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Glyoxylate, a New Marker Metabolite of Type 2 Diabetes
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| Zeitschriftentitel: | Journal of Diabetes Research |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Journal of Diabetes Research, 2014, 2014, S. 1-9 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Hindawi Limited
|
| Schlagwörter: |
| author_facet |
Nikiforova, Victoria J. Giesbertz, Pieter Wiemer, Jan Bethan, Bianca Looser, Ralf Liebenberg, Volker Ruiz Noppinger, Patricia Daniel, Hannelore Rein, Dietrich Nikiforova, Victoria J. Giesbertz, Pieter Wiemer, Jan Bethan, Bianca Looser, Ralf Liebenberg, Volker Ruiz Noppinger, Patricia Daniel, Hannelore Rein, Dietrich |
|---|---|
| author |
Nikiforova, Victoria J. Giesbertz, Pieter Wiemer, Jan Bethan, Bianca Looser, Ralf Liebenberg, Volker Ruiz Noppinger, Patricia Daniel, Hannelore Rein, Dietrich |
| spellingShingle |
Nikiforova, Victoria J. Giesbertz, Pieter Wiemer, Jan Bethan, Bianca Looser, Ralf Liebenberg, Volker Ruiz Noppinger, Patricia Daniel, Hannelore Rein, Dietrich Journal of Diabetes Research Glyoxylate, a New Marker Metabolite of Type 2 Diabetes Endocrinology Endocrinology, Diabetes and Metabolism |
| author_sort |
nikiforova, victoria j. |
| spelling |
Nikiforova, Victoria J. Giesbertz, Pieter Wiemer, Jan Bethan, Bianca Looser, Ralf Liebenberg, Volker Ruiz Noppinger, Patricia Daniel, Hannelore Rein, Dietrich 2314-6745 2314-6753 Hindawi Limited Endocrinology Endocrinology, Diabetes and Metabolism http://dx.doi.org/10.1155/2014/685204 <jats:p>Type 2 diabetes (T2D) is characterized by a variety of metabolic impairments that are closely linked to nonenzymatic glycation reactions of proteins and peptides resulting in advanced glycation end-products (AGEs). Reactive aldehydes derived from sugars play an important role in the generation of AGEs. Using metabolite profiling to characterize human plasma from diabetic versus nondiabetic subjects we observed in a recent study that the reactive aldehyde glyoxylate was increased before high levels of plasma glucose, typical for a diabetic condition, could be measured. Following this observation, we explored the relevance of increased glyoxylate in diabetic subjects and in diabetic C57BLKS/J-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msup><mml:mrow><mml:mtext mathvariant="normal">L</mml:mtext><mml:mtext mathvariant="normal">e</mml:mtext><mml:mtext mathvariant="normal">p</mml:mtext><mml:mtext mathvariant="normal">r</mml:mtext></mml:mrow><mml:mrow><mml:msup><mml:mrow><mml:mi>d</mml:mi><mml:mi>b</mml:mi><mml:mo>/</mml:mo><mml:mi>d</mml:mi><mml:mi>b</mml:mi></mml:mrow><mml:mrow><mml:mo>-</mml:mo><mml:mo>/</mml:mo><mml:mo>-</mml:mo></mml:mrow></mml:msup></mml:mrow></mml:msup></mml:mrow></mml:math>mice in the pathophysiology of diabetes. A retrospective study using samples of long-term blood donors revealed that glyoxylate levels unlike glucose levels became significantly elevated up to 3 years prior to diabetes diagnosis (difference to control<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.034</mml:mn></mml:math>). Elevated glyoxylate levels impact on newly identified mechanisms linking hyperglycemia and AGE production with diabetes-associated complications such as diabetic nephropathy. Glyoxylate in its metabolic network may serve as an early marker in diabetes diagnosis with predictive qualities for associated complications and as potential to guide the development of new antidiabetic therapies.</jats:p> Glyoxylate, a New Marker Metabolite of Type 2 Diabetes Journal of Diabetes Research |
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| title |
Glyoxylate, a New Marker Metabolite of Type 2 Diabetes |
| title_unstemmed |
Glyoxylate, a New Marker Metabolite of Type 2 Diabetes |
| title_full |
Glyoxylate, a New Marker Metabolite of Type 2 Diabetes |
| title_fullStr |
Glyoxylate, a New Marker Metabolite of Type 2 Diabetes |
| title_full_unstemmed |
