Eintrag weiter verarbeiten
Mechanism of production of intestinal secretion by negative luminal pressure.
Gespeichert in:
| Zeitschriftentitel: | American Journal of Physiology-Endocrinology and Metabolism |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | American Journal of Physiology-Endocrinology and Metabolism, 233, 1977, 5, S. E416 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Physiological Society
|
| Schlagwörter: |
| author_facet |
Hakim, A A Papeleux, C B Lane, J B Lifson, N Yablonski, M E Hakim, A A Papeleux, C B Lane, J B Lifson, N Yablonski, M E |
|---|---|
| author |
Hakim, A A Papeleux, C B Lane, J B Lifson, N Yablonski, M E |
| spellingShingle |
Hakim, A A Papeleux, C B Lane, J B Lifson, N Yablonski, M E American Journal of Physiology-Endocrinology and Metabolism Mechanism of production of intestinal secretion by negative luminal pressure. Physiology (medical) Physiology Endocrinology, Diabetes and Metabolism |
| author_sort |
hakim, a a |
| spelling |
Hakim, A A Papeleux, C B Lane, J B Lifson, N Yablonski, M E 0193-1849 1522-1555 American Physiological Society Physiology (medical) Physiology Endocrinology, Diabetes and Metabolism http://dx.doi.org/10.1152/ajpendo.1977.233.5.e416 <jats:p> The relationships between luminal hydrostatic pressure and fluid transport by dog jejunum in vivo studied as a sheet in the Wells clamp were compared with quantitative predictions from a model proposed for the mechanism of the secretion produced by elevated venous pressure. According to the model, the secretion produced by increasing venous pressure and the secretion produced by negative luminal pressure are both passive filtrates contingent on a transepithelial pressure of a few centimeters of H2O. We consider that the agreement between the observed and predicted responses to luminal pressure provides strong support for the model. In particular, a) the observations displayed a predicted gross asymmetry in rates of fluid transfer with isotonic fluids depending on whether the luminal pressure was positive or negative; b) the observed magnitude of the negative luminal pressure required for the onset of secretion agreed with predictions; and c) the secretion contained significant amounts of protein at about 25% of the plasma concentration. </jats:p> Mechanism of production of intestinal secretion by negative luminal pressure. American Journal of Physiology-Endocrinology and Metabolism |
| doi_str_mv |
10.1152/ajpendo.1977.233.5.e416 |
| facet_avail |
Online |
| finc_class_facet |
Biologie Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1Mi9hanBlbmRvLjE5NzcuMjMzLjUuZTQxNg |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1Mi9hanBlbmRvLjE5NzcuMjMzLjUuZTQxNg |
| institution |
DE-Pl11 DE-Rs1 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-D161 DE-Gla1 DE-Zi4 DE-15 |
| imprint |
American Physiological Society, 1977 |
| imprint_str_mv |
American Physiological Society, 1977 |
| issn |
0193-1849 1522-1555 |
| issn_str_mv |
0193-1849 1522-1555 |
| language |
English |
| mega_collection |
American Physiological Society (CrossRef) |
| match_str |
hakim1977mechanismofproductionofintestinalsecretionbynegativeluminalpressure |
| publishDateSort |
1977 |
| publisher |
American Physiological Society |
| recordtype |
ai |
| record_format |
ai |
| series |
American Journal of Physiology-Endocrinology and Metabolism |
| source_id |
49 |
| title |
Mechanism of production of intestinal secretion by negative luminal pressure. |
| title_unstemmed |
Mechanism of production of intestinal secretion by negative luminal pressure. |
| title_full |
Mechanism of production of intestinal secretion by negative luminal pressure. |
| title_fullStr |
Mechanism of production of intestinal secretion by negative luminal pressure. |
| title_full_unstemmed |
Mechanism of production of intestinal secretion by negative luminal pressure. |
| title_short |
Mechanism of production of intestinal secretion by negative luminal pressure. |
| title_sort |
mechanism of production of intestinal secretion by negative luminal pressure. |
| topic |
Physiology (medical) Physiology Endocrinology, Diabetes and Metabolism |
| url |
http://dx.doi.org/10.1152/ajpendo.1977.233.5.e416 |
| publishDate |
1977 |
| physical |
E416 |
| description |
<jats:p> The relationships between luminal hydrostatic pressure and fluid transport by dog jejunum in vivo studied as a sheet in the Wells clamp were compared with quantitative predictions from a model proposed for the mechanism of the secretion produced by elevated venous pressure. According to the model, the secretion produced by increasing venous pressure and the secretion produced by negative luminal pressure are both passive filtrates contingent on a transepithelial pressure of a few centimeters of H2O. We consider that the agreement between the observed and predicted responses to luminal pressure provides strong support for the model. In particular, a) the observations displayed a predicted gross asymmetry in rates of fluid transfer with isotonic fluids depending on whether the luminal pressure was positive or negative; b) the observed magnitude of the negative luminal pressure required for the onset of secretion agreed with predictions; and c) the secretion contained significant amounts of protein at about 25% of the plasma concentration. </jats:p> |
| container_issue |
5 |
| container_start_page |
0 |
| container_title |
American Journal of Physiology-Endocrinology and Metabolism |
| container_volume |
