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Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines
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| Zeitschriftentitel: | PPAR Research |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | PPAR Research, 2007, 2007, S. 1-9 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Hindawi Limited
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| Schlagwörter: |
| author_facet |
Martinasso, G. Oraldi, M. Trombetta, A. Maggiora, M. Bertetto, O. Canuto, R. A. Muzio, G. Martinasso, G. Oraldi, M. Trombetta, A. Maggiora, M. Bertetto, O. Canuto, R. A. Muzio, G. |
|---|---|
| author |
Martinasso, G. Oraldi, M. Trombetta, A. Maggiora, M. Bertetto, O. Canuto, R. A. Muzio, G. |
| spellingShingle |
Martinasso, G. Oraldi, M. Trombetta, A. Maggiora, M. Bertetto, O. Canuto, R. A. Muzio, G. PPAR Research Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines Pharmacology (medical) Drug Discovery |
| author_sort |
martinasso, g. |
| spelling |
Martinasso, G. Oraldi, M. Trombetta, A. Maggiora, M. Bertetto, O. Canuto, R. A. Muzio, G. 1687-4757 1687-4765 Hindawi Limited Pharmacology (medical) Drug Discovery http://dx.doi.org/10.1155/2007/93416 <jats:p>PPAR involvement in cell growth was investigated “in vivo” and “in vitro” and was correlated with cell proliferation and apoptotic death. “In vivo” PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E1"><mml:mi>γ</mml:mi></mml:math>and<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E2"><mml:mi>α</mml:mi></mml:math>were evaluated in colon cancer specimens and adjacent nonneoplastic colonic mucosa. PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E3"><mml:mi>γ</mml:mi></mml:math>increased in most cancer specimens versus mucosa, with a decrease in c-Myc and in PCNA proteins, suggesting that colon cancer growth is due to increased cell survival rather than increased proliferation. The prevalence of survival over proliferation was confirmed by Bcl-2 or Bcl-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E4"><mml:mrow><mml:msub><mml:mtext>X</mml:mtext><mml:mi>L</mml:mi></mml:msub></mml:mrow></mml:math>increase in cancer versus mucosa, and by decreased PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E5"><mml:mi>α</mml:mi></mml:math>. “In vitro” PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E6"><mml:mi>γ</mml:mi></mml:math>and PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E7"><mml:mi>α</mml:mi></mml:math>were evaluated in human tumor and normal cell lines, treated with natural or synthetic ligands. PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E8"><mml:mi>γ</mml:mi></mml:math>was involved in inhibiting cell proliferation with a decrease in c-Myc protein, whereas PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E9"><mml:mi>α</mml:mi></mml:math>was involved in inducing apoptosis with modulation of Bcl-2 and Bad proteins. This involvement was confirmed using specific antagonists of two PPARs. Moreover, the results obtained on treating cell lines with PPAR ligands confirm observations in colon cancer: there is an inverse correlation between PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E10"><mml:mi>α</mml:mi></mml:math>and Bcl-2 and between PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E11"><mml:mi>γ</mml:mi></mml:math>and c-Myc.</jats:p> Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines PPAR Research |
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10.1155/2007/93416 |
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Online Free |
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Hindawi Limited, 2007 |
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Hindawi Limited, 2007 |
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PPAR Research |
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| title |
Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines |
| title_unstemmed |
Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines |
| title_full |
Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines |
| title_fullStr |
Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines |
| title_full_unstemmed |
Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines |
| title_short |
Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines |
| title_sort |
involvement of ppars in cell proliferation and apoptosis in human colon cancer specimens and in normal and cancer cell lines |
| topic |
Pharmacology (medical) Drug Discovery |
| url |
http://dx.doi.org/10.1155/2007/93416 |
| publishDate |
2007 |
| physical |
1-9 |
| description |
<jats:p>PPAR involvement in cell growth was investigated “in vivo” and “in vitro” and was correlated with cell proliferation and apoptotic death. “In vivo” PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E1"><mml:mi>γ</mml:mi></mml:math>and<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E2"><mml:mi>α</mml:mi></mml:math>were evaluated in colon cancer specimens and adjacent nonneoplastic colonic mucosa. PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E3"><mml:mi>γ</mml:mi></mml:math>increased in most cancer specimens versus mucosa, with a decrease in c-Myc and in PCNA proteins, suggesting that colon cancer growth is due to increased cell survival rather than increased proliferation. The prevalence of survival over proliferation was confirmed by Bcl-2 or Bcl-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E4"><mml:mrow><mml:msub><mml:mtext>X</mml:mtext><mml:mi>L</mml:mi></mml:msub></mml:mrow></mml:math>increase in cancer versus mucosa, and by decreased PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E5"><mml:mi>α</mml:mi></mml:math>. “In vitro” PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E6"><mml:mi>γ</mml:mi></mml:math>and PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E7"><mml:mi>α</mml:mi></mml:math>were evaluated in human tumor and normal cell lines, treated with natural or synthetic ligands. PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E8"><mml:mi>γ</mml:mi></mml:math>was involved in inhibiting cell proliferation with a decrease in c-Myc protein, whereas PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E9"><mml:mi>α</mml:mi></mml:math>was involved in inducing apoptosis with modulation of Bcl-2 and Bad proteins. This involvement was confirmed using specific antagonists of two PPARs. Moreover, the results obtained on treating cell lines with PPAR ligands confirm observations in colon cancer: there is an inverse correlation between PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E10"><mml:mi>α</mml:mi></mml:math>and Bcl-2 and between PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E11"><mml:mi>γ</mml:mi></mml:math>and c-Myc.</jats:p> |
