann, Caroline Flach Cardozo Junior, Euclides Lara Lourenço, Emerson Luiz Botelho Gasparotto Junior, Arquimedes 1741-427X 1741-4288 Hindawi Limited Complementary and alternative medicine http://dx.doi.org/10.1155/2015/475380 <jats:p>Although<jats:italic>Vitex megapotamica</jats:italic>(Spreng.) Moldenke is used in Brazilian folk medicine as hypolipidemic drug no study has been conducted to evaluate the effects of this species in an experimental model of atherosclerosis. So, the aim of this study was to evaluate the possible renoprotective activity of methanolic extract obtained from<jats:italic>Vitex megapotamica</jats:italic>(MEVM) using C57BL/6 LDLr-null mice submitted to high fat diet (HFD). MEVM was orally administered at doses of 30, 100, and 300 mg/kg, for three weeks, starting from the 2nd week of HFD. Systolic blood pressure (SBP) and diuretic activity were measured weekly. At the end of experiments the serum lipids, atherogenic index serum (AIS), oxidative stress, and markers of renal function were determined. HFD induced a significant increase in the systolic blood pressure, dyslipidemia, increase in AIS, and lipid peroxidation accompanied by an important reduction in renal function. Treatment with MEVM was able to prevent increase in SBP, total cholesterol, triglycerides, AIS, urea, and creatinine levels in LDLr-null mice. These effects were accompanied by a significant reduction in oxidative stress and renal injury. The data reported here support the potential of<jats:italic>Vitex megapotamica</jats:italic>as candidate to be an herbal medicine used in cardiovascular or renal diseases.</jats:p> Renoprotective Effects of<i>Vitex megapotamica</i>(Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet Evidence-Based Complementary and Alternative Medicine |
| spellingShingle | Araújo, Valdinei de Oliveira, Gasparotto, Francielly Mourão, Pires, Vanessa Aranega, Maciel, Aline Antunes, Ortmann, Caroline Flach, Cardozo Junior, Euclides Lara, Lourenço, Emerson Luiz Botelho, Gasparotto Junior, Arquimedes, Evidence-Based Complementary and Alternative Medicine, Renoprotective Effects ofVitex megapotamica(Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet, Complementary and alternative medicine |
| title | Renoprotective Effects ofVitex megapotamica(Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet |
| title_full | Renoprotective Effects ofVitex megapotamica(Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet |
| title_fullStr | Renoprotective Effects ofVitex megapotamica(Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet |
| title_full_unstemmed | Renoprotective Effects ofVitex megapotamica(Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet |
| title_short | Renoprotective Effects ofVitex megapotamica(Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet |
| title_sort | renoprotective effects of<i>vitex megapotamica</i>(spreng.) moldenke in c57bl/6 ldlr-null mice undergoing high fat diet |
| title_unstemmed | Renoprotective Effects ofVitex megapotamica(Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet |
| topic | Complementary and alternative medicine |
| url | http://dx.doi.org/10.1155/2015/475380 |