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Revascularization and endothelial progenitor cells in stroke
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| Zeitschriftentitel: | American Journal of Physiology-Cell Physiology |
|---|---|
| Personen und Körperschaften: | , , |
| In: | American Journal of Physiology-Cell Physiology, 315, 2018, 5, S. C664-C674 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Physiological Society
|
| Schlagwörter: |
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Esquiva, Gema Grayston, Alba Rosell, Anna Esquiva, Gema Grayston, Alba Rosell, Anna |
|---|---|
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Esquiva, Gema Grayston, Alba Rosell, Anna |
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Esquiva, Gema Grayston, Alba Rosell, Anna American Journal of Physiology-Cell Physiology Revascularization and endothelial progenitor cells in stroke Cell Biology Physiology |
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esquiva, gema |
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Esquiva, Gema Grayston, Alba Rosell, Anna 0363-6143 1522-1563 American Physiological Society Cell Biology Physiology http://dx.doi.org/10.1152/ajpcell.00200.2018 <jats:p>Stroke is one of the leading causes of death and disability worldwide. Tremendous improvements have been achieved in the acute care of stroke patients with the implementation of stroke units, thrombolytic drugs, and endovascular trombectomies. However, stroke survivors with neurological deficits require long periods of neurorehabilitation, which is the only approved therapy for poststroke recovery. With this scenario, more treatments are urgently needed, and only the understanding of the mechanisms of brain recovery might contribute to identify new therapeutic agents. Fortunately, brain injury after stroke is counteracted by the birth and migration of several populations of progenitor cells towards the injured areas, where angiogenesis and vascular remodeling play a key role providing trophic support and guidance during neurorepair. Endothelial progenitor cells (EPCs) constitute a pool of circulating bone-marrow derived cells that mobilize after an ischemic injury with the potential to incorporate into the damaged endothelium, to form new vessels, or to secrete trophic factors stimulating vessel remodeling. The circulating levels of EPCs are altered after stroke, and several subpopulations have proved to boost brain neurorepair in preclinical models of cerebral ischemia. The goal of this review is to discuss the current state of the neuroreparative actions of EPCs, focusing on their paracrine signaling mechanisms thorough their secretome and released extracellular vesicles.</jats:p> Revascularization and endothelial progenitor cells in stroke American Journal of Physiology-Cell Physiology |
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Revascularization and endothelial progenitor cells in stroke |
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Revascularization and endothelial progenitor cells in stroke |
| title_full |
Revascularization and endothelial progenitor cells in stroke |
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Revascularization and endothelial progenitor cells in stroke |
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Revascularization and endothelial progenitor cells in stroke |
| title_short |
Revascularization and endothelial progenitor cells in stroke |
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revascularization and endothelial progenitor cells in stroke |
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Cell Biology Physiology |
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http://dx.doi.org/10.1152/ajpcell.00200.2018 |
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2018 |
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C664-C674 |
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<jats:p>Stroke is one of the leading causes of death and disability worldwide. Tremendous improvements have been achieved in the acute care of stroke patients with the implementation of stroke units, thrombolytic drugs, and endovascular trombectomies. However, stroke survivors with neurological deficits require long periods of neurorehabilitation, which is the only approved therapy for poststroke recovery. With this scenario, more treatments are urgently needed, and only the understanding of the mechanisms of brain recovery might contribute to identify new therapeutic agents. Fortunately, brain injury after stroke is counteracted by the birth and migration of several populations of progenitor cells towards the injured areas, where angiogenesis and vascular remodeling play a key role providing trophic support and guidance during neurorepair. Endothelial progenitor cells (EPCs) constitute a pool of circulating bone-marrow derived cells that mobilize after an ischemic injury with the potential to incorporate into the damaged endothelium, to form new vessels, or to secrete trophic factors stimulating vessel remodeling. The circulating levels of EPCs are altered after stroke, and several subpopulations have proved to boost brain neurorepair in preclinical models of cerebral ischemia. The goal of this review is to discuss the current state of the neuroreparative actions of EPCs, focusing on their paracrine signaling mechanisms thorough their secretome and released extracellular vesicles.</jats:p> |
