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Overexpression of sarcolemmal calcium pump attenuates induction of cardiac gene expression in response to ET-1
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| Zeitschriftentitel: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 281, 2001, 3, S. R699-R705 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Physiological Society
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| Schlagwörter: |
| author_facet |
Piuhola, Jarkko Hammes, Annette Schuh, Kai Neyses, Ludwig Vuolteenaho, Olli Ruskoaho, Heikki Piuhola, Jarkko Hammes, Annette Schuh, Kai Neyses, Ludwig Vuolteenaho, Olli Ruskoaho, Heikki |
|---|---|
| author |
Piuhola, Jarkko Hammes, Annette Schuh, Kai Neyses, Ludwig Vuolteenaho, Olli Ruskoaho, Heikki |
| spellingShingle |
Piuhola, Jarkko Hammes, Annette Schuh, Kai Neyses, Ludwig Vuolteenaho, Olli Ruskoaho, Heikki American Journal of Physiology-Regulatory, Integrative and Comparative Physiology Overexpression of sarcolemmal calcium pump attenuates induction of cardiac gene expression in response to ET-1 Physiology (medical) Physiology |
| author_sort |
piuhola, jarkko |
| spelling |
Piuhola, Jarkko Hammes, Annette Schuh, Kai Neyses, Ludwig Vuolteenaho, Olli Ruskoaho, Heikki 0363-6119 1522-1490 American Physiological Society Physiology (medical) Physiology http://dx.doi.org/10.1152/ajpregu.2001.281.3.r699 <jats:p>The function of the plasma membrane calmodulin-dependent calcium ATPase (PMCA) in myocardium is unknown. PMCA is localized in caveolae, 50- to 100-nm membrane invaginations, which also contain receptors for endothelin-1 (ET-1) and various other ligands. PMCA has been suggested to play a role in regulation of caveolar signal transduction. We studied the effects of the hypertrophic agonist ET-1 and increased coronary perfusion pressure on cardiac synthesis of B-type natriuretic peptide (BNP) in transgenic rats overexpressing the human PMCA 4CI in isolated perfused heart preparation. ET-1 infusion for 2 h increased BNP mRNA levels twofold in left ventricles (LV) of nontransgenic rats, whereas no increase was noted in PMCA rat hearts. Similar responses were seen in adrenomedullin and c- fos mRNA levels, and in immunoreactive BNP secretion. Increased mechanical load produced by elevated perfusion pressure induced similar 1.5- to 1.6-fold increases in LV BNP mRNA in both nontransgenic and PMCA rat hearts. These results show that cardiac overexpression of PMCA attenuates ET-1-stimulated early induction of cardiac gene expression, suggesting that PMCA may modulate myocardial growth responses.</jats:p> Overexpression of sarcolemmal calcium pump attenuates induction of cardiac gene expression in response to ET-1 American Journal of Physiology-Regulatory, Integrative and Comparative Physiology |
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| title |
Overexpression of sarcolemmal calcium pump attenuates induction of cardiac gene expression in response to ET-1 |
| title_unstemmed |
Overexpression of sarcolemmal calcium pump attenuates induction of cardiac gene expression in response to ET-1 |
| title_full |
Overexpression of sarcolemmal calcium pump attenuates induction of cardiac gene expression in response to ET-1 |
| title_fullStr |
Overexpression of sarcolemmal calcium pump attenuates induction of cardiac gene expression in response to ET-1 |
| title_full_unstemmed |
Overexpression of sarcolemmal calcium pump attenuates induction of cardiac gene expression in response to ET-1 |
| title_short |
Overexpression of sarcolemmal calcium pump attenuates induction of cardiac gene expression in response to ET-1 |
| title_sort |
overexpression of sarcolemmal calcium pump attenuates induction of cardiac gene expression in response to et-1 |
| topic |
Physiology (medical) Physiology |
| url |
http://dx.doi.org/10.1152/ajpregu.2001.281.3.r699 |
| publishDate |
2001 |
| physical |
R699-R705 |
| description |
<jats:p>The function of the plasma membrane calmodulin-dependent calcium ATPase (PMCA) in myocardium is unknown. PMCA is localized in caveolae, 50- to 100-nm membrane invaginations, which also contain receptors for endothelin-1 (ET-1) and various other ligands. PMCA has been suggested to play a role in regulation of caveolar signal transduction. We studied the effects of the hypertrophic agonist ET-1 and increased coronary perfusion pressure on cardiac synthesis of B-type natriuretic peptide (BNP) in transgenic rats overexpressing the human PMCA 4CI in isolated perfused heart preparation. ET-1 infusion for 2 h increased BNP mRNA levels twofold in left ventricles (LV) of nontransgenic rats, whereas no increase was noted in PMCA rat hearts. Similar responses were seen in adrenomedullin and c- fos mRNA levels, and in immunoreactive BNP secretion. Increased mechanical load produced by elevated perfusion pressure induced similar 1.5- to 1.6-fold increases in LV BNP mRNA in both nontransgenic and PMCA rat hearts. These results show that cardiac overexpression of PMCA attenuates ET-1-stimulated early induction of cardiac gene expression, suggesting that PMCA may modulate myocardial growth responses.</jats:p> |
