Eintrag weiter verarbeiten
Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate
Gespeichert in:
| Zeitschriftentitel: | Annual Review of Biochemistry |
|---|---|
| Personen und Körperschaften: | , |
| In: | Annual Review of Biochemistry, 71, 2002, 1, S. 435-471 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Annual Reviews
|
| Schlagwörter: |
| author_facet |
Esko, Jeffrey D. Selleck, Scott B. Esko, Jeffrey D. Selleck, Scott B. |
|---|---|
| author |
Esko, Jeffrey D. Selleck, Scott B. |
| spellingShingle |
Esko, Jeffrey D. Selleck, Scott B. Annual Review of Biochemistry Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate Biochemistry |
| author_sort |
esko, jeffrey d. |
| spelling |
Esko, Jeffrey D. Selleck, Scott B. 0066-4154 1545-4509 Annual Reviews Biochemistry http://dx.doi.org/10.1146/annurev.biochem.71.110601.135458 <jats:p>▪ Abstract Virtually every cell type in metazoan organisms produces heparan sulfate. These complex polysaccharides provide docking sites for numerous protein ligands and receptors involved in diverse biological processes, including growth control, signal transduction, cell adhesion, hemostasis, and lipid metabolism. The binding sites consist of relatively small tracts of variably sulfated glucosamine and uronic acid residues in specific arrangements. Their formation occurs in a tissue-specific fashion, generated by the action of a large family of enzymes involved in nucleotide sugar metabolism, polymer formation (glycosyltransferases), and chain processing (sulfotransferases and an epimerase). New insights into the specificity and organization of the biosynthetic apparatus have emerged from genetic studies of cultured cells, nematodes, fruit flies, zebrafish, rodents, and humans. This review covers recent developments in the field and provides a resource for investigators interested in the incredible diversity and specificity of this process.</jats:p> Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate Annual Review of Biochemistry |
| doi_str_mv |
10.1146/annurev.biochem.71.110601.135458 |
| facet_avail |
Online |
| finc_class_facet |
Chemie und Pharmazie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE0Ni9hbm51cmV2LmJpb2NoZW0uNzEuMTEwNjAxLjEzNTQ1OA |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE0Ni9hbm51cmV2LmJpb2NoZW0uNzEuMTEwNjAxLjEzNTQ1OA |
| institution |
DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 |
| imprint |
Annual Reviews, 2002 |
| imprint_str_mv |
Annual Reviews, 2002 |
| issn |
0066-4154 1545-4509 |
| issn_str_mv |
0066-4154 1545-4509 |
| language |
English |
| mega_collection |
Annual Reviews (CrossRef) |
| match_str |
esko2002orderoutofchaosassemblyofligandbindingsitesinheparansulfate |
| publishDateSort |
2002 |
| publisher |
Annual Reviews |
| recordtype |
ai |
| record_format |
ai |
| series |
Annual Review of Biochemistry |
| source_id |
49 |
| title |
Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate |
| title_unstemmed |
Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate |
| title_full |
Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate |
| title_fullStr |
Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate |
| title_full_unstemmed |
Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate |
| title_short |
Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate |
| title_sort |
order out of chaos: assembly of ligand binding sites in heparan sulfate |
| topic |
Biochemistry |
| url |
http://dx.doi.org/10.1146/annurev.biochem.71.110601.135458 |
| publishDate |
2002 |
| physical |
435-471 |
| description |
<jats:p>▪ Abstract Virtually every cell type in metazoan organisms produces heparan sulfate. These complex polysaccharides provide docking sites for numerous protein ligands and receptors involved in diverse biological processes, including growth control, signal transduction, cell adhesion, hemostasis, and lipid metabolism. The binding sites consist of relatively small tracts of variably sulfated glucosamine and uronic acid residues in specific arrangements. Their formation occurs in a tissue-specific fashion, generated by the action of a large family of enzymes involved in nucleotide sugar metabolism, polymer formation (glycosyltransferases), and chain processing (sulfotransferases and an epimerase). New insights into the specificity and organization of the biosynthetic apparatus have emerged from genetic studies of cultured cells, nematodes, fruit flies, zebrafish, rodents, and humans. This review covers recent developments in the field and provides a resource for investigators interested in the incredible diversity and specificity of this process.</jats:p> |
| container_issue |
1 |
| container_start_page |
435 |
| container_title |
Annual Review of Biochemistry |
| container_volume |
