Eintrag weiter verarbeiten
Endothelial dysfunction as a cellular mechanism for vascular failure
Gespeichert in:
| Zeitschriftentitel: | American Journal of Physiology-Heart and Circulatory Physiology |
|---|---|
| Personen und Körperschaften: | , |
| In: | American Journal of Physiology-Heart and Circulatory Physiology, 302, 2012, 3, S. H499-H505 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Physiological Society
|
| Schlagwörter: |
| author_facet |
Hirase, Tetsuaki Node, Koichi Hirase, Tetsuaki Node, Koichi |
|---|---|
| author |
Hirase, Tetsuaki Node, Koichi |
| spellingShingle |
Hirase, Tetsuaki Node, Koichi American Journal of Physiology-Heart and Circulatory Physiology Endothelial dysfunction as a cellular mechanism for vascular failure Physiology (medical) Cardiology and Cardiovascular Medicine Physiology |
| author_sort |
hirase, tetsuaki |
| spelling |
Hirase, Tetsuaki Node, Koichi 0363-6135 1522-1539 American Physiological Society Physiology (medical) Cardiology and Cardiovascular Medicine Physiology http://dx.doi.org/10.1152/ajpheart.00325.2011 <jats:p>The regulation of vascular tone, vascular permeability, and thromboresistance is essential to maintain blood circulation and therefore tissue environments under physiological conditions. Atherogenic stimuli, including diabetes, dyslipidemia, and oxidative stress, induce vascular dysfunction, leading to atherosclerosis, which is a key pathological basis for cardiovascular diseases such as ischemic heart disease and stroke. We have proposed a novel concept termed “vascular failure” to comprehensively recognize the vascular dysfunction that contributes to the development of cardiovascular diseases. Vascular endothelial cells form the vascular endothelium as a monolayer that covers the vascular lumen and serves as an interface between circulating blood and immune cells. Endothelial cells regulate vascular function in collaboration with smooth muscle cells. Endothelial dysfunction under pathophysiological conditions contributes to the development of vascular dysfunction. Here, we address the barrier function and microtubule function of endothelial cells. Endothelial barrier function, mediated by cell-to-cell junctions between endothelial cells, is regulated by small GTPases and kinases. Microtubule function, regulated by the acetylation of tubulin, a component of the microtubules, is a target of atherogenic stimuli. The elucidation of the molecular mechanisms of endothelial dysfunction as a cellular mechanism for vascular failure could provide novel therapeutic targets of cardiovascular diseases.</jats:p> Endothelial dysfunction as a cellular mechanism for vascular failure American Journal of Physiology-Heart and Circulatory Physiology |
| doi_str_mv |
10.1152/ajpheart.00325.2011 |
| facet_avail |
Online Free |
| finc_class_facet |
Biologie Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1Mi9hanBoZWFydC4wMDMyNS4yMDEx |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1Mi9hanBoZWFydC4wMDMyNS4yMDEx |
| institution |
DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 |
| imprint |
American Physiological Society, 2012 |
| imprint_str_mv |
American Physiological Society, 2012 |
| issn |
0363-6135 1522-1539 |
| issn_str_mv |
0363-6135 1522-1539 |
| language |
English |
| mega_collection |
American Physiological Society (CrossRef) |
| match_str |
hirase2012endothelialdysfunctionasacellularmechanismforvascularfailure |
| publishDateSort |
2012 |
| publisher |
American Physiological Society |
| recordtype |
ai |
| record_format |
ai |
| series |
American Journal of Physiology-Heart and Circulatory Physiology |
| source_id |
49 |
| title |
Endothelial dysfunction as a cellular mechanism for vascular failure |
| title_unstemmed |
Endothelial dysfunction as a cellular mechanism for vascular failure |
| title_full |
Endothelial dysfunction as a cellular mechanism for vascular failure |
| title_fullStr |
Endothelial dysfunction as a cellular mechanism for vascular failure |
| title_full_unstemmed |
Endothelial dysfunction as a cellular mechanism for vascular failure |
| title_short |
Endothelial dysfunction as a cellular mechanism for vascular failure |
