Eintrag weiter verarbeiten
Inducing Homeostatic-Like Plasticity in Human Motor Cortex Through Converging Corticocortical Inputs
Gespeichert in:
| Zeitschriftentitel: | Journal of Neurophysiology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Journal of Neurophysiology, 102, 2009, 6, S. 3180-3190 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Physiological Society
|
| Schlagwörter: |
| author_facet |
Pötter-Nerger, Monika Fischer, Sarah Mastroeni, Claudia Groppa, Sergiu Deuschl, Günther Volkmann, Jens Quartarone, Angelo Münchau, Alexander Siebner, Hartwig Roman Pötter-Nerger, Monika Fischer, Sarah Mastroeni, Claudia Groppa, Sergiu Deuschl, Günther Volkmann, Jens Quartarone, Angelo Münchau, Alexander Siebner, Hartwig Roman |
|---|---|
| author |
Pötter-Nerger, Monika Fischer, Sarah Mastroeni, Claudia Groppa, Sergiu Deuschl, Günther Volkmann, Jens Quartarone, Angelo Münchau, Alexander Siebner, Hartwig Roman |
| spellingShingle |
Pötter-Nerger, Monika Fischer, Sarah Mastroeni, Claudia Groppa, Sergiu Deuschl, Günther Volkmann, Jens Quartarone, Angelo Münchau, Alexander Siebner, Hartwig Roman Journal of Neurophysiology Inducing Homeostatic-Like Plasticity in Human Motor Cortex Through Converging Corticocortical Inputs Physiology General Neuroscience |
| author_sort |
pötter-nerger, monika |
| spelling |
Pötter-Nerger, Monika Fischer, Sarah Mastroeni, Claudia Groppa, Sergiu Deuschl, Günther Volkmann, Jens Quartarone, Angelo Münchau, Alexander Siebner, Hartwig Roman 0022-3077 1522-1598 American Physiological Society Physiology General Neuroscience http://dx.doi.org/10.1152/jn.91046.2008 <jats:p> Transcranial stimulation techniques have revealed homeostatic-like metaplasticity in the hand area of the human primary motor cortex (M1<jats:sub>HAND</jats:sub>) that controls stimulation-induced changes in corticospinal excitability. Here we combined two interventional protocols that induce long-term depression (LTD)–like or long-term potentiation (LTP)–like plasticity in left M1<jats:sub>HAND</jats:sub> through different afferents. We hypothesized that the left M1<jats:sub>HAND</jats:sub> would integrate LTP- and LTD-like plasticity in a homeostatic fashion. In ten healthy volunteers, low-intensity repetitive transcranial magnetic stimulation (rTMS) of the left dorsal premotor cortex (PMD) was first applied to produce an LTP-like increase (5 Hz rTMS) or LTD-like decrease (1 Hz rTMS) in corticospinal excitability in left M1<jats:sub>HAND</jats:sub> via premotor-to-motor inputs. Following PMD rTMS, paired-associative stimulation (PAS) was applied to the right median nerve and left M1<jats:sub>HAND</jats:sub> to induce spike-time–dependent plasticity in sensory-to-motor inputs to left M1<jats:sub>HAND</jats:sub>. We adjusted the interstimulus interval to the N20 latency of the median nerve somatosensory-evoked cortical potential to produce an LTP-like increase (PAS<jats:sub>N20+2ms</jats:sub>) or an LTD-like decrease (PAS<jats:sub>N20−5ms</jats:sub>) in corticospinal excitability. The amplitude of motor-evoked potentials was recorded from intrinsic hand muscles to assess stimulation-induced changes in corticospinal excitability. Premotor-to-motor preconditioning triggered a homeostatic response to subsequent sensory-to-motor PAS. After facilitatory 5 Hz rTMS, “facilitatory” PAS<jats:sub>N20+2ms</jats:sub> suppressed corticospinal excitability. Likewise, “inhibitory” PAS<jats:sub>N20−5ms</jats:sub> facilitated corticospinal excitability after “inhibitory” 1 Hz rTMS. There was a negative linear relationship between the excitability changes induced by PMD rTMS and those elicited by subsequent PAS. Excitability changes were not paralleled by changes in performance during a finger-tapping task. These results provide evidence for a homeostatic response pattern in the human M1<jats:sub>HAND</jats:sub> that integrates acute plastic changes evoked through different “input channels.” </jats:p> Inducing Homeostatic-Like Plasticity in Human Motor Cortex Through Converging Corticocortical Inputs Journal of Neurophysiology |
| doi_str_mv |
10.1152/jn.91046.2008 |
| facet_avail |
Online Free |
| finc_class_facet |
Biologie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1Mi9qbi45MTA0Ni4yMDA4 |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1Mi9qbi45MTA0Ni4yMDA4 |