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| author | Piuhola, Jarkko, Hammes, Annette, Schuh, Kai, Neyses, Ludwig, Vuolteenaho, Olli, Ruskoaho, Heikki |
| author_facet | Piuhola, Jarkko, Hammes, Annette, Schuh, Kai, Neyses, Ludwig, Vuolteenaho, Olli, Ruskoaho, Heikki, Piuhola, Jarkko, Hammes, Annette, Schuh, Kai, Neyses, Ludwig, Vuolteenaho, Olli, Ruskoaho, Heikki |
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| description | <jats:p>The function of the plasma membrane calmodulin-dependent calcium ATPase (PMCA) in myocardium is unknown. PMCA is localized in caveolae, 50- to 100-nm membrane invaginations, which also contain receptors for endothelin-1 (ET-1) and various other ligands. PMCA has been suggested to play a role in regulation of caveolar signal transduction. We studied the effects of the hypertrophic agonist ET-1 and increased coronary perfusion pressure on cardiac synthesis of B-type natriuretic peptide (BNP) in transgenic rats overexpressing the human PMCA 4CI in isolated perfused heart preparation. ET-1 infusion for 2 h increased BNP mRNA levels twofold in left ventricles (LV) of nontransgenic rats, whereas no increase was noted in PMCA rat hearts. Similar responses were seen in adrenomedullin and c- fos mRNA levels, and in immunoreactive BNP secretion. Increased mechanical load produced by elevated perfusion pressure induced similar 1.5- to 1.6-fold increases in LV BNP mRNA in both nontransgenic and PMCA rat hearts. These results show that cardiac overexpression of PMCA attenuates ET-1-stimulated early induction of cardiac gene expression, suggesting that PMCA may modulate myocardial growth responses.</jats:p> |
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| imprint_str_mv | American Physiological Society, 2001 |
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| spelling | Piuhola, Jarkko Hammes, Annette Schuh, Kai Neyses, Ludwig Vuolteenaho, Olli Ruskoaho, Heikki 0363-6119 1522-1490 American Physiological Society Physiology (medical) Physiology http://dx.doi.org/10.1152/ajpregu.2001.281.3.r699 <jats:p>The function of the plasma membrane calmodulin-dependent calcium ATPase (PMCA) in myocardium is unknown. PMCA is localized in caveolae, 50- to 100-nm membrane invaginations, which also contain receptors for endothelin-1 (ET-1) and various other ligands. PMCA has been suggested to play a role in regulation of caveolar signal transduction. We studied the effects of the hypertrophic agonist ET-1 and increased coronary perfusion pressure on cardiac synthesis of B-type natriuretic peptide (BNP) in transgenic rats overexpressing the human PMCA 4CI in isolated perfused heart preparation. ET-1 infusion for 2 h increased BNP mRNA levels twofold in left ventricles (LV) of nontransgenic rats, whereas no increase was noted in PMCA rat hearts. Similar responses were seen in adrenomedullin and c- fos mRNA levels, and in immunoreactive BNP secretion. Increased mechanical load produced by elevated perfusion pressure induced similar 1.5- to 1.6-fold increases in LV BNP mRNA in both nontransgenic and PMCA rat hearts. These results show that cardiac overexpression of PMCA attenuates ET-1-stimulated early induction of cardiac gene expression, suggesting that PMCA may modulate myocardial growth responses.</jats:p> Overexpression of sarcolemmal calcium pump attenuates induction of cardiac gene expression in response to ET-1 American Journal of Physiology-Regulatory, Integrative and Comparative Physiology |
| spellingShingle | Piuhola, Jarkko, Hammes, Annette, Schuh, Kai, Neyses, Ludwig, Vuolteenaho, Olli, Ruskoaho, Heikki, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Overexpression of sarcolemmal calcium pump attenuates induction of cardiac gene expression in response to ET-1, Physiology (medical), Physiology |
| title | Overexpression of sarcolemmal calcium pump attenuates induction of cardiac gene expression in response to ET-1 |
| title_full | Overexpression of sarcolemmal calcium pump attenuates induction of cardiac gene expression in response to ET-1 |
| title_fullStr | Overexpression of sarcolemmal calcium pump attenuates induction of cardiac gene expression in response to ET-1 |
| title_full_unstemmed | Overexpression of sarcolemmal calcium pump attenuates induction of cardiac gene expression in response to ET-1 |
| title_short | Overexpression of sarcolemmal calcium pump attenuates induction of cardiac gene expression in response to ET-1 |
| title_sort | overexpression of sarcolemmal calcium pump attenuates induction of cardiac gene expression in response to et-1 |
| title_unstemmed | Overexpression of sarcolemmal calcium pump attenuates induction of cardiac gene expression in response to ET-1 |
| topic | Physiology (medical), Physiology |
| url | http://dx.doi.org/10.1152/ajpregu.2001.281.3.r699 |