Eintrag weiter verarbeiten
Transport of plasma proteins across vasa recta in the renal medulla
Gespeichert in:
| Zeitschriftentitel: | American Journal of Physiology-Renal Physiology |
|---|---|
| Personen und Körperschaften: | , |
| In: | American Journal of Physiology-Renal Physiology, 281, 2001, 3, S. F478-F492 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Physiological Society
|
| Schlagwörter: |
| author_facet |
Zhang, Wensheng Edwards, Aurélie Zhang, Wensheng Edwards, Aurélie |
|---|---|
| author |
Zhang, Wensheng Edwards, Aurélie |
| spellingShingle |
Zhang, Wensheng Edwards, Aurélie American Journal of Physiology-Renal Physiology Transport of plasma proteins across vasa recta in the renal medulla Physiology |
| author_sort |
zhang, wensheng |
| spelling |
Zhang, Wensheng Edwards, Aurélie 1931-857X 1522-1466 American Physiological Society Physiology http://dx.doi.org/10.1152/ajprenal.2001.281.3.f478 <jats:p> In this study, we have extended a mathematical model of microvascular exchange in the renal medulla to elucidate the mechanisms by which plasma proteins are transported between vasa recta and the interstitium. In contrast with other work, a distinction was made between the paracellular pathway and the transcellular route (i.e., water channels) in descending vasa recta (DVR). Our model first indicates that concentration polarization on the interstitial side of vasa recta has a negligible effect on medullary function. Our results also suggest that, whereas proteins are cleared from the interstitium by convection, both diffusion and convection play a role in carrying proteins to the interstitium. In those regions where transcapillary oncotic pressure gradients favor volume influx through the paracellular pathway in DVR, diffusion is the only means by which proteins can penetrate the interstitium. Whether the source of interstitial protein is DVR or ascending vasa recta depends on medullary depth, vasa recta permeability to proteins, and vasa recta reflection coefficients to small solutes and proteins. Finally, our model predicts significant axial protein gradients in the renal medullary interstitium. </jats:p> Transport of plasma proteins across vasa recta in the renal medulla American Journal of Physiology-Renal Physiology |
| doi_str_mv |
10.1152/ajprenal.2001.281.3.f478 |
| facet_avail |
Online Free |
| finc_class_facet |
Biologie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1Mi9hanByZW5hbC4yMDAxLjI4MS4zLmY0Nzg |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1Mi9hanByZW5hbC4yMDAxLjI4MS4zLmY0Nzg |
| institution |
DE-D275 DE-Bn3 DE-Brt1 DE-D161 DE-Zwi2 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 |
| imprint |
American Physiological Society, 2001 |
| imprint_str_mv |
American Physiological Society, 2001 |
| issn |
1931-857X 1522-1466 |
| issn_str_mv |
1931-857X 1522-1466 |
| language |
English |
| mega_collection |
American Physiological Society (CrossRef) |
| match_str |
zhang2001transportofplasmaproteinsacrossvasarectaintherenalmedulla |
| publishDateSort |
2001 |
| publisher |
American Physiological Society |
| recordtype |
ai |
| record_format |
ai |
| series |
American Journal of Physiology-Renal Physiology |
| source_id |
49 |
| title |
Transport of plasma proteins across vasa recta in the renal medulla |
| title_unstemmed |
Transport of plasma proteins across vasa recta in the renal medulla |
| title_full |
Transport of plasma proteins across vasa recta in the renal medulla |
| title_fullStr |
Transport of plasma proteins across vasa recta in the renal medulla |
| title_full_unstemmed |
Transport of plasma proteins across vasa recta in the renal medulla |
| title_short |
Transport of plasma proteins across vasa recta in the renal medulla |
| title_sort |
transport of plasma proteins across vasa recta in the renal medulla |
| topic |
Physiology |
| url |
http://dx.doi.org/10.1152/ajprenal.2001.281.3.f478 |
| publishDate |
2001 |
| physical |
F478-F492 |
| description |
<jats:p> In this study, we have extended a mathematical model of microvascular exchange in the renal medulla to elucidate the mechanisms by which plasma proteins are transported between vasa recta and the interstitium. In contrast with other work, a distinction was made between the paracellular pathway and the transcellular route (i.e., water channels) in descending vasa recta (DVR). Our model first indicates that concentration polarization on the interstitial side of vasa recta has a negligible effect on medullary function. Our results also suggest that, whereas proteins are cleared from the interstitium by convection, both diffusion and convection play a role in carrying proteins to the interstitium. In those regions where transcapillary oncotic pressure gradients favor volume influx through the paracellular pathway in DVR, diffusion is the only means by which proteins can penetrate the interstitium. Whether the source of interstitial protein is DVR or ascending vasa recta depends on medullary depth, vasa recta permeability to proteins, and vasa recta reflection coefficients to small solutes and proteins. Finally, our model predicts significant axial protein gradients in the renal medullary interstitium. </jats:p> |
| container_issue |
3 |
| container_start_page |
0 |
| container_title |
American Journal of Physiology-Renal Physiology |
| container_volume |