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| description | <jats:p>Stroke is one of the leading causes of death and disability worldwide. Tremendous improvements have been achieved in the acute care of stroke patients with the implementation of stroke units, thrombolytic drugs, and endovascular trombectomies. However, stroke survivors with neurological deficits require long periods of neurorehabilitation, which is the only approved therapy for poststroke recovery. With this scenario, more treatments are urgently needed, and only the understanding of the mechanisms of brain recovery might contribute to identify new therapeutic agents. Fortunately, brain injury after stroke is counteracted by the birth and migration of several populations of progenitor cells towards the injured areas, where angiogenesis and vascular remodeling play a key role providing trophic support and guidance during neurorepair. Endothelial progenitor cells (EPCs) constitute a pool of circulating bone-marrow derived cells that mobilize after an ischemic injury with the potential to incorporate into the damaged endothelium, to form new vessels, or to secrete trophic factors stimulating vessel remodeling. The circulating levels of EPCs are altered after stroke, and several subpopulations have proved to boost brain neurorepair in preclinical models of cerebral ischemia. The goal of this review is to discuss the current state of the neuroreparative actions of EPCs, focusing on their paracrine signaling mechanisms thorough their secretome and released extracellular vesicles.</jats:p> |
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| spelling | Esquiva, Gema Grayston, Alba Rosell, Anna 0363-6143 1522-1563 American Physiological Society Cell Biology Physiology http://dx.doi.org/10.1152/ajpcell.00200.2018 <jats:p>Stroke is one of the leading causes of death and disability worldwide. Tremendous improvements have been achieved in the acute care of stroke patients with the implementation of stroke units, thrombolytic drugs, and endovascular trombectomies. However, stroke survivors with neurological deficits require long periods of neurorehabilitation, which is the only approved therapy for poststroke recovery. With this scenario, more treatments are urgently needed, and only the understanding of the mechanisms of brain recovery might contribute to identify new therapeutic agents. Fortunately, brain injury after stroke is counteracted by the birth and migration of several populations of progenitor cells towards the injured areas, where angiogenesis and vascular remodeling play a key role providing trophic support and guidance during neurorepair. Endothelial progenitor cells (EPCs) constitute a pool of circulating bone-marrow derived cells that mobilize after an ischemic injury with the potential to incorporate into the damaged endothelium, to form new vessels, or to secrete trophic factors stimulating vessel remodeling. The circulating levels of EPCs are altered after stroke, and several subpopulations have proved to boost brain neurorepair in preclinical models of cerebral ischemia. The goal of this review is to discuss the current state of the neuroreparative actions of EPCs, focusing on their paracrine signaling mechanisms thorough their secretome and released extracellular vesicles.</jats:p> Revascularization and endothelial progenitor cells in stroke American Journal of Physiology-Cell Physiology |
| spellingShingle | Esquiva, Gema, Grayston, Alba, Rosell, Anna, American Journal of Physiology-Cell Physiology, Revascularization and endothelial progenitor cells in stroke, Cell Biology, Physiology |
| title | Revascularization and endothelial progenitor cells in stroke |
| title_full | Revascularization and endothelial progenitor cells in stroke |
| title_fullStr | Revascularization and endothelial progenitor cells in stroke |
| title_full_unstemmed | Revascularization and endothelial progenitor cells in stroke |
| title_short | Revascularization and endothelial progenitor cells in stroke |
| title_sort | revascularization and endothelial progenitor cells in stroke |
| title_unstemmed | Revascularization and endothelial progenitor cells in stroke |
| topic | Cell Biology, Physiology |
| url | http://dx.doi.org/10.1152/ajpcell.00200.2018 |