| title_sort |
endothelial dysfunction as a cellular mechanism for vascular failure |
| topic |
Physiology (medical) Cardiology and Cardiovascular Medicine Physiology |
| url |
http://dx.doi.org/10.1152/ajpheart.00325.2011 |
| publishDate |
2012 |
| physical |
H499-H505 |
| description |
<jats:p>The regulation of vascular tone, vascular permeability, and thromboresistance is essential to maintain blood circulation and therefore tissue environments under physiological conditions. Atherogenic stimuli, including diabetes, dyslipidemia, and oxidative stress, induce vascular dysfunction, leading to atherosclerosis, which is a key pathological basis for cardiovascular diseases such as ischemic heart disease and stroke. We have proposed a novel concept termed “vascular failure” to comprehensively recognize the vascular dysfunction that contributes to the development of cardiovascular diseases. Vascular endothelial cells form the vascular endothelium as a monolayer that covers the vascular lumen and serves as an interface between circulating blood and immune cells. Endothelial cells regulate vascular function in collaboration with smooth muscle cells. Endothelial dysfunction under pathophysiological conditions contributes to the development of vascular dysfunction. Here, we address the barrier function and microtubule function of endothelial cells. Endothelial barrier function, mediated by cell-to-cell junctions between endothelial cells, is regulated by small GTPases and kinases. Microtubule function, regulated by the acetylation of tubulin, a component of the microtubules, is a target of atherogenic stimuli. The elucidation of the molecular mechanisms of endothelial dysfunction as a cellular mechanism for vascular failure could provide novel therapeutic targets of cardiovascular diseases.</jats:p> |
| container_issue |
3 |
| container_start_page |
0 |
| container_title |
American Journal of Physiology-Heart and Circulatory Physiology |
| container_volume |
302 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792347906605318148 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T18:02:40.817Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Endothelial+dysfunction+as+a+cellular+mechanism+for+vascular+failure&rft.date=2012-02-01&genre=article&issn=1522-1539&volume=302&issue=3&pages=H499-H505&jtitle=American+Journal+of+Physiology-Heart+and+Circulatory+Physiology&atitle=Endothelial+dysfunction+as+a+cellular+mechanism+for+vascular+failure&aulast=Node&aufirst=Koichi&rft_id=info%3Adoi%2F10.1152%2Fajpheart.00325.2011&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792347906605318148 |
| author | Hirase, Tetsuaki, Node, Koichi |
| author_facet | Hirase, Tetsuaki, Node, Koichi, Hirase, Tetsuaki, Node, Koichi |
| author_sort | hirase, tetsuaki |
| container_issue | 3 |
| container_start_page | 0 |
| container_title | American Journal of Physiology-Heart and Circulatory Physiology |
| container_volume | 302 |
| description | <jats:p>The regulation of vascular tone, vascular permeability, and thromboresistance is essential to maintain blood circulation and therefore tissue environments under physiological conditions. Atherogenic stimuli, including diabetes, dyslipidemia, and oxidative stress, induce vascular dysfunction, leading to atherosclerosis, which is a key pathological basis for cardiovascular diseases such as ischemic heart disease and stroke. We have proposed a novel concept termed “vascular failure” to comprehensively recognize the vascular dysfunction that contributes to the development of cardiovascular diseases. Vascular endothelial cells form the vascular endothelium as a monolayer that covers the vascular lumen and serves as an interface between circulating blood and immune cells. Endothelial cells regulate vascular function in collaboration with smooth muscle cells. Endothelial dysfunction under pathophysiological conditions contributes to the development of vascular dysfunction. Here, we address the barrier function and microtubule function of endothelial cells. Endothelial barrier function, mediated by cell-to-cell junctions between endothelial cells, is regulated by small GTPases and kinases. Microtubule function, regulated by the acetylation of tubulin, a component of the microtubules, is a target of atherogenic stimuli. The elucidation of the molecular mechanisms of endothelial dysfunction as a cellular mechanism for vascular failure could provide novel therapeutic targets of cardiovascular diseases.</jats:p> |
