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Pulmonary vasodilator drugs decrease lung liquid production in fetal sheep
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| Zeitschriftentitel: | Journal of Applied Physiology |
|---|---|
| Personen und Körperschaften: | |
| In: | Journal of Applied Physiology, 79, 1995, 4, S. 1212-1218 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Physiological Society
|
| Schlagwörter: |
| author_facet |
Cummings, J. J. Cummings, J. J. |
|---|---|
| author |
Cummings, J. J. |
| spellingShingle |
Cummings, J. J. Journal of Applied Physiology Pulmonary vasodilator drugs decrease lung liquid production in fetal sheep Physiology (medical) Physiology |
| author_sort |
cummings, j. j. |
| spelling |
Cummings, J. J. 8750-7587 1522-1601 American Physiological Society Physiology (medical) Physiology http://dx.doi.org/10.1152/jappl.1995.79.4.1212 <jats:p> To examine a potential relationship between pulmonary vasodilatation and fetal lung liquid production, I measured lung liquid production in 20 fetal sheep at 130 +/- 4 days gestation while using several agents known to increase pulmonary blood flow. Thirty-two studies were done in which left pulmonary arterial flow (Qlpa) was measured by an ultrasonic Doppler flow probe and net lung luminal liquid production (Jv) was measured by plotting the change in lung luminal liquid concentration of radiolabeled albumin, an impermeant tracer that was mixed into the lung liquid at the start of each study. Qlpa and Jv were measured during a 1- to 2-h baseline period and then during a 1- to 2-h infusion period in which the fetuses received either an intravenous infusion of acetylcholine (n = 8), prostaglandin D2 (n = 10), or the leukotriene blocker FPL-55712 (n = 7). These vasodilators work by different mechanisms, each mechanism having been implicated in the decrease in pulmonary vascular resistance seen at birth. Control (saline) infusions (n = 7) caused no change in either Qlpa or Jv over 4 h. All vasodilator agents significantly increased pulmonary blood flow and decreased Jv. Pulmonary arterial pressure did not change significantly in either the control, acetylcholine, prostaglandin, or leukotriene-blocker studies, indicating that pulmonary vascular resistance decreased. Thus agents that increase pulmonary blood flow by mechanisms that occur at birth also decrease lung liquid production in fetal lambs. </jats:p> Pulmonary vasodilator drugs decrease lung liquid production in fetal sheep Journal of Applied Physiology |
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Pulmonary vasodilator drugs decrease lung liquid production in fetal sheep |
| title_unstemmed |
Pulmonary vasodilator drugs decrease lung liquid production in fetal sheep |
| title_full |
Pulmonary vasodilator drugs decrease lung liquid production in fetal sheep |
| title_fullStr |
Pulmonary vasodilator drugs decrease lung liquid production in fetal sheep |
| title_full_unstemmed |
Pulmonary vasodilator drugs decrease lung liquid production in fetal sheep |
| title_short |
Pulmonary vasodilator drugs decrease lung liquid production in fetal sheep |
| title_sort |
pulmonary vasodilator drugs decrease lung liquid production in fetal sheep |
| topic |
Physiology (medical) Physiology |
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http://dx.doi.org/10.1152/jappl.1995.79.4.1212 |
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1995 |
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1212-1218 |
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<jats:p> To examine a potential relationship between pulmonary vasodilatation and fetal lung liquid production, I measured lung liquid production in 20 fetal sheep at 130 +/- 4 days gestation while using several agents known to increase pulmonary blood flow. Thirty-two studies were done in which left pulmonary arterial flow (Qlpa) was measured by an ultrasonic Doppler flow probe and net lung luminal liquid production (Jv) was measured by plotting the change in lung luminal liquid concentration of radiolabeled albumin, an impermeant tracer that was mixed into the lung liquid at the start of each study. Qlpa and Jv were measured during a 1- to 2-h baseline period and then during a 1- to 2-h infusion period in which the fetuses received either an intravenous infusion of acetylcholine (n = 8), prostaglandin D2 (n = 10), or the leukotriene blocker FPL-55712 (n = 7). These vasodilators work by different mechanisms, each mechanism having been implicated in the decrease in pulmonary vascular resistance seen at birth. Control (saline) infusions (n = 7) caused no change in either Qlpa or Jv over 4 h. All vasodilator agents significantly increased pulmonary blood flow and decreased Jv. Pulmonary arterial pressure did not change significantly in either the control, acetylcholine, prostaglandin, or leukotriene-blocker studies, indicating that pulmonary vascular resistance decreased. Thus agents that increase pulmonary blood flow by mechanisms that occur at birth also decrease lung liquid production in fetal lambs. </jats:p> |
