Eintrag weiter verarbeiten
Evidence That Phospholipase D Activation Prevents Group I mGluR-Induced Persistent Prolongation of Epileptiform Bursts
Gespeichert in:
| Zeitschriftentitel: | Journal of Neurophysiology |
|---|---|
| Personen und Körperschaften: | , |
| In: | Journal of Neurophysiology, 91, 2004, 5, S. 2385-2388 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Physiological Society
|
| Schlagwörter: |
| author_facet |
Rico, Marjorie J. Merlin, Lisa R. Rico, Marjorie J. Merlin, Lisa R. |
|---|---|
| author |
Rico, Marjorie J. Merlin, Lisa R. |
| spellingShingle |
Rico, Marjorie J. Merlin, Lisa R. Journal of Neurophysiology Evidence That Phospholipase D Activation Prevents Group I mGluR-Induced Persistent Prolongation of Epileptiform Bursts Physiology General Neuroscience |
| author_sort |
rico, marjorie j. |
| spelling |
Rico, Marjorie J. Merlin, Lisa R. 0022-3077 1522-1598 American Physiological Society Physiology General Neuroscience http://dx.doi.org/10.1152/jn.01140.2003 <jats:p> Selective activation of group I metabotropic glutamate receptors (mGluRs) with ( S)-3,5-dihydroxyphenylglycine (DHPG) in guinea pig hippocampal slices converts 275- to 475-ms picrotoxin-induced interictal bursts into persistent seizure-length discharges typically over 1 s in duration. Here we report that l-cysteine sulfinic acid (CSA), a sulfur-containing amino acid, prevented the induction of this persistent group I mGluR-mediated epileptiform burst prolongation. However, CSA had no effect on baseline interictal bursting activity and failed to suppress the expression of the group I mGluR-induced persistent prolonged bursts once they were fully induced. (2 R,1′ S,2′ R,3′ S)-2-(2′-carboxy-3′-phenylcyclopropyl)glycine (PCCG-13), a selective antagonist at the phospholipase D (PLD)-coupled mGluR, had no effect of its own on DHPG-induced burst prolongation; however, CSA applied in the presence of PCCG-13 could no longer fully block the burst prolongation induced by DHPG, suggesting that CSA's antiepileptogenic effect is mediated by agonist action at this PLD-coupled receptor. These data parallel our previous data revealing that protein synthesis inhibitors prevent induction but not expression of group I mGluR-mediated persistent seizure-length discharges. Hence, PLD activation with CSA may prevent the synthesis of a protein critical for the induction of group I mGluR-mediated epileptogenesis. </jats:p> Evidence That Phospholipase D Activation Prevents Group I mGluR-Induced Persistent Prolongation of Epileptiform Bursts Journal of Neurophysiology |
| doi_str_mv |
10.1152/jn.01140.2003 |
| facet_avail |
Online Free |
| finc_class_facet |
Biologie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1Mi9qbi4wMTE0MC4yMDAz |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1Mi9qbi4wMTE0MC4yMDAz |
| institution |
DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 |
| imprint |
American Physiological Society, 2004 |
| imprint_str_mv |
American Physiological Society, 2004 |
| issn |
1522-1598 0022-3077 |
| issn_str_mv |
1522-1598 0022-3077 |
| language |
English |
| mega_collection |
American Physiological Society (CrossRef) |
| match_str |
rico2004evidencethatphospholipasedactivationpreventsgroupimglurinducedpersistentprolongationofepileptiformbursts |
| publishDateSort |
2004 |
| publisher |
American Physiological Society |
| recordtype |
ai |
| record_format |
ai |
| series |
Journal of Neurophysiology |
| source_id |
49 |
| title |
Evidence That Phospholipase D Activation Prevents Group I mGluR-Induced Persistent Prolongation of Epileptiform Bursts |
| title_unstemmed |
Evidence That Phospholipase D Activation Prevents Group I mGluR-Induced Persistent Prolongation of Epileptiform Bursts |
| title_full |
Evidence That Phospholipase D Activation Prevents Group I mGluR-Induced Persistent Prolongation of Epileptiform Bursts |
| title_fullStr |
Evidence That Phospholipase D Activation Prevents Group I mGluR-Induced Persistent Prolongation of Epileptiform Bursts |
| title_full_unstemmed |
Evidence That Phospholipase D Activation Prevents Group I mGluR-Induced Persistent Prolongation of Epileptiform Bursts |
| title_short |