| institution |
DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Zi4 DE-Gla1 DE-15 DE-Pl11 DE-Rs1 DE-14 DE-105 DE-Ch1 DE-L229 |
| imprint |
American Physiological Society, 2009 |
| imprint_str_mv |
American Physiological Society, 2009 |
| issn |
0022-3077 1522-1598 |
| issn_str_mv |
0022-3077 1522-1598 |
| language |
English |
| mega_collection |
American Physiological Society (CrossRef) |
| match_str |
potternerger2009inducinghomeostaticlikeplasticityinhumanmotorcortexthroughconvergingcorticocorticalinputs |
| publishDateSort |
2009 |
| publisher |
American Physiological Society |
| recordtype |
ai |
| record_format |
ai |
| series |
Journal of Neurophysiology |
| source_id |
49 |
| title |
Inducing Homeostatic-Like Plasticity in Human Motor Cortex Through Converging Corticocortical Inputs |
| title_unstemmed |
Inducing Homeostatic-Like Plasticity in Human Motor Cortex Through Converging Corticocortical Inputs |
| title_full |
Inducing Homeostatic-Like Plasticity in Human Motor Cortex Through Converging Corticocortical Inputs |
| title_fullStr |
Inducing Homeostatic-Like Plasticity in Human Motor Cortex Through Converging Corticocortical Inputs |
| title_full_unstemmed |
Inducing Homeostatic-Like Plasticity in Human Motor Cortex Through Converging Corticocortical Inputs |
| title_short |
Inducing Homeostatic-Like Plasticity in Human Motor Cortex Through Converging Corticocortical Inputs |
| title_sort |
inducing homeostatic-like plasticity in human motor cortex through converging corticocortical inputs |
| topic |
Physiology General Neuroscience |
| url |
http://dx.doi.org/10.1152/jn.91046.2008 |
| publishDate |
2009 |
| physical |
3180-3190 |
| description |
<jats:p> Transcranial stimulation techniques have revealed homeostatic-like metaplasticity in the hand area of the human primary motor cortex (M1<jats:sub>HAND</jats:sub>) that controls stimulation-induced changes in corticospinal excitability. Here we combined two interventional protocols that induce long-term depression (LTD)–like or long-term potentiation (LTP)–like plasticity in left M1<jats:sub>HAND</jats:sub> through different afferents. We hypothesized that the left M1<jats:sub>HAND</jats:sub> would integrate LTP- and LTD-like plasticity in a homeostatic fashion. In ten healthy volunteers, low-intensity repetitive transcranial magnetic stimulation (rTMS) of the left dorsal premotor cortex (PMD) was first applied to produce an LTP-like increase (5 Hz rTMS) or LTD-like decrease (1 Hz rTMS) in corticospinal excitability in left M1<jats:sub>HAND</jats:sub> via premotor-to-motor inputs. Following PMD rTMS, paired-associative stimulation (PAS) was applied to the right median nerve and left M1<jats:sub>HAND</jats:sub> to induce spike-time–dependent plasticity in sensory-to-motor inputs to left M1<jats:sub>HAND</jats:sub>. We adjusted the interstimulus interval to the N20 latency of the median nerve somatosensory-evoked cortical potential to produce an LTP-like increase (PAS<jats:sub>N20+2ms</jats:sub>) or an LTD-like decrease (PAS<jats:sub>N20−5ms</jats:sub>) in corticospinal excitability. The amplitude of motor-evoked potentials was recorded from intrinsic hand muscles to assess stimulation-induced changes in corticospinal excitability. Premotor-to-motor preconditioning triggered a homeostatic response to subsequent sensory-to-motor PAS. After facilitatory 5 Hz rTMS, “facilitatory” PAS<jats:sub>N20+2ms</jats:sub> suppressed corticospinal excitability. Likewise, “inhibitory” PAS<jats:sub>N20−5ms</jats:sub> facilitated corticospinal excitability after “inhibitory” 1 Hz rTMS. There was a negative linear relationship between the excitability changes induced by PMD rTMS and those elicited by subsequent PAS. Excitability changes were not paralleled by changes in performance during a finger-tapping task. These results provide evidence for a homeostatic response pattern in the human M1<jats:sub>HAND</jats:sub> that integrates acute plastic changes evoked through different “input channels.” </jats:p> |
| container_issue |
6 |
| container_start_page |
3180 |
| container_title |
Journal of Neurophysiology |
| container_volume |
