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Responses of Rapidly Adapting Afferent Neurons to Dynamic Stretch of Rat Hairy Skin
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| Zeitschriftentitel: | Journal of Neurophysiology |
|---|---|
| Personen und Körperschaften: | , |
| In: | Journal of Neurophysiology, 80, 1998, 2, S. 745-754 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Physiological Society
|
| Schlagwörter: |
| author_facet |
Prete, Zaccaria Del Grigg, Peter Prete, Zaccaria Del Grigg, Peter |
|---|---|
| author |
Prete, Zaccaria Del Grigg, Peter |
| spellingShingle |
Prete, Zaccaria Del Grigg, Peter Journal of Neurophysiology Responses of Rapidly Adapting Afferent Neurons to Dynamic Stretch of Rat Hairy Skin Physiology General Neuroscience |
| author_sort |
prete, zaccaria del |
| spelling |
Prete, Zaccaria Del Grigg, Peter 0022-3077 1522-1598 American Physiological Society Physiology General Neuroscience http://dx.doi.org/10.1152/jn.1998.80.2.745 <jats:p> Del Prete, Zaccaria and Peter Grigg. Responses of rapidly adapting afferent neurons to dynamic stretch of rat hairy skin. J. Neurophysiol. 80: 745–754, 1998. Twenty-four rapidly adapting (RA) cutaneous afferents were recorded from a preparation of isolated, innervated hairy skin from the rat hindlimb for the purpose of identifying the mechanical variables associated with the initiation of afferent discharge. Neurons were studied while the skin was stretched dynamically along a single direction with the use of a linear actuator and a feedback controller. Input signals were load- or displacement-controlled stretches that followed either periodic or pseudorandom Gaussian noise control signals. When the tissue was actuated, loads and displacements were measured along the direction of stretch and neuronal responses were recorded. All RA afferents were activated by dynamic stretching. None had a sustained response to static stretch. Cross-correlation products, calculated between neuronal responses and either stress- or strain-related variables observed at the time of the spike, revealed a strong relationship between neuronal responses and tensile stress. Neuronal responses were observed at rates of change of stress between +1,000 and −800 kPa/s. Neuronal responses were poorly related to skin strain. Two loading conditions were used along the direction transverse to the stretch. In one condition the sides were unconstrained, so that on axial loading there was zero stress and negative strain along the transverse axis. In the other condition the sides were constrained so that when the tissue was loaded axially there was zero strain and positive stress along the transverse axis. In these two conditions the same level of axial stress was associated with two levels of axial strain. The neuronal responses were determined by the stress and not the strain. Neuronal responses were observed at stresses >5 kPa. It appears that RA afferents make little contribution to signaling limb movements or position in rat hindlimb on the basis of the behavior of rat hindlimb skin, as observed when the limb is rotated. </jats:p> Responses of Rapidly Adapting Afferent Neurons to Dynamic Stretch of Rat Hairy Skin Journal of Neurophysiology |
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| title |
Responses of Rapidly Adapting Afferent Neurons to Dynamic Stretch of Rat Hairy Skin |
| title_unstemmed |
Responses of Rapidly Adapting Afferent Neurons to Dynamic Stretch of Rat Hairy Skin |
| title_full |
Responses of Rapidly Adapting Afferent Neurons to Dynamic Stretch of Rat Hairy Skin |
| title_fullStr |
Responses of Rapidly Adapting Afferent Neurons to Dynamic Stretch of Rat Hairy Skin |
| title_full_unstemmed |
Responses of Rapidly Adapting Afferent Neurons to Dynamic Stretch of Rat Hairy Skin |
| title_short |
Responses of Rapidly Adapting Afferent Neurons to Dynamic Stretch of Rat Hairy Skin |
| title_sort |
responses of rapidly adapting afferent neurons to dynamic stretch of rat hairy skin |
| topic |
Physiology General Neuroscience |
| url |
http://dx.doi.org/10.1152/jn.1998.80.2.745 |
| publishDate |
1998 |
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745-754 |
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<jats:p> Del Prete, Zaccaria and Peter Grigg. Responses of rapidly adapting afferent neurons to dynamic stretch of rat hairy skin. J. Neurophysiol. 80: 745–754, 1998. Twenty-four rapidly adapting (RA) cutaneous afferents were recorded from a preparation of isolated, innervated hairy skin from the rat hindlimb for the purpose of identifying the mechanical variables associated with the initiation of afferent discharge. Neurons were studied while the skin was stretched dynamically along a single direction with the use of a linear actuator and a feedback controller. Input signals were load- or displacement-controlled stretches that followed either periodic or pseudorandom Gaussian noise control signals. When the tissue was actuated, loads and displacements were measured along the direction of stretch and neuronal responses were recorded. All RA afferents were activated by dynamic stretching. None had a sustained response to static stretch. Cross-correlation products, calculated between neuronal responses and either stress- or strain-related variables observed at the time of the spike, revealed a strong relationship between neuronal responses and tensile stress. Neuronal responses were observed at rates of change of stress between +1,000 and −800 kPa/s. Neuronal responses were poorly related to skin strain. Two loading conditions were used along the direction transverse to the stretch. In one condition the sides were unconstrained, so that on axial loading there was zero stress and negative strain along the transverse axis. In the other condition the sides were constrained so that when the tissue was loaded axially there was zero strain and positive stress along the transverse axis. In these two conditions the same level of axial stress was associated with two levels of axial strain. The neuronal responses were determined by the stress and not the strain. Neuronal responses were observed at stresses >5 kPa. It appears that RA afferents make little contribution to signaling limb movements or position in rat hindlimb on the basis of the behavior of rat hindlimb skin, as observed when the limb is rotated. </jats:p> |