281 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792333569761214468 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T14:14:51.437Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Transport+of+plasma+proteins+across+vasa+recta++in+the+renal+medulla&rft.date=2001-09-01&genre=article&issn=1522-1466&volume=281&issue=3&pages=F478-F492&jtitle=American+Journal+of+Physiology-Renal+Physiology&atitle=Transport+of+plasma+proteins+across+vasa+recta++in+the+renal+medulla&aulast=Edwards&aufirst=Aur%C3%A9lie&rft_id=info%3Adoi%2F10.1152%2Fajprenal.2001.281.3.f478&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792333569761214468 |
| author | Zhang, Wensheng, Edwards, Aurélie |
| author_facet | Zhang, Wensheng, Edwards, Aurélie, Zhang, Wensheng, Edwards, Aurélie |
| author_sort | zhang, wensheng |
| container_issue | 3 |
| container_start_page | 0 |
| container_title | American Journal of Physiology-Renal Physiology |
| container_volume | 281 |
| description | <jats:p> In this study, we have extended a mathematical model of microvascular exchange in the renal medulla to elucidate the mechanisms by which plasma proteins are transported between vasa recta and the interstitium. In contrast with other work, a distinction was made between the paracellular pathway and the transcellular route (i.e., water channels) in descending vasa recta (DVR). Our model first indicates that concentration polarization on the interstitial side of vasa recta has a negligible effect on medullary function. Our results also suggest that, whereas proteins are cleared from the interstitium by convection, both diffusion and convection play a role in carrying proteins to the interstitium. In those regions where transcapillary oncotic pressure gradients favor volume influx through the paracellular pathway in DVR, diffusion is the only means by which proteins can penetrate the interstitium. Whether the source of interstitial protein is DVR or ascending vasa recta depends on medullary depth, vasa recta permeability to proteins, and vasa recta reflection coefficients to small solutes and proteins. Finally, our model predicts significant axial protein gradients in the renal medullary interstitium. </jats:p> |
| doi_str_mv | 10.1152/ajprenal.2001.281.3.f478 |
| facet_avail | Online, Free |
| finc_class_facet | Biologie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1Mi9hanByZW5hbC4yMDAxLjI4MS4zLmY0Nzg |
| imprint | American Physiological Society, 2001 |
| imprint_str_mv | American Physiological Society, 2001 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
| issn | 1931-857X, 1522-1466 |
| issn_str_mv | 1931-857X, 1522-1466 |
| language | English |
| last_indexed | 2024-03-01T14:14:51.437Z |
| match_str | zhang2001transportofplasmaproteinsacrossvasarectaintherenalmedulla |
| mega_collection | American Physiological Society (CrossRef) |
| physical | F478-F492 |
| publishDate | 2001 |
| publishDateSort | 2001 |
| publisher | American Physiological Society |
| record_format | ai |
| recordtype | ai |
| series | American Journal of Physiology-Renal Physiology |
| source_id | 49 |
| spelling | Zhang, Wensheng Edwards, Aurélie 1931-857X 1522-1466 American Physiological Society Physiology http://dx.doi.org/10.1152/ajprenal.2001.281.3.f478 <jats:p> In this study, we have extended a mathematical model of microvascular exchange in the renal medulla to elucidate the mechanisms by which plasma proteins are transported between vasa recta and the interstitium. In contrast with other work, a distinction was made between the paracellular pathway and the transcellular route (i.e., water channels) in descending vasa recta (DVR). Our model first indicates that concentration polarization on the interstitial side of vasa recta has a negligible effect on medullary function. Our results also suggest that, whereas proteins are cleared from the interstitium by convection, both diffusion and convection play a role in carrying proteins to the interstitium. In those regions where transcapillary oncotic pressure gradients favor volume influx through the paracellular pathway in DVR, diffusion is the only means by which proteins can penetrate the interstitium. Whether the source of interstitial protein is DVR or ascending vasa recta depends on medullary depth, vasa recta permeability to proteins, and vasa recta reflection coefficients to small solutes and proteins. Finally, our model predicts significant axial protein gradients in the renal medullary interstitium. </jats:p> Transport of plasma proteins across vasa recta in the renal medulla American Journal of Physiology-Renal Physiology |
| spellingShingle | Zhang, Wensheng, Edwards, Aurélie, American Journal of Physiology-Renal Physiology, Transport of plasma proteins across vasa recta in the renal medulla, Physiology |
| title | Transport of plasma proteins across vasa recta in the renal medulla |
| title_full | Transport of plasma proteins across vasa recta in the renal medulla |
| title_fullStr | Transport of plasma proteins across vasa recta in the renal medulla |
| title_full_unstemmed | Transport of plasma proteins across vasa recta in the renal medulla |
| title_short | Transport of plasma proteins across vasa recta in the renal medulla |
| title_sort | transport of plasma proteins across vasa recta in the renal medulla |
| title_unstemmed | Transport of plasma proteins across vasa recta in the renal medulla |
| topic | Physiology |
| url | http://dx.doi.org/10.1152/ajprenal.2001.281.3.f478 |