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Bypassing Border Control: Nuclear Envelope Rupture in Disease
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| Zeitschriftentitel: | Physiology |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Physiology, 33, 2018, 1, S. 39-49 |
| Format: | E-Article |
| Sprache: | Englisch |
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American Physiological Society
|
| Schlagwörter: |
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Houthaeve, Gaëlle Robijns, Joke Braeckmans, Kevin De Vos, Winnok H. Houthaeve, Gaëlle Robijns, Joke Braeckmans, Kevin De Vos, Winnok H. |
|---|---|
| author |
Houthaeve, Gaëlle Robijns, Joke Braeckmans, Kevin De Vos, Winnok H. |
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Houthaeve, Gaëlle Robijns, Joke Braeckmans, Kevin De Vos, Winnok H. Physiology Bypassing Border Control: Nuclear Envelope Rupture in Disease Physiology |
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Houthaeve, Gaëlle Robijns, Joke Braeckmans, Kevin De Vos, Winnok H. 1548-9213 1548-9221 American Physiological Society Physiology http://dx.doi.org/10.1152/physiol.00029.2017 <jats:p>Recent observations in laminopathy patient cells and cancer cells have revealed that the nuclear envelope (NE) can transiently rupture during interphase. NE rupture leads to an uncoordinated exchange of nuclear and cytoplasmic material, thereby deregulating cellular homeostasis. Moreover, concurrently inflicted DNA damage could prime rupture-prone cells for genome instability. Thus, NE rupture may represent a novel pathogenic mechanism that has far-reaching consequences for cell and organism physiology.</jats:p> Bypassing Border Control: Nuclear Envelope Rupture in Disease Physiology |
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Bypassing Border Control: Nuclear Envelope Rupture in Disease |
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Bypassing Border Control: Nuclear Envelope Rupture in Disease |
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Bypassing Border Control: Nuclear Envelope Rupture in Disease |
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Bypassing Border Control: Nuclear Envelope Rupture in Disease |
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Bypassing Border Control: Nuclear Envelope Rupture in Disease |
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Bypassing Border Control: Nuclear Envelope Rupture in Disease |
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bypassing border control: nuclear envelope rupture in disease |
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Physiology |
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http://dx.doi.org/10.1152/physiol.00029.2017 |
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2018 |
| physical |
39-49 |
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<jats:p>Recent observations in laminopathy patient cells and cancer cells have revealed that the nuclear envelope (NE) can transiently rupture during interphase. NE rupture leads to an uncoordinated exchange of nuclear and cytoplasmic material, thereby deregulating cellular homeostasis. Moreover, concurrently inflicted DNA damage could prime rupture-prone cells for genome instability. Thus, NE rupture may represent a novel pathogenic mechanism that has far-reaching consequences for cell and organism physiology.</jats:p> |
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| author | Houthaeve, Gaëlle, Robijns, Joke, Braeckmans, Kevin, De Vos, Winnok H. |
| author_facet | Houthaeve, Gaëlle, Robijns, Joke, Braeckmans, Kevin, De Vos, Winnok H., Houthaeve, Gaëlle, Robijns, Joke, Braeckmans, Kevin, De Vos, Winnok H. |
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| description | <jats:p>Recent observations in laminopathy patient cells and cancer cells have revealed that the nuclear envelope (NE) can transiently rupture during interphase. NE rupture leads to an uncoordinated exchange of nuclear and cytoplasmic material, thereby deregulating cellular homeostasis. Moreover, concurrently inflicted DNA damage could prime rupture-prone cells for genome instability. Thus, NE rupture may represent a novel pathogenic mechanism that has far-reaching consequences for cell and organism physiology.</jats:p> |
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| series | Physiology |
| source_id | 49 |
| spelling | Houthaeve, Gaëlle Robijns, Joke Braeckmans, Kevin De Vos, Winnok H. 1548-9213 1548-9221 American Physiological Society Physiology http://dx.doi.org/10.1152/physiol.00029.2017 <jats:p>Recent observations in laminopathy patient cells and cancer cells have revealed that the nuclear envelope (NE) can transiently rupture during interphase. NE rupture leads to an uncoordinated exchange of nuclear and cytoplasmic material, thereby deregulating cellular homeostasis. Moreover, concurrently inflicted DNA damage could prime rupture-prone cells for genome instability. Thus, NE rupture may represent a novel pathogenic mechanism that has far-reaching consequences for cell and organism physiology.</jats:p> Bypassing Border Control: Nuclear Envelope Rupture in Disease Physiology |
| spellingShingle | Houthaeve, Gaëlle, Robijns, Joke, Braeckmans, Kevin, De Vos, Winnok H., Physiology, Bypassing Border Control: Nuclear Envelope Rupture in Disease, Physiology |
| title | Bypassing Border Control: Nuclear Envelope Rupture in Disease |
| title_full | Bypassing Border Control: Nuclear Envelope Rupture in Disease |
| title_fullStr | Bypassing Border Control: Nuclear Envelope Rupture in Disease |
| title_full_unstemmed | Bypassing Border Control: Nuclear Envelope Rupture in Disease |
| title_short | Bypassing Border Control: Nuclear Envelope Rupture in Disease |
| title_sort | bypassing border control: nuclear envelope rupture in disease |
| title_unstemmed | Bypassing Border Control: Nuclear Envelope Rupture in Disease |
| topic | Physiology |
| url | http://dx.doi.org/10.1152/physiol.00029.2017 |