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Hepatic leukocyte recruitment in a model of acute colitis
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| Zeitschriftentitel: | American Journal of Physiology-Gastrointestinal and Liver Physiology |
|---|---|
| Personen und Körperschaften: | , |
| In: | American Journal of Physiology-Gastrointestinal and Liver Physiology, 283, 2002, 3, S. G561-G566 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Physiological Society
|
| Schlagwörter: |
| author_facet |
Scott, Jeffrey R. Fox-Robichaud, Alison E. Scott, Jeffrey R. Fox-Robichaud, Alison E. |
|---|---|
| author |
Scott, Jeffrey R. Fox-Robichaud, Alison E. |
| spellingShingle |
Scott, Jeffrey R. Fox-Robichaud, Alison E. American Journal of Physiology-Gastrointestinal and Liver Physiology Hepatic leukocyte recruitment in a model of acute colitis Physiology (medical) Gastroenterology Hepatology Physiology |
| author_sort |
scott, jeffrey r. |
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Scott, Jeffrey R. Fox-Robichaud, Alison E. 0193-1857 1522-1547 American Physiological Society Physiology (medical) Gastroenterology Hepatology Physiology http://dx.doi.org/10.1152/ajpgi.00462.2001 <jats:p>There is a close relationship between inflammatory bowel disease (IBD) and various hepatobiliary disorders. The objective of this study was to determine whether hepatic leukocyte recruitment occurs in experimental colitis. We used the murine model of colitis induced by 2,4-dinitrobenezenesulfonic acid (DNBS). Male C57Bl/6 mice received an intrarectal injection of 4 mg DNBS in 100 μl 50% ethanol. Controls received 100 μl 50% ethanol. The hepatic microcirculation was examined at 3 and 14 days post-DNBS by intravital video microscopy. Three days post-DNBS, when mice had developed acute colitis, there was associated hepatic leukocyte recruitment. Within the postsinusoidal venules there was a fourfold increase in the flux of rolling leukocytes that was P-selectin dependent but not α<jats:sub>4</jats:sub>-integrin dependent. There was also an increase in stationary leukocytes within the sinusoids, although this was not associated with an increase in serum alanine transaminase. By 14 days post-DNBS when macroscopic evidence of colonic inflammation was resolved, rolling within the postsinusoidal venules had returned to control levels. In this murine model of colitis, we describe a link between acute colonic inflammation and remote hepatic leukocyte recruitment that is P-selectin dependent. Active IBD may lead to remote hepatic inflammation.</jats:p> Hepatic leukocyte recruitment in a model of acute colitis American Journal of Physiology-Gastrointestinal and Liver Physiology |
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| title |
Hepatic leukocyte recruitment in a model of acute colitis |
| title_unstemmed |
Hepatic leukocyte recruitment in a model of acute colitis |
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Hepatic leukocyte recruitment in a model of acute colitis |
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Hepatic leukocyte recruitment in a model of acute colitis |
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Hepatic leukocyte recruitment in a model of acute colitis |
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Hepatic leukocyte recruitment in a model of acute colitis |
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hepatic leukocyte recruitment in a model of acute colitis |
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Physiology (medical) Gastroenterology Hepatology Physiology |
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http://dx.doi.org/10.1152/ajpgi.00462.2001 |
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2002 |
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G561-G566 |
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<jats:p>There is a close relationship between inflammatory bowel disease (IBD) and various hepatobiliary disorders. The objective of this study was to determine whether hepatic leukocyte recruitment occurs in experimental colitis. We used the murine model of colitis induced by 2,4-dinitrobenezenesulfonic acid (DNBS). Male C57Bl/6 mice received an intrarectal injection of 4 mg DNBS in 100 μl 50% ethanol. Controls received 100 μl 50% ethanol. The hepatic microcirculation was examined at 3 and 14 days post-DNBS by intravital video microscopy. Three days post-DNBS, when mice had developed acute colitis, there was associated hepatic leukocyte recruitment. Within the postsinusoidal venules there was a fourfold increase in the flux of rolling leukocytes that was P-selectin dependent but not α<jats:sub>4</jats:sub>-integrin dependent. There was also an increase in stationary leukocytes within the sinusoids, although this was not associated with an increase in serum alanine transaminase. By 14 days post-DNBS when macroscopic evidence of colonic inflammation was resolved, rolling within the postsinusoidal venules had returned to control levels. In this murine model of colitis, we describe a link between acute colonic inflammation and remote hepatic leukocyte recruitment that is P-selectin dependent. Active IBD may lead to remote hepatic inflammation.</jats:p> |
