Eintrag weiter verarbeiten
Chloride in Vesicular Trafficking and Function
Gespeichert in:
| Zeitschriftentitel: | Annual Review of Physiology |
|---|---|
| Personen und Körperschaften: | , |
| In: | Annual Review of Physiology, 75, 2013, 1, S. 453-477 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Annual Reviews
|
| Schlagwörter: |
| author_facet |
Stauber, Tobias Jentsch, Thomas J. Stauber, Tobias Jentsch, Thomas J. |
|---|---|
| author |
Stauber, Tobias Jentsch, Thomas J. |
| spellingShingle |
Stauber, Tobias Jentsch, Thomas J. Annual Review of Physiology Chloride in Vesicular Trafficking and Function Physiology |
| author_sort |
stauber, tobias |
| spelling |
Stauber, Tobias Jentsch, Thomas J. 0066-4278 1545-1585 Annual Reviews Physiology http://dx.doi.org/10.1146/annurev-physiol-030212-183702 <jats:p> Luminal acidification is of pivotal importance for the physiology of the secretory and endocytic pathways and its diverse trafficking events. Acidification by the proton-pumping V-ATPase requires charge compensation by counterion currents that are commonly attributed to chloride. The molecular identification of intracellular chloride transporters and the improvement of methodologies for measuring intraorganellar pH and chloride have facilitated the investigation of the physiology of vesicular chloride transport. New data question the requirement of chloride for pH regulation of various organelles and furthermore ascribe functions to chloride that are beyond merely electrically shunting the proton pump. This review surveys the currently established and proposed intracellular chloride transporters and gives an overview of membrane-trafficking steps that are affected by the perturbation of chloride transport. Finally, potential mechanisms of membrane-trafficking modulation by chloride are discussed and put into the context of organellar ion homeostasis in general. </jats:p> Chloride in Vesicular Trafficking and Function Annual Review of Physiology |
| doi_str_mv |
10.1146/annurev-physiol-030212-183702 |
| facet_avail |
Online |
| finc_class_facet |
Biologie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE0Ni9hbm51cmV2LXBoeXNpb2wtMDMwMjEyLTE4MzcwMg |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE0Ni9hbm51cmV2LXBoeXNpb2wtMDMwMjEyLTE4MzcwMg |
| institution |
DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 |
| imprint |
Annual Reviews, 2013 |
| imprint_str_mv |
Annual Reviews, 2013 |
| issn |
0066-4278 1545-1585 |
| issn_str_mv |
0066-4278 1545-1585 |
| language |
English |
| mega_collection |
Annual Reviews (CrossRef) |
| match_str |
stauber2013chlorideinvesiculartraffickingandfunction |
| publishDateSort |
2013 |
| publisher |
Annual Reviews |
| recordtype |
ai |
| record_format |
ai |
| series |
Annual Review of Physiology |
| source_id |
49 |
| title |
Chloride in Vesicular Trafficking and Function |
| title_unstemmed |
Chloride in Vesicular Trafficking and Function |
| title_full |
Chloride in Vesicular Trafficking and Function |
| title_fullStr |
Chloride in Vesicular Trafficking and Function |
| title_full_unstemmed |
Chloride in Vesicular Trafficking and Function |
| title_short |
Chloride in Vesicular Trafficking and Function |
| title_sort |
chloride in vesicular trafficking and function |
| topic |
Physiology |
| url |
http://dx.doi.org/10.1146/annurev-physiol-030212-183702 |
| publishDate |
2013 |
| physical |
453-477 |
| description |
<jats:p> Luminal acidification is of pivotal importance for the physiology of the secretory and endocytic pathways and its diverse trafficking events. Acidification by the proton-pumping V-ATPase requires charge compensation by counterion currents that are commonly attributed to chloride. The molecular identification of intracellular chloride transporters and the improvement of methodologies for measuring intraorganellar pH and chloride have facilitated the investigation of the physiology of vesicular chloride transport. New data question the requirement of chloride for pH regulation of various organelles and furthermore ascribe functions to chloride that are beyond merely electrically shunting the proton pump. This review surveys the currently established and proposed intracellular chloride transporters and gives an overview of membrane-trafficking steps that are affected by the perturbation of chloride transport. Finally, potential mechanisms of membrane-trafficking modulation by chloride are discussed and put into the context of organellar ion homeostasis in general. </jats:p> |
| container_issue |
1 |
| container_start_page |
453 |
| container_title |
Annual Review of Physiology |
| container_volume |
