Eintrag weiter verarbeiten
Hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose
Gespeichert in:
| Zeitschriftentitel: | American Journal of Physiology-Endocrinology and Metabolism |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | American Journal of Physiology-Endocrinology and Metabolism, 287, 2004, 2, S. E269-E274 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Physiological Society
|
| Schlagwörter: |
| author_facet |
Camacho, Raul C. Lacy, D. Brooks James, Freyja D. Coker, Robert H. Wasserman, David H. Camacho, Raul C. Lacy, D. Brooks James, Freyja D. Coker, Robert H. Wasserman, David H. |
|---|---|
| author |
Camacho, Raul C. Lacy, D. Brooks James, Freyja D. Coker, Robert H. Wasserman, David H. |
| spellingShingle |
Camacho, Raul C. Lacy, D. Brooks James, Freyja D. Coker, Robert H. Wasserman, David H. American Journal of Physiology-Endocrinology and Metabolism Hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose Physiology (medical) Physiology Endocrinology, Diabetes and Metabolism |
| author_sort |
camacho, raul c. |
| spelling |
Camacho, Raul C. Lacy, D. Brooks James, Freyja D. Coker, Robert H. Wasserman, David H. 0193-1849 1522-1555 American Physiological Society Physiology (medical) Physiology Endocrinology, Diabetes and Metabolism http://dx.doi.org/10.1152/ajpendo.00040.2004 <jats:p>The purpose of this study was to determine whether the sedentary dog is able to autoregulate glucose production (R<jats:sub>a</jats:sub>) in response to non-insulin-induced changes (<20 mg/dl) in arterial glucose. Dogs had catheters implanted >16 days before study. Protocols consisted of basal (−30 to 0 min) and bilateral renal arterial phloridzin infusion (0–180 min) periods. Somatostatin was infused, and glucagon and insulin were replaced to basal levels. In one protocol (Phl ± Glc), glucose was allowed to fall from t = 0–90 min. This was followed by a period when glucose was infused to restore euglycemia (90–150 min) and a period when glucose was allowed to fall again (150–180 min). In a second protocol (EC), glucose was infused to compensate for the renal glucose loss due to phloridzin and maintain euglycemia from t = 0–180 min. Arterial insulin, glucagon, cortisol, and catecholamines remained at basal in both protocols. In Phl ± Glc, glucose fell by ∼20 mg/dl by t = 90 min with phloridzin infusion. R<jats:sub>a</jats:sub>did not change from basal in Phl ± Glc despite the fall in glucose for the first 90 min. R<jats:sub>a</jats:sub>was significantly suppressed with restoration of euglycemia from t = 90–150 min ( P < 0.05) and returned to basal when glucose was allowed to fall from t = 150–180 min. R<jats:sub>a</jats:sub>did not change from basal in EC. In conclusion, the liver autoregulates R<jats:sub>a</jats:sub>in response to small changes in glucose independently of changes in pancreatic hormones at rest. However, the liver of the resting dog is more sensitive to a small increment, rather than decrement, in arterial glucose.</jats:p> Hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose American Journal of Physiology-Endocrinology and Metabolism |
| doi_str_mv |
10.1152/ajpendo.00040.2004 |
| facet_avail |
Online Free |
| finc_class_facet |
Biologie Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1Mi9hanBlbmRvLjAwMDQwLjIwMDQ |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1Mi9hanBlbmRvLjAwMDQwLjIwMDQ |
| institution |
DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 |
| imprint |
American Physiological Society, 2004 |
| imprint_str_mv |
American Physiological Society, 2004 |
| issn |
0193-1849 1522-1555 |
| issn_str_mv |
0193-1849 1522-1555 |
| language |
English |
| mega_collection |
American Physiological Society (CrossRef) |
| match_str |
camacho2004hepaticglucoseautoregulationresponsestosmallnoninsulininducedchangesinarterialglucose |
| publishDateSort |
2004 |
| publisher |
American Physiological Society |
| recordtype |
ai |
| record_format |
ai |
| series |
American Journal of Physiology-Endocrinology and Metabolism |
| source_id |
49 |
| title |
Hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose |
| title_unstemmed |
Hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose |
| title_full |
Hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose |
| title_fullStr |
Hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose |
| title_full_unstemmed |
Hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose |
| title_short |
Hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose |
