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Functional mapping for genetic control of programmed cell death
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| Zeitschriftentitel: | Physiological Genomics |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Physiological Genomics, 25, 2006, 3, S. 458-469 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Physiological Society
|
| Schlagwörter: |
| author_facet |
Cui, Yuehua Zhu, Jun Wu, Rongling Cui, Yuehua Zhu, Jun Wu, Rongling |
|---|---|
| author |
Cui, Yuehua Zhu, Jun Wu, Rongling |
| spellingShingle |
Cui, Yuehua Zhu, Jun Wu, Rongling Physiological Genomics Functional mapping for genetic control of programmed cell death Genetics Physiology |
| author_sort |
cui, yuehua |
| spelling |
Cui, Yuehua Zhu, Jun Wu, Rongling 1094-8341 1531-2267 American Physiological Society Genetics Physiology http://dx.doi.org/10.1152/physiolgenomics.00181.2005 <jats:p>“Naturally occurring” or “programmed” cell death (PCD) in which the cell uses specialized cellular machinery to kill itself is a ubiquitous phenomenon that occurs early in organ development. Such a cell suicide mechanism that enables metazoans to control cell number and eliminate cells threatening the organism’s survival has been thought to be under genetic control. In this report, we develop a novel statistical model for mapping specific genes or quantitative trait loci (QTL) that are responsible for the PCD process based on polymorphic molecular markers. This model incorporates the biological mechanisms of PCD that undergoes two different developmental stages, exponential growth and polynomial death. We derived a parametric approach to model the exponential growth and a nonparametric approach based on the Legendre function to model the polynomial death. A series of stationary and nonstationary models has been used to approximate the structure of the covariance matrix among cell numbers at a multitude of different times. The statistical behavior of our model is investigated through simulation studies and validated by a real example in rice.</jats:p> Functional mapping for genetic control of programmed cell death Physiological Genomics |
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American Physiological Society, 2006 |
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1094-8341 1531-2267 |
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Physiological Genomics |
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| title |
Functional mapping for genetic control of programmed cell death |
| title_unstemmed |
Functional mapping for genetic control of programmed cell death |
| title_full |
Functional mapping for genetic control of programmed cell death |
| title_fullStr |
Functional mapping for genetic control of programmed cell death |
| title_full_unstemmed |
Functional mapping for genetic control of programmed cell death |
| title_short |
Functional mapping for genetic control of programmed cell death |
| title_sort |
functional mapping for genetic control of programmed cell death |
| topic |
Genetics Physiology |
| url |
http://dx.doi.org/10.1152/physiolgenomics.00181.2005 |
| publishDate |
2006 |
| physical |
458-469 |
| description |
<jats:p>“Naturally occurring” or “programmed” cell death (PCD) in which the cell uses specialized cellular machinery to kill itself is a ubiquitous phenomenon that occurs early in organ development. Such a cell suicide mechanism that enables metazoans to control cell number and eliminate cells threatening the organism’s survival has been thought to be under genetic control. In this report, we develop a novel statistical model for mapping specific genes or quantitative trait loci (QTL) that are responsible for the PCD process based on polymorphic molecular markers. This model incorporates the biological mechanisms of PCD that undergoes two different developmental stages, exponential growth and polynomial death. We derived a parametric approach to model the exponential growth and a nonparametric approach based on the Legendre function to model the polynomial death. A series of stationary and nonstationary models has been used to approximate the structure of the covariance matrix among cell numbers at a multitude of different times. The statistical behavior of our model is investigated through simulation studies and validated by a real example in rice.</jats:p> |
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| author | Cui, Yuehua, Zhu, Jun, Wu, Rongling |
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| description | <jats:p>“Naturally occurring” or “programmed” cell death (PCD) in which the cell uses specialized cellular machinery to kill itself is a ubiquitous phenomenon that occurs early in organ development. Such a cell suicide mechanism that enables metazoans to control cell number and eliminate cells threatening the organism’s survival has been thought to be under genetic control. In this report, we develop a novel statistical model for mapping specific genes or quantitative trait loci (QTL) that are responsible for the PCD process based on polymorphic molecular markers. This model incorporates the biological mechanisms of PCD that undergoes two different developmental stages, exponential growth and polynomial death. We derived a parametric approach to model the exponential growth and a nonparametric approach based on the Legendre function to model the polynomial death. A series of stationary and nonstationary models has been used to approximate the structure of the covariance matrix among cell numbers at a multitude of different times. The statistical behavior of our model is investigated through simulation studies and validated by a real example in rice.</jats:p> |
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| imprint_str_mv | American Physiological Society, 2006 |
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| physical | 458-469 |
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| publisher | American Physiological Society |
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| series | Physiological Genomics |
| source_id | 49 |
| spelling | Cui, Yuehua Zhu, Jun Wu, Rongling 1094-8341 1531-2267 American Physiological Society Genetics Physiology http://dx.doi.org/10.1152/physiolgenomics.00181.2005 <jats:p>“Naturally occurring” or “programmed” cell death (PCD) in which the cell uses specialized cellular machinery to kill itself is a ubiquitous phenomenon that occurs early in organ development. Such a cell suicide mechanism that enables metazoans to control cell number and eliminate cells threatening the organism’s survival has been thought to be under genetic control. In this report, we develop a novel statistical model for mapping specific genes or quantitative trait loci (QTL) that are responsible for the PCD process based on polymorphic molecular markers. This model incorporates the biological mechanisms of PCD that undergoes two different developmental stages, exponential growth and polynomial death. We derived a parametric approach to model the exponential growth and a nonparametric approach based on the Legendre function to model the polynomial death. A series of stationary and nonstationary models has been used to approximate the structure of the covariance matrix among cell numbers at a multitude of different times. The statistical behavior of our model is investigated through simulation studies and validated by a real example in rice.</jats:p> Functional mapping for genetic control of programmed cell death Physiological Genomics |
| spellingShingle | Cui, Yuehua, Zhu, Jun, Wu, Rongling, Physiological Genomics, Functional mapping for genetic control of programmed cell death, Genetics, Physiology |
| title | Functional mapping for genetic control of programmed cell death |
| title_full | Functional mapping for genetic control of programmed cell death |
| title_fullStr | Functional mapping for genetic control of programmed cell death |
| title_full_unstemmed | Functional mapping for genetic control of programmed cell death |
| title_short | Functional mapping for genetic control of programmed cell death |
| title_sort | functional mapping for genetic control of programmed cell death |
| title_unstemmed | Functional mapping for genetic control of programmed cell death |
| topic | Genetics, Physiology |
| url | http://dx.doi.org/10.1152/physiolgenomics.00181.2005 |