Evidence That Phospholipase D Activation Prevents Group I mGluR-Induced Persistent Prolongation of Epileptiform Bursts |
| title_sort |
evidence that phospholipase d activation prevents group i mglur-induced persistent prolongation of epileptiform bursts |
| topic |
Physiology General Neuroscience |
| url |
http://dx.doi.org/10.1152/jn.01140.2003 |
| publishDate |
2004 |
| physical |
2385-2388 |
| description |
<jats:p> Selective activation of group I metabotropic glutamate receptors (mGluRs) with ( S)-3,5-dihydroxyphenylglycine (DHPG) in guinea pig hippocampal slices converts 275- to 475-ms picrotoxin-induced interictal bursts into persistent seizure-length discharges typically over 1 s in duration. Here we report that l-cysteine sulfinic acid (CSA), a sulfur-containing amino acid, prevented the induction of this persistent group I mGluR-mediated epileptiform burst prolongation. However, CSA had no effect on baseline interictal bursting activity and failed to suppress the expression of the group I mGluR-induced persistent prolonged bursts once they were fully induced. (2 R,1′ S,2′ R,3′ S)-2-(2′-carboxy-3′-phenylcyclopropyl)glycine (PCCG-13), a selective antagonist at the phospholipase D (PLD)-coupled mGluR, had no effect of its own on DHPG-induced burst prolongation; however, CSA applied in the presence of PCCG-13 could no longer fully block the burst prolongation induced by DHPG, suggesting that CSA's antiepileptogenic effect is mediated by agonist action at this PLD-coupled receptor. These data parallel our previous data revealing that protein synthesis inhibitors prevent induction but not expression of group I mGluR-mediated persistent seizure-length discharges. Hence, PLD activation with CSA may prevent the synthesis of a protein critical for the induction of group I mGluR-mediated epileptogenesis. </jats:p> |
| container_issue |
5 |
| container_start_page |
2385 |
| container_title |
Journal of Neurophysiology |
| container_volume |
91 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792337051120566277 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T15:10:10.879Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Evidence+That+Phospholipase+D+Activation+Prevents+Group+I+mGluR-Induced+Persistent+Prolongation+of+Epileptiform+Bursts&rft.date=2004-05-01&genre=article&issn=1522-1598&volume=91&issue=5&spage=2385&epage=2388&pages=2385-2388&jtitle=Journal+of+Neurophysiology&atitle=Evidence+That+Phospholipase+D+Activation+Prevents+Group+I+mGluR-Induced+Persistent+Prolongation+of+Epileptiform+Bursts&aulast=Merlin&aufirst=Lisa+R.&rft_id=info%3Adoi%2F10.1152%2Fjn.01140.2003&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792337051120566277 |
| author | Rico, Marjorie J., Merlin, Lisa R. |
| author_facet | Rico, Marjorie J., Merlin, Lisa R., Rico, Marjorie J., Merlin, Lisa R. |
| author_sort | rico, marjorie j. |
| container_issue | 5 |
| container_start_page | 2385 |
| container_title | Journal of Neurophysiology |
| container_volume | 91 |
| description | <jats:p> Selective activation of group I metabotropic glutamate receptors (mGluRs) with ( S)-3,5-dihydroxyphenylglycine (DHPG) in guinea pig hippocampal slices converts 275- to 475-ms picrotoxin-induced interictal bursts into persistent seizure-length discharges typically over 1 s in duration. Here we report that l-cysteine sulfinic acid (CSA), a sulfur-containing amino acid, prevented the induction of this persistent group I mGluR-mediated epileptiform burst prolongation. However, CSA had no effect on baseline interictal bursting activity and failed to suppress the expression of the group I mGluR-induced persistent prolonged bursts once they were fully induced. (2 R,1′ S,2′ R,3′ S)-2-(2′-carboxy-3′-phenylcyclopropyl)glycine (PCCG-13), a selective antagonist at the phospholipase D (PLD)-coupled mGluR, had no effect of its own on DHPG-induced burst prolongation; however, CSA applied in the presence of PCCG-13 could no longer fully block the burst prolongation induced by DHPG, suggesting that CSA's antiepileptogenic effect is mediated by agonist action at this PLD-coupled receptor. These data parallel our previous data revealing that protein synthesis inhibitors prevent induction but not expression of group I mGluR-mediated persistent seizure-length discharges. Hence, PLD activation with CSA may prevent the synthesis of a protein critical for the induction of group I mGluR-mediated epileptogenesis. </jats:p> |