102 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792330488903368707 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T13:25:53.065Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Inducing+Homeostatic-Like+Plasticity+in+Human+Motor+Cortex+Through+Converging+Corticocortical+Inputs&rft.date=2009-12-01&genre=article&issn=1522-1598&volume=102&issue=6&spage=3180&epage=3190&pages=3180-3190&jtitle=Journal+of+Neurophysiology&atitle=Inducing+Homeostatic-Like+Plasticity+in+Human+Motor+Cortex+Through+Converging+Corticocortical+Inputs&aulast=Siebner&aufirst=Hartwig+Roman&rft_id=info%3Adoi%2F10.1152%2Fjn.91046.2008&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792330488903368707 |
| author | Pötter-Nerger, Monika, Fischer, Sarah, Mastroeni, Claudia, Groppa, Sergiu, Deuschl, Günther, Volkmann, Jens, Quartarone, Angelo, Münchau, Alexander, Siebner, Hartwig Roman |
| author_facet | Pötter-Nerger, Monika, Fischer, Sarah, Mastroeni, Claudia, Groppa, Sergiu, Deuschl, Günther, Volkmann, Jens, Quartarone, Angelo, Münchau, Alexander, Siebner, Hartwig Roman, Pötter-Nerger, Monika, Fischer, Sarah, Mastroeni, Claudia, Groppa, Sergiu, Deuschl, Günther, Volkmann, Jens, Quartarone, Angelo, Münchau, Alexander, Siebner, Hartwig Roman |
| author_sort | pötter-nerger, monika |
| container_issue | 6 |
| container_start_page | 3180 |
| container_title | Journal of Neurophysiology |
| container_volume | 102 |
| description | <jats:p> Transcranial stimulation techniques have revealed homeostatic-like metaplasticity in the hand area of the human primary motor cortex (M1<jats:sub>HAND</jats:sub>) that controls stimulation-induced changes in corticospinal excitability. Here we combined two interventional protocols that induce long-term depression (LTD)–like or long-term potentiation (LTP)–like plasticity in left M1<jats:sub>HAND</jats:sub> through different afferents. We hypothesized that the left M1<jats:sub>HAND</jats:sub> would integrate LTP- and LTD-like plasticity in a homeostatic fashion. In ten healthy volunteers, low-intensity repetitive transcranial magnetic stimulation (rTMS) of the left dorsal premotor cortex (PMD) was first applied to produce an LTP-like increase (5 Hz rTMS) or LTD-like decrease (1 Hz rTMS) in corticospinal excitability in left M1<jats:sub>HAND</jats:sub> via premotor-to-motor inputs. Following PMD rTMS, paired-associative stimulation (PAS) was applied to the right median nerve and left M1<jats:sub>HAND</jats:sub> to induce spike-time–dependent plasticity in sensory-to-motor inputs to left M1<jats:sub>HAND</jats:sub>. We adjusted the interstimulus interval to the N20 latency of the median nerve somatosensory-evoked cortical potential to produce an LTP-like increase (PAS<jats:sub>N20+2ms</jats:sub>) or an LTD-like decrease (PAS<jats:sub>N20−5ms</jats:sub>) in corticospinal excitability. The amplitude of motor-evoked potentials was recorded from intrinsic hand muscles to assess stimulation-induced changes in corticospinal excitability. Premotor-to-motor preconditioning triggered a homeostatic response to subsequent sensory-to-motor PAS. After facilitatory 5 Hz rTMS, “facilitatory” PAS<jats:sub>N20+2ms</jats:sub> suppressed corticospinal excitability. Likewise, “inhibitory” PAS<jats:sub>N20−5ms</jats:sub> facilitated corticospinal excitability after “inhibitory” 1 Hz rTMS. There was a negative linear relationship between the excitability changes induced by PMD rTMS and those elicited by subsequent PAS. Excitability changes were not paralleled by changes in performance during a finger-tapping task. These results provide evidence for a homeostatic response pattern in the human M1<jats:sub>HAND</jats:sub> that integrates acute plastic changes evoked through different “input channels.” </jats:p> |
| doi_str_mv | 10.1152/jn.91046.2008 |
| facet_avail | Online, Free |
| finc_class_facet | Biologie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1Mi9qbi45MTA0Ni4yMDA4 |
| imprint | American Physiological Society, 2009 |
| imprint_str_mv | American Physiological Society, 2009 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Zi4, DE-Gla1, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-105, DE-Ch1, DE-L229 |
| issn | 0022-3077, 1522-1598 |
| issn_str_mv | 0022-3077, 1522-1598 |
| language | English |
| last_indexed | 2024-03-01T13:25:53.065Z |
| match_str | potternerger2009inducinghomeostaticlikeplasticityinhumanmotorcortexthroughconvergingcorticocorticalinputs |