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| description | <jats:p>There is a close relationship between inflammatory bowel disease (IBD) and various hepatobiliary disorders. The objective of this study was to determine whether hepatic leukocyte recruitment occurs in experimental colitis. We used the murine model of colitis induced by 2,4-dinitrobenezenesulfonic acid (DNBS). Male C57Bl/6 mice received an intrarectal injection of 4 mg DNBS in 100 μl 50% ethanol. Controls received 100 μl 50% ethanol. The hepatic microcirculation was examined at 3 and 14 days post-DNBS by intravital video microscopy. Three days post-DNBS, when mice had developed acute colitis, there was associated hepatic leukocyte recruitment. Within the postsinusoidal venules there was a fourfold increase in the flux of rolling leukocytes that was P-selectin dependent but not α<jats:sub>4</jats:sub>-integrin dependent. There was also an increase in stationary leukocytes within the sinusoids, although this was not associated with an increase in serum alanine transaminase. By 14 days post-DNBS when macroscopic evidence of colonic inflammation was resolved, rolling within the postsinusoidal venules had returned to control levels. In this murine model of colitis, we describe a link between acute colonic inflammation and remote hepatic leukocyte recruitment that is P-selectin dependent. Active IBD may lead to remote hepatic inflammation.</jats:p> |
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| spelling | Scott, Jeffrey R. Fox-Robichaud, Alison E. 0193-1857 1522-1547 American Physiological Society Physiology (medical) Gastroenterology Hepatology Physiology http://dx.doi.org/10.1152/ajpgi.00462.2001 <jats:p>There is a close relationship between inflammatory bowel disease (IBD) and various hepatobiliary disorders. The objective of this study was to determine whether hepatic leukocyte recruitment occurs in experimental colitis. We used the murine model of colitis induced by 2,4-dinitrobenezenesulfonic acid (DNBS). Male C57Bl/6 mice received an intrarectal injection of 4 mg DNBS in 100 μl 50% ethanol. Controls received 100 μl 50% ethanol. The hepatic microcirculation was examined at 3 and 14 days post-DNBS by intravital video microscopy. Three days post-DNBS, when mice had developed acute colitis, there was associated hepatic leukocyte recruitment. Within the postsinusoidal venules there was a fourfold increase in the flux of rolling leukocytes that was P-selectin dependent but not α<jats:sub>4</jats:sub>-integrin dependent. There was also an increase in stationary leukocytes within the sinusoids, although this was not associated with an increase in serum alanine transaminase. By 14 days post-DNBS when macroscopic evidence of colonic inflammation was resolved, rolling within the postsinusoidal venules had returned to control levels. In this murine model of colitis, we describe a link between acute colonic inflammation and remote hepatic leukocyte recruitment that is P-selectin dependent. Active IBD may lead to remote hepatic inflammation.</jats:p> Hepatic leukocyte recruitment in a model of acute colitis American Journal of Physiology-Gastrointestinal and Liver Physiology |
| spellingShingle | Scott, Jeffrey R., Fox-Robichaud, Alison E., American Journal of Physiology-Gastrointestinal and Liver Physiology, Hepatic leukocyte recruitment in a model of acute colitis, Physiology (medical), Gastroenterology, Hepatology, Physiology |
| title | Hepatic leukocyte recruitment in a model of acute colitis |
| title_full | Hepatic leukocyte recruitment in a model of acute colitis |
| title_fullStr | Hepatic leukocyte recruitment in a model of acute colitis |
| title_full_unstemmed | Hepatic leukocyte recruitment in a model of acute colitis |
| title_short | Hepatic leukocyte recruitment in a model of acute colitis |
| title_sort | hepatic leukocyte recruitment in a model of acute colitis |
| title_unstemmed | Hepatic leukocyte recruitment in a model of acute colitis |
| topic | Physiology (medical), Gastroenterology, Hepatology, Physiology |
| url | http://dx.doi.org/10.1152/ajpgi.00462.2001 |