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| description | <jats:p> To examine a potential relationship between pulmonary vasodilatation and fetal lung liquid production, I measured lung liquid production in 20 fetal sheep at 130 +/- 4 days gestation while using several agents known to increase pulmonary blood flow. Thirty-two studies were done in which left pulmonary arterial flow (Qlpa) was measured by an ultrasonic Doppler flow probe and net lung luminal liquid production (Jv) was measured by plotting the change in lung luminal liquid concentration of radiolabeled albumin, an impermeant tracer that was mixed into the lung liquid at the start of each study. Qlpa and Jv were measured during a 1- to 2-h baseline period and then during a 1- to 2-h infusion period in which the fetuses received either an intravenous infusion of acetylcholine (n = 8), prostaglandin D2 (n = 10), or the leukotriene blocker FPL-55712 (n = 7). These vasodilators work by different mechanisms, each mechanism having been implicated in the decrease in pulmonary vascular resistance seen at birth. Control (saline) infusions (n = 7) caused no change in either Qlpa or Jv over 4 h. All vasodilator agents significantly increased pulmonary blood flow and decreased Jv. Pulmonary arterial pressure did not change significantly in either the control, acetylcholine, prostaglandin, or leukotriene-blocker studies, indicating that pulmonary vascular resistance decreased. Thus agents that increase pulmonary blood flow by mechanisms that occur at birth also decrease lung liquid production in fetal lambs. </jats:p> |
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| imprint_str_mv | American Physiological Society, 1995 |
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| spelling | Cummings, J. J. 8750-7587 1522-1601 American Physiological Society Physiology (medical) Physiology http://dx.doi.org/10.1152/jappl.1995.79.4.1212 <jats:p> To examine a potential relationship between pulmonary vasodilatation and fetal lung liquid production, I measured lung liquid production in 20 fetal sheep at 130 +/- 4 days gestation while using several agents known to increase pulmonary blood flow. Thirty-two studies were done in which left pulmonary arterial flow (Qlpa) was measured by an ultrasonic Doppler flow probe and net lung luminal liquid production (Jv) was measured by plotting the change in lung luminal liquid concentration of radiolabeled albumin, an impermeant tracer that was mixed into the lung liquid at the start of each study. Qlpa and Jv were measured during a 1- to 2-h baseline period and then during a 1- to 2-h infusion period in which the fetuses received either an intravenous infusion of acetylcholine (n = 8), prostaglandin D2 (n = 10), or the leukotriene blocker FPL-55712 (n = 7). These vasodilators work by different mechanisms, each mechanism having been implicated in the decrease in pulmonary vascular resistance seen at birth. Control (saline) infusions (n = 7) caused no change in either Qlpa or Jv over 4 h. All vasodilator agents significantly increased pulmonary blood flow and decreased Jv. Pulmonary arterial pressure did not change significantly in either the control, acetylcholine, prostaglandin, or leukotriene-blocker studies, indicating that pulmonary vascular resistance decreased. Thus agents that increase pulmonary blood flow by mechanisms that occur at birth also decrease lung liquid production in fetal lambs. </jats:p> Pulmonary vasodilator drugs decrease lung liquid production in fetal sheep Journal of Applied Physiology |
| spellingShingle | Cummings, J. J., Journal of Applied Physiology, Pulmonary vasodilator drugs decrease lung liquid production in fetal sheep, Physiology (medical), Physiology |
| title | Pulmonary vasodilator drugs decrease lung liquid production in fetal sheep |
| title_full | Pulmonary vasodilator drugs decrease lung liquid production in fetal sheep |
| title_fullStr | Pulmonary vasodilator drugs decrease lung liquid production in fetal sheep |
| title_full_unstemmed | Pulmonary vasodilator drugs decrease lung liquid production in fetal sheep |
| title_short | Pulmonary vasodilator drugs decrease lung liquid production in fetal sheep |
| title_sort | pulmonary vasodilator drugs decrease lung liquid production in fetal sheep |
| title_unstemmed | Pulmonary vasodilator drugs decrease lung liquid production in fetal sheep |
| topic | Physiology (medical), Physiology |
| url | http://dx.doi.org/10.1152/jappl.1995.79.4.1212 |