| mega_collection | American Physiological Society (CrossRef) |
| physical | 3180-3190 |
| publishDate | 2009 |
| publishDateSort | 2009 |
| publisher | American Physiological Society |
| record_format | ai |
| recordtype | ai |
| series | Journal of Neurophysiology |
| source_id | 49 |
| spelling | Pötter-Nerger, Monika Fischer, Sarah Mastroeni, Claudia Groppa, Sergiu Deuschl, Günther Volkmann, Jens Quartarone, Angelo Münchau, Alexander Siebner, Hartwig Roman 0022-3077 1522-1598 American Physiological Society Physiology General Neuroscience http://dx.doi.org/10.1152/jn.91046.2008 <jats:p> Transcranial stimulation techniques have revealed homeostatic-like metaplasticity in the hand area of the human primary motor cortex (M1<jats:sub>HAND</jats:sub>) that controls stimulation-induced changes in corticospinal excitability. Here we combined two interventional protocols that induce long-term depression (LTD)–like or long-term potentiation (LTP)–like plasticity in left M1<jats:sub>HAND</jats:sub> through different afferents. We hypothesized that the left M1<jats:sub>HAND</jats:sub> would integrate LTP- and LTD-like plasticity in a homeostatic fashion. In ten healthy volunteers, low-intensity repetitive transcranial magnetic stimulation (rTMS) of the left dorsal premotor cortex (PMD) was first applied to produce an LTP-like increase (5 Hz rTMS) or LTD-like decrease (1 Hz rTMS) in corticospinal excitability in left M1<jats:sub>HAND</jats:sub> via premotor-to-motor inputs. Following PMD rTMS, paired-associative stimulation (PAS) was applied to the right median nerve and left M1<jats:sub>HAND</jats:sub> to induce spike-time–dependent plasticity in sensory-to-motor inputs to left M1<jats:sub>HAND</jats:sub>. We adjusted the interstimulus interval to the N20 latency of the median nerve somatosensory-evoked cortical potential to produce an LTP-like increase (PAS<jats:sub>N20+2ms</jats:sub>) or an LTD-like decrease (PAS<jats:sub>N20−5ms</jats:sub>) in corticospinal excitability. The amplitude of motor-evoked potentials was recorded from intrinsic hand muscles to assess stimulation-induced changes in corticospinal excitability. Premotor-to-motor preconditioning triggered a homeostatic response to subsequent sensory-to-motor PAS. After facilitatory 5 Hz rTMS, “facilitatory” PAS<jats:sub>N20+2ms</jats:sub> suppressed corticospinal excitability. Likewise, “inhibitory” PAS<jats:sub>N20−5ms</jats:sub> facilitated corticospinal excitability after “inhibitory” 1 Hz rTMS. There was a negative linear relationship between the excitability changes induced by PMD rTMS and those elicited by subsequent PAS. Excitability changes were not paralleled by changes in performance during a finger-tapping task. These results provide evidence for a homeostatic response pattern in the human M1<jats:sub>HAND</jats:sub> that integrates acute plastic changes evoked through different “input channels.” </jats:p> Inducing Homeostatic-Like Plasticity in Human Motor Cortex Through Converging Corticocortical Inputs Journal of Neurophysiology |
| spellingShingle | Pötter-Nerger, Monika, Fischer, Sarah, Mastroeni, Claudia, Groppa, Sergiu, Deuschl, Günther, Volkmann, Jens, Quartarone, Angelo, Münchau, Alexander, Siebner, Hartwig Roman, Journal of Neurophysiology, Inducing Homeostatic-Like Plasticity in Human Motor Cortex Through Converging Corticocortical Inputs, Physiology, General Neuroscience |
| title | Inducing Homeostatic-Like Plasticity in Human Motor Cortex Through Converging Corticocortical Inputs |
| title_full | Inducing Homeostatic-Like Plasticity in Human Motor Cortex Through Converging Corticocortical Inputs |
| title_fullStr | Inducing Homeostatic-Like Plasticity in Human Motor Cortex Through Converging Corticocortical Inputs |
| title_full_unstemmed | Inducing Homeostatic-Like Plasticity in Human Motor Cortex Through Converging Corticocortical Inputs |
| title_short | Inducing Homeostatic-Like Plasticity in Human Motor Cortex Through Converging Corticocortical Inputs |
| title_sort | inducing homeostatic-like plasticity in human motor cortex through converging corticocortical inputs |
| title_unstemmed | Inducing Homeostatic-Like Plasticity in Human Motor Cortex Through Converging Corticocortical Inputs |
| topic | Physiology, General Neuroscience |
| url | http://dx.doi.org/10.1152/jn.91046.2008 |