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Control mechanisms of bicarbonate transport across the rat proximal convoluted tubule
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| Zeitschriftentitel: | American Journal of Physiology-Renal Physiology |
|---|---|
| Personen und Körperschaften: | , , |
| In: | American Journal of Physiology-Renal Physiology, 242, 1982, 5, S. F532-F543 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Physiological Society
|
| Schlagwörter: |
| author_facet |
Chan, Y. L. Biagi, B. Giebisch, G. Chan, Y. L. Biagi, B. Giebisch, G. |
|---|---|
| author |
Chan, Y. L. Biagi, B. Giebisch, G. |
| spellingShingle |
Chan, Y. L. Biagi, B. Giebisch, G. American Journal of Physiology-Renal Physiology Control mechanisms of bicarbonate transport across the rat proximal convoluted tubule Physiology |
| author_sort |
chan, y. l. |
| spelling |
Chan, Y. L. Biagi, B. Giebisch, G. 1931-857X 1522-1466 American Physiological Society Physiology http://dx.doi.org/10.1152/ajprenal.1982.242.5.f532 <jats:p> Bicarbonate transport (JHCO3) was studied in rat proximal convoluted tubules by luminal and peritubular microperfusion, and the effects on tubular bicarbonate transport of selective changes in luminal and peritubular bicarbonate concentrations and of changes in luminal flow rate were evaluated. A pH glass electrode was used to measure [HCO3(-)] and gave results similar to those of a microcalorimetric method. Increasing the tubular and peritubular [HCO3(-)] at constant luminal perfusion rate (10 nl.min-1) augmented JHCO3, but JHCO3 increased more when pH changes were prevented by PCO2 adjustments (constant peritubular pH) than when pH was allowed to rise with the increase in [HCO3(-)] (constant PCO2). Elevation of the tubular HCO3(-) load by raising [HCO3(-)] stimulated JHCO3 more than when the HCO3(-) load was raised by enhancing luminal perfusion rate at constant [HCO3(-)] An increase in PCO2 at constant peritubular pH increased JHCO3. Diamox and benzolamide inhibited JHCO3 at luminal concentrations of 2-4 X 10(-4) M, yet a small but significant fraction of JHCO3 remained intact. Capillary perfusion with 4-acetamido-4'-isothiocyanostilbene-2,2'-disulfonic acid (5 X 10(-4) M) depressed JHCO3 by 70%. Acute changes in luminal and peritubular potassium concentrations (range, 2-6 meq/liter) had no effect on JHCO3, but JHCO3 increased moderately but significantly in severe dietary hypokalemia. </jats:p> Control mechanisms of bicarbonate transport across the rat proximal convoluted tubule American Journal of Physiology-Renal Physiology |
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10.1152/ajprenal.1982.242.5.f532 |
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American Physiological Society, 1982 |
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American Physiological Society, 1982 |
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1931-857X 1522-1466 |
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1982 |
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American Physiological Society |
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American Journal of Physiology-Renal Physiology |
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49 |
| title |
Control mechanisms of bicarbonate transport across the rat proximal convoluted tubule |
| title_unstemmed |
Control mechanisms of bicarbonate transport across the rat proximal convoluted tubule |
| title_full |
Control mechanisms of bicarbonate transport across the rat proximal convoluted tubule |
| title_fullStr |
Control mechanisms of bicarbonate transport across the rat proximal convoluted tubule |
| title_full_unstemmed |
Control mechanisms of bicarbonate transport across the rat proximal convoluted tubule |
| title_short |
Control mechanisms of bicarbonate transport across the rat proximal convoluted tubule |
| title_sort |
control mechanisms of bicarbonate transport across the rat proximal convoluted tubule |
| topic |
Physiology |
| url |
http://dx.doi.org/10.1152/ajprenal.1982.242.5.f532 |
| publishDate |
1982 |
| physical |
F532-F543 |
| description |
<jats:p> Bicarbonate transport (JHCO3) was studied in rat proximal convoluted tubules by luminal and peritubular microperfusion, and the effects on tubular bicarbonate transport of selective changes in luminal and peritubular bicarbonate concentrations and of changes in luminal flow rate were evaluated. A pH glass electrode was used to measure [HCO3(-)] and gave results similar to those of a microcalorimetric method. Increasing the tubular and peritubular [HCO3(-)] at constant luminal perfusion rate (10 nl.min-1) augmented JHCO3, but JHCO3 increased more when pH changes were prevented by PCO2 adjustments (constant peritubular pH) than when pH was allowed to rise with the increase in [HCO3(-)] (constant PCO2). Elevation of the tubular HCO3(-) load by raising [HCO3(-)] stimulated JHCO3 more than when the HCO3(-) load was raised by enhancing luminal perfusion rate at constant [HCO3(-)] An increase in PCO2 at constant peritubular pH increased JHCO3. Diamox and benzolamide inhibited JHCO3 at luminal concentrations of 2-4 X 10(-4) M, yet a small but significant fraction of JHCO3 remained intact. Capillary perfusion with 4-acetamido-4'-isothiocyanostilbene-2,2'-disulfonic acid (5 X 10(-4) M) depressed JHCO3 by 70%. Acute changes in luminal and peritubular potassium concentrations (range, 2-6 meq/liter) had no effect on JHCO3, but JHCO3 increased moderately but significantly in severe dietary hypokalemia. </jats:p> |
