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Regulation of Receptor Tyrosine Kinase Signaling by GRKs and β-Arrestins
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| Zeitschriftentitel: | Annual Review of Physiology |
|---|---|
| Personen und Körperschaften: | , |
| In: | Annual Review of Physiology, 69, 2007, 1, S. 561-577 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Annual Reviews
|
| Schlagwörter: |
| author_facet |
Hupfeld, Christopher J. Olefsky, Jerrold M. Hupfeld, Christopher J. Olefsky, Jerrold M. |
|---|---|
| author |
Hupfeld, Christopher J. Olefsky, Jerrold M. |
| spellingShingle |
Hupfeld, Christopher J. Olefsky, Jerrold M. Annual Review of Physiology Regulation of Receptor Tyrosine Kinase Signaling by GRKs and β-Arrestins Physiology |
| author_sort |
hupfeld, christopher j. |
| spelling |
Hupfeld, Christopher J. Olefsky, Jerrold M. 0066-4278 1545-1585 Annual Reviews Physiology http://dx.doi.org/10.1146/annurev.physiol.69.022405.154626 <jats:p> Receptor tyrosine kinases (RTKs) are a unique family of cell surface receptors, each containing a common intracellular domain that has tyrosine kinase activity. However, RTKs share many signaling molecules with another unique family of cell surface receptors, the seven-transmembrane receptors (7TMRs), and these receptor families can activate similar signaling cascades. In this review of RTK signaling, we describe the role of cross talk between RTKs and 7TMRs, focusing specifically on the role played in this process by β-arrestins and by G proteins. </jats:p> Regulation of Receptor Tyrosine Kinase Signaling by GRKs and β-Arrestins Annual Review of Physiology |
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Annual Reviews, 2007 |
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Annual Reviews, 2007 |
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0066-4278 1545-1585 |
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2007 |
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Annual Reviews |
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Annual Review of Physiology |
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49 |
| title |
Regulation of Receptor Tyrosine Kinase Signaling by GRKs and β-Arrestins |
| title_unstemmed |
Regulation of Receptor Tyrosine Kinase Signaling by GRKs and β-Arrestins |
| title_full |
Regulation of Receptor Tyrosine Kinase Signaling by GRKs and β-Arrestins |
| title_fullStr |
Regulation of Receptor Tyrosine Kinase Signaling by GRKs and β-Arrestins |
| title_full_unstemmed |
Regulation of Receptor Tyrosine Kinase Signaling by GRKs and β-Arrestins |
| title_short |
Regulation of Receptor Tyrosine Kinase Signaling by GRKs and β-Arrestins |
| title_sort |
regulation of receptor tyrosine kinase signaling by grks and β-arrestins |
| topic |
Physiology |
| url |
http://dx.doi.org/10.1146/annurev.physiol.69.022405.154626 |
| publishDate |
2007 |
| physical |
561-577 |
| description |
<jats:p> Receptor tyrosine kinases (RTKs) are a unique family of cell surface receptors, each containing a common intracellular domain that has tyrosine kinase activity. However, RTKs share many signaling molecules with another unique family of cell surface receptors, the seven-transmembrane receptors (7TMRs), and these receptor families can activate similar signaling cascades. In this review of RTK signaling, we describe the role of cross talk between RTKs and 7TMRs, focusing specifically on the role played in this process by β-arrestins and by G proteins. </jats:p> |
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| author | Hupfeld, Christopher J., Olefsky, Jerrold M. |
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| container_title | Annual Review of Physiology |
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| description | <jats:p> Receptor tyrosine kinases (RTKs) are a unique family of cell surface receptors, each containing a common intracellular domain that has tyrosine kinase activity. However, RTKs share many signaling molecules with another unique family of cell surface receptors, the seven-transmembrane receptors (7TMRs), and these receptor families can activate similar signaling cascades. In this review of RTK signaling, we describe the role of cross talk between RTKs and 7TMRs, focusing specifically on the role played in this process by β-arrestins and by G proteins. </jats:p> |
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| imprint | Annual Reviews, 2007 |
| imprint_str_mv | Annual Reviews, 2007 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| physical | 561-577 |
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| series | Annual Review of Physiology |
| source_id | 49 |
| spelling | Hupfeld, Christopher J. Olefsky, Jerrold M. 0066-4278 1545-1585 Annual Reviews Physiology http://dx.doi.org/10.1146/annurev.physiol.69.022405.154626 <jats:p> Receptor tyrosine kinases (RTKs) are a unique family of cell surface receptors, each containing a common intracellular domain that has tyrosine kinase activity. However, RTKs share many signaling molecules with another unique family of cell surface receptors, the seven-transmembrane receptors (7TMRs), and these receptor families can activate similar signaling cascades. In this review of RTK signaling, we describe the role of cross talk between RTKs and 7TMRs, focusing specifically on the role played in this process by β-arrestins and by G proteins. </jats:p> Regulation of Receptor Tyrosine Kinase Signaling by GRKs and β-Arrestins Annual Review of Physiology |
| spellingShingle | Hupfeld, Christopher J., Olefsky, Jerrold M., Annual Review of Physiology, Regulation of Receptor Tyrosine Kinase Signaling by GRKs and β-Arrestins, Physiology |
| title | Regulation of Receptor Tyrosine Kinase Signaling by GRKs and β-Arrestins |
| title_full | Regulation of Receptor Tyrosine Kinase Signaling by GRKs and β-Arrestins |
| title_fullStr | Regulation of Receptor Tyrosine Kinase Signaling by GRKs and β-Arrestins |
| title_full_unstemmed | Regulation of Receptor Tyrosine Kinase Signaling by GRKs and β-Arrestins |
| title_short | Regulation of Receptor Tyrosine Kinase Signaling by GRKs and β-Arrestins |
| title_sort | regulation of receptor tyrosine kinase signaling by grks and β-arrestins |
| title_unstemmed | Regulation of Receptor Tyrosine Kinase Signaling by GRKs and β-Arrestins |
| topic | Physiology |
| url | http://dx.doi.org/10.1146/annurev.physiol.69.022405.154626 |