233 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792320697585893385 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T10:50:15.52Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Mechanism+of+production+of+intestinal+secretion+by+negative+luminal+pressure.&rft.date=1977-11-01&genre=article&issn=1522-1555&volume=233&issue=5&pages=E416&jtitle=American+Journal+of+Physiology-Endocrinology+and+Metabolism&atitle=Mechanism+of+production+of+intestinal+secretion+by+negative+luminal+pressure.&aulast=Yablonski&aufirst=M+E&rft_id=info%3Adoi%2F10.1152%2Fajpendo.1977.233.5.e416&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792320697585893385 |
| author | Hakim, A A, Papeleux, C B, Lane, J B, Lifson, N, Yablonski, M E |
| author_facet | Hakim, A A, Papeleux, C B, Lane, J B, Lifson, N, Yablonski, M E, Hakim, A A, Papeleux, C B, Lane, J B, Lifson, N, Yablonski, M E |
| author_sort | hakim, a a |
| container_issue | 5 |
| container_start_page | 0 |
| container_title | American Journal of Physiology-Endocrinology and Metabolism |
| container_volume | 233 |
| description | <jats:p> The relationships between luminal hydrostatic pressure and fluid transport by dog jejunum in vivo studied as a sheet in the Wells clamp were compared with quantitative predictions from a model proposed for the mechanism of the secretion produced by elevated venous pressure. According to the model, the secretion produced by increasing venous pressure and the secretion produced by negative luminal pressure are both passive filtrates contingent on a transepithelial pressure of a few centimeters of H2O. We consider that the agreement between the observed and predicted responses to luminal pressure provides strong support for the model. In particular, a) the observations displayed a predicted gross asymmetry in rates of fluid transfer with isotonic fluids depending on whether the luminal pressure was positive or negative; b) the observed magnitude of the negative luminal pressure required for the onset of secretion agreed with predictions; and c) the secretion contained significant amounts of protein at about 25% of the plasma concentration. </jats:p> |
| doi_str_mv | 10.1152/ajpendo.1977.233.5.e416 |
| facet_avail | Online |
| finc_class_facet | Biologie, Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1Mi9hanBlbmRvLjE5NzcuMjMzLjUuZTQxNg |
| imprint | American Physiological Society, 1977 |
| imprint_str_mv | American Physiological Society, 1977 |
| institution | DE-Pl11, DE-Rs1, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15 |
| issn | 0193-1849, 1522-1555 |
| issn_str_mv | 0193-1849, 1522-1555 |
| language | English |
| last_indexed | 2024-03-01T10:50:15.52Z |
| match_str | hakim1977mechanismofproductionofintestinalsecretionbynegativeluminalpressure |
| mega_collection | American Physiological Society (CrossRef) |
| physical | E416 |
| publishDate | 1977 |
| publishDateSort | 1977 |
| publisher | American Physiological Society |
| record_format | ai |
| recordtype | ai |
| series | American Journal of Physiology-Endocrinology and Metabolism |
| source_id | 49 |
| spelling | Hakim, A A Papeleux, C B Lane, J B Lifson, N Yablonski, M E 0193-1849 1522-1555 American Physiological Society Physiology (medical) Physiology Endocrinology, Diabetes and Metabolism http://dx.doi.org/10.1152/ajpendo.1977.233.5.e416 <jats:p> The relationships between luminal hydrostatic pressure and fluid transport by dog jejunum in vivo studied as a sheet in the Wells clamp were compared with quantitative predictions from a model proposed for the mechanism of the secretion produced by elevated venous pressure. According to the model, the secretion produced by increasing venous pressure and the secretion produced by negative luminal pressure are both passive filtrates contingent on a transepithelial pressure of a few centimeters of H2O. We consider that the agreement between the observed and predicted responses to luminal pressure provides strong support for the model. In particular, a) the observations displayed a predicted gross asymmetry in rates of fluid transfer with isotonic fluids depending on whether the luminal pressure was positive or negative; b) the observed magnitude of the negative luminal pressure required for the onset of secretion agreed with predictions; and c) the secretion contained significant amounts of protein at about 25% of the plasma concentration. </jats:p> Mechanism of production of intestinal secretion by negative luminal pressure. American Journal of Physiology-Endocrinology and Metabolism |
| spellingShingle | Hakim, A A, Papeleux, C B, Lane, J B, Lifson, N, Yablonski, M E, American Journal of Physiology-Endocrinology and Metabolism, Mechanism of production of intestinal secretion by negative luminal pressure., Physiology (medical), Physiology, Endocrinology, Diabetes and Metabolism |
| title | Mechanism of production of intestinal secretion by negative luminal pressure. |
| title_full | Mechanism of production of intestinal secretion by negative luminal pressure. |
| title_fullStr | Mechanism of production of intestinal secretion by negative luminal pressure. |
| title_full_unstemmed | Mechanism of production of intestinal secretion by negative luminal pressure. |
| title_short | Mechanism of production of intestinal secretion by negative luminal pressure. |
| title_sort | mechanism of production of intestinal secretion by negative luminal pressure. |
| title_unstemmed | Mechanism of production of intestinal secretion by negative luminal pressure. |
| topic | Physiology (medical), Physiology, Endocrinology, Diabetes and Metabolism |
| url | http://dx.doi.org/10.1152/ajpendo.1977.233.5.e416 |