| title_sort |
hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose |
| topic |
Physiology (medical) Physiology Endocrinology, Diabetes and Metabolism |
| url |
http://dx.doi.org/10.1152/ajpendo.00040.2004 |
| publishDate |
2004 |
| physical |
E269-E274 |
| description |
<jats:p>The purpose of this study was to determine whether the sedentary dog is able to autoregulate glucose production (R<jats:sub>a</jats:sub>) in response to non-insulin-induced changes (<20 mg/dl) in arterial glucose. Dogs had catheters implanted >16 days before study. Protocols consisted of basal (−30 to 0 min) and bilateral renal arterial phloridzin infusion (0–180 min) periods. Somatostatin was infused, and glucagon and insulin were replaced to basal levels. In one protocol (Phl ± Glc), glucose was allowed to fall from t = 0–90 min. This was followed by a period when glucose was infused to restore euglycemia (90–150 min) and a period when glucose was allowed to fall again (150–180 min). In a second protocol (EC), glucose was infused to compensate for the renal glucose loss due to phloridzin and maintain euglycemia from t = 0–180 min. Arterial insulin, glucagon, cortisol, and catecholamines remained at basal in both protocols. In Phl ± Glc, glucose fell by ∼20 mg/dl by t = 90 min with phloridzin infusion. R<jats:sub>a</jats:sub>did not change from basal in Phl ± Glc despite the fall in glucose for the first 90 min. R<jats:sub>a</jats:sub>was significantly suppressed with restoration of euglycemia from t = 90–150 min ( P < 0.05) and returned to basal when glucose was allowed to fall from t = 150–180 min. R<jats:sub>a</jats:sub>did not change from basal in EC. In conclusion, the liver autoregulates R<jats:sub>a</jats:sub>in response to small changes in glucose independently of changes in pancreatic hormones at rest. However, the liver of the resting dog is more sensitive to a small increment, rather than decrement, in arterial glucose.</jats:p> |
| container_issue |
2 |
| container_start_page |
0 |
| container_title |
American Journal of Physiology-Endocrinology and Metabolism |
| container_volume |
287 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792344220887941121 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T17:04:09.548Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Hepatic+glucose+autoregulation%3A+responses+to+small%2C+non-insulin-induced+changes+in+arterial+glucose&rft.date=2004-08-01&genre=article&issn=1522-1555&volume=287&issue=2&pages=E269-E274&jtitle=American+Journal+of+Physiology-Endocrinology+and+Metabolism&atitle=Hepatic+glucose+autoregulation%3A+responses+to+small%2C+non-insulin-induced+changes+in+arterial+glucose&aulast=Wasserman&aufirst=David+H.&rft_id=info%3Adoi%2F10.1152%2Fajpendo.00040.2004&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792344220887941121 |
| author | Camacho, Raul C., Lacy, D. Brooks, James, Freyja D., Coker, Robert H., Wasserman, David H. |
| author_facet | Camacho, Raul C., Lacy, D. Brooks, James, Freyja D., Coker, Robert H., Wasserman, David H., Camacho, Raul C., Lacy, D. Brooks, James, Freyja D., Coker, Robert H., Wasserman, David H. |
| author_sort | camacho, raul c. |
| container_issue | 2 |
| container_start_page | 0 |
| container_title | American Journal of Physiology-Endocrinology and Metabolism |
| container_volume | 287 |
| description | <jats:p>The purpose of this study was to determine whether the sedentary dog is able to autoregulate glucose production (R<jats:sub>a</jats:sub>) in response to non-insulin-induced changes (<20 mg/dl) in arterial glucose. Dogs had catheters implanted >16 days before study. Protocols consisted of basal (−30 to 0 min) and bilateral renal arterial phloridzin infusion (0–180 min) periods. Somatostatin was infused, and glucagon and insulin were replaced to basal levels. In one protocol (Phl ± Glc), glucose was allowed to fall from t = 0–90 min. This was followed by a period when glucose was infused to restore euglycemia (90–150 min) and a period when glucose was allowed to fall again (150–180 min). In a second protocol (EC), glucose was infused to compensate for the renal glucose loss due to phloridzin and maintain euglycemia from t = 0–180 min. Arterial insulin, glucagon, cortisol, and catecholamines remained at basal in both protocols. In Phl ± Glc, glucose fell by ∼20 mg/dl by t = 90 min with phloridzin infusion. R<jats:sub>a</jats:sub>did not change from basal in Phl ± Glc despite the fall in glucose for the first 90 min. R<jats:sub>a</jats:sub>was significantly suppressed with restoration of euglycemia from t = 90–150 min ( P < 0.05) and returned to basal when glucose was allowed to fall from t = 150–180 min. R<jats:sub>a</jats:sub>did not change from basal in EC. In conclusion, the liver autoregulates R<jats:sub>a</jats:sub>in response to small changes in glucose independently of changes in pancreatic hormones at rest. However, the liver of the resting dog is more sensitive to a small increment, rather than decrement, in arterial glucose.</jats:p> |