| doi_str_mv | 10.1152/jn.01140.2003 |
| facet_avail | Online, Free |
| finc_class_facet | Biologie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1Mi9qbi4wMTE0MC4yMDAz |
| imprint | American Physiological Society, 2004 |
| imprint_str_mv | American Physiological Society, 2004 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
| issn | 1522-1598, 0022-3077 |
| issn_str_mv | 1522-1598, 0022-3077 |
| language | English |
| last_indexed | 2024-03-01T15:10:10.879Z |
| match_str | rico2004evidencethatphospholipasedactivationpreventsgroupimglurinducedpersistentprolongationofepileptiformbursts |
| mega_collection | American Physiological Society (CrossRef) |
| physical | 2385-2388 |
| publishDate | 2004 |
| publishDateSort | 2004 |
| publisher | American Physiological Society |
| record_format | ai |
| recordtype | ai |
| series | Journal of Neurophysiology |
| source_id | 49 |
| spelling | Rico, Marjorie J. Merlin, Lisa R. 0022-3077 1522-1598 American Physiological Society Physiology General Neuroscience http://dx.doi.org/10.1152/jn.01140.2003 <jats:p> Selective activation of group I metabotropic glutamate receptors (mGluRs) with ( S)-3,5-dihydroxyphenylglycine (DHPG) in guinea pig hippocampal slices converts 275- to 475-ms picrotoxin-induced interictal bursts into persistent seizure-length discharges typically over 1 s in duration. Here we report that l-cysteine sulfinic acid (CSA), a sulfur-containing amino acid, prevented the induction of this persistent group I mGluR-mediated epileptiform burst prolongation. However, CSA had no effect on baseline interictal bursting activity and failed to suppress the expression of the group I mGluR-induced persistent prolonged bursts once they were fully induced. (2 R,1′ S,2′ R,3′ S)-2-(2′-carboxy-3′-phenylcyclopropyl)glycine (PCCG-13), a selective antagonist at the phospholipase D (PLD)-coupled mGluR, had no effect of its own on DHPG-induced burst prolongation; however, CSA applied in the presence of PCCG-13 could no longer fully block the burst prolongation induced by DHPG, suggesting that CSA's antiepileptogenic effect is mediated by agonist action at this PLD-coupled receptor. These data parallel our previous data revealing that protein synthesis inhibitors prevent induction but not expression of group I mGluR-mediated persistent seizure-length discharges. Hence, PLD activation with CSA may prevent the synthesis of a protein critical for the induction of group I mGluR-mediated epileptogenesis. </jats:p> Evidence That Phospholipase D Activation Prevents Group I mGluR-Induced Persistent Prolongation of Epileptiform Bursts Journal of Neurophysiology |
| spellingShingle | Rico, Marjorie J., Merlin, Lisa R., Journal of Neurophysiology, Evidence That Phospholipase D Activation Prevents Group I mGluR-Induced Persistent Prolongation of Epileptiform Bursts, Physiology, General Neuroscience |
| title | Evidence That Phospholipase D Activation Prevents Group I mGluR-Induced Persistent Prolongation of Epileptiform Bursts |
| title_full | Evidence That Phospholipase D Activation Prevents Group I mGluR-Induced Persistent Prolongation of Epileptiform Bursts |
| title_fullStr | Evidence That Phospholipase D Activation Prevents Group I mGluR-Induced Persistent Prolongation of Epileptiform Bursts |
| title_full_unstemmed | Evidence That Phospholipase D Activation Prevents Group I mGluR-Induced Persistent Prolongation of Epileptiform Bursts |
| title_short | Evidence That Phospholipase D Activation Prevents Group I mGluR-Induced Persistent Prolongation of Epileptiform Bursts |
| title_sort | evidence that phospholipase d activation prevents group i mglur-induced persistent prolongation of epileptiform bursts |
| title_unstemmed | Evidence That Phospholipase D Activation Prevents Group I mGluR-Induced Persistent Prolongation of Epileptiform Bursts |
| topic | Physiology, General Neuroscience |
| url | http://dx.doi.org/10.1152/jn.01140.2003 |