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| description | <jats:p> Del Prete, Zaccaria and Peter Grigg. Responses of rapidly adapting afferent neurons to dynamic stretch of rat hairy skin. J. Neurophysiol. 80: 745–754, 1998. Twenty-four rapidly adapting (RA) cutaneous afferents were recorded from a preparation of isolated, innervated hairy skin from the rat hindlimb for the purpose of identifying the mechanical variables associated with the initiation of afferent discharge. Neurons were studied while the skin was stretched dynamically along a single direction with the use of a linear actuator and a feedback controller. Input signals were load- or displacement-controlled stretches that followed either periodic or pseudorandom Gaussian noise control signals. When the tissue was actuated, loads and displacements were measured along the direction of stretch and neuronal responses were recorded. All RA afferents were activated by dynamic stretching. None had a sustained response to static stretch. Cross-correlation products, calculated between neuronal responses and either stress- or strain-related variables observed at the time of the spike, revealed a strong relationship between neuronal responses and tensile stress. Neuronal responses were observed at rates of change of stress between +1,000 and −800 kPa/s. Neuronal responses were poorly related to skin strain. Two loading conditions were used along the direction transverse to the stretch. In one condition the sides were unconstrained, so that on axial loading there was zero stress and negative strain along the transverse axis. In the other condition the sides were constrained so that when the tissue was loaded axially there was zero strain and positive stress along the transverse axis. In these two conditions the same level of axial stress was associated with two levels of axial strain. The neuronal responses were determined by the stress and not the strain. Neuronal responses were observed at stresses >5 kPa. It appears that RA afferents make little contribution to signaling limb movements or position in rat hindlimb on the basis of the behavior of rat hindlimb skin, as observed when the limb is rotated. </jats:p> |
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| spelling | Prete, Zaccaria Del Grigg, Peter 0022-3077 1522-1598 American Physiological Society Physiology General Neuroscience http://dx.doi.org/10.1152/jn.1998.80.2.745 <jats:p> Del Prete, Zaccaria and Peter Grigg. Responses of rapidly adapting afferent neurons to dynamic stretch of rat hairy skin. J. Neurophysiol. 80: 745–754, 1998. Twenty-four rapidly adapting (RA) cutaneous afferents were recorded from a preparation of isolated, innervated hairy skin from the rat hindlimb for the purpose of identifying the mechanical variables associated with the initiation of afferent discharge. Neurons were studied while the skin was stretched dynamically along a single direction with the use of a linear actuator and a feedback controller. Input signals were load- or displacement-controlled stretches that followed either periodic or pseudorandom Gaussian noise control signals. When the tissue was actuated, loads and displacements were measured along the direction of stretch and neuronal responses were recorded. All RA afferents were activated by dynamic stretching. None had a sustained response to static stretch. Cross-correlation products, calculated between neuronal responses and either stress- or strain-related variables observed at the time of the spike, revealed a strong relationship between neuronal responses and tensile stress. Neuronal responses were observed at rates of change of stress between +1,000 and −800 kPa/s. Neuronal responses were poorly related to skin strain. Two loading conditions were used along the direction transverse to the stretch. In one condition the sides were unconstrained, so that on axial loading there was zero stress and negative strain along the transverse axis. In the other condition the sides were constrained so that when the tissue was loaded axially there was zero strain and positive stress along the transverse axis. In these two conditions the same level of axial stress was associated with two levels of axial strain. The neuronal responses were determined by the stress and not the strain. Neuronal responses were observed at stresses >5 kPa. It appears that RA afferents make little contribution to signaling limb movements or position in rat hindlimb on the basis of the behavior of rat hindlimb skin, as observed when the limb is rotated. </jats:p> Responses of Rapidly Adapting Afferent Neurons to Dynamic Stretch of Rat Hairy Skin Journal of Neurophysiology |
| spellingShingle | Prete, Zaccaria Del, Grigg, Peter, Journal of Neurophysiology, Responses of Rapidly Adapting Afferent Neurons to Dynamic Stretch of Rat Hairy Skin, Physiology, General Neuroscience |
| title | Responses of Rapidly Adapting Afferent Neurons to Dynamic Stretch of Rat Hairy Skin |
| title_full | Responses of Rapidly Adapting Afferent Neurons to Dynamic Stretch of Rat Hairy Skin |
| title_fullStr | Responses of Rapidly Adapting Afferent Neurons to Dynamic Stretch of Rat Hairy Skin |
| title_full_unstemmed | Responses of Rapidly Adapting Afferent Neurons to Dynamic Stretch of Rat Hairy Skin |
| title_short | Responses of Rapidly Adapting Afferent Neurons to Dynamic Stretch of Rat Hairy Skin |
| title_sort | responses of rapidly adapting afferent neurons to dynamic stretch of rat hairy skin |
| title_unstemmed | Responses of Rapidly Adapting Afferent Neurons to Dynamic Stretch of Rat Hairy Skin |
| topic | Physiology, General Neuroscience |
| url | http://dx.doi.org/10.1152/jn.1998.80.2.745 |