| doi_str_mv | 10.1152/ajpendo.00040.2004 |
| facet_avail | Online, Free |
| finc_class_facet | Biologie, Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1Mi9hanBlbmRvLjAwMDQwLjIwMDQ |
| imprint | American Physiological Society, 2004 |
| imprint_str_mv | American Physiological Society, 2004 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
| issn | 0193-1849, 1522-1555 |
| issn_str_mv | 0193-1849, 1522-1555 |
| language | English |
| last_indexed | 2024-03-01T17:04:09.548Z |
| match_str | camacho2004hepaticglucoseautoregulationresponsestosmallnoninsulininducedchangesinarterialglucose |
| mega_collection | American Physiological Society (CrossRef) |
| physical | E269-E274 |
| publishDate | 2004 |
| publishDateSort | 2004 |
| publisher | American Physiological Society |
| record_format | ai |
| recordtype | ai |
| series | American Journal of Physiology-Endocrinology and Metabolism |
| source_id | 49 |
| spelling | Camacho, Raul C. Lacy, D. Brooks James, Freyja D. Coker, Robert H. Wasserman, David H. 0193-1849 1522-1555 American Physiological Society Physiology (medical) Physiology Endocrinology, Diabetes and Metabolism http://dx.doi.org/10.1152/ajpendo.00040.2004 <jats:p>The purpose of this study was to determine whether the sedentary dog is able to autoregulate glucose production (R<jats:sub>a</jats:sub>) in response to non-insulin-induced changes (<20 mg/dl) in arterial glucose. Dogs had catheters implanted >16 days before study. Protocols consisted of basal (−30 to 0 min) and bilateral renal arterial phloridzin infusion (0–180 min) periods. Somatostatin was infused, and glucagon and insulin were replaced to basal levels. In one protocol (Phl ± Glc), glucose was allowed to fall from t = 0–90 min. This was followed by a period when glucose was infused to restore euglycemia (90–150 min) and a period when glucose was allowed to fall again (150–180 min). In a second protocol (EC), glucose was infused to compensate for the renal glucose loss due to phloridzin and maintain euglycemia from t = 0–180 min. Arterial insulin, glucagon, cortisol, and catecholamines remained at basal in both protocols. In Phl ± Glc, glucose fell by ∼20 mg/dl by t = 90 min with phloridzin infusion. R<jats:sub>a</jats:sub>did not change from basal in Phl ± Glc despite the fall in glucose for the first 90 min. R<jats:sub>a</jats:sub>was significantly suppressed with restoration of euglycemia from t = 90–150 min ( P < 0.05) and returned to basal when glucose was allowed to fall from t = 150–180 min. R<jats:sub>a</jats:sub>did not change from basal in EC. In conclusion, the liver autoregulates R<jats:sub>a</jats:sub>in response to small changes in glucose independently of changes in pancreatic hormones at rest. However, the liver of the resting dog is more sensitive to a small increment, rather than decrement, in arterial glucose.</jats:p> Hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose American Journal of Physiology-Endocrinology and Metabolism |
| spellingShingle | Camacho, Raul C., Lacy, D. Brooks, James, Freyja D., Coker, Robert H., Wasserman, David H., American Journal of Physiology-Endocrinology and Metabolism, Hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose, Physiology (medical), Physiology, Endocrinology, Diabetes and Metabolism |
| title | Hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose |
| title_full | Hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose |
| title_fullStr | Hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose |
| title_full_unstemmed | Hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose |
| title_short | Hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose |
| title_sort | hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose |
| title_unstemmed | Hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose |
| topic | Physiology (medical), Physiology, Endocrinology, Diabetes and Metabolism |
| url | http://dx.doi.org/10.1152/ajpendo.00040.2004 |