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Fox, James G.
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Fox, James G.
spellingShingle Rogers, Arlin B.
Fox, James G.
American Journal of Physiology-Gastrointestinal and Liver Physiology
Inflammation and Cancer I. Rodent models of infectious gastrointestinal and liver cancer
Physiology (medical)
Gastroenterology
Hepatology
Physiology
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title Inflammation and Cancer I. Rodent models of infectious gastrointestinal and liver cancer
title_unstemmed Inflammation and Cancer I. Rodent models of infectious gastrointestinal and liver cancer
title_full Inflammation and Cancer I. Rodent models of infectious gastrointestinal and liver cancer
title_fullStr Inflammation and Cancer I. Rodent models of infectious gastrointestinal and liver cancer
title_full_unstemmed Inflammation and Cancer I. Rodent models of infectious gastrointestinal and liver cancer
title_short Inflammation and Cancer I. Rodent models of infectious gastrointestinal and liver cancer
title_sort inflammation and cancer i. rodent models of infectious gastrointestinal and liver cancer
topic Physiology (medical)
Gastroenterology
Hepatology
Physiology
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description <jats:p>Chronic gastrointestinal and liver infections account for a significant percentage of human cancer deaths. Rodent models help elucidate how infection can lead to malignancy. Helicobacter pylori, the leading cause of human gastric tumors, produces similar disease in Mongolian gerbils. H. pylori, H. felis, and H. hepaticus induce stomach, lower bowel, or liver tumors in susceptible wild-type and genetically engineered mice. Immune dysregulated mice recapitulate features of inflammatory bowel disease including colon carcinoma. Hepatitis B and C virus transgenic mice provide insights into viral hepatitis and hepatocellular carcinoma. Rodent models enhance our understanding of infectious cancer pathogenesis and suggest novel targets for intervention.</jats:p>
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spelling Rogers, Arlin B. Fox, James G. 0193-1857 1522-1547 American Physiological Society Physiology (medical) Gastroenterology Hepatology Physiology http://dx.doi.org/10.1152/ajpgi.00499.2003 <jats:p>Chronic gastrointestinal and liver infections account for a significant percentage of human cancer deaths. Rodent models help elucidate how infection can lead to malignancy. Helicobacter pylori, the leading cause of human gastric tumors, produces similar disease in Mongolian gerbils. H. pylori, H. felis, and H. hepaticus induce stomach, lower bowel, or liver tumors in susceptible wild-type and genetically engineered mice. Immune dysregulated mice recapitulate features of inflammatory bowel disease including colon carcinoma. Hepatitis B and C virus transgenic mice provide insights into viral hepatitis and hepatocellular carcinoma. Rodent models enhance our understanding of infectious cancer pathogenesis and suggest novel targets for intervention.</jats:p> Inflammation and Cancer I. Rodent models of infectious gastrointestinal and liver cancer American Journal of Physiology-Gastrointestinal and Liver Physiology
spellingShingle Rogers, Arlin B., Fox, James G., American Journal of Physiology-Gastrointestinal and Liver Physiology, Inflammation and Cancer I. Rodent models of infectious gastrointestinal and liver cancer, Physiology (medical), Gastroenterology, Hepatology, Physiology
title Inflammation and Cancer I. Rodent models of infectious gastrointestinal and liver cancer
title_full Inflammation and Cancer I. Rodent models of infectious gastrointestinal and liver cancer
title_fullStr Inflammation and Cancer I. Rodent models of infectious gastrointestinal and liver cancer
title_full_unstemmed Inflammation and Cancer I. Rodent models of infectious gastrointestinal and liver cancer
title_short Inflammation and Cancer I. Rodent models of infectious gastrointestinal and liver cancer
title_sort inflammation and cancer i. rodent models of infectious gastrointestinal and liver cancer
title_unstemmed Inflammation and Cancer I. Rodent models of infectious gastrointestinal and liver cancer
topic Physiology (medical), Gastroenterology, Hepatology, Physiology
url http://dx.doi.org/10.1152/ajpgi.00499.2003