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| description | <jats:p>PPAR involvement in cell growth was investigated “in vivo” and “in vitro” and was correlated with cell proliferation and apoptotic death. “In vivo” PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E1"><mml:mi>γ</mml:mi></mml:math>and<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E2"><mml:mi>α</mml:mi></mml:math>were evaluated in colon cancer specimens and adjacent nonneoplastic colonic mucosa. PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E3"><mml:mi>γ</mml:mi></mml:math>increased in most cancer specimens versus mucosa, with a decrease in c-Myc and in PCNA proteins, suggesting that colon cancer growth is due to increased cell survival rather than increased proliferation. The prevalence of survival over proliferation was confirmed by Bcl-2 or Bcl-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E4"><mml:mrow><mml:msub><mml:mtext>X</mml:mtext><mml:mi>L</mml:mi></mml:msub></mml:mrow></mml:math>increase in cancer versus mucosa, and by decreased PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E5"><mml:mi>α</mml:mi></mml:math>. “In vitro” PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E6"><mml:mi>γ</mml:mi></mml:math>and PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E7"><mml:mi>α</mml:mi></mml:math>were evaluated in human tumor and normal cell lines, treated with natural or synthetic ligands. PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E8"><mml:mi>γ</mml:mi></mml:math>was involved in inhibiting cell proliferation with a decrease in c-Myc protein, whereas PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E9"><mml:mi>α</mml:mi></mml:math>was involved in inducing apoptosis with modulation of Bcl-2 and Bad proteins. This involvement was confirmed using specific antagonists of two PPARs. Moreover, the results obtained on treating cell lines with PPAR ligands confirm observations in colon cancer: there is an inverse correlation between PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E10"><mml:mi>α</mml:mi></mml:math>and Bcl-2 and between PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E11"><mml:mi>γ</mml:mi></mml:math>and c-Myc.</jats:p> |
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| spelling | Martinasso, G. Oraldi, M. Trombetta, A. Maggiora, M. Bertetto, O. Canuto, R. A. Muzio, G. 1687-4757 1687-4765 Hindawi Limited Pharmacology (medical) Drug Discovery http://dx.doi.org/10.1155/2007/93416 <jats:p>PPAR involvement in cell growth was investigated “in vivo” and “in vitro” and was correlated with cell proliferation and apoptotic death. “In vivo” PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E1"><mml:mi>γ</mml:mi></mml:math>and<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E2"><mml:mi>α</mml:mi></mml:math>were evaluated in colon cancer specimens and adjacent nonneoplastic colonic mucosa. PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E3"><mml:mi>γ</mml:mi></mml:math>increased in most cancer specimens versus mucosa, with a decrease in c-Myc and in PCNA proteins, suggesting that colon cancer growth is due to increased cell survival rather than increased proliferation. The prevalence of survival over proliferation was confirmed by Bcl-2 or Bcl-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E4"><mml:mrow><mml:msub><mml:mtext>X</mml:mtext><mml:mi>L</mml:mi></mml:msub></mml:mrow></mml:math>increase in cancer versus mucosa, and by decreased PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E5"><mml:mi>α</mml:mi></mml:math>. “In vitro” PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E6"><mml:mi>γ</mml:mi></mml:math>and PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E7"><mml:mi>α</mml:mi></mml:math>were evaluated in human tumor and normal cell lines, treated with natural or synthetic ligands. PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E8"><mml:mi>γ</mml:mi></mml:math>was involved in inhibiting cell proliferation with a decrease in c-Myc protein, whereas PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E9"><mml:mi>α</mml:mi></mml:math>was involved in inducing apoptosis with modulation of Bcl-2 and Bad proteins. This involvement was confirmed using specific antagonists of two PPARs. Moreover, the results obtained on treating cell lines with PPAR ligands confirm observations in colon cancer: there is an inverse correlation between PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E10"><mml:mi>α</mml:mi></mml:math>and Bcl-2 and between PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E11"><mml:mi>γ</mml:mi></mml:math>and c-Myc.</jats:p> Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines PPAR Research |
| spellingShingle | Martinasso, G., Oraldi, M., Trombetta, A., Maggiora, M., Bertetto, O., Canuto, R. A., Muzio, G., PPAR Research, Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines, Pharmacology (medical), Drug Discovery |
| title | Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines |
| title_full | Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines |
| title_fullStr | Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines |
| title_full_unstemmed | Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines |
| title_short | Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines |
| title_sort | involvement of ppars in cell proliferation and apoptosis in human colon cancer specimens and in normal and cancer cell lines |
| title_unstemmed | Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines |
| topic | Pharmacology (medical), Drug Discovery |
| url | http://dx.doi.org/10.1155/2007/93416 |