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| author | Chan, Y. L., Biagi, B., Giebisch, G. |
| author_facet | Chan, Y. L., Biagi, B., Giebisch, G., Chan, Y. L., Biagi, B., Giebisch, G. |
| author_sort | chan, y. l. |
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| description | <jats:p> Bicarbonate transport (JHCO3) was studied in rat proximal convoluted tubules by luminal and peritubular microperfusion, and the effects on tubular bicarbonate transport of selective changes in luminal and peritubular bicarbonate concentrations and of changes in luminal flow rate were evaluated. A pH glass electrode was used to measure [HCO3(-)] and gave results similar to those of a microcalorimetric method. Increasing the tubular and peritubular [HCO3(-)] at constant luminal perfusion rate (10 nl.min-1) augmented JHCO3, but JHCO3 increased more when pH changes were prevented by PCO2 adjustments (constant peritubular pH) than when pH was allowed to rise with the increase in [HCO3(-)] (constant PCO2). Elevation of the tubular HCO3(-) load by raising [HCO3(-)] stimulated JHCO3 more than when the HCO3(-) load was raised by enhancing luminal perfusion rate at constant [HCO3(-)] An increase in PCO2 at constant peritubular pH increased JHCO3. Diamox and benzolamide inhibited JHCO3 at luminal concentrations of 2-4 X 10(-4) M, yet a small but significant fraction of JHCO3 remained intact. Capillary perfusion with 4-acetamido-4'-isothiocyanostilbene-2,2'-disulfonic acid (5 X 10(-4) M) depressed JHCO3 by 70%. Acute changes in luminal and peritubular potassium concentrations (range, 2-6 meq/liter) had no effect on JHCO3, but JHCO3 increased moderately but significantly in severe dietary hypokalemia. </jats:p> |
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| imprint | American Physiological Society, 1982 |
| imprint_str_mv | American Physiological Society, 1982 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161 |
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| series | American Journal of Physiology-Renal Physiology |
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| spelling | Chan, Y. L. Biagi, B. Giebisch, G. 1931-857X 1522-1466 American Physiological Society Physiology http://dx.doi.org/10.1152/ajprenal.1982.242.5.f532 <jats:p> Bicarbonate transport (JHCO3) was studied in rat proximal convoluted tubules by luminal and peritubular microperfusion, and the effects on tubular bicarbonate transport of selective changes in luminal and peritubular bicarbonate concentrations and of changes in luminal flow rate were evaluated. A pH glass electrode was used to measure [HCO3(-)] and gave results similar to those of a microcalorimetric method. Increasing the tubular and peritubular [HCO3(-)] at constant luminal perfusion rate (10 nl.min-1) augmented JHCO3, but JHCO3 increased more when pH changes were prevented by PCO2 adjustments (constant peritubular pH) than when pH was allowed to rise with the increase in [HCO3(-)] (constant PCO2). Elevation of the tubular HCO3(-) load by raising [HCO3(-)] stimulated JHCO3 more than when the HCO3(-) load was raised by enhancing luminal perfusion rate at constant [HCO3(-)] An increase in PCO2 at constant peritubular pH increased JHCO3. Diamox and benzolamide inhibited JHCO3 at luminal concentrations of 2-4 X 10(-4) M, yet a small but significant fraction of JHCO3 remained intact. Capillary perfusion with 4-acetamido-4'-isothiocyanostilbene-2,2'-disulfonic acid (5 X 10(-4) M) depressed JHCO3 by 70%. Acute changes in luminal and peritubular potassium concentrations (range, 2-6 meq/liter) had no effect on JHCO3, but JHCO3 increased moderately but significantly in severe dietary hypokalemia. </jats:p> Control mechanisms of bicarbonate transport across the rat proximal convoluted tubule American Journal of Physiology-Renal Physiology |
| spellingShingle | Chan, Y. L., Biagi, B., Giebisch, G., American Journal of Physiology-Renal Physiology, Control mechanisms of bicarbonate transport across the rat proximal convoluted tubule, Physiology |
| title | Control mechanisms of bicarbonate transport across the rat proximal convoluted tubule |
| title_full | Control mechanisms of bicarbonate transport across the rat proximal convoluted tubule |
| title_fullStr | Control mechanisms of bicarbonate transport across the rat proximal convoluted tubule |
| title_full_unstemmed | Control mechanisms of bicarbonate transport across the rat proximal convoluted tubule |
| title_short | Control mechanisms of bicarbonate transport across the rat proximal convoluted tubule |
| title_sort | control mechanisms of bicarbonate transport across the rat proximal convoluted tubule |
| title_unstemmed | Control mechanisms of bicarbonate transport across the rat proximal convoluted tubule |
| topic | Physiology |
| url | http://dx.doi.org/10.1152/ajprenal.1982.242.5.f532 |