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Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes
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| Zeitschriftentitel: | American Journal of Physiology-Heart and Circulatory Physiology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , |
| In: | American Journal of Physiology-Heart and Circulatory Physiology, 269, 1995, 5, S. H1791-H1802 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Physiological Society
|
| Schlagwörter: |
| author_facet |
Zhang, X. Dostal, D. E. Reiss, K. Cheng, W. Kajstura, J. Li, P. Huang, H. Sonnenblick, E. H. Meggs, L. G. Baker, K. M. et, al. Zhang, X. Dostal, D. E. Reiss, K. Cheng, W. Kajstura, J. Li, P. Huang, H. Sonnenblick, E. H. Meggs, L. G. Baker, K. M. et, al. |
|---|---|
| author |
Zhang, X. Dostal, D. E. Reiss, K. Cheng, W. Kajstura, J. Li, P. Huang, H. Sonnenblick, E. H. Meggs, L. G. Baker, K. M. et, al. |
| spellingShingle |
Zhang, X. Dostal, D. E. Reiss, K. Cheng, W. Kajstura, J. Li, P. Huang, H. Sonnenblick, E. H. Meggs, L. G. Baker, K. M. et, al. American Journal of Physiology-Heart and Circulatory Physiology Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes Physiology (medical) Cardiology and Cardiovascular Medicine Physiology |
| author_sort |
zhang, x. |
| spelling |
Zhang, X. Dostal, D. E. Reiss, K. Cheng, W. Kajstura, J. Li, P. Huang, H. Sonnenblick, E. H. Meggs, L. G. Baker, K. M. et, al. 0363-6135 1522-1539 American Physiological Society Physiology (medical) Cardiology and Cardiovascular Medicine Physiology http://dx.doi.org/10.1152/ajpheart.1995.269.5.h1791 <jats:p> To date, the demonstration that the molecular components of the renin-angiotensin system (RAS) are present in adult ventricular myocytes is lacking. In addition, whether the RAS is upregulated under conditions of overload and myocyte hypertrophy in vivo remains to be determined. By employing an in vivo model of ischemic cardiomyopathy in rats, we document that adult myocytes express genes for renin, angiotensinogen, angiotensin-converting enzyme (ACE), and angiotensin II (ANG II) receptors. Moreover, renin, ACE, and ANG II receptor mRNAs increased in stressed myocytes undergoing cellular hypertrophy. At the protein level, the percentage of myocytes containing renin, ANG I, and ANG II was significantly increased in the overloaded heart. The number of binding sites for ANG II per myocyte also markedly increased under this setting. These results provide direct evidence of the existence of a myocyte RAS, which may be activated in pathological states of the heart to support myocyte growth and contractile function. </jats:p> Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes American Journal of Physiology-Heart and Circulatory Physiology |
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American Journal of Physiology-Heart and Circulatory Physiology |
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| title |
Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes |
| title_unstemmed |
Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes |
| title_full |
Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes |
| title_fullStr |
Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes |
| title_full_unstemmed |
Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes |
| title_short |
Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes |
| title_sort |
identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes |
| topic |
Physiology (medical) Cardiology and Cardiovascular Medicine Physiology |
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http://dx.doi.org/10.1152/ajpheart.1995.269.5.h1791 |
| publishDate |
1995 |
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H1791-H1802 |
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<jats:p> To date, the demonstration that the molecular components of the renin-angiotensin system (RAS) are present in adult ventricular myocytes is lacking. In addition, whether the RAS is upregulated under conditions of overload and myocyte hypertrophy in vivo remains to be determined. By employing an in vivo model of ischemic cardiomyopathy in rats, we document that adult myocytes express genes for renin, angiotensinogen, angiotensin-converting enzyme (ACE), and angiotensin II (ANG II) receptors. Moreover, renin, ACE, and ANG II receptor mRNAs increased in stressed myocytes undergoing cellular hypertrophy. At the protein level, the percentage of myocytes containing renin, ANG I, and ANG II was significantly increased in the overloaded heart. The number of binding sites for ANG II per myocyte also markedly increased under this setting. These results provide direct evidence of the existence of a myocyte RAS, which may be activated in pathological states of the heart to support myocyte growth and contractile function. </jats:p> |