71 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792348599836737543 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T18:13:45.514Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Order+Out+of+Chaos%3A+Assembly+of+Ligand+Binding+Sites+in+Heparan+Sulfate&rft.date=2002-06-01&genre=article&issn=1545-4509&volume=71&issue=1&spage=435&epage=471&pages=435-471&jtitle=Annual+Review+of+Biochemistry&atitle=Order+Out+of+Chaos%3A+Assembly+of+Ligand+Binding+Sites+in+Heparan+Sulfate&aulast=Selleck&aufirst=Scott+B.&rft_id=info%3Adoi%2F10.1146%2Fannurev.biochem.71.110601.135458&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792348599836737543 |
| author | Esko, Jeffrey D., Selleck, Scott B. |
| author_facet | Esko, Jeffrey D., Selleck, Scott B., Esko, Jeffrey D., Selleck, Scott B. |
| author_sort | esko, jeffrey d. |
| container_issue | 1 |
| container_start_page | 435 |
| container_title | Annual Review of Biochemistry |
| container_volume | 71 |
| description | <jats:p>▪ Abstract Virtually every cell type in metazoan organisms produces heparan sulfate. These complex polysaccharides provide docking sites for numerous protein ligands and receptors involved in diverse biological processes, including growth control, signal transduction, cell adhesion, hemostasis, and lipid metabolism. The binding sites consist of relatively small tracts of variably sulfated glucosamine and uronic acid residues in specific arrangements. Their formation occurs in a tissue-specific fashion, generated by the action of a large family of enzymes involved in nucleotide sugar metabolism, polymer formation (glycosyltransferases), and chain processing (sulfotransferases and an epimerase). New insights into the specificity and organization of the biosynthetic apparatus have emerged from genetic studies of cultured cells, nematodes, fruit flies, zebrafish, rodents, and humans. This review covers recent developments in the field and provides a resource for investigators interested in the incredible diversity and specificity of this process.</jats:p> |
| doi_str_mv | 10.1146/annurev.biochem.71.110601.135458 |
| facet_avail | Online |
| finc_class_facet | Chemie und Pharmazie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE0Ni9hbm51cmV2LmJpb2NoZW0uNzEuMTEwNjAxLjEzNTQ1OA |
| imprint | Annual Reviews, 2002 |
| imprint_str_mv | Annual Reviews, 2002 |
| institution | DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1 |
| issn | 0066-4154, 1545-4509 |
| issn_str_mv | 0066-4154, 1545-4509 |
| language | English |
| last_indexed | 2024-03-01T18:13:45.514Z |
| match_str | esko2002orderoutofchaosassemblyofligandbindingsitesinheparansulfate |
| mega_collection | Annual Reviews (CrossRef) |
| physical | 435-471 |
| publishDate | 2002 |
| publishDateSort | 2002 |
| publisher | Annual Reviews |
| record_format | ai |
| recordtype | ai |
| series | Annual Review of Biochemistry |
| source_id | 49 |
| spelling | Esko, Jeffrey D. Selleck, Scott B. 0066-4154 1545-4509 Annual Reviews Biochemistry http://dx.doi.org/10.1146/annurev.biochem.71.110601.135458 <jats:p>▪ Abstract Virtually every cell type in metazoan organisms produces heparan sulfate. These complex polysaccharides provide docking sites for numerous protein ligands and receptors involved in diverse biological processes, including growth control, signal transduction, cell adhesion, hemostasis, and lipid metabolism. The binding sites consist of relatively small tracts of variably sulfated glucosamine and uronic acid residues in specific arrangements. Their formation occurs in a tissue-specific fashion, generated by the action of a large family of enzymes involved in nucleotide sugar metabolism, polymer formation (glycosyltransferases), and chain processing (sulfotransferases and an epimerase). New insights into the specificity and organization of the biosynthetic apparatus have emerged from genetic studies of cultured cells, nematodes, fruit flies, zebrafish, rodents, and humans. This review covers recent developments in the field and provides a resource for investigators interested in the incredible diversity and specificity of this process.</jats:p> Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate Annual Review of Biochemistry |
| spellingShingle | Esko, Jeffrey D., Selleck, Scott B., Annual Review of Biochemistry, Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate, Biochemistry |
| title | Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate |
| title_full | Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate |
| title_fullStr | Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate |
| title_full_unstemmed | Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate |
| title_short | Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate |
| title_sort | order out of chaos: assembly of ligand binding sites in heparan sulfate |
| title_unstemmed | Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate |
| topic | Biochemistry |
| url | http://dx.doi.org/10.1146/annurev.biochem.71.110601.135458 |