Glyoxylate, a New Marker Metabolite of Type 2 Diabetes |
| title_short |
Glyoxylate, a New Marker Metabolite of Type 2 Diabetes |
| title_sort |
glyoxylate, a new marker metabolite of type 2 diabetes |
| topic |
Endocrinology Endocrinology, Diabetes and Metabolism |
| url |
http://dx.doi.org/10.1155/2014/685204 |
| publishDate |
2014 |
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1-9 |
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<jats:p>Type 2 diabetes (T2D) is characterized by a variety of metabolic impairments that are closely linked to nonenzymatic glycation reactions of proteins and peptides resulting in advanced glycation end-products (AGEs). Reactive aldehydes derived from sugars play an important role in the generation of AGEs. Using metabolite profiling to characterize human plasma from diabetic versus nondiabetic subjects we observed in a recent study that the reactive aldehyde glyoxylate was increased before high levels of plasma glucose, typical for a diabetic condition, could be measured. Following this observation, we explored the relevance of increased glyoxylate in diabetic subjects and in diabetic C57BLKS/J-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msup><mml:mrow><mml:mtext mathvariant="normal">L</mml:mtext><mml:mtext mathvariant="normal">e</mml:mtext><mml:mtext mathvariant="normal">p</mml:mtext><mml:mtext mathvariant="normal">r</mml:mtext></mml:mrow><mml:mrow><mml:msup><mml:mrow><mml:mi>d</mml:mi><mml:mi>b</mml:mi><mml:mo>/</mml:mo><mml:mi>d</mml:mi><mml:mi>b</mml:mi></mml:mrow><mml:mrow><mml:mo>-</mml:mo><mml:mo>/</mml:mo><mml:mo>-</mml:mo></mml:mrow></mml:msup></mml:mrow></mml:msup></mml:mrow></mml:math>mice in the pathophysiology of diabetes. A retrospective study using samples of long-term blood donors revealed that glyoxylate levels unlike glucose levels became significantly elevated up to 3 years prior to diabetes diagnosis (difference to control<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.034</mml:mn></mml:math>). Elevated glyoxylate levels impact on newly identified mechanisms linking hyperglycemia and AGE production with diabetes-associated complications such as diabetic nephropathy. Glyoxylate in its metabolic network may serve as an early marker in diabetes diagnosis with predictive qualities for associated complications and as potential to guide the development of new antidiabetic therapies.</jats:p> |
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| author | Nikiforova, Victoria J., Giesbertz, Pieter, Wiemer, Jan, Bethan, Bianca, Looser, Ralf, Liebenberg, Volker, Ruiz Noppinger, Patricia, Daniel, Hannelore, Rein, Dietrich |
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| description | <jats:p>Type 2 diabetes (T2D) is characterized by a variety of metabolic impairments that are closely linked to nonenzymatic glycation reactions of proteins and peptides resulting in advanced glycation end-products (AGEs). Reactive aldehydes derived from sugars play an important role in the generation of AGEs. Using metabolite profiling to characterize human plasma from diabetic versus nondiabetic subjects we observed in a recent study that the reactive aldehyde glyoxylate was increased before high levels of plasma glucose, typical for a diabetic condition, could be measured. Following this observation, we explored the relevance of increased glyoxylate in diabetic subjects and in diabetic C57BLKS/J-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msup><mml:mrow><mml:mtext mathvariant="normal">L</mml:mtext><mml:mtext mathvariant="normal">e</mml:mtext><mml:mtext mathvariant="normal">p</mml:mtext><mml:mtext mathvariant="normal">r</mml:mtext></mml:mrow><mml:mrow><mml:msup><mml:mrow><mml:mi>d</mml:mi><mml:mi>b</mml:mi><mml:mo>/</mml:mo><mml:mi>d</mml:mi><mml:mi>b</mml:mi></mml:mrow><mml:mrow><mml:mo>-</mml:mo><mml:mo>/</mml:mo><mml:mo>-</mml:mo></mml:mrow></mml:msup></mml:mrow></mml:msup></mml:mrow></mml:math>mice in the pathophysiology of diabetes. A retrospective study using samples of