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| author | Zhang, X., Dostal, D. E., Reiss, K., Cheng, W., Kajstura, J., Li, P., Huang, H., Sonnenblick, E. H., Meggs, L. G., Baker, K. M., et, al. |
| author_facet | Zhang, X., Dostal, D. E., Reiss, K., Cheng, W., Kajstura, J., Li, P., Huang, H., Sonnenblick, E. H., Meggs, L. G., Baker, K. M., et, al., Zhang, X., Dostal, D. E., Reiss, K., Cheng, W., Kajstura, J., Li, P., Huang, H., Sonnenblick, E. H., Meggs, L. G., Baker, K. M., et, al. |
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| description | <jats:p> To date, the demonstration that the molecular components of the renin-angiotensin system (RAS) are present in adult ventricular myocytes is lacking. In addition, whether the RAS is upregulated under conditions of overload and myocyte hypertrophy in vivo remains to be determined. By employing an in vivo model of ischemic cardiomyopathy in rats, we document that adult myocytes express genes for renin, angiotensinogen, angiotensin-converting enzyme (ACE), and angiotensin II (ANG II) receptors. Moreover, renin, ACE, and ANG II receptor mRNAs increased in stressed myocytes undergoing cellular hypertrophy. At the protein level, the percentage of myocytes containing renin, ANG I, and ANG II was significantly increased in the overloaded heart. The number of binding sites for ANG II per myocyte also markedly increased under this setting. These results provide direct evidence of the existence of a myocyte RAS, which may be activated in pathological states of the heart to support myocyte growth and contractile function. </jats:p> |
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| imprint_str_mv | American Physiological Society, 1995 |
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| series | American Journal of Physiology-Heart and Circulatory Physiology |
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| spelling | Zhang, X. Dostal, D. E. Reiss, K. Cheng, W. Kajstura, J. Li, P. Huang, H. Sonnenblick, E. H. Meggs, L. G. Baker, K. M. et, al. 0363-6135 1522-1539 American Physiological Society Physiology (medical) Cardiology and Cardiovascular Medicine Physiology http://dx.doi.org/10.1152/ajpheart.1995.269.5.h1791 <jats:p> To date, the demonstration that the molecular components of the renin-angiotensin system (RAS) are present in adult ventricular myocytes is lacking. In addition, whether the RAS is upregulated under conditions of overload and myocyte hypertrophy in vivo remains to be determined. By employing an in vivo model of ischemic cardiomyopathy in rats, we document that adult myocytes express genes for renin, angiotensinogen, angiotensin-converting enzyme (ACE), and angiotensin II (ANG II) receptors. Moreover, renin, ACE, and ANG II receptor mRNAs increased in stressed myocytes undergoing cellular hypertrophy. At the protein level, the percentage of myocytes containing renin, ANG I, and ANG II was significantly increased in the overloaded heart. The number of binding sites for ANG II per myocyte also markedly increased under this setting. These results provide direct evidence of the existence of a myocyte RAS, which may be activated in pathological states of the heart to support myocyte growth and contractile function. </jats:p> Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes American Journal of Physiology-Heart and Circulatory Physiology |
| spellingShingle | Zhang, X., Dostal, D. E., Reiss, K., Cheng, W., Kajstura, J., Li, P., Huang, H., Sonnenblick, E. H., Meggs, L. G., Baker, K. M., et, al., American Journal of Physiology-Heart and Circulatory Physiology, Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes, Physiology (medical), Cardiology and Cardiovascular Medicine, Physiology |
| title | Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes |
| title_full | Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes |
| title_fullStr | Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes |
| title_full_unstemmed | Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes |
| title_short | Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes |
| title_sort | identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes |
| title_unstemmed | Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes |
| topic | Physiology (medical), Cardiology and Cardiovascular Medicine, Physiology |
| url | http://dx.doi.org/10.1152/ajpheart.1995.269.5.h1791 |