75 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792347092056801286 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T17:49:42.684Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Chloride+in+Vesicular+Trafficking+and+Function&rft.date=2013-02-10&genre=article&issn=1545-1585&volume=75&issue=1&spage=453&epage=477&pages=453-477&jtitle=Annual+Review+of+Physiology&atitle=Chloride+in+Vesicular+Trafficking+and+Function&aulast=Jentsch&aufirst=Thomas+J.&rft_id=info%3Adoi%2F10.1146%2Fannurev-physiol-030212-183702&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792347092056801286 |
| author | Stauber, Tobias, Jentsch, Thomas J. |
| author_facet | Stauber, Tobias, Jentsch, Thomas J., Stauber, Tobias, Jentsch, Thomas J. |
| author_sort | stauber, tobias |
| container_issue | 1 |
| container_start_page | 453 |
| container_title | Annual Review of Physiology |
| container_volume | 75 |
| description | <jats:p> Luminal acidification is of pivotal importance for the physiology of the secretory and endocytic pathways and its diverse trafficking events. Acidification by the proton-pumping V-ATPase requires charge compensation by counterion currents that are commonly attributed to chloride. The molecular identification of intracellular chloride transporters and the improvement of methodologies for measuring intraorganellar pH and chloride have facilitated the investigation of the physiology of vesicular chloride transport. New data question the requirement of chloride for pH regulation of various organelles and furthermore ascribe functions to chloride that are beyond merely electrically shunting the proton pump. This review surveys the currently established and proposed intracellular chloride transporters and gives an overview of membrane-trafficking steps that are affected by the perturbation of chloride transport. Finally, potential mechanisms of membrane-trafficking modulation by chloride are discussed and put into the context of organellar ion homeostasis in general. </jats:p> |
| doi_str_mv | 10.1146/annurev-physiol-030212-183702 |
| facet_avail | Online |
| finc_class_facet | Biologie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE0Ni9hbm51cmV2LXBoeXNpb2wtMDMwMjEyLTE4MzcwMg |
| imprint | Annual Reviews, 2013 |
| imprint_str_mv | Annual Reviews, 2013 |
| institution | DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1 |
| issn | 0066-4278, 1545-1585 |
| issn_str_mv | 0066-4278, 1545-1585 |
| language | English |
| last_indexed | 2024-03-01T17:49:42.684Z |
| match_str | stauber2013chlorideinvesiculartraffickingandfunction |
| mega_collection | Annual Reviews (CrossRef) |
| physical | 453-477 |
| publishDate | 2013 |
| publishDateSort | 2013 |
| publisher | Annual Reviews |
| record_format | ai |
| recordtype | ai |
| series | Annual Review of Physiology |
| source_id | 49 |
| spelling | Stauber, Tobias Jentsch, Thomas J. 0066-4278 1545-1585 Annual Reviews Physiology http://dx.doi.org/10.1146/annurev-physiol-030212-183702 <jats:p> Luminal acidification is of pivotal importance for the physiology of the secretory and endocytic pathways and its diverse trafficking events. Acidification by the proton-pumping V-ATPase requires charge compensation by counterion currents that are commonly attributed to chloride. The molecular identification of intracellular chloride transporters and the improvement of methodologies for measuring intraorganellar pH and chloride have facilitated the investigation of the physiology of vesicular chloride transport. New data question the requirement of chloride for pH regulation of various organelles and furthermore ascribe functions to chloride that are beyond merely electrically shunting the proton pump. This review surveys the currently established and proposed intracellular chloride transporters and gives an overview of membrane-trafficking steps that are affected by the perturbation of chloride transport. Finally, potential mechanisms of membrane-trafficking modulation by chloride are discussed and put into the context of organellar ion homeostasis in general. </jats:p> Chloride in Vesicular Trafficking and Function Annual Review of Physiology |
| spellingShingle | Stauber, Tobias, Jentsch, Thomas J., Annual Review of Physiology, Chloride in Vesicular Trafficking and Function, Physiology |
| title | Chloride in Vesicular Trafficking and Function |
| title_full | Chloride in Vesicular Trafficking and Function |
| title_fullStr | Chloride in Vesicular Trafficking and Function |
| title_full_unstemmed | Chloride in Vesicular Trafficking and Function |
| title_short | Chloride in Vesicular Trafficking and Function |
| title_sort | chloride in vesicular trafficking and function |
| title_unstemmed | Chloride in Vesicular Trafficking and Function |
| topic | Physiology |
| url | http://dx.doi.org/10.1146/annurev-physiol-030212-183702 |