long-term blood donors revealed that glyoxylate levels unlike glucose levels became significantly elevated up to 3 years prior to diabetes diagnosis (difference to control<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.034</mml:mn></mml:math>). Elevated glyoxylate levels impact on newly identified mechanisms linking hyperglycemia and AGE production with diabetes-associated complications such as diabetic nephropathy. Glyoxylate in its metabolic network may serve as an early marker in diabetes diagnosis with predictive qualities for associated complications and as potential to guide the development of new antidiabetic therapies.</jats:p> |
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| spelling | Nikiforova, Victoria J. Giesbertz, Pieter Wiemer, Jan Bethan, Bianca Looser, Ralf Liebenberg, Volker Ruiz Noppinger, Patricia Daniel, Hannelore Rein, Dietrich 2314-6745 2314-6753 Hindawi Limited Endocrinology Endocrinology, Diabetes and Metabolism http://dx.doi.org/10.1155/2014/685204 <jats:p>Type 2 diabetes (T2D) is characterized by a variety of metabolic impairments that are closely linked to nonenzymatic glycation reactions of proteins and peptides resulting in advanced glycation end-products (AGEs). Reactive aldehydes derived from sugars play an important role in the generation of AGEs. Using metabolite profiling to characterize human plasma from diabetic versus nondiabetic subjects we observed in a recent study that the reactive aldehyde glyoxylate was increased before high levels of plasma glucose, typical for a diabetic condition, could be measured. Following this observation, we explored the relevance of increased glyoxylate in diabetic subjects and in diabetic C57BLKS/J-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msup><mml:mrow><mml:mtext mathvariant="normal">L</mml:mtext><mml:mtext mathvariant="normal">e</mml:mtext><mml:mtext mathvariant="normal">p</mml:mtext><mml:mtext mathvariant="normal">r</mml:mtext></mml:mrow><mml:mrow><mml:msup><mml:mrow><mml:mi>d</mml:mi><mml:mi>b</mml:mi><mml:mo>/</mml:mo><mml:mi>d</mml:mi><mml:mi>b</mml:mi></mml:mrow><mml:mrow><mml:mo>-</mml:mo><mml:mo>/</mml:mo><mml:mo>-</mml:mo></mml:mrow></mml:msup></mml:mrow></mml:msup></mml:mrow></mml:math>mice in the pathophysiology of diabetes. A retrospective study using samples of long-term blood donors revealed that glyoxylate levels unlike glucose levels became significantly elevated up to 3 years prior to diabetes diagnosis (difference to control<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.034</mml:mn></mml:math>). Elevated glyoxylate levels impact on newly identified mechanisms linking hyperglycemia and AGE production with diabetes-associated complications such as diabetic nephropathy. Glyoxylate in its metabolic network may serve as an early marker in diabetes diagnosis with predictive qualities for associated complications and as potential to guide the development of new antidiabetic therapies.</jats:p> Glyoxylate, a New Marker Metabolite of Type 2 Diabetes Journal of Diabetes Research |
| spellingShingle | Nikiforova, Victoria J., Giesbertz, Pieter, Wiemer, Jan, Bethan, Bianca, Looser, Ralf, Liebenberg, Volker, Ruiz Noppinger, Patricia, Daniel, Hannelore, Rein, Dietrich, Journal of Diabetes Research, Glyoxylate, a New Marker Metabolite of Type 2 Diabetes, Endocrinology, Endocrinology, Diabetes and Metabolism |
| title | Glyoxylate, a New Marker Metabolite of Type 2 Diabetes |
| title_full | Glyoxylate, a New Marker Metabolite of Type 2 Diabetes |
| title_fullStr | Glyoxylate, a New Marker Metabolite of Type 2 Diabetes |
| title_full_unstemmed | Glyoxylate, a New Marker Metabolite of Type 2 Diabetes |
| title_short | Glyoxylate, a New Marker Metabolite of Type 2 Diabetes |
| title_sort | glyoxylate, a new marker metabolite of type 2 diabetes |
| title_unstemmed | Glyoxylate, a New Marker Metabolite of Type 2 Diabetes |
| topic | Endocrinology, Endocrinology, Diabetes and Metabolism |
| url | http://dx.doi.org/10.1155/2014/685204 |