| doi_str_mv | 10.1152/ajpheart.00325.2011 |
| facet_avail | Online, Free |
| finc_class_facet | Biologie, Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1Mi9hanBoZWFydC4wMDMyNS4yMDEx |
| imprint | American Physiological Society, 2012 |
| imprint_str_mv | American Physiological Society, 2012 |
| institution | DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1 |
| issn | 0363-6135, 1522-1539 |
| issn_str_mv | 0363-6135, 1522-1539 |
| language | English |
| last_indexed | 2024-03-01T18:02:40.817Z |
| match_str | hirase2012endothelialdysfunctionasacellularmechanismforvascularfailure |
| mega_collection | American Physiological Society (CrossRef) |
| physical | H499-H505 |
| publishDate | 2012 |
| publishDateSort | 2012 |
| publisher | American Physiological Society |
| record_format | ai |
| recordtype | ai |
| series | American Journal of Physiology-Heart and Circulatory Physiology |
| source_id | 49 |
| spelling | Hirase, Tetsuaki Node, Koichi 0363-6135 1522-1539 American Physiological Society Physiology (medical) Cardiology and Cardiovascular Medicine Physiology http://dx.doi.org/10.1152/ajpheart.00325.2011 <jats:p>The regulation of vascular tone, vascular permeability, and thromboresistance is essential to maintain blood circulation and therefore tissue environments under physiological conditions. Atherogenic stimuli, including diabetes, dyslipidemia, and oxidative stress, induce vascular dysfunction, leading to atherosclerosis, which is a key pathological basis for cardiovascular diseases such as ischemic heart disease and stroke. We have proposed a novel concept termed “vascular failure” to comprehensively recognize the vascular dysfunction that contributes to the development of cardiovascular diseases. Vascular endothelial cells form the vascular endothelium as a monolayer that covers the vascular lumen and serves as an interface between circulating blood and immune cells. Endothelial cells regulate vascular function in collaboration with smooth muscle cells. Endothelial dysfunction under pathophysiological conditions contributes to the development of vascular dysfunction. Here, we address the barrier function and microtubule function of endothelial cells. Endothelial barrier function, mediated by cell-to-cell junctions between endothelial cells, is regulated by small GTPases and kinases. Microtubule function, regulated by the acetylation of tubulin, a component of the microtubules, is a target of atherogenic stimuli. The elucidation of the molecular mechanisms of endothelial dysfunction as a cellular mechanism for vascular failure could provide novel therapeutic targets of cardiovascular diseases.</jats:p> Endothelial dysfunction as a cellular mechanism for vascular failure American Journal of Physiology-Heart and Circulatory Physiology |
| spellingShingle | Hirase, Tetsuaki, Node, Koichi, American Journal of Physiology-Heart and Circulatory Physiology, Endothelial dysfunction as a cellular mechanism for vascular failure, Physiology (medical), Cardiology and Cardiovascular Medicine, Physiology |
| title | Endothelial dysfunction as a cellular mechanism for vascular failure |
| title_full | Endothelial dysfunction as a cellular mechanism for vascular failure |
| title_fullStr | Endothelial dysfunction as a cellular mechanism for vascular failure |
| title_full_unstemmed | Endothelial dysfunction as a cellular mechanism for vascular failure |
| title_short | Endothelial dysfunction as a cellular mechanism for vascular failure |
| title_sort | endothelial dysfunction as a cellular mechanism for vascular failure |
| title_unstemmed | Endothelial dysfunction as a cellular mechanism for vascular failure |
| topic | Physiology (medical), Cardiology and Cardiovascular Medicine, Physiology |
| url | http://dx.doi.org/10.1152/ajpheart.00325.2011 |